Reactome | SEC24C [cytosol]

SEC24C [cytosol]

Stable Identifier

R-HSA-203988

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Protein transport protein Sec24C, S24C_HUMAN

Locations in the PathwayBrowser

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - ER to Golgi Anterograde Transport (Homo sapiens)
        
        COPII-mediated vesicle transport (Homo sapiens)
        
        BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Homo sapiens)
        
        COPII cargo:receptors [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        SEC23A:SEC24C,D:GOSR2,STX5 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        SEC24C,D [cytosol] (Homo sapiens)
        
        SEC24C [cytosol] (Homo sapiens)
        
        procollagen VII:SEC24C:SEC23A [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        SEC24C [cytosol] (Homo sapiens)
        
        COPII cargo:receptors:v:SNAREs:GOLGA2:GORASP1:USO1 homodimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC23A:SEC24C,D:GOSR2,STX5 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC24C,D [cytosol] (Homo sapiens)
        
        SEC24C [cytosol] (Homo sapiens)
        
        COPII coat binds TRAPPCII and RAB1:GDP (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC23A:SEC24C,D:GOSR2,STX5 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC24C,D [cytosol] (Homo sapiens)
        
        SEC24C [cytosol] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC23A:SEC24C,D:GOSR2,STX5 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC24C,D [cytosol] (Homo sapiens)
        
        SEC24C [cytosol] (Homo sapiens)
        
        CSNK1D phosphorylates SEC23 (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC23A:SEC24C,D:GOSR2,STX5 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC24C,D [cytosol] (Homo sapiens)
        
        SEC24C [cytosol] (Homo sapiens)
        
        COPII cargo:receptors:v:SNAREs:GOLGA2:GORASP1:USO1 homodimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC23A:SEC24C,D:GOSR2,STX5 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC24C,D [cytosol] (Homo sapiens)
        
        SEC24C [cytosol] (Homo sapiens)
        
        Inner coat assembly and cargo binding (Homo sapiens)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23A:SEC24C,D:GOSR2,STX5 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24C,D [cytosol] (Homo sapiens)
        
        SEC24C [cytosol] (Homo sapiens)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23A:SEC24C,D:GOSR2,STX5 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24C,D [cytosol] (Homo sapiens)
        
        SEC24C [cytosol] (Homo sapiens)
        
        SEC23:SEC24 [cytosol] (Homo sapiens)
        
        SEC24 [cytosol] (Homo sapiens)
        
        SEC24C [cytosol] (Homo sapiens)
        
        Loss of SAR1B GTPase (Homo sapiens)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23A:SEC24C,D:GOSR2,STX5 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24C,D [cytosol] (Homo sapiens)
        
        SEC24C [cytosol] (Homo sapiens)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23A:SEC24C,D:GOSR2,STX5 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24C,D [cytosol] (Homo sapiens)
        
        SEC24C [cytosol] (Homo sapiens)
        
        SEC23:SEC24 [cytosol] (Homo sapiens)
        
        SEC24 [cytosol] (Homo sapiens)
        
        SEC24C [cytosol] (Homo sapiens)
        
        Nucleotide exchange on RAB1 (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC23A:SEC24C,D:GOSR2,STX5 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC24C,D [cytosol] (Homo sapiens)
        
        SEC24C [cytosol] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC23A:SEC24C,D:GOSR2,STX5 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC24C,D [cytosol] (Homo sapiens)
        
        SEC24C [cytosol] (Homo sapiens)
        
        PP6 dephosphorylates SEC24 (Homo sapiens)
        
        SEC24 [cytosol] (Homo sapiens)
        
        SEC24C [cytosol] (Homo sapiens)
        
        RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC23A:SEC24C,D:GOSR2,STX5 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC24C,D [cytosol] (Homo sapiens)
        
        SEC24C [cytosol] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC23A:SEC24C,D:GOSR2,STX5 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC24C,D [cytosol] (Homo sapiens)
        
        SEC24C [cytosol] (Homo sapiens)
        
        SEC16 complex binds SAR1B:GTP:SEC23:SEC24 (Homo sapiens)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23A:SEC24C,D:GOSR2,STX5 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24C,D [cytosol] (Homo sapiens)
        
        SEC24C [cytosol] (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23A:SEC24C,D:GOSR2,STX5 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24C,D [cytosol] (Homo sapiens)
        
        SEC24C [cytosol] (Homo sapiens)
        
        SEC31:SEC13 and v-SNARE recruitment (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23A:SEC24C,D:GOSR2,STX5 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24C,D [cytosol] (Homo sapiens)
        
        SEC24C [cytosol] (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer:SEC13:SEC31:SEC23IP:v-SNARES [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23A:SEC24C,D:GOSR2,STX5 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24C,D [cytosol] (Homo sapiens)
        
        SEC24C [cytosol] (Homo sapiens)
        
        Vesicle budding (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer:SEC13:SEC31:SEC23IP:v-SNARES [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23A:SEC24C,D:GOSR2,STX5 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24C,D [cytosol] (Homo sapiens)
        
        SEC24C [cytosol] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC23A:SEC24C,D:GOSR2,STX5 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC24C,D [cytosol] (Homo sapiens)
        
        SEC24C [cytosol] (Homo sapiens)
        
        Cargo concentration in the ER (Homo sapiens)
        
        Inner coat assembly and cargo binding (Homo sapiens)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23A:SEC24C,D:GOSR2,STX5 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24C,D [cytosol] (Homo sapiens)
        
        SEC24C [cytosol] (Homo sapiens)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23A:SEC24C,D:GOSR2,STX5 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24C,D [cytosol] (Homo sapiens)
        
        SEC24C [cytosol] (Homo sapiens)
        
        SEC23:SEC24 [cytosol] (Homo sapiens)
        
        SEC24 [cytosol] (Homo sapiens)
        
        SEC24C [cytosol] (Homo sapiens)
        
        MIA2 and MIA3 load procollagen VII into COPII vesicles (Homo sapiens)
        
        SEC24C [cytosol] (Homo sapiens)
        
        SEC4C,D bind GOSR2 and STX5 (Homo sapiens)
        
        SEC23A:SEC24C,D:GOSR2,STX5 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24C,D [cytosol] (Homo sapiens)
        
        SEC24C [cytosol] (Homo sapiens)
        
        SEC24C,D [cytosol] (Homo sapiens)
        
        SEC24C [cytosol] (Homo sapiens)

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - ER to Golgi Anterograde Transport (Homo sapiens)
    - COPII-mediated vesicle transport (Homo sapiens)
      - BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Homo sapiens)
        
        COPII cargo:receptors [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        SEC23A:SEC24C,D:GOSR2,STX5 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        SEC24C,D [cytosol] (Homo sapiens)
        
        SEC24C [cytosol] (Homo sapiens)
        
        procollagen VII:SEC24C:SEC23A [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        SEC24C [cytosol] (Homo sapiens)
        
        COPII cargo:receptors:v:SNAREs:GOLGA2:GORASP1:USO1 homodimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC23A:SEC24C,D:GOSR2,STX5 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC24C,D [cytosol] (Homo sapiens)
        
        SEC24C [cytosol] (Homo sapiens)
      - COPII coat binds TRAPPCII and RAB1:GDP (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC23A:SEC24C,D:GOSR2,STX5 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC24C,D [cytosol] (Homo sapiens)
        
        SEC24C [cytosol] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC23A:SEC24C,D:GOSR2,STX5 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC24C,D [cytosol] (Homo sapiens)
        
        SEC24C [cytosol] (Homo sapiens)
      - CSNK1D phosphorylates SEC23 (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC23A:SEC24C,D:GOSR2,STX5 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC24C,D [cytosol] (Homo sapiens)
        
        SEC24C [cytosol] (Homo sapiens)
        
        COPII cargo:receptors:v:SNAREs:GOLGA2:GORASP1:USO1 homodimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC23A:SEC24C,D:GOSR2,STX5 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC24C,D [cytosol] (Homo sapiens)
        
        SEC24C [cytosol] (Homo sapiens)
      - Inner coat assembly and cargo binding (Homo sapiens)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23A:SEC24C,D:GOSR2,STX5 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24C,D [cytosol] (Homo sapiens)
        
        SEC24C [cytosol] (Homo sapiens)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23A:SEC24C,D:GOSR2,STX5 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24C,D [cytosol] (Homo sapiens)
        
        SEC24C [cytosol] (Homo sapiens)
        
        SEC23:SEC24 [cytosol] (Homo sapiens)
        
        SEC24 [cytosol] (Homo sapiens)
        
        SEC24C [cytosol] (Homo sapiens)
      - Loss of SAR1B GTPase (Homo sapiens)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23A:SEC24C,D:GOSR2,STX5 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24C,D [cytosol] (Homo sapiens)
        
        SEC24C [cytosol] (Homo sapiens)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23A:SEC24C,D:GOSR2,STX5 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24C,D [cytosol] (Homo sapiens)
        
        SEC24C [cytosol] (Homo sapiens)
        
        SEC23:SEC24 [cytosol] (Homo sapiens)
        
        SEC24 [cytosol] (Homo sapiens)
        
        SEC24C [cytosol] (Homo sapiens)
      - Nucleotide exchange on RAB1 (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC23A:SEC24C,D:GOSR2,STX5 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC24C,D [cytosol] (Homo sapiens)
        
        SEC24C [cytosol] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC23A:SEC24C,D:GOSR2,STX5 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC24C,D [cytosol] (Homo sapiens)
        
        SEC24C [cytosol] (Homo sapiens)
      - PP6 dephosphorylates SEC24 (Homo sapiens)
        
        SEC24 [cytosol] (Homo sapiens)
        
        SEC24C [cytosol] (Homo sapiens)
      - RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC23A:SEC24C,D:GOSR2,STX5 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC24C,D [cytosol] (Homo sapiens)
        
        SEC24C [cytosol] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC23A:SEC24C,D:GOSR2,STX5 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC24C,D [cytosol] (Homo sapiens)
        
        SEC24C [cytosol] (Homo sapiens)
      - SEC16 complex binds SAR1B:GTP:SEC23:SEC24 (Homo sapiens)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23A:SEC24C,D:GOSR2,STX5 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24C,D [cytosol] (Homo sapiens)
        
        SEC24C [cytosol] (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23A:SEC24C,D:GOSR2,STX5 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24C,D [cytosol] (Homo sapiens)
        
        SEC24C [cytosol] (Homo sapiens)
      - SEC31:SEC13 and v-SNARE recruitment (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23A:SEC24C,D:GOSR2,STX5 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24C,D [cytosol] (Homo sapiens)
        
        SEC24C [cytosol] (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer:SEC13:SEC31:SEC23IP:v-SNARES [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23A:SEC24C,D:GOSR2,STX5 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24C,D [cytosol] (Homo sapiens)
        
        SEC24C [cytosol] (Homo sapiens)
      - Vesicle budding (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer:SEC13:SEC31:SEC23IP:v-SNARES [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23A:SEC24C,D:GOSR2,STX5 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24C,D [cytosol] (Homo sapiens)
        
        SEC24C [cytosol] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC23A:SEC24C,D:GOSR2,STX5 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC24C,D [cytosol] (Homo sapiens)
        
        SEC24C [cytosol] (Homo sapiens)
    - Cargo concentration in the ER (Homo sapiens)
      - Inner coat assembly and cargo binding (Homo sapiens)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23A:SEC24C,D:GOSR2,STX5 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24C,D [cytosol] (Homo sapiens)
        
        SEC24C [cytosol] (Homo sapiens)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23A:SEC24C,D:GOSR2,STX5 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24C,D [cytosol] (Homo sapiens)
        
        SEC24C [cytosol] (Homo sapiens)
        
        SEC23:SEC24 [cytosol] (Homo sapiens)
        
        SEC24 [cytosol] (Homo sapiens)
        
        SEC24C [cytosol] (Homo sapiens)
      - MIA2 and MIA3 load procollagen VII into COPII vesicles (Homo sapiens)
        
        SEC24C [cytosol] (Homo sapiens)
      - SEC4C,D bind GOSR2 and STX5 (Homo sapiens)
        
        SEC23A:SEC24C,D:GOSR2,STX5 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24C,D [cytosol] (Homo sapiens)
        
        SEC24C [cytosol] (Homo sapiens)
        
        SEC24C,D [cytosol] (Homo sapiens)
        
        SEC24C [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P53992 SEC24C

Gene Names

SEC24C, KIAA0079

Chain

chain:1-1094

Reference Genes

BioGPS Gene:9632 SEC24C

COSMIC (genes):SEC24C SEC24C

CTD Gene:9632 SEC24C

dbSNP Gene:9632 SEC24C

ENSEMBL:ENSG00000176986 SEC24C

HGNC:10705 SEC24C

KEGG:hsa:9632 SEC24C

Monarch:9632 SEC24C

NCBI Gene:9632 SEC24C

OMIM:607185 SEC24C

UCSC:P53992 SEC24C

Reference Transcript

Other Identifiers

11718639_a_at

11753200_a_at

11755383_a_at

16706082

202361_PM_at

202361_at

3251849

3251850

3251851

3251852

3251853

3251854

3251856

3251857

3251858

3251859

3251860

3251861

3251862

3251863

3251864

3251865

3251866

3251867

3251868

3251869

3251871

3251872

3251873

3251874

3251875

3251876

3251878

3251879

3251881

3251882

3251883

3251885

3251887

3251888

3251889

3251890

3251891

3251892

3251893

3251894

3251895

3251896

3251897

3251898

3251899

3251900

3251901

3251902

3251903

3251904

3251905

3251906

38117_at

7928369

7928395

9632

A_14_P104672

A_14_P200272

A_24_P255338

A_33_P3317123

D38555_at

GE57198

GO:0000149

GO:0001701

GO:0005515

GO:0005737

GO:0005783

GO:0005789

GO:0005829

GO:0006886

GO:0006888

GO:0008270

GO:0012507

GO:0015031

GO:0016020

GO:0016192

GO:0030127

GO:0031410

GO:0043226

GO:0046872

GO:0048856

GO:0070971

GO:0090110

HMNXSV003000764

HMNXSV003043041

ILMN_1676600

ILMN_1706758

PH_hs_0031363

TC10000468.hg

g4758633_3p_at

g4758633_3p_x_at

Participates

as an input of

MIA2 and MIA3 load procollagen VII into COPII vesicles (Homo sapiens)

as a component of

procollagen VII:SEC24C:SEC23A [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)

as a member of

Other forms of this molecule

p-SEC24C [cytosol]

SEC24C [ER to Golgi transport vesicle membrane]

SEC24C [endoplasmic reticulum membrane]

Inferred To

Sec24c [cytosol] (Mus musculus)

Sec24c [cytosol] (Rattus norvegicus)

sec24l [cytosol] (Dictyostelium discoideum)

SEC24C [cytosol] (Bos taurus)

SEC24C [cytosol] (Canis familiaris)

SEC24C [cytosol] (Gallus gallus)

SEC24C [cytosol] (Plasmodium falciparum)

SEC24C [cytosol] (Schizosaccharomyces pombe)

SEC24C [cytosol] (Sus scrofa)

SFB3 [cytosol] (Saccharomyces cerevisiae)

sec-24.1 [cytosol] (Caenorhabditis elegans)

Sec24CD [cytosol] (Drosophila melanogaster)

sec24c [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_004913.2, NP_940999.1

ENSEMBL

ENST00000339365, ENSP00000343405, ENST00000345254, ENSP00000321845

OpenTargets

ENSG00000176986

HPA

ENSG00000176986-SEC24C

PRO

P53992

Pharos - Targets

P53992

GlyGen

P53992

Orphanet

SEC24C

PDB

3EH2, 6PU1, 8CL3

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15436 SEC23A	4	SEC23A [endoplasmic reticulum membrane] (R-HSA-203976) SEC23A [cytosol] (R-HSA-203972) SEC23A [ER to Golgi transport vesicle membrane] (R-HSA-204024) p-S738,T744 SEC23A [cytosol] (R-HSA-5685740)	0.811	8
UniProt:Q15437 SC23B			0.745	5
UniProt:P00540 MOS			0.666	4
UniProt:O43516 WIPF1	1	WIPF1 [cytosol] (R-HSA-201874)	0.556	3
UniProt:P53829 CAF40			0.556	3
UniProt:P20081	1	FPR1 [cytosol] (R-SCE-2026007)	0.556	3
UniProt:Q96PV0 SYNGAP1	1	SYNGAP1 [cytosol] (R-HSA-5658217)	0.527	3
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	7

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