Reactome | BCR [cytosol]

BCR [cytosol]

Stable Identifier

R-HSA-195200

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Bcr

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P11274 BCR

Gene Names

BCR, BCR1, D22S11

Chain

chain:1-1271

Reference Genes

BioGPS Gene:613 BCR

COSMIC (genes):BCR BCR

CTD Gene:613 BCR

dbSNP Gene:613 BCR

ENSEMBL:ENSG00000186716 BCR

ENSEMBL_homo_sapiens_GENE:ENSG00000186716.21 BCR

HGNC:1014 BCR

KEGG Gene (Homo sapiens):613 BCR

Monarch:613 BCR

NCBI Gene:613 BCR

OMIM:151410 BCR

UCSC:P11274 BCR

Reference Transcript

Other Identifiers

11726280_a_at

11726281_x_at

11726282_s_at

11748359_s_at

11749115_x_at

11752764_x_at

11752988_a_at

11752989_x_at

11753006_a_at

11753007_x_at

1333_f_at

16927907

202315_PM_s_at

202315_s_at

2043_s_at

217223_PM_s_at

217223_s_at

226602_PM_s_at

226602_s_at

34679_at

3901466

3937955

3937958

3937959

3937960

3938989

3938997

3939005

3939008

3939177

3939185

3939186

3939187

3939188

3939197

3939199

3939200

3939202

3939203

3939204

3939205

3939212

3939213

3939216

3939217

3939218

3939220

3939222

3939225

3939233

3939235

3939237

3939238

3939241

3939243

3939246

3939247

3939249

3939250

3939251

3939252

3939253

3939979

3939982

3939987

3939989

3939992

3939995

3939996

3952316

3952322

3952331

3952333

3953699

3953702

3954008

3954009

3954014

3955217

3955220

3955224

3955232

537_f_at

613

64904_at

68350_s_at

74612_s_at

754_s_at

8071691

8074730

91639_at

91641_g_at

A_23_P503115

A_24_P127235

A_24_P162073

A_24_P873764

A_32_P56713

GE82611

GE86739

GO:0000166

GO:0002376

GO:0002692

GO:0003013

GO:0003014

GO:0003824

GO:0004674

GO:0004713

GO:0005085

GO:0005096

GO:0005515

GO:0005524

GO:0005576

GO:0005615

GO:0005829

GO:0005886

GO:0006468

GO:0006886

GO:0006909

GO:0006954

GO:0007010

GO:0007155

GO:0007165

GO:0007264

GO:0007420

GO:0014069

GO:0016020

GO:0016192

GO:0016301

GO:0016310

GO:0016477

GO:0016740

GO:0023052

GO:0030036

GO:0030154

GO:0030216

GO:0030424

GO:0032496

GO:0032991

GO:0034330

GO:0035023

GO:0035556

GO:0036211

GO:0042472

GO:0042995

GO:0043114

GO:0043197

GO:0043226

GO:0043312

GO:0043314

GO:0043547

GO:0045202

GO:0048041

GO:0048856

GO:0048870

GO:0048872

GO:0050728

GO:0050766

GO:0050804

GO:0050877

GO:0050885

GO:0051056

GO:0051171

GO:0051649

GO:0051726

GO:0055085

GO:0060216

GO:0060268

GO:0060313

GO:0065002

GO:0070062

GO:0071222

GO:0090630

GO:0098685

GO:0098772

GO:0098978

GO:0106310

GO:0140096

GO:1905517

GO:1905522

GO:2000378

HMNXSV003010355

HMNXSV003040590

HMNXSV003058001

Hs.234799.2.S1_3p_a_at

Hs.296429.1.A1_3p_a_at

Hs.296429.1.A1_3p_x_at

ILMN_1668907

ILMN_1670398

ILMN_1680683

ILMN_1792592

ILMN_2333146

PH_hs_0033657

PH_hs_0040337

TC22000129.hg

TC22000154.hg

TC22000587.hg

TC22001011.hg

TC22001012.hg

TC22001014.hg

TC22001027.hg

X02596_at

p33809

Participates

as a candidate of

as a member of

RAC2 GEFs [cytosol] (Homo sapiens)

Other forms of this molecule

BCR(1-584)-p-FGFR1(429-822) fusion [cytosol]

p-Y177-BCR(1-584)-p-FGFR1(429-822) fusion [cytosol]

BCR(1-584)-FGFR1(429-822) fusion [cytosol]

Inferred To

RhoGAP1A [cytosol] (Drosophila melanogaster)

Bcr [cytosol] (Mus musculus)

Bcr [cytosol] (Rattus norvegicus)

bcr [cytosol] (Xenopus tropicalis)

BCR [cytosol] (Bos taurus)

BCR [cytosol] (Canis familiaris)

BCR [cytosol] (Gallus gallus)

BCR [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_067585.2, NP_004318.3

Guide to Pharmacology - Targets

2755

OpenTargets

ENSG00000186716

ZINC - Substances

BCR_HUMAN

ZINC target

P11274

PRO

P11274

PDB

5N7E, 2AIN, 5N6R, 5OC7, 1K1F

GeneCards

P11274

HPA

ENSG00000186716-BCR

Ensembl

ENST00000305877, ENST00000359540, ENSP00000303507, ENSG00000186716, ENSP00000352535

Pharos - Targets

P11274

ZINC - Predictions - Purchasable

BCR_HUMAN

Orphanet

15365

HMDB Protein

HMDBP01966

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.928	13
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.595	5
UniProt:P63104 YWHAZ	2	YWHAZ [nucleoplasm] (R-HSA-450469) YWHAZ [cytosol] (R-HSA-206099)	0.527	2
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.527	2
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.527	2
UniProt:P55735 SEC13	4	SEC13 [lysosomal membrane] (R-HSA-9638246) SEC13 [ER to Golgi transport vesicle membrane] (R-HSA-204012) SEC13 [cytosol] (R-HSA-203981) SEC13 [endoplasmic reticulum membrane] (R-HSA-203994)	0.527	4
UniProt:Q96CW1 AP2M1	6	AP2M1 [plasma membrane] (R-HSA-167585) AP2M1 [lysosomal membrane] (R-HSA-196144) AP2M1 [cytosol] (R-HSA-182227) AP2M1 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130423) AP2M1 [endolysosome membrane] (R-HSA-6784828) p-T156 AP2M1 [cytosol] (R-HSA-8856805)	0.527	3
UniProt:O75386 TULP3	1	TULP3 [cilium] (R-HSA-5610445)	0.527	2
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.519	2
UniProt:P15311 EZR	3	p-Y146,Y354-EZR [cytosol] (R-HSA-374572) p-T567-EZR [cytosol] (R-HSA-374559) EZR [cytosol] (R-HSA-9020826)	0.483	3

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