Reactome | Polyglutamyl-TUBA1C [cytosol]

Polyglutamyl-TUBA1C [cytosol]

Stable Identifier

R-HSA-8867401

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

TUBA1C, Tubulin alpha-1C chain, alpha tubulin 6

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Carboxyterminal post-translational modifications of tubulin (Homo sapiens)
    - CCPs deglutamylate tubulin (Homo sapiens)
      - Polyglutamylated microtubule [cytosol] (Homo sapiens)
        
        Polyglutamyl microtubule protofilament [cytosol] (Homo sapiens)
        
        Polyglutamyl alpha-beta tubulin dimer [cytosol] (Homo sapiens)
        
        Polyglutamyl alpha tubulin:GTP [cytosol] (Homo sapiens)
        
        Polyglutamyl alpha tubulin [cytosol] (Homo sapiens)
        
        Polyglutamyl-TUBA1C [cytosol] (Homo sapiens)
    - Polyglutamylase complex (TTLL1) polyglutamylates alpha subunits of tubulin (Homo sapiens)
      - Polyglutamylated microtubule [cytosol] (Homo sapiens)
        
        Polyglutamyl microtubule protofilament [cytosol] (Homo sapiens)
        
        Polyglutamyl alpha-beta tubulin dimer [cytosol] (Homo sapiens)
        
        Polyglutamyl alpha tubulin:GTP [cytosol] (Homo sapiens)
        
        Polyglutamyl alpha tubulin [cytosol] (Homo sapiens)
        
        Polyglutamyl-TUBA1C [cytosol] (Homo sapiens)
    - TTLLs polyglutamylate tubulin (Homo sapiens)
      - Polyglutamylated microtubule [cytosol] (Homo sapiens)
        
        Polyglutamyl microtubule protofilament [cytosol] (Homo sapiens)
        
        Polyglutamyl alpha-beta tubulin dimer [cytosol] (Homo sapiens)
        
        Polyglutamyl alpha tubulin:GTP [cytosol] (Homo sapiens)
        
        Polyglutamyl alpha tubulin [cytosol] (Homo sapiens)
        
        Polyglutamyl-TUBA1C [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9BQE3 TUBA1C

Gene Names

TUBA1C, TUBA6

Chain

chain:1-449, chain:1-448

Reference Genes

BioGPS Gene:84790 TUBA1C

COSMIC (genes):TUBA1C TUBA1C

CTD Gene:84790 TUBA1C

dbSNP Gene:84790 TUBA1C

ENSEMBL:ENSG00000167553 TUBA1C

ENSEMBL:ENSG00000167553.17 TUBA1C

HGNC:20768 TUBA1C

KEGG Gene (Homo sapiens):84790 TUBA1C

Monarch:84790 TUBA1C

NCBI Gene:84790 TUBA1C

UCSC:Q9BQE3 TUBA1C

Reference Transcript

RefSeq:NM_032704.4 TUBA1C

Other Identifiers

11756670_x_at

11758282_s_at

209251_PM_x_at

209251_x_at

211750_PM_x_at

211750_x_at

212639_PM_x_at

212639_x_at

2872626

3344242

3413809

3413815

3413816

3413819

3413821

3413822

3413823

3413824

3413825

3413826

3413848

3453740

3453741

3453742

3453743

3453748

3453749

3453844

3453845

3453849

7955179

84790

A_23_P128154

A_24_P188071

GE83486

GO:0000166

GO:0000226

GO:0000278

GO:0003824

GO:0005198

GO:0005200

GO:0005515

GO:0005525

GO:0005634

GO:0005737

GO:0005856

GO:0005874

GO:0005881

GO:0007010

GO:0007017

GO:0015630

GO:0016787

GO:0030705

GO:0031982

GO:0043226

GO:0045121

GO:0046872

GO:0051301

HMNXSV003046005

ILMN_1742167

PH_hs_0028341

TC12000363.hg

TC12002866.hg

g13436316_3p_s_at

Participates

as a candidate of

Polyglutamyl alpha tubulin [cytosol] (Homo sapiens)

Other forms of this molecule

AcK-TUBA1C [cytosol]

Ac K40 TUBA1C [axonemal microtubule]

TUBA1C folding intermediate [cytosol]

TUBA1C unfolded [cytosol]

L-isoglutamyl polyglycyl-TUBA1C [cytosol]

TUBA1C(1-448) [cytosol]

TUBA1C [axonemal microtubule]

TUBA1C [cytosol]

Inferred To

tuba1c [cytosol] (Xenopus tropicalis)

Homologues of Polyglutamyl-TUBA1C [cytosol] (Dictyostelium discoideum)

Homologues of Polyglutamyl-TUBA1C [cytosol] (Plasmodium falciparum)

Homologues of Polyglutamyl-TUBA1C [cytosol] (Saccharomyces cerevisiae)

Homologues of Polyglutamyl-TUBA1C [cytosol] (Schizosaccharomyces pombe)

LOC100141266 [cytosol] (Bos taurus)

Polyglutamyl-TUBA1C [cytosol] (Dictyostelium discoideum)

Polyglutamyl-TUBA1C [cytosol] (Gallus gallus)

Polyglutamyl-TUBA1C [cytosol] (Mus musculus)

Polyglutamyl-TUBA1C [cytosol] (Plasmodium falciparum)

Polyglutamyl-TUBA1C [cytosol] (Rattus norvegicus)

Polyglutamyl-TUBA1C [cytosol] (Saccharomyces cerevisiae)

Polyglutamyl-TUBA1C [cytosol] (Schizosaccharomyces pombe)

LOC100127131 [cytosol] (Sus scrofa)

Modified Residues

Name

L-isoglutamyl-polyglutamic acid at unknown position

PsiMod Name

L-isoglutamyl-polyglutamic acid

PsiMod Definition

A protein modification that effectively converts an L-glutamic acid residue to isoglutamyl-polyglutamic acid, forming an isopeptide bond with a polyglutamic acid.

Cross References

RefSeq

NP_116093.1

OpenTargets

ENSG00000167553

HPA

ENSG00000167553-TUBA1C

GeneCards

Q9BQE3

Ensembl

ENST00000301072, ENSG00000167553, ENSP00000301072

PRO

Q9BQE3

Pharos - Targets

Q9BQE3

HMDB Protein

HMDBP08595

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P08670 VIM	11	VIM(2-85) [cytosol] (R-HSA-350264) VIM(86-466) [cytosol] (R-HSA-350294) VIM(430-466) [cytosol] (R-HSA-350316) VIM(2-429) [cytosol] (R-HSA-350317) VIM(260-466) [cytosol] (R-HSA-350314) VIM(2-259) [cytosol] (R-HSA-350323) VIM [cytosol] (R-HSA-201600) Vimentin [late endosome lumen] (R-HSA-9660019) Vimentin [microtubule organizing center] (R-HSA-9657898) Vimentin [cytosol] (R-HSA-9646687) Vimentin [lysosomal lumen] (R-HSA-9659977)	0.556	3
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.527	6

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