Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
Docs
User Guide
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
Data Model
Computational inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyze Data
Species Comparison
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site map
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
Docs
User Guide
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
Data Model
Computational inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyze Data
Species Comparison
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site map
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Download
Search ...
Go!
PHB
Stable Identifier
R-HSA-5672944
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction (Homo sapiens)
Oncogenic MAPK signaling (Homo sapiens)
Paradoxical activation of RAF signaling by kinase inactive BRAF (Homo sapiens)
Inactive BRAF mutants bind mutant RAS:GTP (Homo sapiens)
PHB [cytosol] (Homo sapiens)
Signaling by RAS mutants (Homo sapiens)
RAS mutants bind inactive RAF (Homo sapiens)
PHB [cytosol] (Homo sapiens)
Signaling by moderate kinase activity BRAF mutants (Homo sapiens)
Moderate kinase activity BRAF mutants bind RAS:GTP (Homo sapiens)
PHB [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
RAF activation (Homo sapiens)
"Activator" RAF:YWHAB dimer binds RAS:GTP (Homo sapiens)
PHB [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P35232 PHB
Gene Names
PHB
Chain
initiator methionine:1, chain:2-272
Reference Genes
BioGPS Gene:5245 PHB
COSMIC (genes):PHB PHB
CTD Gene:5245 PHB
dbSNP Gene:5245 PHB
ENSEMBL:ENSG00000167085 PHB
ENSEMBL:ENSG00000167085 PHB
HGNC:8912 PHB
KEGG Gene (Homo sapiens):hsa:5245 PHB
Monarch:5245 PHB
NCBI Gene:5245 PHB
OMIM:176705 PHB
UCSC:P35232 PHB
Reference Transcript
RefSeq:NM_002634.3 PHB
RefSeq:XM_017024763.1 PHB
RefSeq:NM_001281715.1 PHB
RefSeq:NM_001281497.1 PHB
RefSeq:NM_001281496.1 PHB
Other Identifiers
11720609_at
11720610_x_at
11751776_a_at
16846416
1LU7
200658_s_at
200659_s_at
2338404
3280
3328113
3453061
3453064
3454751
36592_at
3660848
3761808
3761809
3761810
3761811
3761812
3761816
3761817
3761818
3761819
3761820
3761822
3761823
3761824
3761825
3761826
4016898
5245
8016552
80405_f_at
A8K401
A_23_P130040
A_24_P262355
AAB21614
AAH13401
AAH95460
AAO18340
AAP36079
AC091180
AK290766
AK302258
AK312649
BAF83455
BAG35532
BAG63609
BC013401
BC095460
BT007411
CCDS11548
CCDS62244
CH471109
EAW94680
EAW94681
ENSG00000167085
ENSP00000300408
ENSP00000425035
ENSP00000479488
ENSP00000484113
ENST00000300408
ENST00000511832
ENST00000614445
ENST00000617874
EntrezGene:5245
g6031190_3p_a_at
GE61229
GO:0000122
GO:0000981
GO:0001649
GO:0001850
GO:0001851
GO:0002376
GO:0003674
GO:0003677
GO:0003700
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005623
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005743
GO:0005768
GO:0005769
GO:0005886
GO:0005887
GO:0006259
GO:0006355
GO:0006464
GO:0006810
GO:0006851
GO:0006950
GO:0007005
GO:0007165
GO:0008022
GO:0008150
GO:0008219
GO:0008283
GO:0008285
GO:0009056
GO:0009058
GO:0009986
GO:0010628
GO:0010942
GO:0010944
GO:0016020
GO:0016575
GO:0019899
GO:0030154
GO:0030308
GO:0031410
GO:0031871
GO:0034641
GO:0040007
GO:0042177
GO:0042826
GO:0042981
GO:0043209
GO:0043226
GO:0044212
GO:0045745
GO:0045892
GO:0045893
GO:0045917
GO:0050821
GO:0050847
GO:0051276
GO:0051604
GO:0055085
GO:0060766
GO:0070062
GO:0070373
GO:0070374
GO:0071354
GO:0071897
GO:2000323
HGNC:8912
HPA003280
Hs.75323.0.A1_3p_a_at
ILMN_1692651
IPR000163
IPR001107
IPR036013
L14272
MIM:114480
MIM:176705
NM_001281496
NM_001281497
NM_001281715
NM_002634
NP_001268425
NP_001268426
NP_001268644
NP_002625
PF01145
PH_hs_0004311
PHB
PHB-201
PHB-210
PHB-214
PHB-215
PR00679
S85655
S85655_at
SM00244
TC17001664.hg
uc002iox.3
uc032fmd.2
uc032fme.2
uc060haq.1
UPI000000DCDE
UPI00017A80FF
XM_017024763
XP_016880252
This entity regulates
Positive Regulation
Positive regulation by 'PHB [cytosol]'
Positive regulation by 'PHB [cytosol]'
Positive regulation by 'PHB [cytosol]'
Positive regulation by 'PHB [cytosol]'
Other forms of this molecule
PHB [mitochondrial inner membrane]
Inferred To
PHB [cytosol] (Bos taurus)
PHB [cytosol] (Caenorhabditis elegans)
PHB [cytosol] (Canis familiaris)
PHB [cytosol] (Danio rerio)
PHB [cytosol] (Drosophila melanogaster)
PHB [cytosol] (Gallus gallus)
PHB [cytosol] (Mus musculus)
PHB [cytosol] (Sus scrofa)
PHB [cytosol] (Xenopus tropicalis)
Homologues of PHB [cytosol] (Sus scrofa)
Cross References
RefSeq
NP_001268425.1
,
NP_002625.1
,
XP_016880252.1
,
NP_001268644.1
,
NP_001268426.1
GeneCards
P35232
PRO
P35232
PDB
1LU7
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P04637 TP53
27
TP53 [cytosol]
(R-HSA-8869337)
Unfolded TP53 [cytosol]
(R-HSA-6813797)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6782509)
SUMO2,3-K386-TP53 [nucleoplasm]
(R-HSA-2997661)
Me2K-370,382-TP53 [nucleoplasm]
(R-HSA-3222242)
Ac-K120,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-6805656)
Ac-K120,K382,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-6805631)
Ac-K382,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-5628868)
p-T55-TP53 [nucleoplasm]
(R-HSA-6805400)
p-S15,S20,S392-TP53 [nucleoplasm]
(R-HSA-6805053)
p-S15,S392-TP53 [nucleoplasm]
(R-HSA-3222015)
p-S315-TP53 [nucleoplasm]
(R-HSA-6805106)
p-S15,S20,S46-TP53 [nucleoplasm]
(R-HSA-6798369)
p-S15,S33,S46-TP53 [nucleoplasm]
(R-HSA-6805268)
p-S15,S20,S269,T284-TP53 [nucleoplasm]
(R-HSA-6805133)
PolyUb,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-6804446)
MeK-370,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-3222226)
Me2-K373-TP53 [nucleoplasm]
(R-HSA-6805759)
Me1-K372,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-6805719)
p-S15,S20,Me-R333,Me2-R335,R337-TP53 [nucleoplasm]
(R-HSA-6804378)
Me-K382,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-3222124)
p-S37-TP53 [nucleoplasm]
(R-HSA-3239022)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6793679)
PolyUb-TP53 [cytosol]
(R-HSA-6793681)
p-S15,S20-TP53 [nucleoplasm]
(R-HSA-69683)
p-S15-TP53 [nucleoplasm]
(R-HSA-69507)
TP53 [nucleoplasm]
(R-HSA-69488)
0.619
6
UniProt:P19320 VCAM1
1
VCAM1 [plasma membrane]
(R-HSA-197834)
0.527
4
UniProt:Q496Y0 LONF3
0.524
2
UniProt:P27105 STOM
4
STOM [azurophil granule membrane]
(R-HSA-6800997)
STOM [tertiary granule membrane]
(R-HSA-6800960)
STOM [plasma membrane]
(R-HSA-6806258)
STOM [specific granule membrane]
(R-HSA-6799569)
0.508
2
UniProt:Q96IW7 SEC22A
3
SEC22A [ER to Golgi transport vesicle membrane]
(R-HSA-5688560)
SEC22A [endoplasmic reticulum membrane]
(R-HSA-5216111)
SEC22A [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-5688562)
0.488
2
UniProt:P04578-PRO_0000038428 ENV
0.462
4
UniProt:P56180-2 TPTE
0.462
2
© 2018
Reactome
