Reactome | DIAPH1 [cytosol]

DIAPH1 [cytosol]

Stable Identifier

R-HSA-5665970

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Protein diaphanous homolog 1, Diaphanous-related formin-1, DRF1, DIAP1

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Developmental Biology (Homo sapiens)

- MITF-M-regulated melanocyte development (Homo sapiens)
  - MITF-M-dependent gene expression (Homo sapiens)
    - Regulation of MITF-M dependent genes involved in invasion (Homo sapiens)
      - MITF-M-dependent DIAPH1 expression (Homo sapiens)
        
        DIAPH1 [cytosol] (Homo sapiens)
        
        DIAPH1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:O60610 DIAPH1

Gene Names

DIAPH1, DIAP1

Chain

chain:1-1272

Reference Genes

BioGPS Gene:1729 DIAPH1

COSMIC (genes):DIAPH1 DIAPH1

CTD Gene:1729 DIAPH1

dbSNP Gene:1729 DIAPH1

ENSEMBL:ENSG00000131504 DIAPH1

HGNC:2876 DIAPH1

KEGG:hsa:1729 DIAPH1

Monarch:1729 DIAPH1

NCBI Gene:1729 DIAPH1

OMIM:602121 DIAPH1

UCSC:O60610 DIAPH1

Reference Transcript

Other Identifiers

11745167_a_at

11745168_s_at

11745169_a_at

11745170_a_at

11745171_x_at

11745415_a_at

11745416_x_at

11753135_a_at

17000858

1729

209190_PM_s_at

209190_s_at

213514_PM_s_at

213514_s_at

215541_PM_s_at

215541_s_at

2878663

2878664

2878665

2878667

2878670

2878671

2878672

2878673

2878674

2878675

2878676

2878677

2878678

2878679

2878681

2878683

2878684

2878687

2878692

2878693

2878694

2878695

2878696

2878697

2878699

2878700

2878701

2878702

2878703

2878704

2878705

2878706

2878707

2878710

2878711

2878712

2878713

2878714

2878715

2878716

2878717

2878723

2878724

2878725

33920_at

8114658

A_23_P213344

A_24_P323104

A_33_P3243683

GE54439

GO:0003723

GO:0003779

GO:0005102

GO:0005515

GO:0005634

GO:0005737

GO:0005813

GO:0005815

GO:0005819

GO:0005829

GO:0005856

GO:0005884

GO:0005886

GO:0007010

GO:0007605

GO:0008092

GO:0008360

GO:0016043

GO:0030036

GO:0030041

GO:0030667

GO:0031267

GO:0032587

GO:0032886

GO:0035372

GO:0042995

GO:0043226

GO:0044325

GO:0050877

GO:0051279

GO:0051493

GO:0065003

GO:0071420

GO:0072686

GO:0101003

HMNXSV003048008

Hs.26584.1.S1_3p_a_at

Hs.26584.2.S1_3p_a_at

ILMN_1661554

ILMN_2321416

PH_hs_0028610

TC05001870.hg

g2947237_3p_a_at

Participates

as a member of

RHOB endosome effectors [cytosol] (Homo sapiens)

as a component of

DIAPH1 [cytosol] (Homo sapiens)

Other forms of this molecule

DIAPH1 [secretory granule membrane]

DIAPH1 [plasma membrane]

DIAPH1 [ficolin-1-rich granule membrane]

Inferred To

Diaph1 [cytosol] (Mus musculus)

Diaph1 [cytosol] (Rattus norvegicus)

Homologues of DIAPH1 [cytosol] (Caenorhabditis elegans)

dia [cytosol] (Drosophila melanogaster)

inft-2 [cytosol] (Caenorhabditis elegans)

cyk-1 [cytosol] (Caenorhabditis elegans)

DIAPH1 [cytosol] (Bos taurus)

DIAPH1 [cytosol] (Canis familiaris)

DIAPH1 [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_005210.3, NP_001073280.1

ENSEMBL

ENSP00000373706, ENSP00000428268, ENST00000518047, ENST00000389054

OpenTargets

ENSG00000131504

HPA

ENSG00000131504-DIAPH1

PRO

O60610

Pharos - Targets

O60610

GlyGen

O60610

Orphanet

DIAPH1

HMDB Protein

HMDBP08344

PDB

8FG1

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P61586 RHOA	6	RHOA [plasma membrane] (R-HSA-194510) RHOA [cell junction] (R-HSA-2134503) RHOA [cytosol] (R-HSA-194866) RHOA [ficolin-1-rich granule membrane] (R-HSA-6804971) RHOA [secretory granule membrane] (R-HSA-6804980) RHOA [endoplasmic reticulum membrane] (R-HSA-5672082)	0.602	3
UniProt:Q15109 AGER	1	AGER [plasma membrane] (R-HSA-197639)	0.581	3
UniProt:P49593 PPM1F	1	PPM1F [cytosol] (R-HSA-9619454)	0.544	3
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.527	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	7