Reactome | FHL2 [nucleoplasm]

FHL2 [nucleoplasm]

Stable Identifier

R-HSA-561161

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Four and a half LIM domains protein 2, FHL2_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q14192 FHL2

Gene Names

FHL2, DRAL, SLIM3

Chain

chain:1-279

Reference Genes

BioGPS Gene:2274 FHL2

COSMIC (genes):FHL2 FHL2

CTD Gene:2274 FHL2

dbSNP Gene:2274 FHL2

ENSEMBL:ENSG00000115641 FHL2

ENSEMBL_homo_sapiens_GENE:ENSG00000115641.19 FHL2

HGNC:3703 FHL2

KEGG Gene (Homo sapiens):2274 FHL2

Monarch:2274 FHL2

NCBI Gene:2274 FHL2

OMIM:602633 FHL2

UCSC:Q14192 FHL2

Reference Transcript

Other Identifiers

11741105_a_at

11741106_x_at

11756134_a_at

16901393

202949_PM_s_at

202949_s_at

2274

2568688

2568689

2568690

2568691

2568692

2568693

2568694

2568695

2568697

2568698

2568700

2568703

2568718

2568721

2568725

2568726

2568727

2568728

2568729

2568730

2568731

2568745

2568746

38422_s_at

8054377

A_23_P108751

A_33_P3362321

A_33_P3362326

GE473731

GE61139

GO:0000122

GO:0001649

GO:0003712

GO:0003714

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005925

GO:0006351

GO:0006355

GO:0006357

GO:0008134

GO:0009725

GO:0012501

GO:0023052

GO:0030018

GO:0030154

GO:0042802

GO:0043066

GO:0043226

GO:0043425

GO:0046872

GO:0048856

GO:0055014

GO:0055015

GO:0060347

GO:0070885

GO:0140110

HMNXSV003012326

HMNXSV003015983

ILMN_1668411

ILMN_1678643

ILMN_2265783

ILMN_2355831

L42176_at

PH_hs_0000884

g4503722_3p_a_at

Participates

as an output of

Expression of FHL2 (Homo sapiens)

Cross References

RefSeq

NP_963851.2, NP_001305826.1, NP_001305824.1, XP_011509100.1, NP_963849.1, NP_001034581.1, NP_001441.4, NP_001305825.1, NP_001305823.1

OpenTargets

ENSG00000115641

HPA

ENSG00000115641-FHL2

GeneCards

Q14192

Ensembl

ENST00000409177, ENST00000358129, ENST00000408995, ENSP00000344266, ENSP00000386665, ENSP00000386633, ENSP00000386892, ENSP00000433567, ENST00000409807, ENST00000393352, ENSP00000322909, ENSP00000377021, ENST00000344213, ENST00000393353, ENSP00000377020, ENSG00000115641, ENST00000530340, ENSP00000350846, ENST00000322142

PRO

Q14192

Pharos - Targets

Q14192

Orphanet

17363

PDB

1X4K, 2MIU, 2D8Z, 1X4L

Interactors (155)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P48380 RFX3			0.904	12
UniProt:Q9UBI6 GNG12	1	GNG12 [plasma membrane] (R-HSA-164367)	0.83	11
UniProt:Q53HC0 CCD92			0.781	10
UniProt:Q9Y5P3 RAI2			0.781	7
UniProt:P14923 JUP	6	JUP [cytosol] (R-HSA-201598) JUP [cornified envelope] (R-HSA-8847739) JUP [specific granule lumen] (R-HSA-6799534) JUP [extracellular region] (R-HSA-6806309) JUP [ficolin-1-rich granule lumen] (R-HSA-6801028) JUP [plasma membrane] (R-HSA-437260)	0.781	7
UniProt:Q9NPI6 DCP1A	1	DCP1A [cytosol] (R-HSA-430043)	0.781	10
UniProt:Q8N9N5 BANP	1	BANP [nucleoplasm] (R-HSA-3221973)	0.743	7
UniProt:Q9NYN1 RASLC			0.742	6
UniProt:Q9NTW7 ZF64B			0.742	8
UniProt:P52739-2 ZNF131			0.718	6
UniProt:Q9H2G9 BLZF1	1	BLZF1 [Golgi membrane] (R-HSA-2422372)	0.718	10
UniProt:Q9BZQ8 NIBA1			0.718	6
UniProt:Q63ZY3 KANK2			0.718	6
UniProt:Q8N9N5-2 BANP			0.718	6
UniProt:P38398 BRCA1	20	polySUMO2,3-BRCA1 [nucleoplasm] (R-HSA-2997624) monoSUMO1-K109-BRCA1 [nucleoplasm] (R-HSA-2997644) BRCA1 M1411T [nucleoplasm] (R-HSA-9702140) BRCA1 M1400V [nucleoplasm] (R-HSA-9701202) BRCA1 L1407P [nucleoplasm] (R-HSA-9702135) BRCA1 Y777* [nucleoplasm] (R-HSA-9702765) BRCA1 S1009* [nucleoplasm] (R-HSA-9702755) BRCA1 P724Lfs12 [nucleoplasm] (R-HSA-9703778) BRCA1 S451 [nucleoplasm] (R-HSA-9702754) BRCA1 S864* [nucleoplasm] (R-HSA-9702752) BRCA1 P897Kfs5 [nucleoplasm] (R-HSA-9703782) BRCA1 N555Kfs17 [nucleoplasm] (R-HSA-9703781) BRCA1 Y1127Sfs6 [nucleoplasm] (R-HSA-9703780) BRCA1 S886Cfs16 [nucleoplasm] (R-HSA-9703802) BRCA1 V83Cfs2 [nucleoplasm] (R-HSA-9703800) BRCA1 T464Pfs11 [nucleoplasm] (R-HSA-9703807) BRCA1 G813Dfs2 [nucleoplasm] (R-HSA-9703549) BRCA1 V340Gfs6 [nucleoplasm] (R-HSA-9703804) BRCA1 Y655* [nucleoplasm] (R-HSA-9702769) BRCA1 W372* [nucleoplasm] (R-HSA-9702768)	0.715	6
UniProt:Q14192 FHL2	1	FHL2 [nucleoplasm] (R-HSA-561161)	0.683	4
UniProt:O75398 DEAF1			0.675	4
UniProt:Q02535 ID3	1	ID3 [nucleoplasm] (R-HSA-9613379)	0.666	4
UniProt:P52747 ZNF143	1	ZNF143 [nucleoplasm] (R-HSA-83837)	0.666	4
UniProt:Q16656 NRF1	1	NRF1 [nucleoplasm] (R-HSA-1592205)	0.666	5
UniProt:Q8IYX7 SAXO1			0.666	4
UniProt:Q2TAL8 QRIC1			0.666	5
UniProt:P05814 CSN2	1	CSN2 [extracellular region] (R-HSA-1254293)	0.666	4
UniProt:Q02086 SP2			0.666	4
UniProt:Q49A26 GLYR1			0.666	4
UniProt:Q96BD5 PHF21A	1	PHF21A [nucleoplasm] (R-HSA-996754)	0.666	5
UniProt:P36508 ZNF76			0.666	4
UniProt:Q12772 SREBF2	5	SREBF2(1-1141) [Golgi membrane] (R-HSA-1655747) SREBF2(1-522) [Golgi membrane] (R-HSA-1655752) SREBF2(1-484) [cytosol] (R-HSA-1655723) SREBF2(1-1141) [endoplasmic reticulum membrane] (R-HSA-1655733) SREBF2(1-484) [nucleoplasm] (R-HSA-1655745)	0.666	5
UniProt:P55347 PKNOX1	1	PKNOX1 [nucleoplasm] (R-HSA-5617496)	0.666	5
UniProt:Q0VD86 INCA1			0.666	5
UniProt:Q9Y4X4 KLF12			0.666	5
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.659	10
UniProt:Q13492 PICALM	3	PICALM [cytosol] (R-HSA-8867593) PICALM [cytoplasmic vesicle membrane] (R-HSA-429812) PICALM [Golgi membrane] (R-HSA-434341)	0.645	8
UniProt:Q12778 FOXO1	5	p-S218-FOXO1 [nucleoplasm] (R-HSA-5692651) Ac-K245,K248,K265-FOXO1 [nucleoplasm] (R-HSA-9626942) FOXO1 [nucleoplasm] (R-HSA-199300) p-T24,S256,S319-FOXO1 [nucleoplasm] (R-HSA-199306) p-T24,S256,S319-FOXO1 [cytosol] (R-HSA-211158)	0.639	8
UniProt:Q9C0C2 TNKS1BP1	1	TNKS1BP1 [cytosol] (R-HSA-430011)	0.623	8
UniProt:B4DE54 B4DE54			0.601	4
UniProt:P49810 PSEN2	2	PSEN2(1-297) [plasma membrane] (R-HSA-201599) PSEN2(298-448) [plasma membrane] (R-HSA-9013329)	0.593	3
UniProt:P51610-1 HCFC1			0.593	5
UniProt:Q06546 GABPA	1	GABPA [nucleoplasm] (R-HSA-1592206)	0.59	2
UniProt:P08047 SP1	1	SP1 [nucleoplasm] (R-HSA-1592223)	0.59	3
UniProt:A1E959 ODAM	1	ODAM [extracellular region] (R-HSA-977149)	0.564	2
UniProt:P98182 ZNF200	1	ZNF200 [nucleoplasm] (R-HSA-974991)	0.556	3
UniProt:Q96JP2 MY15B			0.556	5
UniProt:O95863 SNAI1	1	SNAI1 [nucleoplasm] (R-HSA-2980903)	0.556	3
UniProt:O43699 SIGLEC6	1	SIGLEC6 [plasma membrane] (R-HSA-197708)	0.556	3
UniProt:Q8IVT2 MISP			0.556	3
UniProt:P50150 GNG4	1	GNG4 [plasma membrane] (R-HSA-164350)	0.556	3
UniProt:O14639-4 ABLIM1			0.556	3
UniProt:Q53TS8 CTSRT			0.556	3
UniProt:Q7Z5V6-2 SAXO4			0.556	3
UniProt:Q3KP44 ANR55			0.556	3
UniProt:Q5SW96 LDLRAP1	2	LDLRAP1 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869097) LDLRAP1 [plasma membrane] (R-HSA-171143)	0.556	3
IntAct:EBI-22313194 CCSB ORF ID			0.556	3
UniProt:E9PSE9 E9PSE9			0.556	3
UniProt:O15535 ZSC9			0.556	3
UniProt:Q6ZNG0 ZNF620	1	ZNF620 [nucleoplasm] (R-HSA-2127603)	0.556	3
UniProt:Q8IZP0-5 ABI1			0.556	3
UniProt:Q49A26-4 GLYR1			0.556	3
UniProt:O43189 PHF1	1	PHF1 [nucleoplasm] (R-HSA-5084105)	0.556	3
UniProt:Q9BWG6 SCNM1			0.556	3
UniProt:Q9NQX0 PRDM6			0.556	3
UniProt:O75155 CAND2			0.556	3
UniProt:O75031 HSF2B			0.556	3
IntAct:EBI-22384931 CCSB ORF ID			0.556	3
UniProt:Q49A12 Q49A12			0.556	3
UniProt:Q8TAG6 VEXIN			0.556	3
UniProt:Q5T5P2-6 KIAA1217			0.556	3
UniProt:O94993 SOX30			0.556	3
UniProt:Q9H1P6 CMIP1			0.556	3
IntAct:EBI-22432104 CCSB ORF ID			0.556	3
UniProt:Q9BRR9 ARHGAP9	3	ARHGAP9 [cytosol] (R-HSA-2976572) ARHGAP9 [extracellular region] (R-HSA-6806529) ARHGAP9 [secretory granule lumen] (R-HSA-6804973)	0.556	3
UniProt:P78424 PO6F2			0.556	3
UniProt:Q9UKD1 GMEB2			0.556	3
UniProt:Q86VK4-3 ZNF410			0.556	3
IntAct:EBI-22381398 CCSB ORF ID			0.556	3
UniProt:Q6MZQ0 PRR5L			0.556	3
UniProt:Q9H8W3 F204A			0.556	3
UniProt:Q86UV6-2 TRIM74			0.556	3
UniProt:Q5T3J3 LRIF1			0.556	3
UniProt:P25490 YY1	1	YY1 [nucleoplasm] (R-HSA-4086091)	0.556	5
UniProt:Q8ND83 SLAI1			0.556	3
UniProt:Q658L1 SAXO2			0.556	3
UniProt:Q9NQV5 PRD11			0.556	3
UniProt:Q13422-7 IKZF1			0.556	3
UniProt:Q9UMQ3 BARX2			0.556	3
UniProt:Q96KN3 PKNX2			0.556	3
UniProt:Q04864 REL	2	REL [cytosol] (R-HSA-1168579) REL [nucleoplasm] (R-HSA-1168585)	0.556	3
UniProt:W5RWE1 W5RWE1			0.556	3
UniProt:Q5T749 KPRP	1	KPRP [cytosol] (R-HSA-9839614)	0.556	3
UniProt:Q96D03 DDT4L			0.556	3
IntAct:EBI-22343137 CCSB ORF ID			0.556	3
UniProt:Q5VZL5 ZMYM4			0.556	3
UniProt:Q6IS01 Q6IS01			0.556	3
UniProt:Q6F5E7 TR3N			0.556	3
UniProt:P32780 GTF2H1	1	GTF2H1 [nucleoplasm] (R-HSA-65912)	0.556	3
UniProt:Q8WWY6 MB3L1			0.556	3
UniProt:Q9NQ31 AKIP1			0.556	3
UniProt:Q16656-4 NRF1			0.556	3
UniProt:A0PJW8 DAPL1			0.556	3
UniProt:Q02086-2 SP2			0.556	3
UniProt:Q9C004 SPY4			0.556	3
UniProt:P80217-2 IFI35			0.556	5
UniProt:Q8TDR4 TCP1L			0.556	3
UniProt:Q86UW9 DTX2	1	DTX2 [cytosol] (R-HSA-1604436)	0.556	6
UniProt:Q9UJ55 MAGL2			0.556	3
UniProt:Q14005-2 Q140052			0.556	3
UniProt:A0A0S2Z5G4 A0A0S2Z5G4			0.556	3
UniProt:P33176 KIF5B	3	KIF5B [cytosol] (R-HSA-265181) KIF5B(2-575)-p-7Y-ALK(1063-1620) fusion [cytosol] (R-HSA-9711937) KIF5B(2-575)-ALK(1063-1620) fusion [cytosol] (R-HSA-9711964)	0.556	3
UniProt:P13984 GTF2F2	1	GTF2F2 [nucleoplasm] (R-HSA-65567)	0.556	3
UniProt:P17027 ZNF23	1	ZNF23 [nucleoplasm] (R-HSA-1027395)	0.556	3
UniProt:A2BDD9 A2BDD9			0.556	3
UniProt:Q7Z3K3 POGZ			0.556	3
UniProt:Q0D2K3 RIPP1			0.556	3
UniProt:Q8N9N5-7 BANP			0.556	3
UniProt:O95995 GAS8	1	GAS8 [cytosol] (R-HSA-5633057)	0.556	3
UniProt:Q9NYA3 GOG6A			0.556	3
UniProt:Q9NQ94 A1CF	1	A1CF [nucleoplasm] (R-HSA-3211440)	0.556	3
UniProt:Q8WXI9 GATAD2B	1	GATAD2B [nucleoplasm] (R-HSA-3702079)	0.556	3
UniProt:Q8N720 ZNF655	1	ZNF655 [nucleoplasm] (R-HSA-2127575)	0.556	3
UniProt:Q8TAU3 ZNF417	1	ZNF417 [nucleoplasm] (R-HSA-1247539)	0.556	3
UniProt:Q7L5A3 ATOSB			0.556	3
UniProt:P52739 ZNF131	2	monoSUMO1-K601-ZNF131 [nucleoplasm] (R-HSA-3296152) ZNF131 [nucleoplasm] (R-HSA-3296168)	0.547	3
UniProt:Q9NYA1 SPHK1	4	SPHK1 [nucleoplasm] (R-HSA-9836616) p-S225-SPHK1 [nucleoplasm] (R-HSA-9836613) p-S225-SPHK1 [cytosol] (R-HSA-5218716) SPHK1 [cytosol] (R-HSA-391267)	0.543	7
UniProt:P28908 TNFRSF8	1	TNFRSF8 [plasma membrane] (R-HSA-5668758)	0.527	2
UniProt:Q13011 ECH1	3	ECH1 [mitochondrial matrix] (R-HSA-9838037) ECH1(1-328) [peroxisomal matrix] (R-HSA-9033140) ECH1(1-328) [cytosol] (R-HSA-9033152)	0.527	2
UniProt:P68104 EEF1A1	7	Me3K79-EEF1A1 [cytosol] (R-HSA-8932212) Me3K318-EEF1A1 [cytosol] (R-HSA-8932419) EEF1A1 [secretory granule lumen] (R-HSA-6801479) EEF1A1 [extracellular region] (R-HSA-6806456) EEF1A1 [ficolin-1-rich granule lumen] (R-HSA-6801528) EEF1A1 [cytosol] (R-HSA-156905) EEF1A1 [lysosomal membrane] (R-HSA-9626022)	0.527	3
UniProt:Q9NZN8 CNOT2	1	CNOT2 [cytosol] (R-HSA-429902)	0.527	3
UniProt:Q8WVH0 CPLX3			0.527	2
UniProt:A2VCK2 DCD2B			0.527	2
UniProt:Q7Z6M3 MILR1			0.527	2
UniProt:Q96FX7 TRMT61A	1	TRMT61A [nucleoplasm] (R-HSA-6783477)	0.527	2
UniProt:Q9BRK5 CAB45			0.527	2
UniProt:P60321 NANO2			0.527	2
UniProt:A5YKK6 CNOT1	1	CNOT1 [cytosol] (R-HSA-429892)	0.527	3
UniProt:P47755 CAPZA2	2	CAPZA2 [cytosol] (R-HSA-879448) CAPZA2(265-276) [extracellular region] (R-HSA-879417)	0.527	3
UniProt:Q8TEW6 DOK4	1	DOK4 [cytosol] (R-HSA-8847701)	0.527	2
UniProt:Q9H410 DSN1	3	DSN1 [cytosol] (R-HSA-375308) DSN1 [azurophil granule lumen] (R-HSA-6799218) DSN1 [extracellular region] (R-HSA-6806228)	0.527	2
UniProt:Q9UEU0 VTI1B	2	VTI1B [extracellular region] (R-HSA-8862983) VTI1B [platelet alpha granule lumen] (R-HSA-8862964)	0.527	2
UniProt:P50616 TOB1			0.527	2
UniProt:Q9H3Q1 CDC42EP4	1	CDC42EP4 [cytosol] (R-HSA-9691381)	0.527	2
UniProt:Q9UKZ1 CNOT11	1	CNOT11 [cytosol] (R-HSA-429981)	0.527	3
UniProt:Q8N443 RIBC1			0.527	2
UniProt:P47756 CAPZB	1	CAPZB [cytosol] (R-HSA-879409)	0.527	2
UniProt:P22415 USF1	2	USF1 [nucleoplasm] (R-HSA-9023562) pT153 USF1 [nucleoplasm] (R-HSA-9855887)	0.527	3
UniProt:Q6NZI2 PTRF	2	PTRF [nucleoplasm] (R-HSA-74981) CAVIN1 [plasma membrane] (R-HSA-9714278)	0.527	2
UniProt:Q9Y2G2 CARD8	1	CARD8 [cytosol] (R-HSA-6805447)	0.508	2
UniProt:Q9ERP3 TRI54			0.508	2
UniProt:Q9UBZ9 REV1	1	REV1 [nucleoplasm] (R-HSA-3006726)	0.508	2
UniProt:P05556 ITGB1	2	ITGB1 [endosome membrane] (R-HSA-9611157) ITGB1 [plasma membrane] (R-HSA-57596)	0.508	2
UniProt:P26006-1 ITGA3			0.508	2
UniProt:Q9H9D4 ZN408			0.508	3
UniProt:Q13683 ITGA7	1	ITGA7(34-1181) [plasma membrane] (R-HSA-215940)	0.508	2
UniProt:P10275 AR	4	PolyUb-AR [nucleoplasm] (R-HSA-6782984) monoSUMO1-K386,520-AR [nucleoplasm] (R-HSA-4090320) AR [nucleoplasm] (R-HSA-446174) AR [cytosol] (R-HSA-5618082)	0.508	2
UniProt:P18847 ATF3	1	ATF3 [nucleoplasm] (R-HSA-535543)	0.508	3
UniProt:Q13643 FHL3			0.454	2

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