Reactome | CCT5 [cytosol]

CCT5 [cytosol]

Stable Identifier

R-HSA-390447

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

T-complex protein 1 subunit epsilon (TCP-1-epsilon)

Locations in the PathwayBrowser

Expand all

Organelle biogenesis and maintenance (Homo sapiens)

- Cilium Assembly (Homo sapiens)
  - Cargo trafficking to the periciliary membrane (Homo sapiens)
    - BBSome-mediated cargo-targeting to cilium (Homo sapiens)
      - Formation of the BBSome (Homo sapiens)
        
        BBS/CCT complex [cytosol] (Homo sapiens)
        
        CCT5 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P48643 CCT5

Gene Names

CCT5, CCTE, KIAA0098

Chain

initiator methionine:1, chain:2-541

Reference Genes

BioGPS Gene:22948 CCT5

COSMIC (genes):CCT5 CCT5

CTD Gene:22948 CCT5

dbSNP Gene:22948 CCT5

ENSEMBL:ENSG00000150753 CCT5

HGNC:1618 CCT5

KEGG Gene (Homo sapiens):22948 CCT5

Monarch:22948 CCT5

NCBI Gene:22948 CCT5

OMIM:610150 CCT5

UCSC:P48643 CCT5

Reference Transcript

Other Identifiers

0002120435

11723930_at

11723931_a_at

11747067_a_at

11747068_x_at

11753081_a_at

16983172

208696_at

229068_at

22948

2801527

2801528

2801529

2801530

2801531

2801532

2801536

2801537

2801538

2801539

2801541

2801542

2801543

2801545

2801548

2801549

2801551

2801552

2801553

2801554

2801555

2801556

2801557

2801558

2824817

3494959

3494961

40417_at

46207_at

8104449

A_14_P139927

A_24_P328872

D43950_at

GE63010

GO:0000003

GO:0000166

GO:0003674

GO:0003723

GO:0003729

GO:0003730

GO:0005515

GO:0005524

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005737

GO:0005813

GO:0005815

GO:0005829

GO:0005832

GO:0005856

GO:0005874

GO:0006259

GO:0006457

GO:0006810

GO:0007339

GO:0008092

GO:0008150

GO:0009058

GO:0009615

GO:0031681

GO:0032212

GO:0032991

GO:0034641

GO:0042592

GO:0043167

GO:0043226

GO:0044183

GO:0044297

GO:0048027

GO:0048487

GO:0050821

GO:0051082

GO:0051276

GO:0070062

GO:1901998

GO:1904851

GO:1904871

GO:1904874

HMNXSV003016463

Hs.62713.0.A1_3p_at

ILMN_1706246

PH_hs_0000217

TC05000072.hg

g10834761_3p_s_at

Participates

as a component of

Inferred To

Cct5 [cytosol] (Mus musculus)

Cct5 [cytosol] (Rattus norvegicus)

cct-5 [cytosol] (Caenorhabditis elegans)

CCT5 [cytosol] (Canis familiaris)

CCT5 [cytosol] (Drosophila melanogaster)

CCT5 [cytosol] (Gallus gallus)

CCT5 [cytosol] (Plasmodium falciparum)

CCT5 [cytosol] (Saccharomyces cerevisiae)

CCT5 [cytosol] (Sus scrofa)

cct5 [cytosol] (Danio rerio)

cct5 [cytosol] (Dictyostelium discoideum)

cct5 [cytosol] (Schizosaccharomyces pombe)

Cross References

RefSeq

NP_036205.1, NP_001293084.1

Target Pathogen

5b354852be737e166372e8dd

OpenTargets

ENSG00000150753

GeneCards

P48643

HPA

ENSG00000150753-CCT5

Ensembl

ENST00000280326, ENSP00000423052, ENST00000506600, ENSG00000150753, ENSP00000280326

PRO

P48643

Orphanet

15409

PDB

6QB8, 6NRC, 5UYX, 6NRA, 6NR9, 5UYZ, 6NRB, 6NRD, 6NR8

Interactors (15)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13547 HDAC1	2	SUMO1-K444,K476-HDAC1 [nucleoplasm] (R-HSA-4616030) HDAC1 [nucleoplasm] (R-HSA-205021)	0.643	4
UniProt:Q13418 ILK	1	ILK [cytosol] (R-HSA-432864)	0.643	3
UniProt:Q14164 IKBKE	4	p-S172-IKBKE [cytosol] (R-HSA-450278) IKBKE [cytosol] (R-HSA-450225) p-S172-IKBKE [nucleoplasm] (R-HSA-4755521) SUMO1-K231-p-S172-IKBKE [nucleoplasm] (R-HSA-4755535)	0.564	2
UniProt:P17987 TCP1	1	TCP1 [cytosol] (R-HSA-390448)	0.564	2
UniProt:O75925 PIAS1	1	PIAS1 [nucleoplasm] (R-HSA-877307)	0.556	3
UniProt:P49639 HOXA1	1	HOXA1 [nucleoplasm] (R-HSA-5617464)	0.556	3
UniProt:O95630 STAMBP	1	STAMBP [cytosol] (R-HSA-5693063)	0.556	3
UniProt:O00308 WWP2	1	WWP2 [cytosol] (R-HSA-6807279)	0.556	6
UniProt:Q6NXG1 ESRP1	3	p-ESRP1-RAF1 fusion [cytosol] (R-HSA-6802523) ESRP1 [nucleoplasm] (R-HSA-6803472) ESRP1-RAF1 fusion [cytosol] (R-HSA-6802312)	0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	3
UniProt:P04637 TP53	27	TP53 [cytosol] (R-HSA-8869337) Unfolded TP53 [cytosol] (R-HSA-6813797) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) SUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) Me1-K372,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805719) Me2-K373-TP53 [nucleoplasm] (R-HSA-6805759) Me-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222124) MeK-370,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222226) p-S15,S20,Me-R333,Me2-R335,R337-TP53 [nucleoplasm] (R-HSA-6804378) Me2K-370,382-TP53 [nucleoplasm] (R-HSA-3222242) p-S15,S33,S46-TP53 [nucleoplasm] (R-HSA-6805268) p-S15,S392-TP53 [nucleoplasm] (R-HSA-3222015) p-T55-TP53 [nucleoplasm] (R-HSA-6805400) p-S15,S20,S392-TP53 [nucleoplasm] (R-HSA-6805053) p-S15,S20,S269,T284-TP53 [nucleoplasm] (R-HSA-6805133) p-S315-TP53 [nucleoplasm] (R-HSA-6805106) Ac-K120,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805656) Ac-K120,K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805631) Ac-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-5628868) p-S37-TP53 [nucleoplasm] (R-HSA-3239022) PolyUb,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6804446) p-S15,S20,S46-TP53 [nucleoplasm] (R-HSA-6798369) PolyUb-TP53 [nucleoplasm] (R-HSA-6793679) PolyUb-TP53 [cytosol] (R-HSA-6793681) p-S15,S20-TP53 [nucleoplasm] (R-HSA-69683) p-S15-TP53 [nucleoplasm] (R-HSA-69507) TP53 [nucleoplasm] (R-HSA-69488)	0.547	2
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:Q00535 CDK5	4	p-Y15-CDK5 [cytosol] (R-HSA-399809) CDK5 [nucleoplasm] (R-HSA-8863586) CDK5 [cytosol] (R-HSA-180064) p-Y15,S159-CDK5 [nucleoplasm] (R-HSA-6805249)	0.527	2
UniProt:O43815 STRN	3	STRN(1-265)-PDGFRA(580-1089) fusion [cytosol] (R-HSA-9673902) STRN [cytosol] (R-HSA-9037081) p-11Y STRN(1-265)-PDGFRA(580-1089) fusion [cytosol] (R-HSA-9673908)	0.527	2
UniProt:Q9BUR4 WRAP53	2	Unfolded WRAP53 [cytosol] (R-HSA-6813830) WRAP53 [nucleoplasm] (R-HSA-418386)	0.527	2