Reactome | RPL14 [cytosol]

RPL14 [cytosol]

Stable Identifier

R-HSA-72414

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

60S ribosomal protein L14, CAG-ISL 7

Locations in the PathwayBrowser

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Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular response to starvation (Homo sapiens)
    - Response of EIF2AK4 (GCN2) to amino acid deficiency (Homo sapiens)
      - EIF2AK4 (GCN2) binds tRNA (Homo sapiens)
        
        EIF2AK4:GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL14 [cytosol] (Homo sapiens)
        
        tRNA:EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL14 [cytosol] (Homo sapiens)
      - EIF2AK4 (GCN2) dimer autophosphorylates (Homo sapiens)
        
        tRNA:EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL14 [cytosol] (Homo sapiens)
        
        tRNA:p-T899-EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL14 [cytosol] (Homo sapiens)
      - IMPACT binds GCN1 (Homo sapiens)
        
        GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL14 [cytosol] (Homo sapiens)
        
        IMPACT:GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL14 [cytosol] (Homo sapiens)
      - p-T899-EIF2AK4 (GCN2) phosphorylates EIF2AS1 (Homo sapiens)
        
        tRNA:p-T899-EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL14 [cytosol] (Homo sapiens)

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - Influenza Infection (Homo sapiens)
      - Influenza Viral RNA Transcription and Replication (Homo sapiens)
        
        Viral mRNA Translation (Homo sapiens)
        
        Synthesis of PB1-F2 (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL14 [cytosol] (Homo sapiens)
        
        Viral Protein Synthesis (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL14 [cytosol] (Homo sapiens)

Metabolism of RNA (Homo sapiens)

- Nonsense-Mediated Decay (NMD) (Homo sapiens)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Homo sapiens)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Homo sapiens)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL14 [cytosol] (Homo sapiens)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL14 [cytosol] (Homo sapiens)
    - SMG6 hydrolyzes mRNA with premature termination codon (Homo sapiens)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL14 [cytosol] (Homo sapiens)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Homo sapiens)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL14 [cytosol] (Homo sapiens)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL14 [cytosol] (Homo sapiens)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Homo sapiens)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL14 [cytosol] (Homo sapiens)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL14 [cytosol] (Homo sapiens)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Homo sapiens)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Homo sapiens)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL14 [cytosol] (Homo sapiens)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL14 [cytosol] (Homo sapiens)
- rRNA processing (Homo sapiens)
  - rRNA processing in the nucleus and cytosol (Homo sapiens)
    - Major pathway of rRNA processing in the nucleolus and cytosol (Homo sapiens)
      - 12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL14 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P50914 RPL14

Gene Names

RPL14

Chain

initiator methionine:, chain:2-215

Reference Genes

BioGPS Gene:9045 RPL14

COSMIC (genes):RPL14 RPL14

CTD Gene:9045 RPL14

dbSNP Gene:9045 RPL14

ENSEMBL:ENSG00000188846 RPL14

ENSEMBL_homo_sapiens_GENE:ENSG00000188846.14 RPL14

HGNC:10305 RPL14

KEGG Gene (Homo sapiens):9045 RPL14

Monarch:9045 RPL14

NCBI Gene:9045 RPL14

OMIM:617414 RPL14

UCSC:P50914 RPL14

Reference Transcript

Other Identifiers

11746188_s_at

11753524_x_at

11754417_x_at

11755139_x_at

11756764_x_at

11761889_at

16657217

16657219

16657221

16657223

16939495

18670064

18670065

18670068

18670071

18670073

18670074

18670075

200074_PM_s_at

200074_s_at

213588_PM_x_at

213588_x_at

229544_PM_at

229544_at

2618641

2618642

2618644

2618646

2618647

2618649

2618651

2618652

2618653

2618654

2618655

2618656

2618657

2618658

2618659

2618660

2618661

31907_at

3419473

3419475

3419476

78313_at

7893385

7895538

7896253

7956743

8078984

9045

A_23_P18294

A_24_P385012

D87735_at

GE81339

GE87582

GO:0002181

GO:0003723

GO:0003735

GO:0005198

GO:0005515

GO:0005576

GO:0005615

GO:0005737

GO:0005829

GO:0005840

GO:0006364

GO:0006412

GO:0014069

GO:0016020

GO:0022625

GO:0022626

GO:0042254

GO:0042273

GO:0043226

GO:0045202

GO:0045296

GO:0070062

GO:1990904

HMNXSV003038337

Hs.132882.0.A1_3p_at

ILMN_1726460

ILMN_1786242

ILMN_2404850

PH_hs_0010043

TC03000209.hg

TC03002298.hg

g608516_3p_a_at

g608516_3p_x_at

p26808

Participates

as a component of

Inferred To

Rpl14 [cytosol] (Mus musculus)

Rpl14 [cytosol] (Rattus norvegicus)

RPL14 [cytosol] (Bos taurus)

RPL14 [cytosol] (Canis familiaris)

RPL14 [cytosol] (Gallus gallus)

RPL14 [cytosol] (Plasmodium falciparum)

RPL14 [cytosol] (Sus scrofa)

RPL14B [cytosol] (Saccharomyces cerevisiae)

rpl-14 [cytosol] (Caenorhabditis elegans)

RpL14 [cytosol] (Drosophila melanogaster)

rpl14 [cytosol] (Danio rerio)

rpl14 [cytosol] (Dictyostelium discoideum)

rpl14 [cytosol] (Schizosaccharomyces pombe)

rpl14 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_001030168.1, NP_003964.3

OpenTargets

ENSG00000188846

GeneCards

P50914

HPA

ENSG00000188846-RPL14

Ensembl

ENST00000396203, ENSP00000345156, ENST00000338970, ENSP00000379506, ENSG00000188846

PRO

P50914

Pharos - Targets

P50914

PDB

6IP5, 6LU8, 8OJ0, 8FKS, 8JDJ, 6IP6, 4V6X, 8FL7, 6Z6M, 6ZM7, 7BHP, 6LSR, 6OLI, 7F5S, 8FL3, 8FLD, 8FLE, 8FKT, 8FLA, 8Y0X, 6OM0, 6QZP, 8IPX, 6Y0G, 5LKS, 8GLP, 8FL9, 8OJ8, 6Y6X, 8IPD, 8G60, 6Z6L, 8INK, 8JDM, 8FKZ, 8FKY, 8G5Z, 6OLZ, 8G61, 6Z6N, 8INE, 8IFE, 8FLF, 8FL6, 8JDK, 6OLE, 8IE3, 7XNY, 8OJ5, 8INF, 8IDY, 8FKR, 8JDL, 8FKQ, 7XNX, 8IR1, 8FL2, 6IP8, 8FLC, 8FKV, 8IPY, 8FKU, 4UG0, 6ZME, 5T2C, 8G6J, 5AJ0, 6OLG, 6XA1, 6W6L, 8FL4, 6OLF, 6LQM, 8IDT, 8IFD, 6Y2L, 8FKX, 6ZMO, 6LSS, 8FKW, 8FLB, 8QFD, 6ZMI, 7QVP, 8OHD, 6OM7, 8G5Y, 6Y57, 8IR3, 8FL0, 8FKP, 8Y0W

Interactors (20)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P63244 RACK1	1	GNB2L1 [cytosol] (R-HSA-5626956)	0.638	3
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.615	18
UniProt:P10636-8 MAPT	3	p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) MAPT-8 [cytosol] (R-HSA-9619519)	0.569	6
UniProt:Q99558 MAP3K14	5	p-T559-MAP3K14 [cytosol] (R-HSA-5668531) K48polyUb-NIK [cytosol] (R-HSA-5668525) Active NIK [cytosol] (R-HSA-5607646) MAP3K14 [cytosol] (R-HSA-168189) p-MAP3K14 [cytosol] (R-HSA-168187)	0.564	3
UniProt:P62241 RPS8	2	RPS8 [nucleoplasm] (R-HSA-6791203) RPS8 [cytosol] (R-HSA-72385)	0.527	2
UniProt:O60832 DKC1	1	DKC1 [nucleoplasm] (R-HSA-163102)	0.527	3
UniProt:O96028 NSD2	2	p-S102-WHSC1 [nucleoplasm] (R-HSA-5682984) WHSC1 [nucleoplasm] (R-HSA-1183215)	0.527	3
UniProt:Q13427 PPIG	2	PPIG [cytosol] (R-HSA-9728768) PPIG [nucleoplasm] (R-HSA-9769592)	0.527	2
UniProt:O43159 RRP8	1	RRP8 [nucleoplasm] (R-HSA-427524)	0.527	3
UniProt:Q9NW13 RBM28	1	RBM28 [nucleoplasm] (R-HSA-6791192)	0.527	2
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:Q9H5J8 TAF1D	1	TAF1D [nucleoplasm] (R-HSA-5138533)	0.527	2
UniProt:Q8IY81 FTSJ3	1	FTSJ3 [nucleoplasm] (R-HSA-6791507)	0.527	3
UniProt:P06748 NPM1	11	monoSUMO1-K263-NPM1 [nucleoplasm] (R-HSA-4086039) polySUMO2,3-K263-NPM1 [nucleoplasm] (R-HSA-4086056) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm] (R-HSA-9725010) NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol] (R-HSA-9730703) NPM1(1-117)-ALK(1068-1620) fusion [cytosol] (R-HSA-9730697) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9699861) NPM1(1-117)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699834) NPM1 [granular component] (R-HSA-9017702) NPM1 [nucleoplasm] (R-HSA-606320) NPM1 [cytosol] (R-HSA-3008211) p-S4-NPM1 [cytosol] (R-HSA-6801679)	0.527	2
UniProt:Q15361 TTF1	1	TTF1 [nucleoplasm] (R-HSA-74974)	0.527	3
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.525	2
UniProt:Q8WV24 PHLDA1	3	PHLDA1 [nucleoplasm] (R-HSA-9843223) p-S95-PHLDA1 [cytosol] (R-HSA-8853443) PHLDA1 [cytosol] (R-HSA-8853431)	0.508	2
UniProt:Q9NR30 DDX21	1	DDX21 [nucleoplasm] (R-HSA-5250652)	0.483	2
UniProt:P62753 RPS6	4	RPS6 [nucleoplasm] (R-HSA-6790606) 3OHR147-RPS6 [cytosol] (R-HSA-9629876) p-5S-RPS6 [cytosol] (R-HSA-165727) RPS6 [cytosol] (R-HSA-72381)	0.483	2
UniProt:P03372 ESR1	10	p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) p-S167-ESR1 [cytosol] (R-HSA-9841254) Me260-ESR1 [cytosol] (R-HSA-9632177) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.462	2

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