Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
DSP [cornified envelope]
Stable Identifier
R-HSA-8847736
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cornified envelope
Synonyms
Desmoplakin
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Keratinization (Homo sapiens)
Formation of the cornified envelope (Homo sapiens)
Plasma membrane resorption (Homo sapiens)
Mature cornified envelope [cornified envelope] (Homo sapiens)
No FGN-cornified envelope:CDSN [cornified envelope] (Homo sapiens)
No FGN-Cornified envelope [cornified envelope] (Homo sapiens)
No FGN-early cornified envelope [cornified envelope] (Homo sapiens)
Keratin tonofilament:Desmosome network [cornified envelope] (Homo sapiens)
Keratin tonofilament:Desmosome [cornified envelope] (Homo sapiens)
Desmosome [cornified envelope] (Homo sapiens)
DSP [cornified envelope] (Homo sapiens)
External Reference Information
External Reference
UniProt:P15924 DSP
Gene Names
DSP
Chain
chain:1-2871
Reference Genes
BioGPS Gene:1832 DSP
COSMIC (genes):DSP DSP
CTD Gene:1832 DSP
dbSNP Gene:1832 DSP
ENSEMBL:ENSG00000096696 DSP
ENSEMBL_homo_sapiens_GENE:ENSG00000096696.16 DSP
HGNC:3052 DSP
KEGG Gene (Homo sapiens):1832 DSP
Monarch:1832 DSP
NCBI Gene:1832 DSP
OMIM:125647 DSP
UCSC:P15924 DSP
Reference Transcript
RefSeq:NM_004415.3 DSP
RefSeq:NM_001008844.2 DSP
RefSeq:NM_001319034.1 DSP
Other Identifiers
11739501_a_at
11757507_s_at
17004612
1832
200606_PM_at
200606_at
2893793
2893795
2893796
2893797
2893800
2893801
2893802
2893804
2893807
2893808
2893809
2893810
2893811
2893812
2893813
2893814
2893815
2893816
2893817
2893818
2893819
2893820
2893821
2893822
2893823
2893824
2893825
2893826
2893827
2893828
2893829
2893830
2893831
2893832
2893833
2893834
2893835
2893836
2893837
2893838
2893839
2893840
36133_at
8116780
A_32_P157945
A_33_P3314574
A_33_P3402565
GE56076
GO:0001533
GO:0002934
GO:0003012
GO:0003013
GO:0003223
GO:0003723
GO:0005080
GO:0005198
GO:0005200
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005737
GO:0005856
GO:0005882
GO:0005886
GO:0005911
GO:0005912
GO:0005916
GO:0007010
GO:0007155
GO:0008544
GO:0014704
GO:0016020
GO:0016323
GO:0018149
GO:0030057
GO:0030154
GO:0030216
GO:0031410
GO:0034330
GO:0034332
GO:0036211
GO:0042060
GO:0043226
GO:0043588
GO:0045104
GO:0045109
GO:0048856
GO:0070062
GO:0070161
GO:0086073
GO:0086083
GO:0086091
GO:0090136
GO:0097110
GO:0098609
GO:0098631
GO:0098911
GO:0101003
GO:0150105
HMNXSV003057465
ILMN_1655614
ILMN_1659749
ILMN_1677032
PH_hs_0032773
TC06000060.hg
g4758199_3p_at
g4758199_3p_s_at
Participates
as a component of
Desmosome [cornified envelope] (Homo sapiens)
Other forms of this molecule
DSP [ficolin-1-rich granule membrane]
DSP(?-?) [plasma membrane]
DSP [plasma membrane]
Inferred To
Dsp [cornified envelope]
(Mus musculus)
Dsp [cornified envelope]
(Rattus norvegicus)
DSP [cornified envelope]
(Bos taurus)
DSP [cornified envelope]
(Canis familiaris)
DSP [cornified envelope]
(Sus scrofa)
Cross References
RefSeq
NP_004406.2
,
NP_001008844.1
,
NP_001305963.1
OpenTargets
ENSG00000096696
GeneCards
P15924
HPA
ENSG00000096696-DSP
Ensembl
ENSP00000396591
,
ENSG00000096696
,
ENST00000418664
,
ENST00000379802
,
ENSP00000369129
PRO
P15924
Pharos - Targets
P15924
Orphanet
15895
PDB
3R6N
,
1LM5
,
5DZZ
,
1LM7
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q15691 MAPRE1
1
MAPRE1 [cytosol]
(R-HSA-376240)
0.626
7
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.615
18
UniProt:P14923 JUP
6
JUP [cytosol]
(R-HSA-201598)
JUP [cornified envelope]
(R-HSA-8847739)
JUP [specific granule lumen]
(R-HSA-6799534)
JUP [extracellular region]
(R-HSA-6806309)
JUP [ficolin-1-rich granule lumen]
(R-HSA-6801028)
JUP [plasma membrane]
(R-HSA-437260)
0.573
3
UniProt:P07332 FES
1
FES [cytosol]
(R-HSA-396937)
0.564
2
UniProt:Q76353 Q76353
0.462
2
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text