Reactome | CCT5 [cytosol]

CCT5 [cytosol]

Stable Identifier

R-HSA-390447

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

T-complex protein 1 subunit epsilon (TCP-1-epsilon)

Locations in the PathwayBrowser

Expand all

Organelle biogenesis and maintenance (Homo sapiens)

- Cilium Assembly (Homo sapiens)
  - Cargo trafficking to the periciliary membrane (Homo sapiens)
    - BBSome-mediated cargo-targeting to cilium (Homo sapiens)
      - Formation of the BBSome (Homo sapiens)
        
        BBS/CCT complex [cytosol] (Homo sapiens)
        
        CCT5 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P48643 CCT5

Gene Names

CCT5, CCTE, KIAA0098

Chain

initiator methionine:, chain:2-541

Reference Genes

BioGPS Gene:22948 CCT5

COSMIC (genes):CCT5 CCT5

CTD Gene:22948 CCT5

dbSNP Gene:22948 CCT5

ENSEMBL:ENSG00000150753 CCT5

HGNC:1618 CCT5

KEGG:hsa:22948 CCT5

Monarch:22948 CCT5

NCBI Gene:22948 CCT5

OMIM:610150 CCT5

UCSC:P48643 CCT5

Reference Transcript

Other Identifiers

11723930_at

11723931_a_at

11747067_a_at

11747068_x_at

11753081_a_at

11762828_at

16983172

208696_PM_at

208696_at

229068_PM_at

229068_at

22948

2801527

2801528

2801529

2801530

2801531

2801532

2801536

2801537

2801538

2801539

2801540

2801541

2801542

2801543

2801545

2801546

2801547

2801548

2801549

2801550

2801551

2801552

2801553

2801554

2801555

2801556

2801557

2801558

2824817

3494959

3494961

40417_at

46207_at

8104449

A_14_P111691

A_14_P139927

A_14_P201457

A_24_P328872

D43950_at

GE63010

GO:0003723

GO:0003730

GO:0003824

GO:0005515

GO:0005524

GO:0005737

GO:0005813

GO:0005815

GO:0005829

GO:0005832

GO:0005856

GO:0005874

GO:0006457

GO:0007339

GO:0008092

GO:0009615

GO:0016787

GO:0016887

GO:0031681

GO:0032212

GO:0043226

GO:0044183

GO:0044297

GO:0048027

GO:0048487

GO:0050821

GO:0051082

GO:0051086

GO:0061077

GO:0070062

GO:0140657

GO:0140662

GO:1904871

GO:1904874

HMNXSV003016463

Hs.62713.0.A1_3p_at

ILMN_1706246

PH_hs_0000217

TC05000072.hg

g10834761_3p_s_at

Participates

as a component of

Inferred To

Cct5 [cytosol] (Mus musculus)

Cct5 [cytosol] (Rattus norvegicus)

cct-5 [cytosol] (Caenorhabditis elegans)

CCT5 [cytosol] (Bos taurus)

CCT5 [cytosol] (Canis familiaris)

CCT5 [cytosol] (Drosophila melanogaster)

CCT5 [cytosol] (Gallus gallus)

CCT5 [cytosol] (Plasmodium falciparum)

CCT5 [cytosol] (Saccharomyces cerevisiae)

CCT5 [cytosol] (Sus scrofa)

cct5 [cytosol] (Danio rerio)

cct5 [cytosol] (Dictyostelium discoideum)

cct5 [cytosol] (Schizosaccharomyces pombe)

cct5 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_001293084.1, NP_036205.1

OpenTargets

ENSG00000150753

ENSEMBL

ENSP00000423052, ENSP00000280326, ENST00000280326, ENST00000506600, ENSG00000150753

HPA

ENSG00000150753-CCT5

GeneCards

CCT5

PRO

P48643

Pharos - Targets

P48643

GlyGen

P48643

Orphanet

CCT5

PDB

7NVN, 8I9U, 7TRG, 8SHT, 8SHQ, 7NVM, 8IB8, 6NRB, 8SHN, 8SHO, 7TTT, 8AJM, 8SGC, 8SG9, 8SHL, 8SHD, 8SHE, 7X0A, 7LUM, 7TUB, 8SGQ, 6NR9, 7X7Y, 5UYZ, 7WZ3, 8I1U, 8SFE, 7NVO, 7NVL, 8HKI, 7X0V, 6NRA, 7X0S, 6NRD, 6NRC, 8SHP, 7WU7, 8AJO, 7TTN, 7X3J, 8SG8, 8SHA, 8SHF, 8SHG, 6QB8, 8SH9, 7LUP, 6NR8, 7X3U, 7X6Q, 8SGL, 5UYX, 8SFF

Interactors (30)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P17987 TCP1	1	TCP1 [cytosol] (R-HSA-390448)	0.744	4
UniProt:Q13418 ILK	1	ILK [cytosol] (R-HSA-432864)	0.725	4
UniProt:P67775 PPP2CA	4	PPP2CA [cytosol] (R-HSA-165971) PPP2CA [nucleoplasm] (R-HSA-165978) p-Y307-PPP2CA [cytosol] (R-HSA-8857939) MeL-PPP2CA [nucleoplasm] (R-HSA-8857791)	0.725	4
UniProt:Q13547 HDAC1	2	HDAC1 [nucleoplasm] (R-HSA-205021) monoSUMO1-K444,K476-HDAC1 [nucleoplasm] (R-HSA-4616030)	0.725	5
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.659	3
UniProt:Q13371 PDCL	2	PDCL [cytosol] (R-HSA-6813727) p-S18,S19,S20,S25-PDCL [cytosol] (R-HSA-6814228)	0.643	5
UniProt:Q92466 DDB2	3	DDB2 [nucleoplasm] (R-HSA-53491) PAR-DDB2 [nucleoplasm] (R-HSA-5696654) PolyUb-DDB2 [nucleoplasm] (R-HSA-6783035)	0.643	4
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.615	14
UniProt:Q14164 IKBKE	5	IKBKE [cytosol] (R-HSA-450225) p-S172-IKBKE [cytosol] (R-HSA-450278) K63polyUb-K30,K401-IKBKE [cytosol] (R-HSA-9730436) p-S172-IKBKE [nucleoplasm] (R-HSA-4755521) monoSUMO1-K231-p-S172-IKBKE [nucleoplasm] (R-HSA-4755535)	0.564	2
UniProt:O75925 PIAS1	1	PIAS1 [nucleoplasm] (R-HSA-877307)	0.556	3
UniProt:P49639 HOXA1	1	HOXA1 [nucleoplasm] (R-HSA-5617464)	0.556	3
UniProt:Q6NXG1 ESRP1	3	ESRP1(1-606)-p-RAF1(227-648) fusion [cytosol] (R-HSA-6802523) ESRP1(1-606)-RAF1(227-648) fusion [cytosol] (R-HSA-6802312) ESRP1 [nucleoplasm] (R-HSA-6803472)	0.556	3
UniProt:O95630 STAMBP	1	STAMBP [cytosol] (R-HSA-5693063)	0.556	3
UniProt:Q14457 BECN1	4	BECN1 [cytosol] (R-HSA-1632841) p-S15-BECN1 [cytosol] (R-HSA-5682391) ISG15-K-BECN1 [cytosol] (R-HSA-9853030) K63polyUb-BECN1 [cytosol] (R-HSA-6782989)	0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	3
UniProt:O00308 WWP2	1	WWP2 [cytosol] (R-HSA-6807279)	0.556	6
UniProt:P68400 CSNK2A1	2	CSNK2A1 [cytosol] (R-HSA-201713) CSNK2A1 [nucleoplasm] (R-HSA-6805057)	0.527	2
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400)	0.527	5
UniProt:Q00535 CDK5	4	CDK5 [cytosol] (R-HSA-180064) p-Y15-CDK5 [cytosol] (R-HSA-399809) p-Y15,S159-CDK5 [nucleoplasm] (R-HSA-6805249) CDK5 [nucleoplasm] (R-HSA-8863586)	0.527	2
UniProt:Q9NW82 WDR70	1	WDR70 [nucleoplasm] (R-HSA-9770425)	0.527	2
UniProt:P04049 RAF1	20	p-S338,Y340,Y341-RAF1 [cytosol] (R-HSA-5624465) p-S338-RAF1 [cytosol] (R-HSA-5624469) p-S621-RAF1 S259F [cytosol] (R-HSA-9656124) p-S621-RAF1 S257L [cytosol] (R-HSA-9656121) p-S621-RAF1 P261L [cytosol] (R-HSA-9656106) p-S621-RAF1 N262K [cytosol] (R-HSA-9656101) p-S621-RAF1 P261A [cytosol] (R-HSA-9656103) p-S621-RAF1 P261S [cytosol] (R-HSA-9656113) p-S621-RAF1 S259T [cytosol] (R-HSA-9656130) p-S621-RAF1 P261T [cytosol] (R-HSA-9656115) p-S621-RAF1 P261R [cytosol] (R-HSA-9656110) p-S621-RAF1 S259P [cytosol] (R-HSA-9656127) p-S621-RAF1 T260I [cytosol] (R-HSA-9656136) p-S621-RAF1 T260R [cytosol] (R-HSA-9656139) p-S621-RAF1 V263A [cytosol] (R-HSA-9656148) p-S621-RAF1 R256S [cytosol] (R-HSA-9656119) p-S621-RAF1 T491I [cytosol] (R-HSA-9656143) p-S621-RAF1 D486N [cytosol] (R-HSA-9656088) p-S621-RAF1 S427G [cytosol] (R-HSA-9656134) p-S621-RAF1 L613V [cytosol] (R-HSA-9656098)	0.527	6
UniProt:O43815 STRN	5	STRN [cytosol] (R-HSA-9037081) STRN(1-265)-PDGFRA(580-1089) fusion [cytosol] (R-HSA-9673902) p-11Y-STRN(1-265)-PDGFRA(580-1089) fusion [cytosol] (R-HSA-9673908) STRN(1-137)-ALK(1058-1620) fusion [cytosol] (R-HSA-9700485) STRN(1-137)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9700467)	0.527	2
UniProt:O43684 BUB3	1	BUB3 [cytosol] (R-HSA-141416)	0.527	2
UniProt:Q9BQA1 WDR77	3	WDR77 [cytosol] (R-HSA-191823) pT5-WDR77 [nucleoplasm] (R-HSA-5205602) WDR77 [nucleoplasm] (R-HSA-5205610)	0.527	3
UniProt:Q9BUR4 WRAP53	2	WRAP53 [nucleoplasm] (R-HSA-418386) Unfolded WRAP53 [cytosol] (R-HSA-6813830)	0.527	2
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:P06493 CDK1	11	p-T161-CDK1 [nucleoplasm] (R-HSA-170066) p-T14,Y15,T161-CDK1 [nucleoplasm] (R-HSA-170074) p-T161-CDK1 [cytosol] (R-HSA-157415) p-T14,Y15,T161-CDK1 [cytosol] (R-HSA-170071) CDK1 [cytosol] (R-HSA-170075) CDK1 [nucleoplasm] (R-HSA-68889) p-T14-CDK1 [cytosol] (R-HSA-170064) p-T14-CDK1 [nucleoplasm] (R-HSA-170045) p-T14,T161-CDK1 [nucleoplasm] (R-HSA-170078) p-Y4-CDK1 [cytosol] (R-HSA-9836187) CDK1 [endoplasmic reticulum membrane] (R-HSA-264424)	0.527	2
UniProt:Q15572 TAF1C	1	TAF1C [nucleoplasm] (R-HSA-73687)	0.527	3
UniProt:O15379 HDAC3	2	HDAC3 [nucleoplasm] (R-HSA-442464) Unfolded HDAC3 [cytosol] (R-HSA-6813777)	0.527	4
UniProt:O00628 PEX7	2	PEX7 [peroxisomal membrane] (R-HSA-9033493) PEX7 [cytosol] (R-HSA-9033107)	0.527	3

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