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ATP6V1A [cytosol]
Stable Identifier
R-HSA-912602
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to starvation (Homo sapiens)
Amino acids regulate mTORC1 (Homo sapiens)
RRAGA,B exchanges GDP for GTP (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator [lysosomal membrane] (Homo sapiens)
v-ATPase [lysosomal membrane] (Homo sapiens)
ATP6V1 [cytosol] (Homo sapiens)
ATP6V1A trimer [cytosol] (Homo sapiens)
ATP6V1A [cytosol] (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator [lysosomal membrane] (Homo sapiens)
v-ATPase [lysosomal membrane] (Homo sapiens)
ATP6V1 [cytosol] (Homo sapiens)
ATP6V1A trimer [cytosol] (Homo sapiens)
ATP6V1A [cytosol] (Homo sapiens)
RRAGA,B hydrolyzes GTP (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator [lysosomal membrane] (Homo sapiens)
v-ATPase [lysosomal membrane] (Homo sapiens)
ATP6V1 [cytosol] (Homo sapiens)
ATP6V1A trimer [cytosol] (Homo sapiens)
ATP6V1A [cytosol] (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator [lysosomal membrane] (Homo sapiens)
v-ATPase [lysosomal membrane] (Homo sapiens)
ATP6V1 [cytosol] (Homo sapiens)
ATP6V1A trimer [cytosol] (Homo sapiens)
ATP6V1A [cytosol] (Homo sapiens)
RRAGC,D exchanges GTP for GDP (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator [lysosomal membrane] (Homo sapiens)
v-ATPase [lysosomal membrane] (Homo sapiens)
ATP6V1 [cytosol] (Homo sapiens)
ATP6V1A trimer [cytosol] (Homo sapiens)
ATP6V1A [cytosol] (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GTP [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator [lysosomal membrane] (Homo sapiens)
v-ATPase [lysosomal membrane] (Homo sapiens)
ATP6V1 [cytosol] (Homo sapiens)
ATP6V1A trimer [cytosol] (Homo sapiens)
ATP6V1A [cytosol] (Homo sapiens)
RRAGC,D hydrolyzes GTP (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator [lysosomal membrane] (Homo sapiens)
v-ATPase [lysosomal membrane] (Homo sapiens)
ATP6V1 [cytosol] (Homo sapiens)
ATP6V1A trimer [cytosol] (Homo sapiens)
ATP6V1A [cytosol] (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GTP [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator [lysosomal membrane] (Homo sapiens)
v-ATPase [lysosomal membrane] (Homo sapiens)
ATP6V1 [cytosol] (Homo sapiens)
ATP6V1A trimer [cytosol] (Homo sapiens)
ATP6V1A [cytosol] (Homo sapiens)
mTORC1 binds RHEB:GTP (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator [lysosomal membrane] (Homo sapiens)
v-ATPase [lysosomal membrane] (Homo sapiens)
ATP6V1 [cytosol] (Homo sapiens)
ATP6V1A trimer [cytosol] (Homo sapiens)
ATP6V1A [cytosol] (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator [lysosomal membrane] (Homo sapiens)
v-ATPase [lysosomal membrane] (Homo sapiens)
ATP6V1 [cytosol] (Homo sapiens)
ATP6V1A trimer [cytosol] (Homo sapiens)
ATP6V1A [cytosol] (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator [lysosomal membrane] (Homo sapiens)
v-ATPase [lysosomal membrane] (Homo sapiens)
ATP6V1 [cytosol] (Homo sapiens)
ATP6V1A trimer [cytosol] (Homo sapiens)
ATP6V1A [cytosol] (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator [lysosomal membrane] (Homo sapiens)
v-ATPase [lysosomal membrane] (Homo sapiens)
ATP6V1 [cytosol] (Homo sapiens)
ATP6V1A trimer [cytosol] (Homo sapiens)
ATP6V1A [cytosol] (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator [lysosomal membrane] (Homo sapiens)
v-ATPase [lysosomal membrane] (Homo sapiens)
ATP6V1 [cytosol] (Homo sapiens)
ATP6V1A trimer [cytosol] (Homo sapiens)
ATP6V1A [cytosol] (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator [lysosomal membrane] (Homo sapiens)
v-ATPase [lysosomal membrane] (Homo sapiens)
ATP6V1 [cytosol] (Homo sapiens)
ATP6V1A trimer [cytosol] (Homo sapiens)
ATP6V1A [cytosol] (Homo sapiens)
v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator [lysosomal membrane] (Homo sapiens)
v-ATPase [lysosomal membrane] (Homo sapiens)
ATP6V1 [cytosol] (Homo sapiens)
ATP6V1A trimer [cytosol] (Homo sapiens)
ATP6V1A [cytosol] (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Homo sapiens)
v-ATPase:Ragulator [lysosomal membrane] (Homo sapiens)
v-ATPase [lysosomal membrane] (Homo sapiens)
ATP6V1 [cytosol] (Homo sapiens)
ATP6V1A trimer [cytosol] (Homo sapiens)
ATP6V1A [cytosol] (Homo sapiens)
Developmental Biology (Homo sapiens)
MITF-M-regulated melanocyte development (Homo sapiens)
MITF-M-dependent gene expression (Homo sapiens)
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy (Homo sapiens)
MITF-M-dependent ATP6V1A gene expression (Homo sapiens)
ATP6V1A [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
ROS and RNS production in phagocytes (Homo sapiens)
Intraphagosomal pH is lowered to 5 by V-ATPase (Homo sapiens)
V-ATPase [phagocytic vesicle membrane] (Homo sapiens)
ATP6V1 [cytosol] (Homo sapiens)
ATP6V1A trimer [cytosol] (Homo sapiens)
ATP6V1A [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by Insulin receptor (Homo sapiens)
Insulin receptor recycling (Homo sapiens)
ATP6AP1 binds V-ATPase (Homo sapiens)
V-ATPase [endosome membrane] (Homo sapiens)
ATP6V1 [cytosol] (Homo sapiens)
ATP6V1A trimer [cytosol] (Homo sapiens)
ATP6V1A [cytosol] (Homo sapiens)
V-ATPase:ATP6AP1 [endosome membrane] (Homo sapiens)
V-ATPase [endosome membrane] (Homo sapiens)
ATP6V1 [cytosol] (Homo sapiens)
ATP6V1A trimer [cytosol] (Homo sapiens)
ATP6V1A [cytosol] (Homo sapiens)
Endosome acidification (Homo sapiens)
V-ATPase:ATP6AP1 [endosome membrane] (Homo sapiens)
V-ATPase [endosome membrane] (Homo sapiens)
ATP6V1 [cytosol] (Homo sapiens)
ATP6V1A trimer [cytosol] (Homo sapiens)
ATP6V1A [cytosol] (Homo sapiens)
Transport of small molecules (Homo sapiens)
Ion channel transport (Homo sapiens)
ATP6AP1 binds V-ATPase (Homo sapiens)
V-ATPase [endosome membrane] (Homo sapiens)
ATP6V1 [cytosol] (Homo sapiens)
ATP6V1A trimer [cytosol] (Homo sapiens)
ATP6V1A [cytosol] (Homo sapiens)
V-ATPase:ATP6AP1 [endosome membrane] (Homo sapiens)
V-ATPase [endosome membrane] (Homo sapiens)
ATP6V1 [cytosol] (Homo sapiens)
ATP6V1A trimer [cytosol] (Homo sapiens)
ATP6V1A [cytosol] (Homo sapiens)
Iron uptake and transport (Homo sapiens)
Transferrin endocytosis and recycling (Homo sapiens)
ATP6AP1 binds V-ATPase (Homo sapiens)
V-ATPase [endosome membrane] (Homo sapiens)
ATP6V1 [cytosol] (Homo sapiens)
ATP6V1A trimer [cytosol] (Homo sapiens)
ATP6V1A [cytosol] (Homo sapiens)
V-ATPase:ATP6AP1 [endosome membrane] (Homo sapiens)
V-ATPase [endosome membrane] (Homo sapiens)
ATP6V1 [cytosol] (Homo sapiens)
ATP6V1A trimer [cytosol] (Homo sapiens)
ATP6V1A [cytosol] (Homo sapiens)
Acidification of Tf:TfR1 containing endosome (Homo sapiens)
V-ATPase:ATP6AP1 [endosome membrane] (Homo sapiens)
V-ATPase [endosome membrane] (Homo sapiens)
ATP6V1 [cytosol] (Homo sapiens)
ATP6V1A trimer [cytosol] (Homo sapiens)
ATP6V1A [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P38606 ATP6V1A
Gene Names
ATP6V1A, ATP6A1, ATP6V1A1, VPP2
Chain
initiator methionine:, chain:1-617
Reference Genes
BioGPS Gene:523 ATP6V1A
COSMIC (genes):ATP6V1A ATP6V1A
CTD Gene:523 ATP6V1A
dbSNP Gene:523 ATP6V1A
ENSEMBL:ENSG00000114573 ATP6V1A
HGNC:851 ATP6V1A
KEGG:hsa:523 ATP6V1A
Monarch:523 ATP6V1A
NCBI Gene:523 ATP6V1A
OMIM:607027 ATP6V1A
UCSC:P38606 ATP6V1A
Reference Transcript
RefSeq:NM_001690.3 ATP6V1A
Other Identifiers
11718120_at
11718121_x_at
11718122_a_at
11751178_a_at
11756924_s_at
16944096
201971_PM_s_at
201971_s_at
201972_PM_at
201972_at
2636590
2636597
2636598
2636599
2636600
2636601
2636602
2636603
2636604
2636606
2636608
2636609
2636610
2636611
2636612
2636615
2636617
2636618
2636619
2636620
2636621
2636622
2636623
34889_at
34890_at
3910773
523
8081740
A_23_P211965
A_24_P396994
GE88476
GO:0000139
GO:0000221
GO:0003824
GO:0005215
GO:0005515
GO:0005524
GO:0005654
GO:0005737
GO:0005764
GO:0005765
GO:0005773
GO:0005829
GO:0005886
GO:0005902
GO:0006811
GO:0006879
GO:0007035
GO:0007042
GO:0010008
GO:0015986
GO:0016020
GO:0016241
GO:0016324
GO:0016469
GO:0016787
GO:0016874
GO:0016887
GO:0030133
GO:0030141
GO:0030665
GO:0031090
GO:0031410
GO:0033176
GO:0033180
GO:0036295
GO:0043226
GO:0043231
GO:0046034
GO:0046933
GO:0046961
GO:0048388
GO:0051452
GO:0055085
GO:0055086
GO:0061795
GO:0070062
GO:0097401
GO:0098850
GO:0140657
GO:1901135
GO:1902495
GO:1902600
GO:1904949
HMNXSV003015498
ILMN_1711516
L09235_at
PH_hs_0024782
TC03000583.hg
g4502304_3p_a_at
g6523820_3p_at
Participates
as an output of
MITF-M-dependent ATP6V1A gene expression (Homo sapiens)
as a component of
ATP6V1A trimer [cytosol] (Homo sapiens)
Inferred To
atp6v1a [cytosol]
(Xenopus tropicalis)
ATP6V1A [cytosol]
(Bos taurus)
ATP6V1A [cytosol]
(Caenorhabditis elegans)
ATP6V1A [cytosol]
(Canis familiaris)
ATP6V1A [cytosol]
(Dictyostelium discoideum)
ATP6V1A [cytosol]
(Drosophila melanogaster)
ATP6V1A [cytosol]
(Gallus gallus)
ATP6V1A [cytosol]
(Mus musculus)
ATP6V1A [cytosol]
(Plasmodium falciparum)
ATP6V1A [cytosol]
(Saccharomyces cerevisiae)
ATP6V1A [cytosol]
(Schizosaccharomyces pombe)
ATP6V1A [cytosol]
(Sus scrofa)
Atp6v1a [cytosol]
(Rattus norvegicus)
atp6v1ab [cytosol]
(Danio rerio)
Cross References
RefSeq
NP_001681.2
Guide to Pharmacology - Targets
810
OpenTargets
ENSG00000114573
ENSEMBL
ENSP00000515547
,
ENSP00000417545
,
ENST00000703911
,
ENST00000703904
,
ENSP00000273398
,
ENSP00000515542
,
ENST00000273398
,
ENSP00000515548
,
ENST00000703910
,
ENST00000496747
HPA
ENSG00000114573-ATP6V1A
PRO
P38606
Pharos - Targets
P38606
Orphanet
ATP6V1A
GlyGen
P38606
HMDB Protein
HMDBP01342
PDB
7U4T
,
6WLZ
,
6WM3
,
6WM2
,
7UNF
,
6WM4
Interactors (16)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9Y5K8 ATP6V1D
3
ATP6V1D [plasma membrane]
(R-HSA-6800455)
ATP6V1D [specific granule membrane]
(R-HSA-6799710)
ATP6V1D [cytosol]
(R-HSA-912597)
0.643
6
UniProt:P0DOF2 MATRX
0.632
10
UniProt:P36543 ATP6V1E1
1
ATP6V1E1 [cytosol]
(R-HSA-912606)
0.527
3
UniProt:P0DTC5 M
10
M [plasma membrane]
(R-COV-9755780)
N-glycan M [virion membrane]
(R-COV-9694385)
M [virion membrane]
(R-COV-9694320)
M [endocytic vesicle membrane]
(R-COV-9694563)
N-glycan M [endocytic vesicle membrane]
(R-COV-9694738)
M [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9694439)
N-glycan M [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9694446)
M [endoplasmic reticulum membrane]
(R-COV-9767620)
nascent M [endoplasmic reticulum lumen]
(R-COV-9694279)
N-glycan M [endoplasmic reticulum membrane]
(R-COV-9694684)
0.527
2
UniProt:O75348 ATP6V1G1
1
ATP6V1G1 [cytosol]
(R-HSA-912578)
0.527
3
UniProt:P21283 ATP6V1C1
1
ATP6V1C1 [cytosol]
(R-HSA-912586)
0.527
2
UniProt:Q9UI12 ATP6V1H
2
ATP6V1H [cytosol]
(R-HSA-167578)
ATP6V1H [plasma membrane]
(R-HSA-167602)
0.527
3
UniProt:Q9H444 CHMP4B
2
CHMP4B [cytosol]
(R-HSA-917708)
CHMP4B [endosome membrane]
(R-HSA-9631202)
0.527
2
UniProt:atp6v1g_human EBI-27061705
0.527
2
UniProt:atp6v1c_human EBI-27059051
0.527
3
UniProt:Q8NEY4 ATP6V1C2
1
ATP6V1C2 [cytosol]
(R-HSA-912573)
0.527
2
UniProt:Q96PV0 SYNGAP1
1
SYNGAP1 [cytosol]
(R-HSA-5658217)
0.527
6
UniProt:P21281 ATP6V1B2
1
ATP6V1B2 [cytosol]
(R-HSA-912598)
0.527
3
UniProt:O75787 ATP6AP2
3
ATP6AP2 [tertiary granule membrane]
(R-HSA-6799717)
ATP6AP2 [ficolin-1-rich granule membrane]
(R-HSA-6800921)
ATP6AP2 [plasma membrane]
(R-HSA-2022356)
0.527
2
UniProt:Q93050 ATP6V0A1
5
ATP6V0A1 [secretory granule membrane]
(R-HSA-6801281)
ATP6V0A1 [plasma membrane]
(R-HSA-6806520)
ATP6V0A1 [ficolin-1-rich granule membrane]
(R-HSA-6801296)
ATP6V0A1 [phagocytic vesicle membrane]
(R-HSA-1222308)
ATP6V0A1 [endosome membrane]
(R-HSA-912596)
0.527
3
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.483
12
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