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TUBB3 folding intermediate [cytosol]
Stable Identifier
R-HSA-392806
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
beta tubulin 4 folding intermediate
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Protein folding (Homo sapiens)
Chaperonin-mediated protein folding (Homo sapiens)
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding (Homo sapiens)
Formation of tubulin folding intermediates by CCT/TriC (Homo sapiens)
Hydrolysis of ATP and release of tubulin folding intermediate from CCT/TriC (Homo sapiens)
tubulin-GTP folding intermediate [cytosol] (Homo sapiens)
alpha/beta tubulin folding intermediate [cytosol] (Homo sapiens)
beta-tubulin folding intermediate [cytosol] (Homo sapiens)
TUBB3 folding intermediate [cytosol] (Homo sapiens)
Post-chaperonin tubulin folding pathway (Homo sapiens)
Beta-tubulin:GTP + Cofactor A -> Beta-tubulin:GTP: Cofactor A (Homo sapiens)
GTP:beta-tubulin folding intermediate [cytosol] (Homo sapiens)
beta-tubulin folding intermediate [cytosol] (Homo sapiens)
TUBB3 folding intermediate [cytosol] (Homo sapiens)
cofactor A:GTP:beta-tubulin folding intermediate [cytosol] (Homo sapiens)
GTP:beta-tubulin folding intermediate [cytosol] (Homo sapiens)
beta-tubulin folding intermediate [cytosol] (Homo sapiens)
TUBB3 folding intermediate [cytosol] (Homo sapiens)
Beta-tubulin:GTP + Cofactor D -> Beta-tubulin:GTP: Cofactor D (Homo sapiens)
Cofactor D:GTP:beta tubulin [cytosol] (Homo sapiens)
GTP:beta-tubulin folding intermediate [cytosol] (Homo sapiens)
beta-tubulin folding intermediate [cytosol] (Homo sapiens)
TUBB3 folding intermediate [cytosol] (Homo sapiens)
GTP:beta-tubulin folding intermediate [cytosol] (Homo sapiens)
beta-tubulin folding intermediate [cytosol] (Homo sapiens)
TUBB3 folding intermediate [cytosol] (Homo sapiens)
Beta-tubulin:GTP: Cofactor A+ Cofactor D -> Beta-tubulin:GTP:Cofactor D + Cofactor A (Homo sapiens)
Cofactor D:GTP:beta tubulin [cytosol] (Homo sapiens)
GTP:beta-tubulin folding intermediate [cytosol] (Homo sapiens)
beta-tubulin folding intermediate [cytosol] (Homo sapiens)
TUBB3 folding intermediate [cytosol] (Homo sapiens)
cofactor A:GTP:beta-tubulin folding intermediate [cytosol] (Homo sapiens)
GTP:beta-tubulin folding intermediate [cytosol] (Homo sapiens)
beta-tubulin folding intermediate [cytosol] (Homo sapiens)
TUBB3 folding intermediate [cytosol] (Homo sapiens)
Beta-tubulin:GTP:Cofactor D+alpha-tubulin:GTP:Cofactor E-> Beta-tubulin:GTP:Cofactor D:alpha-tubulin:GTP:Cofactor E (Homo sapiens)
Cofactor D:GTP:beta tubulin [cytosol] (Homo sapiens)
GTP:beta-tubulin folding intermediate [cytosol] (Homo sapiens)
beta-tubulin folding intermediate [cytosol] (Homo sapiens)
TUBB3 folding intermediate [cytosol] (Homo sapiens)
beta tubulin:GTP: Cofactor D:alpha tubulin:GTP:Cofactor E [cytosol] (Homo sapiens)
Cofactor D:GTP:beta tubulin [cytosol] (Homo sapiens)
GTP:beta-tubulin folding intermediate [cytosol] (Homo sapiens)
beta-tubulin folding intermediate [cytosol] (Homo sapiens)
TUBB3 folding intermediate [cytosol] (Homo sapiens)
Beta-tubulin:GTP:Cofactor D:alpha-tubulin:GTP:Cofactor E+ Cofactor C-> Beta-tubulin:GTP:Cofactor D:alpha-tubulin:GTP:Cofactor E:Cofactor C (Homo sapiens)
beta tubulin:GTP: Cofactor D:alpha tubulin:GTP:Cofactor E [cytosol] (Homo sapiens)
Cofactor D:GTP:beta tubulin [cytosol] (Homo sapiens)
GTP:beta-tubulin folding intermediate [cytosol] (Homo sapiens)
beta-tubulin folding intermediate [cytosol] (Homo sapiens)
TUBB3 folding intermediate [cytosol] (Homo sapiens)
beta-tubulin:GTP:Cofactor D:alpha-tubulin:GTP:Cofactor E : Cofactor C [cytosol] (Homo sapiens)
beta tubulin:GTP: Cofactor D:alpha tubulin:GTP:Cofactor E [cytosol] (Homo sapiens)
Cofactor D:GTP:beta tubulin [cytosol] (Homo sapiens)
GTP:beta-tubulin folding intermediate [cytosol] (Homo sapiens)
beta-tubulin folding intermediate [cytosol] (Homo sapiens)
TUBB3 folding intermediate [cytosol] (Homo sapiens)
Beta-tubulin:GTP:Cofactor D:alpha-tubulin:GTP:Cofactor E:Cofactor C-> Beta-tubulin:GDP :alpha-tubulin:GTP heterodimer +Cofactor E+ Cofactor D+ Cofactor C+ Pi (Homo sapiens)
beta-tubulin:GTP:Cofactor D:alpha-tubulin:GTP:Cofactor E : Cofactor C [cytosol] (Homo sapiens)
beta tubulin:GTP: Cofactor D:alpha tubulin:GTP:Cofactor E [cytosol] (Homo sapiens)
Cofactor D:GTP:beta tubulin [cytosol] (Homo sapiens)
GTP:beta-tubulin folding intermediate [cytosol] (Homo sapiens)
beta-tubulin folding intermediate [cytosol] (Homo sapiens)
TUBB3 folding intermediate [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13509 TUBB3
Gene Names
TUBB3, TUBB4
Chain
chain:1-450
Reference Genes
BioGPS Gene:10381 TUBB3
COSMIC (genes):TUBB3 TUBB3
CTD Gene:10381 TUBB3
dbSNP Gene:10381 TUBB3
ENSEMBL:ENSG00000258947 TUBB3
HGNC:20772 TUBB3
KEGG Gene (Homo sapiens):10381 TUBB3
Monarch:10381 TUBB3
NCBI Gene:10381 TUBB3
OMIM:602661 TUBB3
UCSC:Q13509 TUBB3
Reference Transcript
RefSeq:NM_001197181.1 TUBB3
RefSeq:NM_006086.3 TUBB3
Other Identifiers
0004670131
10381
11754593_x_at
202154_x_at
213476_3p_x_at
213476_x_at
2916784
33678_i_at
3674512
3674513
3674515
3674516
3674518
3674521
3674527
3674528
3674529
3674530
4050505
471_f_at
57034_at
7998063
A_14_P128910
A_23_P77493
A_24_P258633
GO:0000166
GO:0000226
GO:0000278
GO:0000902
GO:0003674
GO:0003924
GO:0005198
GO:0005200
GO:0005515
GO:0005525
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005634
GO:0005737
GO:0005856
GO:0005874
GO:0007010
GO:0007017
GO:0007049
GO:0007165
GO:0007411
GO:0008150
GO:0015630
GO:0030027
GO:0030154
GO:0030175
GO:0030182
GO:0030424
GO:0030425
GO:0030426
GO:0038007
GO:0040011
GO:0042277
GO:0042995
GO:0043025
GO:0043167
GO:0043226
GO:0048856
GO:0070062
GO:0071944
GO:1990791
GO:1990890
HMNXSV003003269
HMNXSV003007557
Hs.159154.1.A1_3p_x_at
ILMN_1791726
PH_hs_0030611
TC16001720.hg
U47634_at
g5174736_3p_a_at
Participates
as a member of
beta-tubulin folding intermediate [cytosol] (Homo sapiens)
Other forms of this molecule
TUBB3 unfolded [cytosol]
Polyglycyl-TUBB3 [cytosol]
Polyglutamyl-TUBB3 [cytosol]
TUBB3 [cytosol]
TUBB3 [axonemal microtubule]
Cross References
RefSeq
NP_006077.2
,
NP_001184110.1
ZINC - World Drugs
TBB3_HUMAN
Guide to Pharmacology - Targets
2752
OpenTargets
ENSG00000258947
ZINC - FDA approved
TBB3_HUMAN
ZINC - Substances
TBB3_HUMAN
ZINC target
Q13509
ZINC - Biogenic
TBB3_HUMAN
PRO
Q13509
GlyGen
Q13509
PDB
6E7B
,
5IJ0
,
5IJ9
,
7LXB
,
7M20
,
7M18
,
6WSL
,
6S8L
,
7PJF
,
5JCO
HPA
ENSG00000258947-TUBB3
GeneCards
Q13509
Ensembl
ENSP00000320295
,
ENST00000554444
,
ENSP00000451617
,
ENST00000315491
,
ENSG00000258947
Pharos - Targets
Q13509
ZINC - Predictions - Purchasable
TBB3_HUMAN
Orphanet
19021
HMDB Protein
HMDBP02218
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q5S007 LRRK2
1
LRRK2 [cytosol]
(R-HSA-5661173)
0.482
2
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