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Polyglutamyl-TUBA1C [cytosol]
Stable Identifier
R-HSA-8867401
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
TUBA1C, Tubulin alpha-1C chain, alpha tubulin 6
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Carboxyterminal post-translational modifications of tubulin (Homo sapiens)
CCPs deglutamylate tubulin (Homo sapiens)
Polyglutamylated microtubule [cytosol] (Homo sapiens)
Polyglutamyl microtubule protofilament [cytosol] (Homo sapiens)
Polyglutamyl alpha-beta tubulin dimer [cytosol] (Homo sapiens)
Polyglutamyl alpha tubulin:GTP [cytosol] (Homo sapiens)
Polyglutamyl alpha tubulin [cytosol] (Homo sapiens)
Polyglutamyl-TUBA1C [cytosol] (Homo sapiens)
Polyglutamylase complex (TTLL1) polyglutamylates alpha subunits of tubulin (Homo sapiens)
Polyglutamylated microtubule [cytosol] (Homo sapiens)
Polyglutamyl microtubule protofilament [cytosol] (Homo sapiens)
Polyglutamyl alpha-beta tubulin dimer [cytosol] (Homo sapiens)
Polyglutamyl alpha tubulin:GTP [cytosol] (Homo sapiens)
Polyglutamyl alpha tubulin [cytosol] (Homo sapiens)
Polyglutamyl-TUBA1C [cytosol] (Homo sapiens)
TTLLs polyglutamylate tubulin (Homo sapiens)
Polyglutamylated microtubule [cytosol] (Homo sapiens)
Polyglutamyl microtubule protofilament [cytosol] (Homo sapiens)
Polyglutamyl alpha-beta tubulin dimer [cytosol] (Homo sapiens)
Polyglutamyl alpha tubulin:GTP [cytosol] (Homo sapiens)
Polyglutamyl alpha tubulin [cytosol] (Homo sapiens)
Polyglutamyl-TUBA1C [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9BQE3 TUBA1C
Gene Names
TUBA1C, TUBA6
Chain
chain:1-449, chain:1-448
Reference Genes
BioGPS Gene:84790 TUBA1C
COSMIC (genes):TUBA1C TUBA1C
CTD Gene:84790 TUBA1C
dbSNP Gene:84790 TUBA1C
ENSEMBL:ENSG00000167553 TUBA1C
ENSEMBL_homo_sapiens_GENE:ENSG00000167553.17 TUBA1C
HGNC:20768 TUBA1C
KEGG Gene (Homo sapiens):84790 TUBA1C
Monarch:84790 TUBA1C
NCBI Gene:84790 TUBA1C
UCSC:Q9BQE3 TUBA1C
Reference Transcript
RefSeq:NM_032704.4 TUBA1C
Other Identifiers
11756670_x_at
11758282_s_at
209251_PM_x_at
209251_x_at
211750_PM_x_at
211750_x_at
212639_PM_x_at
212639_x_at
2872626
3344242
3413809
3413815
3413816
3413819
3413821
3413822
3413823
3413824
3413825
3413826
3413848
3453740
3453741
3453742
3453743
3453748
3453749
3453844
3453845
3453849
7955179
84790
A_23_P128154
A_24_P188071
GE83486
GO:0000166
GO:0000226
GO:0000278
GO:0003824
GO:0005198
GO:0005200
GO:0005515
GO:0005525
GO:0005634
GO:0005737
GO:0005856
GO:0005874
GO:0005881
GO:0007010
GO:0007017
GO:0015630
GO:0016787
GO:0030705
GO:0031982
GO:0043226
GO:0046872
GO:0051301
HMNXSV003046005
ILMN_1742167
PH_hs_0028341
TC12000363.hg
TC12002866.hg
g13436316_3p_s_at
Participates
as a candidate of
Polyglutamyl alpha tubulin [cytosol] (Homo sapiens)
Other forms of this molecule
AcK-TUBA1C [cytosol]
Ac K40 TUBA1C [axonemal microtubule]
TUBA1C folding intermediate [cytosol]
TUBA1C unfolded [cytosol]
L-isoglutamyl polyglycyl-TUBA1C [cytosol]
TUBA1C(1-448) [cytosol]
TUBA1C [axonemal microtubule]
TUBA1C [cytosol]
Inferred To
tuba1c [cytosol]
(Xenopus tropicalis)
Homologues of Polyglutamyl-TUBA1C [cytosol]
(Dictyostelium discoideum)
Homologues of Polyglutamyl-TUBA1C [cytosol]
(Plasmodium falciparum)
Polyglutamyl-TUBA1C [cytosol]
(Bos taurus)
Polyglutamyl-TUBA1C [cytosol]
(Dictyostelium discoideum)
Polyglutamyl-TUBA1C [cytosol]
(Mus musculus)
Polyglutamyl-TUBA1C [cytosol]
(Plasmodium falciparum)
Polyglutamyl-TUBA1C [cytosol]
(Rattus norvegicus)
LOC100127131 [cytosol]
(Sus scrofa)
TUBA1C [cytosol]
(Canis familiaris)
Modified Residues
Name
L-isoglutamyl-polyglutamic acid at unknown position
PsiMod Name
L-isoglutamyl-polyglutamic acid
PsiMod Definition
A protein modification that effectively converts an L-glutamic acid residue to isoglutamyl-polyglutamic acid, forming an isopeptide bond with a polyglutamic acid.
Cross References
RefSeq
NP_116093.1
OpenTargets
ENSG00000167553
HPA
ENSG00000167553-TUBA1C
GeneCards
Q9BQE3
Ensembl
ENST00000301072
,
ENSP00000301072
,
ENSG00000167553
PRO
Q9BQE3
Pharos - Targets
Q9BQE3
HMDB Protein
HMDBP08595
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P08670 VIM
11
VIM(2-85) [cytosol]
(R-HSA-350264)
VIM(86-466) [cytosol]
(R-HSA-350294)
VIM(430-466) [cytosol]
(R-HSA-350316)
VIM(2-429) [cytosol]
(R-HSA-350317)
VIM(260-466) [cytosol]
(R-HSA-350314)
VIM(2-259) [cytosol]
(R-HSA-350323)
VIM [cytosol]
(R-HSA-201600)
Vimentin [late endosome lumen]
(R-HSA-9660019)
Vimentin [microtubule organizing center]
(R-HSA-9657898)
Vimentin [cytosol]
(R-HSA-9646687)
Vimentin [lysosomal lumen]
(R-HSA-9659977)
0.556
3
UniProt:P36507 MAP2K2
12
MAP2K2(1-10) [cytosol]
(R-HSA-5211334)
MAP2K2(11-400) [cytosol]
(R-HSA-5211337)
MAP2K2 C125S [cytosol]
(R-HSA-9652070)
MAP2K2 P128Q [cytosol]
(R-HSA-9652082)
MAP2K2 V35M [cytosol]
(R-HSA-9652086)
MAP2K2 Y134C [cytosol]
(R-HSA-9652089)
p-S222,S226-MAP2K2 [cytosol]
(R-HSA-169292)
MAP2K2 [cytosol]
(R-HSA-59504)
p-S,T-MAP2K2 [cytosol]
(R-HSA-109848)
MAP2K2 N126D [cytosol]
(R-HSA-9652079)
MAP2K2 L46F [cytosol]
(R-HSA-9652076)
MAP2K2 F57C [cytosol]
(R-HSA-9652073)
0.527
3
UniProt:P10636-8 MAPT
3
p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
(R-HSA-9836400)
p-S262,S356,S396-MAPT-8 [cytosol]
(R-HSA-9619521)
MAPT-8 [cytosol]
(R-HSA-9619519)
0.527
5
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.527
6
UniProt:Q8N0Z6 TTC5
3
TTC5 [nucleoplasm]
(R-HSA-6804264)
p-S203-TTC5 [nucleoplasm]
(R-HSA-6804261)
p-S203,S221-TTC5 [nucleoplasm]
(R-HSA-6804259)
0.527
2
UniProt:P07437 TUBB
3
TUBB [cytosol]
(R-HSA-9020816)
TUBB [azurophil granule lumen]
(R-HSA-6799370)
TUBB [extracellular region]
(R-HSA-380317)
0.527
2
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