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CCT5 [cytosol]
Stable Identifier
R-HSA-390447
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
T-complex protein 1 subunit epsilon (TCP-1-epsilon)
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Protein folding (Homo sapiens)
Chaperonin-mediated protein folding (Homo sapiens)
Association of TriC/CCT with target proteins during biosynthesis (Homo sapiens)
Association of CCT/TriC with other substrates during biosynthesis (unknown chaperone) (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT5 [cytosol] (Homo sapiens)
CCT/TRiC:substrate complex [cytosol] (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT5 [cytosol] (Homo sapiens)
Association of CCT/TriC with sphingosine kinase 1 (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT5 [cytosol] (Homo sapiens)
CCT/TRiC:ADP:Sphingosine kinase 1 [cytosol] (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT5 [cytosol] (Homo sapiens)
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding (Homo sapiens)
ATP binds G-protein beta associated TRiC/CCT (Homo sapiens)
Unfolded G-protein beta subunit:CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT5 [cytosol] (Homo sapiens)
Unfolded G-protein beta subunit:CCT/TRiC:ATP [cytosol] (Homo sapiens)
CCT/TriC:ATP [cytosol] (Homo sapiens)
CCT5 [cytosol] (Homo sapiens)
ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT (Homo sapiens)
Partially folded G-protein beta subunit:CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT5 [cytosol] (Homo sapiens)
Unfolded G-protein beta subunit:CCT/TRiC:ATP [cytosol] (Homo sapiens)
CCT/TriC:ATP [cytosol] (Homo sapiens)
CCT5 [cytosol] (Homo sapiens)
PDCL binds G-protein beta and TRiC/CCT (Homo sapiens)
Partially folded G-protein beta subunit:CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT5 [cytosol] (Homo sapiens)
p-S18,S19,S20,S25-PDCL:Partially folded G-protein beta subunit:CCT/TRiC:ADP [cytosol] (Homo sapiens)
Partially folded G-protein beta subunit:CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT5 [cytosol] (Homo sapiens)
PDCL promotes G-protein beta 5 folding (Homo sapiens)
GNB5:CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT5 [cytosol] (Homo sapiens)
p-S18,S19,S20,S25-PDCL:Partially folded GNB5:CCT/TRiC:ADP [cytosol] (Homo sapiens)
Partially folded GNB5:CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT5 [cytosol] (Homo sapiens)
PDCL releases folded G-beta from TRiC/CCT (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT5 [cytosol] (Homo sapiens)
p-S18,S19,S20,S25-PDCL:Partially folded G-protein beta 1-4:CCT/TRiC:ADP [cytosol] (Homo sapiens)
Partially folded G-protein beta 1-4:CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT5 [cytosol] (Homo sapiens)
RGS proteins bind GNB5 and CCT/TRiC (Homo sapiens)
GNB5:CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT5 [cytosol] (Homo sapiens)
RGS7,RGS9,(RGS6,RGS11):GNB5:CCT/TRiC:ADP [plasma membrane] (Homo sapiens)
GNB5:CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT5 [cytosol] (Homo sapiens)
Release of GNB5:RGS dimers from CCT/TRiC (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT5 [cytosol] (Homo sapiens)
RGS7,RGS9,(RGS6,RGS11):GNB5:CCT/TRiC:ADP [plasma membrane] (Homo sapiens)
GNB5:CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT5 [cytosol] (Homo sapiens)
TRiC/CCT binds unfolded G-protein beta subunit (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT5 [cytosol] (Homo sapiens)
Unfolded G-protein beta subunit:CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT5 [cytosol] (Homo sapiens)
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding (Homo sapiens)
Folding of actin by CCT/TriC (Homo sapiens)
Exchange of ADP for ATP in CCT/TriC:actin complex (Homo sapiens)
CCT/TRiC:ADP:actin [cytosol] (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT5 [cytosol] (Homo sapiens)
CCT/TRiC:ATP:actin [cytosol] (Homo sapiens)
CCT/TriC:ATP [cytosol] (Homo sapiens)
CCT5 [cytosol] (Homo sapiens)
Hydrolysis of ATP and release of folded actin from CCT/TriC (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT5 [cytosol] (Homo sapiens)
CCT/TRiC:ATP:actin [cytosol] (Homo sapiens)
CCT/TriC:ATP [cytosol] (Homo sapiens)
CCT5 [cytosol] (Homo sapiens)
Formation of tubulin folding intermediates by CCT/TriC (Homo sapiens)
ADP is exchanged for ATP in the (ADP:CCT/TriC):tubulin complex (Homo sapiens)
CCT/TRiC:ADP:non-native tubulin [cytosol] (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT5 [cytosol] (Homo sapiens)
CCT/TRiC:ATP:unfolded tubulin complex [cytosol] (Homo sapiens)
CCT5 [cytosol] (Homo sapiens)
Hydrolysis of ATP and release of tubulin folding intermediate from CCT/TriC (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT5 [cytosol] (Homo sapiens)
CCT/TRiC:ATP:unfolded tubulin complex [cytosol] (Homo sapiens)
CCT5 [cytosol] (Homo sapiens)
Prefoldin mediated transfer of substrate to CCT/TriC (Homo sapiens)
Actin/tubulin:prefoldin complex associates with CCT/TriC (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT5 [cytosol] (Homo sapiens)
actin/tubulin-bound CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
CCT5 [cytosol] (Homo sapiens)
Organelle biogenesis and maintenance (Homo sapiens)
Cilium Assembly (Homo sapiens)
Cargo trafficking to the periciliary membrane (Homo sapiens)
BBSome-mediated cargo-targeting to cilium (Homo sapiens)
Formation of the BBSome (Homo sapiens)
BBS/CCT complex [cytosol] (Homo sapiens)
CCT5 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P48643 CCT5
Gene Names
CCT5, CCTE, KIAA0098
Chain
initiator methionine:1, chain:2-541
Reference Genes
BioGPS Gene:22948 CCT5
COSMIC (genes):CCT5 CCT5
CTD Gene:22948 CCT5
dbSNP Gene:22948 CCT5
ENSEMBL:ENSG00000150753 CCT5
HGNC:1618 CCT5
KEGG Gene (Homo sapiens):22948 CCT5
Monarch:22948 CCT5
NCBI Gene:22948 CCT5
OMIM:610150 CCT5
UCSC:P48643 CCT5
Reference Transcript
RefSeq:NM_001306155.1 CCT5
RefSeq:NM_012073.4 CCT5
Other Identifiers
0002120435
11723930_at
11723931_a_at
11747067_a_at
11747068_x_at
11753081_a_at
16983172
208696_at
229068_at
22948
2801527
2801528
2801529
2801530
2801531
2801532
2801536
2801537
2801538
2801539
2801541
2801542
2801543
2801545
2801548
2801549
2801551
2801552
2801553
2801554
2801555
2801556
2801557
2801558
2824817
3494959
3494961
40417_at
46207_at
8104449
A_14_P139927
A_24_P328872
D43950_at
GE63010
GO:0000003
GO:0000166
GO:0003674
GO:0003723
GO:0003729
GO:0003730
GO:0005515
GO:0005524
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005737
GO:0005813
GO:0005815
GO:0005829
GO:0005832
GO:0005856
GO:0005874
GO:0006259
GO:0006457
GO:0006810
GO:0007339
GO:0008092
GO:0008150
GO:0009058
GO:0009615
GO:0016887
GO:0031681
GO:0032212
GO:0032991
GO:0034641
GO:0042592
GO:0043167
GO:0043226
GO:0044183
GO:0044297
GO:0048027
GO:0048487
GO:0050821
GO:0051082
GO:0051276
GO:0070062
GO:1901998
GO:1904851
GO:1904871
GO:1904874
HMNXSV003016463
Hs.62713.0.A1_3p_at
ILMN_1706246
PH_hs_0000217
TC05000072.hg
g10834761_3p_s_at
Participates
as a component of
BBS/CCT complex [cytosol] (Homo sapiens)
CCT/TRiC:ATP:unfolded tubulin complex [cytosol] (Homo sapiens)
CCT/TriC:ATP [cytosol] (Homo sapiens)
CCT/TRiC:ADP [cytosol] (Homo sapiens)
Inferred To
Cct5 [cytosol]
(Mus musculus)
Cct5 [cytosol]
(Rattus norvegicus)
cct-5 [cytosol]
(Caenorhabditis elegans)
CCT5 [cytosol]
(Canis familiaris)
CCT5 [cytosol]
(Drosophila melanogaster)
CCT5 [cytosol]
(Gallus gallus)
CCT5 [cytosol]
(Plasmodium falciparum)
CCT5 [cytosol]
(Saccharomyces cerevisiae)
CCT5 [cytosol]
(Sus scrofa)
cct5 [cytosol]
(Danio rerio)
cct5 [cytosol]
(Dictyostelium discoideum)
cct5 [cytosol]
(Schizosaccharomyces pombe)
Cross References
RefSeq
NP_001293084.1
,
NP_036205.1
OpenTargets
ENSG00000150753
GeneCards
P48643
HPA
ENSG00000150753-CCT5
Ensembl
ENSP00000280326
,
ENSP00000423052
,
ENST00000506600
,
ENST00000280326
,
ENSG00000150753
PRO
P48643
Pharos - Targets
P48643
GlyGen
P48643
Orphanet
15409
PDB
6NR9
,
6QB8
,
6NRD
,
7LUM
,
6NRB
,
5UYZ
,
6NR8
,
7LUP
,
6NRC
,
6NRA
,
5UYX
Interactors (16)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13418 ILK
1
ILK [cytosol]
(R-HSA-432864)
0.725
4
UniProt:P04637 TP53
20
Unfolded TP53 [cytosol]
(R-HSA-6813797)
TP53 [cytosol]
(R-HSA-8869337)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6782509)
polySUMO2,3-K386-TP53 [nucleoplasm]
(R-HSA-2997661)
TP53 F341C [nucleoplasm]
(R-HSA-9726318)
TP53 G334V [nucleoplasm]
(R-HSA-9726126)
TP53 L330H [nucleoplasm]
(R-HSA-9726124)
TP53 A347T [nucleoplasm]
(R-HSA-9726339)
TP53 R337C [nucleoplasm]
(R-HSA-9726118)
TP53 L344P [nucleoplasm]
(R-HSA-9726075)
TP53 L344R [nucleoplasm]
(R-HSA-9726073)
TP53 R337H [nucleoplasm]
(R-HSA-9726169)
TP53 R337P [nucleoplasm]
(R-HSA-9726168)
TP53 L330P [nucleoplasm]
(R-HSA-9726136)
TP53 L348S [nucleoplasm]
(R-HSA-9726366)
TP53 R337L [nucleoplasm]
(R-HSA-9726163)
TP53 K351E [nucleoplasm]
(R-HSA-9726258)
TP53 F338I [nucleoplasm]
(R-HSA-9726358)
TP53 R342P [nucleoplasm]
(R-HSA-9726101)
TP53 L330R [nucleoplasm]
(R-HSA-9726133)
0.659
3
UniProt:Q13547 HDAC1
2
HDAC1 [nucleoplasm]
(R-HSA-205021)
monoSUMO1-K444,K476-HDAC1 [nucleoplasm]
(R-HSA-4616030)
0.643
4
UniProt:Q14164 IKBKE
4
IKBKE [cytosol]
(R-HSA-450225)
p-S172-IKBKE [cytosol]
(R-HSA-450278)
p-S172-IKBKE [nucleoplasm]
(R-HSA-4755521)
monoSUMO1-K231-p-S172-IKBKE [nucleoplasm]
(R-HSA-4755535)
0.564
2
UniProt:P17987 TCP1
1
TCP1 [cytosol]
(R-HSA-390448)
0.564
2
UniProt:O95630 STAMBP
1
STAMBP [cytosol]
(R-HSA-5693063)
0.556
3
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
3
UniProt:Q6NXG1 ESRP1
3
ESRP1(1-606)-p-RAF1(227-648) fusion [cytosol]
(R-HSA-6802523)
ESRP1(1-606)-RAF1(227-648) fusion [cytosol]
(R-HSA-6802312)
ESRP1 [nucleoplasm]
(R-HSA-6803472)
0.556
3
UniProt:O75925 PIAS1
1
PIAS1 [nucleoplasm]
(R-HSA-877307)
0.556
3
UniProt:O00308 WWP2
1
WWP2 [cytosol]
(R-HSA-6807279)
0.556
6
UniProt:P49639 HOXA1
1
HOXA1 [nucleoplasm]
(R-HSA-5617464)
0.556
3
UniProt:Q00535 CDK5
4
CDK5 [nucleoplasm]
(R-HSA-8863586)
p-Y15,S159-CDK5 [nucleoplasm]
(R-HSA-6805249)
p-Y15-CDK5 [cytosol]
(R-HSA-399809)
CDK5 [cytosol]
(R-HSA-180064)
0.527
2
UniProt:O43815 STRN
5
STRN [cytosol]
(R-HSA-9037081)
STRN(1-265)-PDGFRA(580-1089) fusion [cytosol]
(R-HSA-9673902)
p-11Y STRN(1-265)-PDGFRA(580-1089) fusion [cytosol]
(R-HSA-9673908)
STRN(1-137)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9700485)
STRN(1-137)-p-7Y ALK(1058-1620) fusion [cytosol]
(R-HSA-9700467)
0.527
2
UniProt:P06493 CDK1
10
CDK1 [endoplasmic reticulum membrane]
(R-HSA-264424)
p-T14,T161-CDK1 [nucleoplasm]
(R-HSA-170078)
p-T14-CDK1 [nucleoplasm]
(R-HSA-170045)
p-T14-CDK1 [cytosol]
(R-HSA-170064)
CDK1 [nucleoplasm]
(R-HSA-68889)
CDK1 [cytosol]
(R-HSA-170075)
p-T14,Y15,T161-CDK1 [cytosol]
(R-HSA-170071)
p-T161-CDK1 [cytosol]
(R-HSA-157415)
p-T14,Y15,T161-CDK1 [nucleoplasm]
(R-HSA-170074)
p-T161-CDK1 [nucleoplasm]
(R-HSA-170066)
0.527
2
UniProt:Q9BUR4 WRAP53
2
WRAP53 [nucleoplasm]
(R-HSA-418386)
Unfolded WRAP53 [cytosol]
(R-HSA-6813830)
0.527
2
UniProt:P19320 VCAM1
1
VCAM1 [plasma membrane]
(R-HSA-197834)
0.527
4
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