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PHB [cytosol]
Stable Identifier
R-HSA-5672944
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Oncogenic MAPK signaling (Homo sapiens)
Paradoxical activation of RAF signaling by kinase inactive BRAF (Homo sapiens)
Inactive BRAF mutants bind mutant RAS:GTP (Homo sapiens)
PHB [cytosol] (Homo sapiens)
Signaling by RAS mutants (Homo sapiens)
Signaling downstream of RAS mutants (Homo sapiens)
RAS mutants bind inactive RAF (Homo sapiens)
PHB [cytosol] (Homo sapiens)
Signaling by moderate kinase activity BRAF mutants (Homo sapiens)
Moderate kinase activity BRAF mutants bind RAS:GTP (Homo sapiens)
PHB [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
RAF activation (Homo sapiens)
"Activator" RAF:YWHAB dimer binds RAS:GTP (Homo sapiens)
PHB [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P35232 PHB
Gene Names
PHB, PHB1
Chain
initiator methionine:1, chain:2-272
Reference Genes
BioGPS Gene:5245 PHB
COSMIC (genes):PHB PHB
CTD Gene:5245 PHB
dbSNP Gene:5245 PHB
ENSEMBL:ENSG00000167085 PHB
HGNC:8912 PHB
KEGG Gene (Homo sapiens):5245 PHB
Monarch:5245 PHB
NCBI Gene:5245 PHB
OMIM:176705 PHB
UCSC:P35232 PHB
Reference Transcript
RefSeq:NM_001281496.1 PHB
RefSeq:XM_017024763.1 PHB
RefSeq:NM_002634.3 PHB
RefSeq:NM_001281715.1 PHB
RefSeq:NM_001281497.1 PHB
Other Identifiers
11720609_at
11720610_x_at
11751776_a_at
16846416
200658_s_at
200659_s_at
2338404
3328113
3453061
3453064
3454751
36592_at
3660848
3761807
3761808
3761809
3761810
3761811
3761812
3761816
3761817
3761818
3761819
3761820
3761822
3761823
3761824
3761825
3761826
4016898
5245
8016552
80405_f_at
A_23_P130040
A_24_P262355
GE61229
GO:0000003
GO:0000122
GO:0001541
GO:0001552
GO:0001649
GO:0001850
GO:0001851
GO:0002376
GO:0002377
GO:0003674
GO:0003714
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005743
GO:0005768
GO:0005769
GO:0005886
GO:0005887
GO:0006259
GO:0006355
GO:0006464
GO:0006810
GO:0006851
GO:0006950
GO:0007005
GO:0007165
GO:0007202
GO:0008022
GO:0008150
GO:0008219
GO:0008283
GO:0008285
GO:0009056
GO:0009058
GO:0009986
GO:0010628
GO:0010942
GO:0010944
GO:0014069
GO:0016020
GO:0016575
GO:0019899
GO:0023035
GO:0030061
GO:0030154
GO:0030308
GO:0031100
GO:0031315
GO:0031410
GO:0031871
GO:0032620
GO:0032991
GO:0034097
GO:0034641
GO:0035632
GO:0035902
GO:0039529
GO:0040007
GO:0042113
GO:0042177
GO:0042493
GO:0042826
GO:0042981
GO:0043066
GO:0043226
GO:0043434
GO:0044403
GO:0044830
GO:0045471
GO:0045745
GO:0045892
GO:0045893
GO:0045917
GO:0046718
GO:0046982
GO:0048661
GO:0048856
GO:0050821
GO:0050847
GO:0051276
GO:0051897
GO:0055085
GO:0060766
GO:0070062
GO:0070373
GO:0070374
GO:0071354
GO:0071897
GO:0072538
GO:0098978
GO:0140374
GO:1901224
GO:1990051
GO:2000323
Hs.75323.0.A1_3p_a_at
ILMN_1692651
PH_hs_0004311
S85655_at
TC17001664.hg
g6031190_3p_a_at
This entity regulates
Positively
Inactive BRAF mutants bind mutant RAS:GTP
Moderate kinase activity BRAF mutants bind RAS:GTP
RAS mutants bind inactive RAF
"Activator" RAF:YWHAB dimer binds RAS:GTP
Other forms of this molecule
PHB [mitochondrial inner membrane]
Inferred To
phb [cytosol] (Danio rerio)
phb [cytosol] (Xenopus tropicalis)
Phb [cytosol] (Mus musculus)
Phb [cytosol] (Rattus norvegicus)
PHB [cytosol] (Bos taurus)
PHB [cytosol] (Canis familiaris)
PHB [cytosol] (Sus scrofa)
Cross References
RefSeq
NP_001268426.1
,
NP_001268644.1
,
XP_016880252.1
,
NP_002625.1
,
NP_001268425.1
OpenTargets
ENSG00000167085
HPA
ENSG00000167085-PHB
GeneCards
P35232
Ensembl
ENSG00000167085
,
ENST00000614445
,
ENSP00000479488
,
ENST00000511832
,
ENST00000617874
,
ENSP00000425035
,
ENSP00000300408
,
ENSP00000484113
,
ENST00000300408
PRO
P35232
PDB
1LU7
Interactors (11)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P0C6X7-PRO_0000037310 REP
0.643
4
UniProt:P04637 TP53
27
TP53 [cytosol]
(R-HSA-8869337)
Unfolded TP53 [cytosol]
(R-HSA-6813797)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6782509)
SUMO2,3-K386-TP53 [nucleoplasm]
(R-HSA-2997661)
Me2K-370,382-TP53 [nucleoplasm]
(R-HSA-3222242)
p-S15,S33,S46-TP53 [nucleoplasm]
(R-HSA-6805268)
p-S15,S392-TP53 [nucleoplasm]
(R-HSA-3222015)
p-T55-TP53 [nucleoplasm]
(R-HSA-6805400)
p-S15,S20,S392-TP53 [nucleoplasm]
(R-HSA-6805053)
p-S15,S20,S269,T284-TP53 [nucleoplasm]
(R-HSA-6805133)
p-S315-TP53 [nucleoplasm]
(R-HSA-6805106)
Ac-K120,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-6805656)
Ac-K120,K382,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-6805631)
Ac-K382,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-5628868)
Me2-K373-TP53 [nucleoplasm]
(R-HSA-6805759)
MeK-370,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-3222226)
p-S15,S20,Me-R333,Me2-R335,R337-TP53 [nucleoplasm]
(R-HSA-6804378)
Me-K382,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-3222124)
Me1-K372,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-6805719)
p-S15,S20,S46-TP53 [nucleoplasm]
(R-HSA-6798369)
p-S37-TP53 [nucleoplasm]
(R-HSA-3239022)
PolyUb,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-6804446)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6793679)
PolyUb-TP53 [cytosol]
(R-HSA-6793681)
p-S15,S20-TP53 [nucleoplasm]
(R-HSA-69683)
p-S15-TP53 [nucleoplasm]
(R-HSA-69507)
TP53 [nucleoplasm]
(R-HSA-69488)
0.619
6
UniProt:Q99623 PHB2
1
PHB2 [mitochondrial inner membrane]
(R-HSA-8953721)
0.589
3
UniProt:Q96IW7 SEC22A
3
SEC22A [ER to Golgi transport vesicle membrane]
(R-HSA-5688560)
SEC22A [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-5688562)
SEC22A [endoplasmic reticulum membrane]
(R-HSA-5216111)
0.556
3
UniProt:P19320 VCAM1
1
VCAM1 [plasma membrane]
(R-HSA-197834)
0.527
4
UniProt:Q496Y0 LONF3
0.524
2
UniProt:Q9JLL3 TNR19
0.524
3
UniProt:P27105 STOM
4
STOM [plasma membrane]
(R-HSA-6806258)
STOM [tertiary granule membrane]
(R-HSA-6800960)
STOM [azurophil granule membrane]
(R-HSA-6800997)
STOM [specific granule membrane]
(R-HSA-6799569)
0.508
2
UniProt:Q9NS68 TNR19
0.463
3
UniProt:P04578-PRO_0000038428 ENV
0.462
4
UniProt:P56180-2 TPTE
0.462
2
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