Reactome | MCM7 [nucleoplasm]

MCM7 [nucleoplasm]

Stable Identifier

R-HSA-68555

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Mcm7, DNA replication licensing factor MCM7, CDC47 homolog, P1.1-MCM3

Locations in the PathwayBrowser

Expand all

Cell Cycle (Homo sapiens)

- Cell Cycle Checkpoints (Homo sapiens)
  - G2/M Checkpoints (Homo sapiens)
    - Activation of ATR in response to replication stress (Homo sapiens)
      - Activation of claspin (Homo sapiens)
        
        Cdc45:CDK:DDK:Mcm10:Activated claspin:pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM2-7 [nucleoplasm] (Homo sapiens)
        
        MCM7 [nucleoplasm] (Homo sapiens)
        
        Cdc45:CDK:DDK:Mcm10:claspin:pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM2-7 [nucleoplasm] (Homo sapiens)
        
        MCM7 [nucleoplasm] (Homo sapiens)
      - Loading of claspin onto DNA during replication origin firing (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM2-7 [nucleoplasm] (Homo sapiens)
        
        MCM7 [nucleoplasm] (Homo sapiens)
        
        Cdc45:CDK:DDK:Mcm10:claspin:pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM2-7 [nucleoplasm] (Homo sapiens)
        
        MCM7 [nucleoplasm] (Homo sapiens)
- Cell Cycle, Mitotic (Homo sapiens)
  - Mitotic G1 phase and G1/S transition (Homo sapiens)
    - G1/S Transition (Homo sapiens)
      - Activation of the pre-replicative complex (Homo sapiens)
        
        CDK and DDK associate with the Mcm10:pre-replicative complex (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM2-7 [nucleoplasm] (Homo sapiens)
        
        MCM7 [nucleoplasm] (Homo sapiens)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM2-7 [nucleoplasm] (Homo sapiens)
        
        MCM7 [nucleoplasm] (Homo sapiens)
        
        Cdc45 associates with the pre-replicative complex at the origin (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM2-7 [nucleoplasm] (Homo sapiens)
        
        MCM7 [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM2-7 [nucleoplasm] (Homo sapiens)
        
        MCM7 [nucleoplasm] (Homo sapiens)
        
        Cdt1 is displaced from the pre-replicative complex. (Homo sapiens)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM2-7 [nucleoplasm] (Homo sapiens)
        
        MCM7 [nucleoplasm] (Homo sapiens)
        
        MCM10:pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM2-7 [nucleoplasm] (Homo sapiens)
        
        MCM7 [nucleoplasm] (Homo sapiens)
        
        DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM2-7 [nucleoplasm] (Homo sapiens)
        
        MCM7 [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM2-7 [nucleoplasm] (Homo sapiens)
        
        MCM7 [nucleoplasm] (Homo sapiens)
        
        DNA polymerase alpha:primase binds at the origin (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM2-7 [nucleoplasm] (Homo sapiens)
        
        MCM7 [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon binds at the origin (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM2-7 [nucleoplasm] (Homo sapiens)
        
        MCM7 [nucleoplasm] (Homo sapiens)
        
        Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Homo sapiens)
        
        MCM10:pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM2-7 [nucleoplasm] (Homo sapiens)
        
        MCM7 [nucleoplasm] (Homo sapiens)
        
        pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM2-7 [nucleoplasm] (Homo sapiens)
        
        MCM7 [nucleoplasm] (Homo sapiens)
        
        Mcm2-7 is phosphorylated by DDK (Homo sapiens)
        
        MCM2-7 [nucleoplasm] (Homo sapiens)
        
        MCM7 [nucleoplasm] (Homo sapiens)
        
        p-MCM2-7 [nucleoplasm] (Homo sapiens)
        
        MCM2-7 [nucleoplasm] (Homo sapiens)
        
        MCM7 [nucleoplasm] (Homo sapiens)
  - S Phase (Homo sapiens)
    - Synthesis of DNA (Homo sapiens)
      - DNA strand elongation (Homo sapiens)
        
        Unwinding of DNA (Homo sapiens)
        
        MCM2-7 mediated fork unwinding (Homo sapiens)
        
        MCM2-7 [nucleoplasm] (Homo sapiens)
        
        MCM7 [nucleoplasm] (Homo sapiens)
        
        Multiple proteins are localized at replication fork (Homo sapiens)
        
        MCM2-7 [nucleoplasm] (Homo sapiens)
        
        MCM7 [nucleoplasm] (Homo sapiens)
        
        Unwinding complex at replication fork [nucleoplasm] (Homo sapiens)
        
        MCM2-7 [nucleoplasm] (Homo sapiens)
        
        MCM7 [nucleoplasm] (Homo sapiens)
      - Switching of origins to a post-replicative state (Homo sapiens)
        
        Mcm4,6,7 trimer forms and associates with the replication fork (Homo sapiens)
        
        MCM2-7 [nucleoplasm] (Homo sapiens)
        
        MCM7 [nucleoplasm] (Homo sapiens)
        
        Mcm4,6,7 complex [nucleoplasm] (Homo sapiens)
        
        MCM7 [nucleoplasm] (Homo sapiens)
        
        Orc1 removal from chromatin (Homo sapiens)
        
        Orc1 is phosphorylated by cyclin A/CDK2 (Homo sapiens)
        
        pre-replicative complex (Orc1-minus) [nucleoplasm] (Homo sapiens)
        
        MCM2-7 [nucleoplasm] (Homo sapiens)
        
        MCM7 [nucleoplasm] (Homo sapiens)
        
        pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM2-7 [nucleoplasm] (Homo sapiens)
        
        MCM7 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P33993 MCM7

Gene Names

MCM7, CDC47, MCM2

Chain

initiator methionine:1, chain:2-719

Reference Genes

BioGPS Gene:4176 MCM7

COSMIC (genes):MCM7 MCM7

CTD Gene:4176 MCM7

dbSNP Gene:4176 MCM7

ENSEMBL:ENSG00000166508 MCM7

HGNC:6950 MCM7

KEGG Gene (Homo sapiens):4176 MCM7

Monarch:4176 MCM7

NCBI Gene:4176 MCM7

OMIM:600592 MCM7

UCSC:P33993 MCM7

Reference Transcript

Other Identifiers

0002320609

0002650671

0006290292

11729603_a_at

11752905_a_at

11753558_x_at

11755469_x_at

17060412

208795_s_at

210983_s_at

3063686

3063687

3063688

3063689

3063690

3063696

3063697

3063699

3063700

3063701

3063702

3063703

3063704

3063705

3063708

3063709

3063710

3063711

3063712

3063713

3063714

3063715

3063717

3063718

3063719

3063721

3063723

3063724

3063725

3063726

4176

8141395

947_at

A_23_P93690

A_33_P3258223

D55716_at

GE57265

GO:0000082

GO:0000166

GO:0000228

GO:0000278

GO:0000727

GO:0000784

GO:0000785

GO:0003674

GO:0003677

GO:0003678

GO:0003688

GO:0003697

GO:0004386

GO:0005515

GO:0005524

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0005829

GO:0006259

GO:0006260

GO:0006267

GO:0006268

GO:0006270

GO:0006271

GO:0006950

GO:0006974

GO:0007049

GO:0008150

GO:0008283

GO:0009058

GO:0016020

GO:0016787

GO:0016887

GO:0022607

GO:0032991

GO:0034641

GO:0042325

GO:0042493

GO:0042555

GO:0043167

GO:0043226

GO:0051276

GO:0065003

GO:0071310

GO:0071364

GO:0071466

GO:1990518

ILMN_1663195

ILMN_1704702

ILMN_1800654

PH_hs_0020775

TC07001654.hg

g1255616_3p_a_at

g12751125_3p_a_at

Participant Of

hasComponent

Inferred To

mcm7 [nucleoplasm] (Danio rerio)

mcm7 [nucleoplasm] (Schizosaccharomyces pombe)

mcm7 [nucleoplasm] (Xenopus tropicalis)

mcm-7 [nucleoplasm] (Caenorhabditis elegans)

Mcm7 [nucleoplasm] (Drosophila melanogaster)

Mcm7 [nucleoplasm] (Mus musculus)

Mcm7 [nucleoplasm] (Rattus norvegicus)

Ghost homologue of MCM7 [nucleoplasm] (Gallus gallus)

MCM7 [nucleoplasm] (Canis familiaris)

MCM7 [nucleoplasm] (Dictyostelium discoideum)

MCM7 [nucleoplasm] (Plasmodium falciparum)

MCM7 [nucleoplasm] (Saccharomyces cerevisiae)

MCM7 [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

NP_005907.3, NP_877577.1, NP_001265524.1

Target Pathogen

5b354852be737e166372e836

OpenTargets

ENSG00000166508

IntEnz

3.6.4.12

GeneCards

P33993

HPA

ENSG00000166508-MCM7

Ensembl

ENSP00000344006, ENST00000621318, ENSP00000307288, ENST00000303887, ENSP00000346171, ENST00000343023, ENSP00000483795, ENSG00000166508, ENST00000354230

PRO

P33993

HMDB Protein

HMDBP10786

PDB

6XTY, 6XTX

Interactors (14)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P49736 MCM2	1	MCM2 [nucleoplasm] (R-HSA-68557)	0.903	22
UniProt:P01106 MYC	2	PolyUb-MYC [nucleoplasm] (R-HSA-6783169) MYC [nucleoplasm] (R-HSA-188379)	0.731	7
UniProt:P25205 MCM3	1	MCM3 [nucleoplasm] (R-HSA-68546)	0.69	11
UniProt:Q9Y6K9 IKBKG	12	IKBKG [nucleoplasm] (R-HSA-4755413) SUMO1-K277,K309-IKBKG [nucleoplasm] (R-HSA-4755449) IKBKG D406V [cytosol] (R-HSA-5262943) IKBKG L153R [cytosol] (R-HSA-5262879) IKBKG E391* [cytosol] (R-HSA-5262924) IKBKG C417R [cytosol] (R-HSA-5262858) IKBKG R173G [cytosol] (R-HSA-5262966) IKBKG R175P [cytosol] (R-HSA-5262916) IKBKG 420Wro447 [cytosol] (R-HSA-5262978) Ub-285-IKBKG [cytosol] (R-HSA-741397) K63polyUb-NEMO [cytosol] (R-HSA-202530) IKBKG [cytosol] (R-HSA-168108)	0.609	2
UniProt:P33992 MCM5	1	MCM5 [nucleoplasm] (R-HSA-68551)	0.59	8
UniProt:Q08945 SSRP1	1	SSRP1 [nucleoplasm] (R-HSA-65105)	0.564	2
UniProt:Q15742 NAB2	1	NAB2 [nucleoplasm] (R-HSA-9612177)	0.556	3
UniProt:Q08379 GOLGA2	3	GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.556	3
UniProt:P14373 TRIM27	2	TRIM27 [cytosol] (R-HSA-8851002) TRIM27 [nucleoplasm] (R-HSA-2997690)	0.556	3
UniProt:P62805 H4C1	19	SUMO3-HIST1H4 [nucleoplasm] (R-HSA-4570531) HIST1H4A [extracellular region] (R-HSA-977569) SUMO1-HIST1H4 [nucleoplasm] (R-HSA-4570518) 4xAcK-HIST1H4A [nucleoplasm] (R-HSA-427390) AcK5,12-HIST1H4A [nucleoplasm] (R-HSA-212078) AcK17-HIST1H4 [nucleoplasm] (R-HSA-427469) AcK13-HIST1H4 [nucleoplasm] (R-HSA-4568744) AcK6-HIST1H4 [nucleoplasm] (R-HSA-4568748) AcK17-HIST1H4 [nucleoplasm] (R-HSA-4568749) AcK9-HIST1H4 [nucleoplasm] (R-HSA-4568758) Me2aR4-HIST1H4 [nucleoplasm] (R-HSA-5229015) Me2sR4-HIST1H4 [nucleoplasm] (R-HSA-4754243) MeR4-HIST1H4 [nucleoplasm] (R-HSA-4754240) Me3K21-HIST1H4 [nucleoplasm] (R-HSA-5651656) MeK21-HIST1H4 [nucleoplasm] (R-HSA-5423110) AcK-HIST1H4 [nucleoplasm] (R-HSA-3451124) MeK-HIST1H4A [nucleoplasm] (R-HSA-2172676) HIST1H4 [nucleoplasm] (R-HSA-181902) Me2K21-HIST1H4 [nucleoplasm] (R-HSA-5651652)	0.527	3
UniProt:P46527 CDKN1B	8	CDKN1B [nucleoplasm] (R-HSA-182563) CDKN1B [cytosol] (R-HSA-198622) p-T187-CDKN1B [nucleoplasm] (R-HSA-187525) p-Y88-CDKN1B [nucleoplasm] (R-HSA-8942808) p-Y88-CDKN1B [cytosol] (R-HSA-8848438) p-T157-CDKN1B [cytosol] (R-HSA-198629) p-S10 CDKN1B [nucleoplasm] (R-HSA-9632832) p-S10 CDKN1B [cytosol] (R-HSA-9632829)	0.527	2
UniProt:Q9Y468 L3MBTL1	1	L3MBTL1 [nucleoplasm] (R-HSA-3222110)	0.527	2
UniProt:P53350 PLK1	4	p-T210-PLK1 [nucleoplasm] (R-HSA-3002800) PLK1 [nucleoplasm] (R-HSA-156720) p-T210-PLK1 [cytosol] (R-HSA-3000318) PLK1 [cytosol] (R-HSA-164603)	0.524	4
UniProt:P07948 LYN	5	LYN [cytosol] (R-HSA-354251) LYN [plasma membrane] (R-HSA-197943) p-Y396-LYN [plasma membrane] (R-HSA-2454229) MyrG2-PalmC3-LYN [plasma membrane] (R-HSA-9606875) p-Y397-LYN [cytosol] (R-HSA-8942608)	0.499	4

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