Reactome | SF3B3 [nucleoplasm]

SF3B3 [nucleoplasm]

Stable Identifier

R-HSA-71973

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

SAP130, Splicing factor 3B subunit 3 (Spliceosome associated protein 130) (SAP 130) (SF3b130) (Pre-mRNA splicing factor SF3b 130 kDa subunit), Splicing factor 3B subunit 3, Spliceosome associated protein 130, SAP 130, SF3b130, Pre-mRNA splicing factor SF3b 130 kDa subunit, STAF130

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q15393 SF3B3

Gene Names

SF3B3, KIAA0017, SAP130

Chain

chain:1-1217

Reference Genes

BioGPS Gene:23450 SF3B3

COSMIC (genes):SAP130 SAP130

COSMIC (genes):SF3B3 SF3B3

CTD Gene:23450 SF3B3

dbSNP Gene:23450 SF3B3

ENSEMBL:ENSG00000189091 SF3B3

HGNC:10770 SF3B3

KEGG:hsa:23450 SF3B3

Monarch:23450 SF3B3

NCBI Gene:23450 SF3B3

OMIM:605592 SF3B3

UCSC:Q15393 SF3B3

Reference Transcript

RefSeq:NM_012426.4 SF3B3

Other Identifiers

11722175_a_at

11722176_a_at

11753125_a_at

16820787

16820818

200687_PM_s_at

200687_s_at

200688_PM_at

200688_at

23450

32753_at

3667282

3667283

3667284

3667285

3667286

3667287

3667288

3667289

3667291

3667292

3667293

3667295

3667296

3667297

3667298

3667299

3667300

3667301

3667302

3667303

3667304

3667305

3667306

3667307

3667308

3667310

3667311

3667312

3667313

3667315

3667316

3667318

3667320

3667321

3667322

3667324

3667325

3667326

3667327

3667328

3667329

3667331

3667333

3667334

7997099

A_14_P108655

A_14_P116542

A_14_P123019

A_21_P0000471

A_23_P135914

A_24_P945396

A_32_P173298

D13642_at

GE79989

GO:0000124

GO:0000375

GO:0000398

GO:0003676

GO:0003723

GO:0005515

GO:0005634

GO:0005654

GO:0005681

GO:0005684

GO:0005686

GO:0005689

GO:0005730

GO:0006282

GO:0006355

GO:0006397

GO:0008380

GO:0016071

GO:0030620

GO:0042177

GO:0043226

GO:0043484

GO:0044877

GO:0045893

GO:0065003

GO:0071005

GO:0071013

GO:1903241

HMNXSV003005429

HMNXSV003051189

ILMN_1803110

PH_hs_0011553

PH_hs_0035682

RNA33602|snoRNA_scaRNA_198_87

TC16000579.hg

TC16000580.hg

g11034822_3p_a_at

g285998_3p_at

Participates

as a component of

SF3B [nucleoplasm] (Homo sapiens)

Inferred To

sf3b3 [nucleoplasm] (Danio rerio)

sf3b3 [nucleoplasm] (Dictyostelium discoideum)

sf3b3 [nucleoplasm] (Xenopus tropicalis)

Sf3b3 [nucleoplasm] (Drosophila melanogaster)

Sf3b3 [nucleoplasm] (Mus musculus)

Sf3b3 [nucleoplasm] (Rattus norvegicus)

teg-4 [nucleoplasm] (Caenorhabditis elegans)

SF3B3 [nucleoplasm] (Bos taurus)

SF3B3 [nucleoplasm] (Canis familiaris)

SF3B3 [nucleoplasm] (Gallus gallus)

SF3B3 [nucleoplasm] (Plasmodium falciparum)

SF3B3 [nucleoplasm] (Sus scrofa)

prp12 [nucleoplasm] (Schizosaccharomyces pombe)

Cross References

OpenTargets

ENSG00000189091

ENSEMBL

ENSG00000189091, ENSP00000305790, ENST00000302516

ZINC - FDA approved

SF3B3_HUMAN

ZINC - Substances

SF3B3_HUMAN

ZINC - Biogenic

SF3B3_HUMAN

ZINC target

Q15393

PRO

Q15393

GlyGen

Q15393

PDB

8QZS, 7KTS, 6Y50, 8QXD, 7Q4O, 6FF7, 7Q3L, 6QX9, 8I0U, 8I0T, 6EN4, 8I0P, 5IFE, 8H6E, 5Z57, 7EVN, 7B0I, 8R08, 7OMF, 6AH0, 7ONB, 8H6K, 7B9C, 8QO9, 8R0A, 7ABH, 6AHD, 6FF4, 8I0V, 5Z58, 7DVQ, 5O9Z, 6Y5Q, 8HK1, 7ABG, 7OPI, 8I0S, 7QTT, 8CH6, 7ABI, 8H7G, 8I0R, 7VPX, 5Z56, 7B91, 7Q4P, 7B92, 5ZYA, 8R0B, 8Y7E, 8RM5, 8H6J, 8H6L, 7EVO, 8R09

HPA

ENSG00000189091-SF3B3

GeneCards

SF3B3

Pharos - Targets

Q15393

ZINC - Predictions - Purchasable

SF3B3_HUMAN

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P09661 SNRPA1	1	SNRPA1 [nucleoplasm] (R-HSA-71958)	0.643	5
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.615	12
UniProt:P00441 SOD1	5	SOD1 [cytosol] (R-HSA-350697) 2xHC-SOD1 [cytosol] (R-HSA-3299726) 2xHC-SOD1 [mitochondrial intermembrane space] (R-HSA-3777108) SOD1 [mitochondrial intermembrane space] (R-HSA-3777082) SOD1 [extracellular region] (R-HSA-350705)	0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	3
UniProt:P55212 CASP6	5	CASP6(194-293) [cytosol] (R-HSA-266128) CASP6(24-179) [cytosol] (R-HSA-350313) CASP6(24-179) [nucleoplasm] (R-HSA-352247) CASP6(194-293) [nucleoplasm] (R-HSA-352246) CASP6 (1-293) [cytosol] (R-HSA-6798132)	0.556	3
UniProt:P62304 SNRPE	2	SNRPE [cytosol] (R-HSA-191782) SNRPE [nucleoplasm] (R-HSA-71905)	0.527	3
UniProt:O43143 DHX15	1	DHX15 [nucleoplasm] (R-HSA-5688097)	0.527	2
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.527	3
UniProt:O75533 SF3B1	1	SF3B1 [nucleoplasm] (R-HSA-71968)	0.527	3
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400)	0.527	3
UniProt:P14678 SNRPB	4	2xMe-SNRPB [cytosol] (R-HSA-192218) SNRPB [cytosol] (R-HSA-191798) Me2-R108,R112-SNRPB [nucleoplasm] (R-HSA-192213) SNRPB [nucleoplasm] (R-HSA-71896)	0.527	2
UniProt:P53350 PLK1	4	PLK1 [cytosol] (R-HSA-164603) p-T210-PLK1 [nucleoplasm] (R-HSA-3002800) p-T210-PLK1 [cytosol] (R-HSA-3000318) PLK1 [nucleoplasm] (R-HSA-156720)	0.508	2
UniProt:Q9H9Z2 LIN28A	1	LIN28A [cytosol] (R-HSA-500391)	0.462	3