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PSMD7 [nucleoplasm]
Stable Identifier
R-HSA-174309
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
26S proteasome non-ATPase regulatory subunit 7, 26S proteasome regulatory subunit S12, Proteasome subunit p40, Mov34 protein homolog
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G1 phase and G1/S transition (Homo sapiens)
G1/S Transition (Homo sapiens)
Cyclin E associated events during G1/S transition (Homo sapiens)
SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
19S regulatory particle [nucleoplasm] (Homo sapiens)
19S RP lid [nucleoplasm] (Homo sapiens)
19S RP lid particle 2 [nucleoplasm] (Homo sapiens)
19S RP Lid Module 1 [nucleoplasm] (Homo sapiens)
PSMD7:PSMD12:PSMD13:PSMD14 [nucleoplasm] (Homo sapiens)
PSMD7 [nucleoplasm] (Homo sapiens)
Regulation of mitotic cell cycle (Homo sapiens)
APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Homo sapiens)
APC/C:Cdh1-mediated degradation of Skp2 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
19S regulatory particle [nucleoplasm] (Homo sapiens)
19S RP lid [nucleoplasm] (Homo sapiens)
19S RP lid particle 2 [nucleoplasm] (Homo sapiens)
19S RP Lid Module 1 [nucleoplasm] (Homo sapiens)
PSMD7:PSMD12:PSMD13:PSMD14 [nucleoplasm] (Homo sapiens)
PSMD7 [nucleoplasm] (Homo sapiens)
Autodegradation of Cdh1 by Cdh1:APC/C (Homo sapiens)
Degradation of multiubiquitinated Cdh1 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
19S regulatory particle [nucleoplasm] (Homo sapiens)
19S RP lid [nucleoplasm] (Homo sapiens)
19S RP lid particle 2 [nucleoplasm] (Homo sapiens)
19S RP Lid Module 1 [nucleoplasm] (Homo sapiens)
PSMD7:PSMD12:PSMD13:PSMD14 [nucleoplasm] (Homo sapiens)
PSMD7 [nucleoplasm] (Homo sapiens)
S Phase (Homo sapiens)
Cyclin A:Cdk2-associated events at S phase entry (Homo sapiens)
SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
19S regulatory particle [nucleoplasm] (Homo sapiens)
19S RP lid [nucleoplasm] (Homo sapiens)
19S RP lid particle 2 [nucleoplasm] (Homo sapiens)
19S RP Lid Module 1 [nucleoplasm] (Homo sapiens)
PSMD7:PSMD12:PSMD13:PSMD14 [nucleoplasm] (Homo sapiens)
PSMD7 [nucleoplasm] (Homo sapiens)
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to chemical stress (Homo sapiens)
KEAP1-NFE2L2 pathway (Homo sapiens)
Nuclear events mediated by NFE2L2 (Homo sapiens)
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 (Homo sapiens)
Ub,pS335,S338,T NFE2L2 is degraded (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
19S regulatory particle [nucleoplasm] (Homo sapiens)
19S RP lid [nucleoplasm] (Homo sapiens)
19S RP lid particle 2 [nucleoplasm] (Homo sapiens)
19S RP Lid Module 1 [nucleoplasm] (Homo sapiens)
PSMD7:PSMD12:PSMD13:PSMD14 [nucleoplasm] (Homo sapiens)
PSMD7 [nucleoplasm] (Homo sapiens)
DNA Replication (Homo sapiens)
DNA Replication Pre-Initiation (Homo sapiens)
Assembly of the pre-replicative complex (Homo sapiens)
Ubiquitinated geminin is degraded by the proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
19S regulatory particle [nucleoplasm] (Homo sapiens)
19S RP lid [nucleoplasm] (Homo sapiens)
19S RP lid particle 2 [nucleoplasm] (Homo sapiens)
19S RP Lid Module 1 [nucleoplasm] (Homo sapiens)
PSMD7:PSMD12:PSMD13:PSMD14 [nucleoplasm] (Homo sapiens)
PSMD7 [nucleoplasm] (Homo sapiens)
Developmental Biology (Homo sapiens)
Gastrulation (Homo sapiens)
Formation of paraxial mesoderm (Homo sapiens)
Somitogenesis (Homo sapiens)
RIPPLY2 binds TBX6 and recruits the 26S proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
19S regulatory particle [nucleoplasm] (Homo sapiens)
19S RP lid [nucleoplasm] (Homo sapiens)
19S RP lid particle 2 [nucleoplasm] (Homo sapiens)
19S RP Lid Module 1 [nucleoplasm] (Homo sapiens)
PSMD7:PSMD12:PSMD13:PSMD14 [nucleoplasm] (Homo sapiens)
PSMD7 [nucleoplasm] (Homo sapiens)
TBX6:RIPPLY2:26S proteasome [nucleoplasm] (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
19S regulatory particle [nucleoplasm] (Homo sapiens)
19S RP lid [nucleoplasm] (Homo sapiens)
19S RP lid particle 2 [nucleoplasm] (Homo sapiens)
19S RP Lid Module 1 [nucleoplasm] (Homo sapiens)
PSMD7:PSMD12:PSMD13:PSMD14 [nucleoplasm] (Homo sapiens)
PSMD7 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX2 (Homo sapiens)
Regulation of RUNX2 expression and activity (Homo sapiens)
26S proteasome degrades PolyUb-RUNX2 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
19S regulatory particle [nucleoplasm] (Homo sapiens)
19S RP lid [nucleoplasm] (Homo sapiens)
19S RP lid particle 2 [nucleoplasm] (Homo sapiens)
19S RP Lid Module 1 [nucleoplasm] (Homo sapiens)
PSMD7:PSMD12:PSMD13:PSMD14 [nucleoplasm] (Homo sapiens)
PSMD7 [nucleoplasm] (Homo sapiens)
Transcriptional regulation by RUNX3 (Homo sapiens)
Regulation of RUNX3 expression and activity (Homo sapiens)
Polyubiquitinated RUNX3 is degraded by the proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
19S regulatory particle [nucleoplasm] (Homo sapiens)
19S RP lid [nucleoplasm] (Homo sapiens)
19S RP lid particle 2 [nucleoplasm] (Homo sapiens)
19S RP Lid Module 1 [nucleoplasm] (Homo sapiens)
PSMD7:PSMD12:PSMD13:PSMD14 [nucleoplasm] (Homo sapiens)
PSMD7 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Hedgehog (Homo sapiens)
Hedgehog 'on' state (Homo sapiens)
GLI2,3 are degraded by the proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
19S regulatory particle [nucleoplasm] (Homo sapiens)
19S RP lid [nucleoplasm] (Homo sapiens)
19S RP lid particle 2 [nucleoplasm] (Homo sapiens)
19S RP Lid Module 1 [nucleoplasm] (Homo sapiens)
PSMD7:PSMD12:PSMD13:PSMD14 [nucleoplasm] (Homo sapiens)
PSMD7 [nucleoplasm] (Homo sapiens)
Signaling by NOTCH (Homo sapiens)
Signaling by NOTCH4 (Homo sapiens)
Negative regulation of NOTCH4 signaling (Homo sapiens)
Proteasome degrades ubiquitinated NICD4 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
19S regulatory particle [nucleoplasm] (Homo sapiens)
19S RP lid [nucleoplasm] (Homo sapiens)
19S RP lid particle 2 [nucleoplasm] (Homo sapiens)
19S RP Lid Module 1 [nucleoplasm] (Homo sapiens)
PSMD7:PSMD12:PSMD13:PSMD14 [nucleoplasm] (Homo sapiens)
PSMD7 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P51665 PSMD7
Gene Names
PSMD7, MOV34L
Chain
chain:1-324
Reference Genes
BioGPS Gene:5713 PSMD7
COSMIC (genes):PSMD7 PSMD7
CTD Gene:5713 PSMD7
dbSNP Gene:5713 PSMD7
ENSEMBL:ENSG00000103035 PSMD7
ENSEMBL_homo_sapiens_GENE:ENSG00000103035.11 PSMD7
HGNC:9565 PSMD7
KEGG Gene (Homo sapiens):5713 PSMD7
Monarch:5713 PSMD7
NCBI Gene:5713 PSMD7
OMIM:157970 PSMD7
UCSC:P51665 PSMD7
Reference Transcript
RefSeq:NM_002811.4 PSMD7
Other Identifiers
11729113_a_at
11729114_s_at
11746059_a_at
16821021
201705_PM_at
201705_at
3668618
3668619
3668625
3668626
3668627
3668628
3668629
3668631
3668634
3668635
3668636
3668637
3668638
3668639
3668640
40276_at
5713
7997230
945_at
A_14_P114737
A_23_P106741
D50063_at
GE57237
GO:0000502
GO:0003824
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005654
GO:0005829
GO:0005838
GO:0008233
GO:0008237
GO:0016020
GO:0016787
GO:0030163
GO:0031410
GO:0034774
GO:0042803
GO:0043161
GO:0043226
GO:0070062
GO:0140096
GO:1904813
HMNXSV003019799
ILMN_1776173
PH_hs_0025797
TC16000612.hg
g4506230_3p_at
Participates
as a component of
PSMD7:PSMD12:PSMD13:PSMD14 [nucleoplasm] (Homo sapiens)
Other forms of this molecule
PSMD7 [secretory granule lumen]
PSMD7 [extracellular region]
PSMD7 [ficolin-1-rich granule lumen]
PSMD7 [cytosol]
Inferred To
Rpn8 [nucleoplasm]
(Drosophila melanogaster)
rpn-8 [nucleoplasm]
(Caenorhabditis elegans)
PSMD7 [nucleoplasm]
(Bos taurus)
PSMD7 [nucleoplasm]
(Canis familiaris)
PSMD7 [nucleoplasm]
(Gallus gallus)
PSMD7 [nucleoplasm]
(Sus scrofa)
psmd7 [nucleoplasm]
(Danio rerio)
psmd7 [nucleoplasm]
(Xenopus tropicalis)
Psmd7 [nucleoplasm]
(Mus musculus)
Psmd7 [nucleoplasm]
(Rattus norvegicus)
psmD7 [nucleoplasm]
(Dictyostelium discoideum)
Cross References
RefSeq
NP_002802.2
OpenTargets
ENSG00000103035
GeneCards
P51665
HPA
ENSG00000103035-PSMD7
Ensembl
ENSP00000219313
,
ENST00000219313
,
ENSG00000103035
PRO
P51665
Pharos - Targets
P51665
PDB
7W39
,
5VGZ
,
5VFR
,
5VFS
,
7W38
,
5T0I
,
7W37
,
5VFP
,
5T0H
,
5VFQ
,
2O96
,
5T0C
,
2O95
,
6MSD
,
7QXN
,
5VFU
,
5VHH
,
6MSB
,
5L4K
,
7W3J
,
7QYA
,
7QY7
,
7W3I
,
6WJN
,
7QXX
,
6MSJ
,
7W3G
,
5VHS
,
7W3H
,
6WJD
,
5T0J
,
8CVT
,
7QXW
,
6MSK
,
5GJQ
,
7W3C
,
5VHI
,
7W3F
,
7QXP
,
5GJR
,
6MSH
,
5T0G
,
7QXU
,
6MSG
,
5VHF
,
7QYB
,
7W3M
,
7W3A
,
5VFT
,
7W3B
,
5LN3
,
7W3K
,
5M32
Interactors (38)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O00487 PSMD14
5
PSMD14 [secretory granule lumen]
(R-HSA-6800926)
PSMD14 [extracellular region]
(R-HSA-6806511)
PSMD14 [ficolin-1-rich granule lumen]
(R-HSA-6800419)
PSMD14 [nucleoplasm]
(R-HSA-174329)
PSMD14 [cytosol]
(R-HSA-68722)
0.904
16
UniProt:Q15008 PSMD6
5
PSMD6 [secretory granule lumen]
(R-HSA-6801036)
PSMD6 [extracellular region]
(R-HSA-6806486)
PSMD6 [ficolin-1-rich granule lumen]
(R-HSA-6800440)
PSMD6 [nucleoplasm]
(R-HSA-174316)
PSMD6 [cytosol]
(R-HSA-68804)
0.802
6
UniProt:Q9Y5K5 UCHL5
2
UCHL5 [cytosol]
(R-HSA-1629778)
UCHL5 [nucleoplasm]
(R-HSA-5689584)
0.788
6
UniProt:P62195 PSMC5
2
PSMC5 [nucleoplasm]
(R-HSA-174312)
PSMC5 [cytosol]
(R-HSA-68780)
0.788
6
UniProt:P62191 PSMC1
2
PSMC1 [nucleoplasm]
(R-HSA-174338)
PSMC1 [cytosol]
(R-HSA-68768)
0.788
6
UniProt:P62333 PSMC6
2
PSMC6 [nucleoplasm]
(R-HSA-174319)
PSMC6 [cytosol]
(R-HSA-68783)
0.745
4
UniProt:P43686 PSMC4
2
PSMC4 [nucleoplasm]
(R-HSA-174315)
PSMC4 [cytosol]
(R-HSA-68777)
0.744
6
UniProt:O75832 PSMD10
1
PSMD10 [cytosol]
(R-HSA-68788)
0.744
5
UniProt:O00231 PSMD11
5
PSMD11 [secretory granule lumen]
(R-HSA-6800943)
PSMD11 [extracellular region]
(R-HSA-6806441)
PSMD11 [ficolin-1-rich granule lumen]
(R-HSA-6800436)
PSMD11 [nucleoplasm]
(R-HSA-174327)
PSMD11 [cytosol]
(R-HSA-68790)
0.731
5
UniProt:O00232 PSMD12
5
PSMD12 [secretory granule lumen]
(R-HSA-6800934)
PSMD12 [extracellular region]
(R-HSA-6806480)
PSMD12 [ficolin-1-rich granule lumen]
(R-HSA-6800416)
PSMD12 [nucleoplasm]
(R-HSA-174339)
PSMD12 [cytosol]
(R-HSA-68792)
0.725
5
UniProt:Q16186 ADRM1
2
ADRM1 [nucleoplasm]
(R-HSA-9918361)
ADRM1 [cytosol]
(R-HSA-5665939)
0.725
5
UniProt:Q13200 PSMD2
5
PSMD2 [secretory granule lumen]
(R-HSA-6800919)
PSMD2 [extracellular region]
(R-HSA-6806479)
PSMD2 [ficolin-1-rich granule lumen]
(R-HSA-6800435)
PSMD2 [nucleoplasm]
(R-HSA-174311)
PSMD2 [cytosol]
(R-HSA-68796)
0.725
6
UniProt:O43242 PSMD3
5
PSMD3 [secretory granule lumen]
(R-HSA-6800873)
PSMD3 [extracellular region]
(R-HSA-6806443)
PSMD3 [ficolin-1-rich granule lumen]
(R-HSA-6800408)
PSMD3 [nucleoplasm]
(R-HSA-174328)
PSMD3 [cytosol]
(R-HSA-68798)
0.725
5
UniProt:Q9UNM6 PSMD13
5
PSMD13 [secretory granule lumen]
(R-HSA-6800983)
PSMD13 [extracellular region]
(R-HSA-6806469)
PSMD13 [ficolin-1-rich granule lumen]
(R-HSA-6800413)
PSMD13 [nucleoplasm]
(R-HSA-174326)
PSMD13 [cytosol]
(R-HSA-68794)
0.669
4
UniProt:Q9BRP4 PAAF1
1
PAAF1 [cytosol]
(R-HSA-9907973)
0.669
4
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.666
10
UniProt:P55036 PSMD4
1
PSMD4 [cytosol]
(R-HSA-68800)
0.643
4
UniProt:Q16401 PSMD5
1
PSMD5 [cytosol]
(R-HSA-68802)
0.643
4
UniProt:P20618 PSMB1
7
PSMB1(1-28) [cytosol]
(R-HSA-9908143)
pro-PSMB1 [cytosol]
(R-HSA-9908139)
PSMB1 [secretory granule lumen]
(R-HSA-6803287)
PSMB1 [extracellular region]
(R-HSA-6806477)
PSMB1 [ficolin-1-rich granule lumen]
(R-HSA-6803340)
PSMB1 [nucleoplasm]
(R-HSA-174347)
PSMB1 [cytosol]
(R-HSA-68738)
0.643
3
UniProt:P48556 PSMD8
2
PSMD8 [nucleoplasm]
(R-HSA-174318)
PSMD8 [cytosol]
(R-HSA-68808)
0.643
4
UniProt:P28065 PSMB9
3
PSMB9(1-20) [cytosol]
(R-HSA-9908132)
PSMB9 [cytosol]
(R-HSA-68765)
pro-PSMB9 [cytosol]
(R-HSA-9908136)
0.643
5
UniProt:P17980 PSMC3
5
PSMC3 [secretory granule lumen]
(R-HSA-6800917)
PSMC3 [extracellular region]
(R-HSA-6806496)
PSMC3 [ficolin-1-rich granule lumen]
(R-HSA-6800429)
PSMC3 [nucleoplasm]
(R-HSA-174313)
PSMC3 [cytosol]
(R-HSA-68774)
0.643
4
UniProt:Q9Y4K3 TRAF6
8
K48polyUb-TRAF6 [cytosol]
(R-HSA-6783233)
PolyUb-TRAF6 [cytosol]
(R-HSA-6782845)
TRAF6 [endosome membrane]
(R-HSA-450272)
K63polyUb-TRAF6 [endosome membrane]
(R-HSA-450227)
TRAF6 [cytosol]
(R-HSA-166366)
K63polyUb-TRAF6 [cytosol]
(R-HSA-2685681)
K63polyUb-TRAF6 [plasma membrane]
(R-HSA-936980)
TRAF6 [plasma membrane]
(R-HSA-936955)
0.589
2
UniProt:P54252 ATXN3
2
ATXN3 [nucleoplasm]
(R-HSA-6783285)
ATXN3 [cytosol]
(R-HSA-5625607)
0.556
9
UniProt:Q5VTR2 RNF20
2
RNF20 [cytosol]
(R-HSA-9715141)
RNF20 [nucleoplasm]
(R-HSA-5689011)
0.527
2
UniProt:Q96EN9 REX1B
0.527
3
UniProt:Q01850 CDR2
0.527
2
UniProt:Q53HC0 CCD92
0.527
2
UniProt:O60826 CCDC22
2
CCDC22 [nucleoplasm]
(R-HSA-8955644)
CCDC22 [cytosol]
(R-HSA-8955640)
0.527
2
UniProt:P35998 PSMC2
5
PSMC2 [secretory granule lumen]
(R-HSA-6800994)
PSMC2 [extracellular region]
(R-HSA-6806472)
PSMC2 [ficolin-1-rich granule lumen]
(R-HSA-6800421)
PSMC2 [nucleoplasm]
(R-HSA-174332)
PSMC2 [cytosol]
(R-HSA-68771)
0.527
2
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.527
9
UniProt:Q99460 PSMD1
4
PSMD1 [extracellular region]
(R-HSA-6806194)
PSMD1 [azurophil granule lumen]
(R-HSA-6798741)
PSMD1 [nucleoplasm]
(R-HSA-174348)
PSMD1 [cytosol]
(R-HSA-68786)
0.527
3
UniProt:Q86UP2 KTN1
4
KTN1 [plasma membrane]
(R-HSA-9696518)
p-KTN1 [endoplasmic reticulum lumen]
(R-HSA-8956968)
KTN1 [endoplasmic reticulum lumen]
(R-HSA-8956694)
KTN1 [endoplasmic reticulum membrane]
(R-HSA-201604)
0.527
2
UniProt:Q5VIR6 VPS53
1
VPS53 [trans-Golgi network membrane]
(R-HSA-6811031)
0.527
2
UniProt:Q6PJG6 BRAT1
0.527
2
UniProt:P49720 PSMB3
2
PSMB3 [nucleoplasm]
(R-HSA-174341)
PSMB3 [cytosol]
(R-HSA-68747)
0.527
3
UniProt:P54252-1 ATXN3
0.499
2
UniProt:P04578-PRO_0000038427 ENV
0.462
2
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