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HSPA5 [endoplasmic reticulum membrane]
Stable Identifier
R-HSA-351315
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
Synonyms
78 kDa glucose-regulated protein, BiP, GRP78
Icon
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Unfolded Protein Response (UPR) (Homo sapiens)
ATF6 (ATF6-alpha) activates chaperones (Homo sapiens)
ATF6 (ATF6-alpha) activates chaperone genes (Homo sapiens)
Expression of BIP (78 kDa Glucose-regulated protein, GRP78, HSPA5) (Homo sapiens)
HSPA5 [endoplasmic reticulum membrane] (Homo sapiens)
ATF6:HSPA5 (ATF6-alpha:BiP) dissociates and HSPA5 binds unfolded protein (Homo sapiens)
ATF6:BiP [endoplasmic reticulum membrane] (Homo sapiens)
HSPA5 [endoplasmic reticulum membrane] (Homo sapiens)
ATF6B (ATF6-beta) activates chaperones (Homo sapiens)
ATF6B:HSPA5 (ATF6-beta:BiP) dissociates and HSPA5 binds unfolded protein (Homo sapiens)
ATP6B:BiP [endoplasmic reticulum membrane] (Homo sapiens)
HSPA5 [endoplasmic reticulum membrane] (Homo sapiens)
IRE1alpha activates chaperones (Homo sapiens)
IRE1:BiP dissociates in response to unfolded protein (Homo sapiens)
IRE1:BiP [endoplasmic reticulum membrane] (Homo sapiens)
HSPA5 [endoplasmic reticulum membrane] (Homo sapiens)
PERK regulates gene expression (Homo sapiens)
Dissociation of PERK:BiP Heterodimer (Homo sapiens)
PERK:BiP [endoplasmic reticulum membrane] (Homo sapiens)
HSPA5 [endoplasmic reticulum membrane] (Homo sapiens)
Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
Response to elevated platelet cytosolic Ca2+ (Homo sapiens)
Platelet degranulation (Homo sapiens)
Release of 78 kDa glucose-regulated protein (Homo sapiens)
HSPA5 [endoplasmic reticulum membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P11021 HSPA5
Gene Names
HSPA5, GRP78
Chain
signal peptide:1-18, chain:19-654
Reference Genes
BioGPS Gene:3309 HSPA5
COSMIC (genes):HSPA5 HSPA5
CTD Gene:3309 HSPA5
dbSNP Gene:3309 HSPA5
ENSEMBL:ENSG00000044574 HSPA5
ENSEMBL_homo_sapiens_GENE:ENSG00000044574.9 HSPA5
HGNC:5238 HSPA5
KEGG Gene (Homo sapiens):3309 HSPA5
Monarch:3309 HSPA5
NCBI Gene:3309 HSPA5
OMIM:138120 HSPA5
Reference Transcript
RefSeq:NM_005347.4 HSPA5
Other Identifiers
11725930_s_at
11725931_at
11725932_a_at
11725933_at
11725934_x_at
11758169_s_at
17098411
211936_PM_at
211936_at
230031_PM_at
230031_at
2331066
2331070
2331074
2331076
2331077
2750337
2750344
2750345
2750346
3225399
3225400
3225401
3225402
3225403
3225404
3225406
3225407
3225408
3225410
3225411
3225413
3225416
3225417
3225418
3225419
3225420
3309
36614_at
47634_at
8164165
A_24_P18190
A_24_P98411
GE86936
GO:0000166
GO:0003824
GO:0005509
GO:0005515
GO:0005524
GO:0005576
GO:0005615
GO:0005634
GO:0005737
GO:0005739
GO:0005783
GO:0005788
GO:0005789
GO:0005793
GO:0005829
GO:0005886
GO:0005925
GO:0006351
GO:0006355
GO:0006457
GO:0006886
GO:0006983
GO:0008180
GO:0009986
GO:0012501
GO:0016020
GO:0016787
GO:0016887
GO:0019899
GO:0019904
GO:0021589
GO:0021680
GO:0021762
GO:0023052
GO:0030163
GO:0030335
GO:0030433
GO:0030496
GO:0030512
GO:0030968
GO:0031072
GO:0031204
GO:0031333
GO:0031398
GO:0031410
GO:0031625
GO:0032991
GO:0034663
GO:0034975
GO:0034976
GO:0035437
GO:0036211
GO:0036503
GO:0042026
GO:0042149
GO:0042470
GO:0043022
GO:0043066
GO:0043226
GO:0043231
GO:0044183
GO:0045296
GO:0045944
GO:0048856
GO:0048870
GO:0051082
GO:0051085
GO:0051087
GO:0051603
GO:0051787
GO:0055085
GO:0060904
GO:0065003
GO:0070062
GO:0071353
GO:0140657
GO:0140662
GO:1903891
GO:1903894
GO:1903895
GO:1903897
HMNXSV003037349
Hs.75410.1.S1_3p_at
Hs.75410.4.A1_3p_at
ILMN_1773865
M19645_at
PH_hs_0023711
TC09001589.hg
Participates
as an input of
Release of 78 kDa glucose-regulated protein (Homo sapiens)
as an output of
Expression of BIP (78 kDa Glucose-regulated protein, GRP78, HSPA5) (Homo sapiens)
as a component of
IRE1:BiP [endoplasmic reticulum membrane] (Homo sapiens)
ATP6B:BiP [endoplasmic reticulum membrane] (Homo sapiens)
ATF6:BiP [endoplasmic reticulum membrane] (Homo sapiens)
PERK:BiP [endoplasmic reticulum membrane] (Homo sapiens)
Other forms of this molecule
HSPA5 [extracellular region]
HSPA5 [endoplasmic reticulum lumen]
HSPA5 [cytosol]
HSPA5 [nucleoplasm]
HSPA5 [lumenal side of endoplasmic reticulum membrane]
Inferred To
hsp-3 [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
hspa5 [endoplasmic reticulum membrane]
(Xenopus tropicalis)
HSPA5 [endoplasmic reticulum membrane]
(Bos taurus)
HSPA5 [endoplasmic reticulum membrane]
(Canis familiaris)
HSPA5 [endoplasmic reticulum membrane]
(Drosophila melanogaster)
HSPA5 [endoplasmic reticulum membrane]
(Gallus gallus)
HSPA5 [endoplasmic reticulum membrane]
(Mus musculus)
HSPA5 [endoplasmic reticulum membrane]
(Rattus norvegicus)
HSPA5 [endoplasmic reticulum membrane]
(Saccharomyces cerevisiae)
HSPA5 [endoplasmic reticulum membrane]
(Schizosaccharomyces pombe)
HSPA5 [endoplasmic reticulum membrane]
(Sus scrofa)
bip2 [endoplasmic reticulum membrane]
(Dictyostelium discoideum)
Cross References
RefSeq
NP_005338.1
Guide to Pharmacology - Targets
3193
OpenTargets
ENSG00000044574
ZINC - Substances
GRP78_HUMAN
ZINC target
P11021
ZINC - Biogenic
GRP78_HUMAN
PRO
P11021
PDB
5E86
,
6DWS
,
3LDP
,
5E85
,
6DFO
,
6ASY
,
3LDL
,
3IUC
,
7N1R
,
5EVZ
,
5F0X
,
3LDN
,
6DFM
,
5E84
,
5EX5
,
6CZ1
,
3LDO
,
6DO2
,
5EXW
,
5EY4
,
5F2R
,
6ZMD
,
5F1X
ZINC - Metabolites
GRP78_HUMAN
IntEnz
3.6.4.10
GeneCards
P11021
HPA
ENSG00000044574-HSPA5
Ensembl
ENSG00000044574
,
ENST00000324460
,
ENSP00000324173
Pharos - Targets
P11021
ZINC - Predictions - Purchasable
GRP78_HUMAN
Interactors (106)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9UBS4 DNAJB11
1
DNAJB11 [endoplasmic reticulum lumen]
(R-HSA-381040)
0.829
5
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.774
25
UniProt:P0DTC2 S
20
S(686-815) [plasma membrane]
(R-COV-9770188)
Spike S2' Fragment [plasma membrane]
(R-COV-9770189)
S1 [plasma membrane]
(R-COV-9769950)
fully glycosylated Spike [plasma membrane]
(R-COV-9733472)
nascent Spike [endoplasmic reticulum lumen]
(R-COV-9694796)
14-sugar N-glycan unfolded Spike [endoplasmic reticulum lumen]
(R-COV-9694459)
Man(9) N-glycan unfolded Spike [endoplasmic reticulum lumen]
(R-COV-9696892)
high-mannose N-glycan unfolded Spike [endoplasmic reticulum lumen]
(R-COV-9696875)
high-mannose N-glycan folded Spike [endoplasmic reticulum lumen]
(R-COV-9696880)
high-mannose N-glycan folded Spike [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9766369)
high-mannose N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9696943)
di-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9696920)
tri-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9697006)
fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9696997)
complex N-glycan-PALM-Spike S2 Fragment [plasma membrane]
(R-COV-9769952)
fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9698330)
fully glycosylated Spike [virion membrane]
(R-COV-9698327)
complex N-glycan-PALM-Spike S1 Fragment [endocytic vesicle membrane]
(R-COV-9694745)
complex N-glycan-PALM-Spike S2 Fragment [endocytic vesicle membrane]
(R-COV-9694343)
complex N-glycan-PALM-Spike S2 Fragment [virion membrane]
(R-COV-9694791)
0.746
8
UniProt:Q9H173 SIL1
0.744
10
UniProt:Q13573 SNW1
1
SNW1 [nucleoplasm]
(R-HSA-351663)
0.742
5
UniProt:Q9BYF1 ACE2
5
ACE2(18-805) [plasma membrane]
(R-HSA-2022344)
ACE2 [endoplasmic reticulum lumen]
(R-HSA-9683474)
glycosylated-ACE2 [endocytic vesicle membrane]
(R-HSA-9686721)
ACE2 [endocytic vesicle membrane]
(R-HSA-9698958)
glycosylated-ACE2 [plasma membrane]
(R-HSA-9683480)
0.722
6
ChEBI:132781 HA15
0.687
8
UniProt:Q9Y4L1 HYOU1
3
HYOU1 [extracellular region]
(R-HSA-3221939)
HYOU1 [endocytic vesicle lumen]
(R-HSA-3221924)
HYOU1 [endoplasmic reticulum lumen]
(R-HSA-535542)
0.669
3
UniProt:P05067 APP
20
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.666
6
UniProt:P04626 ERBB2
20
ERBB2 G309E [plasma membrane]
(R-HSA-9665342)
ERBB2 G309A [plasma membrane]
(R-HSA-9665349)
ERBB2 S310F [plasma membrane]
(R-HSA-9665350)
ERBB2 S310Y [plasma membrane]
(R-HSA-9665344)
p-6Y-ERBB2 G309A [plasma membrane]
(R-HSA-9665381)
p-6Y-ERBB2 G309E [plasma membrane]
(R-HSA-9665382)
p-6Y-ERBB2 S310F [plasma membrane]
(R-HSA-9665379)
p-6Y-ERBB2 S310Y [plasma membrane]
(R-HSA-9665385)
p-Y-ERBB2 L755P [plasma membrane]
(R-HSA-9654268)
p-Y-ERBB2 I767M [plasma membrane]
(R-HSA-9654303)
p-Y-ERBB2 T798I [plasma membrane]
(R-HSA-9654618)
p-Y-ERBB2 Y772_A775dup [plasma membrane]
(R-HSA-9665652)
p-Y-ERBB2 T862A [plasma membrane]
(R-HSA-9654695)
p-Y-ERBB2 T798M [plasma membrane]
(R-HSA-9654615)
p-Y-ERBB2 H878Y [plasma membrane]
(R-HSA-9654833)
p-Y-ERBB2 V777L [plasma membrane]
(R-HSA-9654401)
p-Y-ERBB2 L755S [plasma membrane]
(R-HSA-9654194)
p-Y-ERBB2 V777E [plasma membrane]
(R-HSA-9654397)
p-Y-ERBB2 V777M [plasma membrane]
(R-HSA-9654398)
p-Y-ERBB2 L755M [plasma membrane]
(R-HSA-9654191)
0.659
3
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.659
4
UniProt:P10636-8 MAPT
3
p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
(R-HSA-9836400)
p-S262,S356,S396-MAPT-8 [cytosol]
(R-HSA-9619521)
MAPT-8 [cytosol]
(R-HSA-9619519)
0.643
7
UniProt:O94905 ERLIN2
3
ERLIN2 [endoplasmic reticulum membrane]
(R-HSA-8866520)
EML4(1-186)insVSLKRRIELTVEYPWRCGALSPTSNCRTG-p-8Y-FGFR1(1-822) [plasma membrane]
(R-HSA-8853122)
EML4(1-186)insVSLKRRIELTVEYPWRCGALSPTSNCRTG-FGFR1(1-822) [plasma membrane]
(R-HSA-8853148)
0.643
3
UniProt:Q15691 MAPRE1
1
MAPRE1 [cytosol]
(R-HSA-376240)
0.638
4
UniProt:Q92874 DNSL2
0.623
3
UniProt:P36955 PEDF
0.623
3
UniProt:O75460-1 ERN1
0.612
4
UniProt:Q6E0U4 DMKN
1
DMKN [secretory granule lumen]
(R-HSA-9839542)
0.602
3
UniProt:Q9NZJ5 EIF2AK3
3
EIF2AK3 [endoplasmic reticulum membrane]
(R-HSA-381046)
EIF2AK3(30-144)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9713456)
EIF2AK3(30-144)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9713454)
0.589
4
UniProt:Q96IZ0 PAWR
0.581
8
UniProt:Q62627 PAWR
0.576
4
UniProt:P04049 RAF1
20
p-S338,Y340,Y341-RAF1 [cytosol]
(R-HSA-5624465)
p-S338-RAF1 [cytosol]
(R-HSA-5624469)
p-S621-RAF1 S259F [cytosol]
(R-HSA-9656124)
p-S621-RAF1 S257L [cytosol]
(R-HSA-9656121)
p-S621-RAF1 P261L [cytosol]
(R-HSA-9656106)
p-S621-RAF1 N262K [cytosol]
(R-HSA-9656101)
p-S621-RAF1 P261A [cytosol]
(R-HSA-9656103)
p-S621-RAF1 P261S [cytosol]
(R-HSA-9656113)
p-S621-RAF1 S259T [cytosol]
(R-HSA-9656130)
p-S621-RAF1 P261T [cytosol]
(R-HSA-9656115)
p-S621-RAF1 P261R [cytosol]
(R-HSA-9656110)
p-S621-RAF1 S259P [cytosol]
(R-HSA-9656127)
p-S621-RAF1 T260I [cytosol]
(R-HSA-9656136)
p-S621-RAF1 T260R [cytosol]
(R-HSA-9656139)
p-S621-RAF1 V263A [cytosol]
(R-HSA-9656148)
p-S621-RAF1 R256S [cytosol]
(R-HSA-9656119)
p-S621-RAF1 T491I [cytosol]
(R-HSA-9656143)
p-S621-RAF1 D486N [cytosol]
(R-HSA-9656088)
p-S621-RAF1 S427G [cytosol]
(R-HSA-9656134)
p-S621-RAF1 L613V [cytosol]
(R-HSA-9656098)
0.576
5
UniProt:P29322 EPHA8
2
EPHA8 [plasma membrane]
(R-HSA-2682321)
p-Y610,Y616-EPHA8 [plasma membrane]
(R-HSA-3928350)
0.569
3
UniProt:Q9Y328 NSG2
0.564
2
UniProt:P49184 DNASE1L1
2
DNASE1L1 [extracellular region]
(R-HSA-6806320)
DNASE1L1 [specific granule lumen]
(R-HSA-6799554)
0.564
3
UniProt:Q15084 PDIA6
3
PDIA6 [endoplasmic reticulum membrane]
(R-HSA-535530)
p-PDIA6 [endoplasmic reticulum lumen]
(R-HSA-8957031)
PDIA6 [endoplasmic reticulum lumen]
(R-HSA-3009049)
0.564
2
UniProt:P09544 WNT2
9
WNT2 [extracellular region]
(R-HSA-201690)
N4GlycoAsn-PalmS WNT2 [extracellular exosome]
(R-HSA-3781947)
N4GlycoAsn-PalmS WNT2 [endocytic vesicle membrane]
(R-HSA-3781972)
WNT2 [endoplasmic reticulum lumen]
(R-HSA-3238284)
N4GlycoAsn-WNT2 [endoplasmic reticulum lumen]
(R-HSA-3238226)
N4GlycoAsn-PalmS WNT2 [endoplasmic reticulum lumen]
(R-HSA-3238340)
N4GlycoAsn-PalmS WNT2 [Golgi lumen]
(R-HSA-3247819)
N4GlycoAsn-PalmS WNT2 [extracellular region]
(R-HSA-3247825)
N4GlycoAsn-PalmS WNT2 [plasma membrane]
(R-HSA-3247827)
0.564
2
UniProt:P14625 HSP90B1
4
HSP90B1 [endocytic vesicle lumen]
(R-HSA-3221623)
HSP90B1 [extracellular region]
(R-HSA-3221653)
p-HSP90B1 [endoplasmic reticulum lumen]
(R-HSA-8957016)
HSP90B1 [endoplasmic reticulum lumen]
(R-HSA-981545)
0.564
2
UniProt:P61619 SEC61A1
2
SEC61A1 [endoplasmic reticulum membrane]
(R-HSA-444591)
SEC61A1 [phagocytic vesicle membrane]
(R-HSA-1236813)
0.558
3
UniProt:Q9UHI5 SLC7A8
1
SLC7A8 [plasma membrane]
(R-HSA-352156)
0.556
3
UniProt:Q13404 UBE2V1
1
UBE2V1 [cytosol]
(R-HSA-205753)
0.556
3
UniProt:Q9ULD4-2 Q9ULD42
0.556
3
UniProt:Q6PF05 TT23L
0.556
3
UniProt:Q15486 GUSP1
0.556
3
UniProt:Q91YW3
5
Dnajc3 [extracellular region]
(R-MMU-6806239)
Dnajc3 [azurophil granule lumen]
(R-MMU-6799146)
Dnajc3 [cytosol]
(R-MMU-448199)
phospho-Dnajc3 [endoplasmic reticulum lumen]
(R-MMU-8956975)
Dnajc3 [endoplasmic reticulum lumen]
(R-MMU-448201)
0.544
2
UniProt:P58166 INHBE
1
INHBE [extracellular region]
(R-HSA-1449700)
0.527
2
UniProt:Q9BTY2 FUCA2
4
FUCA2 [extracellular region]
(R-HSA-6806227)
FUCA2 [azurophil granule lumen]
(R-HSA-6798772)
p-FUCA2 [endoplasmic reticulum lumen]
(R-HSA-8957005)
FUCA2 [endoplasmic reticulum lumen]
(R-HSA-8956727)
0.527
2
UniProt:P13497 BMP1
1
BMP1 [extracellular region]
(R-HSA-2002393)
0.527
2
UniProt:P05111 INHA
1
INHA [extracellular region]
(R-HSA-1449702)
0.527
2
UniProt:O60513 B4GALT4
1
B4GALT4 [Golgi membrane]
(R-HSA-975911)
0.527
2
UniProt:Q77M19 Q77M19
0.527
2
UniProt:P0DPA2 VSIG8
0.527
2
UniProt:Q6XE38 SG1D4
0.527
2
UniProt:Q96DN2 VWCE
0.527
2
UniProt:Q86YC3 LRC33
0.527
2
UniProt:Q8NG41 NPB
2
NPB(25-48) [extracellular region]
(R-HSA-374794)
NPB(25-53) [extracellular region]
(R-HSA-374790)
0.527
2
UniProt:O95968 SG1D1
0.527
3
UniProt:Q92905 COPS5
2
COPS5 [nucleoplasm]
(R-HSA-5697019)
COPS5 [cytosol]
(R-HSA-416963)
0.527
2
UniProt:Q8IV13 CCNJL
0.527
4
UniProt:P07307 ASGR2
1
PALM-C54,58-ASGR2 [plasma membrane]
(R-HSA-8855706)
0.527
2
UniProt:Q92598 HSPH1
3
HSPH1 [cytosol]
(R-HSA-3299412)
HSPH1 [endocytic vesicle lumen]
(R-HSA-3221904)
HSPH1 [extracellular region]
(R-HSA-3221883)
0.527
2
UniProt:Q96S86 HPLN3
0.527
2
UniProt:P49286 MTNR1B
1
MTNR1B [plasma membrane]
(R-HSA-419349)
0.527
2
UniProt:O96009 NAPSA
1
NAPSA [multivesicular body lumen]
(R-HSA-5684975)
0.527
2
UniProt:Q9UKU9 ANGL2
0.527
2
UniProt:Q14392 LRC32
0.527
2
UniProt:Q17R55 F187B
0.527
2
UniProt:Q9H6X2 ANTXR1
0.527
3
UniProt:Q7Z4N8 P4HA3
1
P4HA3 [endoplasmic reticulum lumen]
(R-HSA-2980915)
0.527
2
UniProt:Q99592 ZBT18
0.527
2
UniProt:Q8IW92 GLB1L2
1
GLB1L2 [lysosomal lumen]
(R-HSA-9840308)
0.527
2
UniProt:P48039 MTNR1A
1
MTNR1A [plasma membrane]
(R-HSA-419316)
0.527
2
UniProt:Q6NSJ0 MYORG
0.527
2
UniProt:Q16842 ST3GAL2
1
ST3GAL2 [Golgi membrane]
(R-HSA-981482)
0.527
2
UniProt:A5D8T8 CL18A
0.527
2
UniProt:Q96PQ1 SIGLEC12
1
SIGLEC12 [plasma membrane]
(R-HSA-197729)
0.527
2
UniProt:P48052 CBPA2
0.527
2
UniProt:Q8WWA0 ITLN1
1
ITLN1 [extracellular region]
(R-HSA-6804515)
0.527
4
UniProt:Q8TE60 ADAMTS18
4
ADAMTS18 [extracellular region]
(R-HSA-3791290)
ADAMTS18 [endoplasmic reticulum lumen]
(R-HSA-5173116)
glc-fuc-ADAMTS18 [endoplasmic reticulum lumen]
(R-HSA-5173291)
O-fuc-ADAMTS18 [endoplasmic reticulum lumen]
(R-HSA-5173143)
0.527
2
UniProt:Q6UXI7 VITRN
0.527
2
UniProt:O00755 WNT7A
9
WNT7A [extracellular region]
(R-HSA-517404)
N4GlycoAsn-PalmS WNT7A [extracellular exosome]
(R-HSA-3781951)
N4GlycoAsn-PalmS WNT7A [endocytic vesicle membrane]
(R-HSA-3781961)
WNT7A [endoplasmic reticulum lumen]
(R-HSA-3238312)
N4GlycoAsn-WNT7A [endoplasmic reticulum lumen]
(R-HSA-3238249)
N4GlycoAsn-PalmS WNT7A [endoplasmic reticulum lumen]
(R-HSA-3238354)
N4GlycoAsn-PalmS WNT7A [Golgi lumen]
(R-HSA-3247778)
N4GlycoAsn-PalmS WNT7A [extracellular region]
(R-HSA-3247774)
N4GlycoAsn-PalmS WNT7A [plasma membrane]
(R-HSA-3247833)
0.527
2
UniProt:Q8IXA5 SACA3
0.527
2
UniProt:Q5FYB1 ARSI
2
OxA-ARSI [endoplasmic reticulum lumen]
(R-HSA-1614360)
ARSI [endoplasmic reticulum lumen]
(R-HSA-1609671)
0.527
2
UniProt:Q9Y581 INSL6
0.527
2
UniProt:Q9UI38 TSP50
0.527
3
UniProt:O95757 HSPA4L
2
HSPA4L [cytosol]
(R-HSA-5251943)
HSPA4L [nucleoplasm]
(R-HSA-5252053)
0.527
2
UniProt:P07478 PRSS2
2
PRSS2 [azurophil granule lumen]
(R-HSA-6799229)
PRSS2(24-247) [extracellular region]
(R-HSA-1460243)
0.527
2
UniProt:Q9H4B8 DPEP3
0.527
2
UniProt:Q8WXQ8 CBPA5
0.527
2
UniProt:P25685 DNAJB1
3
p-S149,S151,S171 DNAJB1 [cytosol]
(R-HSA-5690241)
DNAJB1 [cytosol]
(R-HSA-3299666)
DNAJB1 [nucleoplasm]
(R-HSA-5082366)
0.527
2
UniProt:P01222 TSHB
1
TSHB [extracellular region]
(R-HSA-378957)
0.527
2
UniProt:P01019 AGT
7
AGT(36-41) [extracellular region]
(R-HSA-2022355)
AGT(35-41) [extracellular region]
(R-HSA-2022354)
AGT(34-40) [extracellular region]
(R-HSA-2022351)
AGT(34-42) [extracellular region]
(R-HSA-2022348)
AGT [extracellular region]
(R-HSA-1998759)
AGT(34-43) [extracellular region]
(R-HSA-2022346)
AGT(34-41) [extracellular region]
(R-HSA-374187)
0.527
2
UniProt:Q9HD89 RETN
3
RETN [specific granule lumen]
(R-HSA-6799355)
RETN [extracellular region]
(R-HSA-6806172)
RETN [azurophil granule lumen]
(R-HSA-6799357)
0.527
2
UniProt:O43323 DHH
10
DHH(33-?) [extracellular region]
(R-HSA-5362781)
N4glycoAsn-2xHC-DHH(23-396) [endoplasmic reticulum lumen]
(R-HSA-5362388)
CHOL-DHH(23-198) [endoplasmic reticulum lumen]
(R-HSA-5358291)
N4glycoAsn-DHH(199-396) [endoplasmic reticulum lumen]
(R-HSA-5358287)
2xHC-DHH(23-396) [endoplasmic reticulum lumen]
(R-HSA-5358275)
ub-N4glycoAsn-DHH(199-396) [cytosol]
(R-HSA-5362368)
ub-N4glycoAsn-DHH(199-396) [endoplasmic reticulum lumen]
(R-HSA-5362411)
CHOL-N-palmitoyl-L-cysteine-DHH(23-198) [endoplasmic reticulum lumen]
(R-HSA-5362442)
CHOL-N-palmitoyl-L-cysteine-DHH(23-198) [plasma membrane]
(R-HSA-5362420)
CHOL-N-palmitoyl-L-cysteine-DHH(23-198) [extracellular region]
(R-HSA-445155)
0.527
2
UniProt:P15056 BRAF
20
BRAF(1-380)-MACF1(600-7388)fusion [cytosol]
(R-HSA-6802402)
p-BRAF(1-380)-MACF1(600-7388) fusion [cytosol]
(R-HSA-6802536)
BRAF E501G [cytosol]
(R-HSA-9651132)
BRAF D594N [cytosol]
(R-HSA-6802299)
BRAF D638E [cytosol]
(R-HSA-9651125)
BRAF G596R [cytosol]
(R-HSA-6802385)
BRAF D594V [cytosol]
(R-HSA-6802305)
BRAF G596V [cytosol]
(R-HSA-9651138)
BRAF G466E [cytosol]
(R-HSA-6802374)
BRAF D594G [cytosol]
(R-HSA-6802295)
BRAF L505H [cytosol]
(R-HSA-9648845)
BRAF F595L [cytosol]
(R-HSA-6802316)
BRAF L597V [cytosol]
(R-HSA-6802397)
BRAF G464E [cytosol]
(R-HSA-6802369)
BRAF N581D [cytosol]
(R-HSA-9651152)
BRAF E586K [cytosol]
(R-HSA-6802308)
BRAF V600K [cytosol]
(R-HSA-6802502)
BRAF A246P [cytosol]
(R-HSA-9651123)
BRAF G469V [cytosol]
(R-HSA-9648620)
BRAF T244P [cytosol]
(R-HSA-9651165)
0.527
3
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.527
5
UniProt:P56705 WNT4
9
WNT4 [extracellular region]
(R-HSA-517385)
N4GlycoAsn-PalmS WNT4 [extracellular exosome]
(R-HSA-3781964)
N4GlycoAsn-PalmS WNT4 [endocytic vesicle membrane]
(R-HSA-3781978)
WNT4 [endoplasmic reticulum lumen]
(R-HSA-3238297)
N4GlycoAsn-WNT4 [endoplasmic reticulum lumen]
(R-HSA-3238235)
N4GlycoAsn-PalmS WNT4 [endoplasmic reticulum lumen]
(R-HSA-3238347)
N4GlycoAsn-PalmS WNT4 [Golgi lumen]
(R-HSA-3247779)
N4GlycoAsn-PalmS WNT4 [extracellular region]
(R-HSA-3247794)
N4GlycoAsn-PalmS WNT4 [plasma membrane]
(R-HSA-3247809)
0.527
3
UniProt:P27824 CANX
2
CANX [lumenal side of endoplasmic reticulum membrane]
(R-HSA-983091)
CANX [endoplasmic reticulum lumen]
(R-HSA-195906)
0.527
2
UniProt:Q13043 STK4
4
STK4(1-487) [cytosol]
(R-HSA-201627)
p-T183-STK4(1-326) [cytosol]
(R-HSA-2028682)
p-T183-STK4(1-487) [cytosol]
(R-HSA-2028258)
STK4(327-487) [cytosol]
(R-HSA-2028668)
0.527
3
UniProt:Q07954 LRP1
2
LRP1 [plasma membrane]
(R-HSA-1454844)
LRP1 [endocytic vesicle membrane]
(R-HSA-2230981)
0.527
2
UniProt:P0DTC9 N
13
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane]
(R-COV-9729325)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus]
(R-COV-9729339)
N [plasma membrane]
(R-COV-9694356)
SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol]
(R-COV-9756489)
N [cytosol]
(R-COV-9694300)
p-S188,206-N [cytosol]
(R-COV-9729324)
p-8S-N [cytosol]
(R-COV-9729335)
p-8S,2T-N [cytosol]
(R-COV-9729277)
p-11S,2T-N [cytosol]
(R-COV-9729264)
p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729308)
ADPr-p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729275)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9729341)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729340)
0.527
3
UniProt:Q6T424 Q6T424
0.525
3
UniProt:K0BRG7 K0BRG7
0.524
9
UniProt:P08670 VIM
11
VIM(2-85) [cytosol]
(R-HSA-350264)
VIM(86-466) [cytosol]
(R-HSA-350294)
VIM(430-466) [cytosol]
(R-HSA-350316)
VIM(2-429) [cytosol]
(R-HSA-350317)
VIM(260-466) [cytosol]
(R-HSA-350314)
VIM(2-259) [cytosol]
(R-HSA-350323)
VIM [cytosol]
(R-HSA-201600)
Vimentin [late endosome lumen]
(R-HSA-9660019)
Vimentin [microtubule organizing center]
(R-HSA-9657898)
Vimentin [cytosol]
(R-HSA-9646687)
Vimentin [lysosomal lumen]
(R-HSA-9659977)
0.508
3
UniProt:O95868 LY6G6D
2
cleaved GPI-LY6G6D [extracellular region]
(R-HSA-8943397)
GPI-LY6G6D [plasma membrane]
(R-HSA-8940814)
0.499
2
UniProt:Q9NYU1 UGGT2
1
UGGT2 [endoplasmic reticulum lumen]
(R-HSA-548863)
0.499
2
UniProt:P01721 IGLV6-57
2
Ig lambda chain V-VI region AR [plasma membrane]
(R-HSA-2038816)
Ig lambda chain V-VI region AR [extracellular region]
(R-HSA-983569)
0.499
3
UniProt:Q6URK8 SMIP8
0.499
2
UniProt:Q9UBS3 DNAJB9
1
DNAJB9 [endoplasmic reticulum membrane]
(R-HSA-381010)
0.499
2
UniProt:P02452 COL1A1
20
3x4Hyp-3Hyp-GlcGalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen]
(R-HSA-2023648)
3x4Hyp-GlcGalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen]
(R-HSA-2023667)
GlcGalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen]
(R-HSA-2023604)
GalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen]
(R-HSA-2022999)
3x4Hyp-3Hyp-GalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen]
(R-HSA-2023559)
3x4Hyp-GalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen]
(R-HSA-2023582)
COL1A1(23-1464) [endoplasmic reticulum lumen]
(R-HSA-1650777)
3x4Hyp-COL1A1(23-1464) [endoplasmic reticulum lumen]
(R-HSA-1985659)
3x4Hyp-3Hyp-COL1A1(23-1464) [endoplasmic reticulum lumen]
(R-HSA-2022446)
3x4Hyp-5Hyl-COL1A1(23-1464) [endoplasmic reticulum lumen]
(R-HSA-2022951)
3x4Hyp-3Hyp-5Hyl-COL1A1(23-1464) [endoplasmic reticulum lumen]
(R-HSA-2022954)
5Hyl-COL1A1(23-1464) [endoplasmic reticulum lumen]
(R-HSA-1985663)
Lysyl-pyrrolyl 5-hydroxylysyl collagen alpha-1(I) chain [extracellular region]
(R-HSA-2396137)
Lysyl-pyrrolyl 3,4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region]
(R-HSA-2396440)
Lysyl-pyrrolyl 4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region]
(R-HSA-2396471)
Lysyl-pyridinolyl 5-hydroxylysyl collagen alpha-1(I) chain [extracellular region]
(R-HSA-2396464)
Lysyl-pyridinolyl 4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region]
(R-HSA-2396068)
Lysyl-pyridinolyl 3,4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region]
(R-HSA-2396388)
Dehydrolysinonorlysyl 4-hydroxyprolyl collagen alpha-1(I) chain [extracellular region]
(R-HSA-2396315)
Dehydrolysinonorlysyl 4-Hyp 5-Gal-Hyl collagen alpha-1(I) chain [extracellular region]
(R-HSA-2396441)
0.499
2
UniProt:P36780 VE2
0.488
2
UniProt:Q5NES6 Q5NES6
0.488
2
UniProt:Q2MV58 TCTN1
1
TCTN1 [cytosol]
(R-HSA-5626659)
0.483
3
UniProt:P31749 AKT1
14
p-T308,S473-AKT1 E17K [nucleoplasm]
(R-HSA-2399994)
p-T308,S473-AKT1 E17K [cytosol]
(R-HSA-2243935)
AKT1 E17K [cytosol]
(R-HSA-2219526)
p-S473-AKT1 E17K [plasma membrane]
(R-HSA-2243944)
AKT1 E17K [plasma membrane]
(R-HSA-1500573)
p-S473-AKT1 [cytosol]
(R-HSA-9841264)
p-T308,S473-AKT1 [plasma membrane]
(R-HSA-199430)
p-Y315,Y326-AKT1 [cytosol]
(R-HSA-8848757)
p-T308-AKT1 [cytosol]
(R-HSA-198634)
AKT1 [cytosol]
(R-HSA-58252)
AKT1 [plasma membrane]
(R-HSA-199416)
p-S473-AKT1 [plasma membrane]
(R-HSA-377265)
p-T308,S473-AKT1 [cytosol]
(R-HSA-198356)
p-T308,S473-AKT1 [nucleoplasm]
(R-HSA-198357)
0.471
2
UniProt:Q8N0X7 SPART
0.462
2
UniProt:Q00005 2ABB
0.462
2
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