Reactome | PPIB [endoplasmic reticulum lumen]

PPIB [endoplasmic reticulum lumen]

Stable Identifier

R-HSA-1980262

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum lumen

Synonyms

Peptidyl-prolyl cis-trans isomerase B, Cyclophilin B, PPIB_HUMAN, CypB

Locations in the PathwayBrowser

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Extracellular matrix organization (Homo sapiens)

- Collagen formation (Homo sapiens)
  - Collagen biosynthesis and modifying enzymes (Homo sapiens)
    - Collagen prolyl 3-hydroxylase converts 4-Hyp collagen to 3,4-Hyp collagen (Homo sapiens)
      - Prolyl 3-hydroxylases:Fe2+:3,4-Hyp collagen propeptides [endoplasmic reticulum lumen] (Homo sapiens)
        
        Prolyl 3-hydroxylases:Fe2+ [endoplasmic reticulum lumen] (Homo sapiens)
        
        Prolyl 3-hydroxylases [endoplasmic reticulum lumen] (Homo sapiens)
        
        LEPRE1:PPIB:CRTAP [endoplasmic reticulum lumen] (Homo sapiens)
        
        PPIB [endoplasmic reticulum lumen] (Homo sapiens)
      - Prolyl 3-hydroxylases:Fe2+:4-Hyp collagen propeptides [endoplasmic reticulum lumen] (Homo sapiens)
        
        Prolyl 3-hydroxylases:Fe2+ [endoplasmic reticulum lumen] (Homo sapiens)
        
        Prolyl 3-hydroxylases [endoplasmic reticulum lumen] (Homo sapiens)
        
        LEPRE1:PPIB:CRTAP [endoplasmic reticulum lumen] (Homo sapiens)
        
        PPIB [endoplasmic reticulum lumen] (Homo sapiens)
    - P3HB binds 4-Hyp-collagen propeptides (Homo sapiens)
      - Prolyl 3-hydroxylases:Fe2+ [endoplasmic reticulum lumen] (Homo sapiens)
        
        Prolyl 3-hydroxylases [endoplasmic reticulum lumen] (Homo sapiens)
        
        LEPRE1:PPIB:CRTAP [endoplasmic reticulum lumen] (Homo sapiens)
        
        PPIB [endoplasmic reticulum lumen] (Homo sapiens)
      - Prolyl 3-hydroxylases:Fe2+:4-Hyp collagen propeptides [endoplasmic reticulum lumen] (Homo sapiens)
        
        Prolyl 3-hydroxylases:Fe2+ [endoplasmic reticulum lumen] (Homo sapiens)
        
        Prolyl 3-hydroxylases [endoplasmic reticulum lumen] (Homo sapiens)
        
        LEPRE1:PPIB:CRTAP [endoplasmic reticulum lumen] (Homo sapiens)
        
        PPIB [endoplasmic reticulum lumen] (Homo sapiens)
    - Procollagen triple helix formation (Homo sapiens)
      - LEPRE1:PPIB:CRTAP [endoplasmic reticulum lumen] (Homo sapiens)
        
        PPIB [endoplasmic reticulum lumen] (Homo sapiens)
    - Prolyl 3-hydroxylases:Fe2+:3,4-Hyp collagen propeptides dissociates (Homo sapiens)
      - Prolyl 3-hydroxylases:Fe2+ [endoplasmic reticulum lumen] (Homo sapiens)
        
        Prolyl 3-hydroxylases [endoplasmic reticulum lumen] (Homo sapiens)
        
        LEPRE1:PPIB:CRTAP [endoplasmic reticulum lumen] (Homo sapiens)
        
        PPIB [endoplasmic reticulum lumen] (Homo sapiens)
      - Prolyl 3-hydroxylases:Fe2+:3,4-Hyp collagen propeptides [endoplasmic reticulum lumen] (Homo sapiens)
        
        Prolyl 3-hydroxylases:Fe2+ [endoplasmic reticulum lumen] (Homo sapiens)
        
        Prolyl 3-hydroxylases [endoplasmic reticulum lumen] (Homo sapiens)
        
        LEPRE1:PPIB:CRTAP [endoplasmic reticulum lumen] (Homo sapiens)
        
        PPIB [endoplasmic reticulum lumen] (Homo sapiens)

External Reference Information

External Reference

UniProt:P23284 PPIB

Gene Names

PPIB, CYPB

Chain

signal peptide:1-33, chain:34-216

Reference Genes

BioGPS Gene:5479 PPIB

COSMIC (genes):PPIB PPIB

CTD Gene:5479 PPIB

dbSNP Gene:5479 PPIB

ENSEMBL:ENSG00000166794 PPIB

ENSEMBL_homo_sapiens_GENE:ENSG00000166794.6 PPIB

HGNC:9255 PPIB

KEGG Gene (Homo sapiens):5479 PPIB

Monarch:5479 PPIB

NCBI Gene:5479 PPIB

OMIM:123841 PPIB

UCSC:P23284 PPIB

Reference Transcript

RefSeq:NM_000942.4 PPIB

Other Identifiers

11715607_at

11715608_x_at

16810514

200967_PM_at

200967_at

200968_PM_s_at

200968_s_at

35823_at

3628996

3628997

3628999

3629004

3629006

3629008

3629009

3629010

5479

7989619

A_24_P304723

GE61612

GO:0000413

GO:0002376

GO:0003723

GO:0003755

GO:0003824

GO:0005515

GO:0005518

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005737

GO:0005783

GO:0005788

GO:0005790

GO:0005829

GO:0005925

GO:0006457

GO:0016018

GO:0016020

GO:0016853

GO:0030593

GO:0031410

GO:0032991

GO:0034663

GO:0036211

GO:0040018

GO:0042470

GO:0043226

GO:0043231

GO:0044794

GO:0044829

GO:0048471

GO:0048856

GO:0048870

GO:0050821

GO:0051082

GO:0060348

GO:0061077

GO:0070062

GO:0070063

GO:0140096

HMNXSV003008113

ILMN_1703622

M63573_at

PH_hs_0025361

TC15001549.hg

g4758949_3p_at

Participates

as a component of

LEPRE1:PPIB:CRTAP [endoplasmic reticulum lumen] (Homo sapiens)

Other forms of this molecule

PPIB [cytosol]

Cross References

RefSeq

NP_000933.1

OpenTargets

ENSG00000166794

GeneCards

P23284

HPA

ENSG00000166794-PPIB

Ensembl

ENSG00000166794, ENST00000300026, ENSP00000300026

ZINC target

P23284

PRO

P23284

Pharos - Targets

P23284

Orphanet

18826

HMDB Protein

HMDBP10692

PDB

1CYN, 3ICH, 3ICI

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P40855 PEX19	1	PEX19 [cytosol] (R-HSA-3009036)	0.718	6
UniProt:P10636-8 MAPT	3	p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) MAPT-8 [cytosol] (R-HSA-9619519)	0.643	5
UniProt:Q06547-2 GABPB1	1	NRF2 beta-2 subunit [nucleoplasm] (R-HSA-1592200)	0.556	3
UniProt:Q8N9N5 BANP	1	BANP [nucleoplasm] (R-HSA-3221973)	0.556	3
UniProt:P09017 HOXC4	1	HOXC4 [nucleoplasm] (R-HSA-5617871)	0.556	3
UniProt:P02452 COL1A1	20	3x4Hyp-3Hyp-GlcGalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023648) 3x4Hyp-GlcGalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023667) GlcGalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023604) GalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2022999) 3x4Hyp-3Hyp-GalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023559) 3x4Hyp-GalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023582) COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-1650777) 3x4Hyp-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-1985659) 3x4Hyp-3Hyp-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2022446) 3x4Hyp-5Hyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2022951) 3x4Hyp-3Hyp-5Hyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2022954) 5Hyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-1985663) Lysyl-pyrrolyl 5-hydroxylysyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396137) Lysyl-pyrrolyl 3,4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396440) Lysyl-pyrrolyl 4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396471) Lysyl-pyridinolyl 5-hydroxylysyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396464) Lysyl-pyridinolyl 4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396068) Lysyl-pyridinolyl 3,4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396388) Dehydrolysinonorlysyl 4-hydroxyprolyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396315) Dehydrolysinonorlysyl 4-Hyp 5-Gal-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396441)	0.499	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	4

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