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ITGA2 [plasma membrane]
Stable Identifier
R-HSA-57562
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Integrin alpha-2, Platelet membrane glycoprotein Ia, GPIa, Collagen receptor, VLA-2 alpha chain, CD49b
Icon
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
L1CAM interactions (Homo sapiens)
CHL1 interactions (Homo sapiens)
CHL1 interacts with beta1 integrins (Homo sapiens)
CHL1:alpha1beta1/alpha2beta1 integrins [plasma membrane] (Homo sapiens)
Integrin alpha1beta1, alpha2beta1, alpha10beta1 [plasma membrane] (Homo sapiens)
ITGA2:ITGB1 [plasma membrane] (Homo sapiens)
ITGA2 [plasma membrane] (Homo sapiens)
Integrin alpha1beta1, alpha2beta1, alpha10beta1 [plasma membrane] (Homo sapiens)
ITGA2:ITGB1 [plasma membrane] (Homo sapiens)
ITGA2 [plasma membrane] (Homo sapiens)
Extracellular matrix organization (Homo sapiens)
ECM proteoglycans (Homo sapiens)
TNC binds Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1 (Homo sapiens)
Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1 [plasma membrane] (Homo sapiens)
ITGA2:ITGB1 [plasma membrane] (Homo sapiens)
ITGA2 [plasma membrane] (Homo sapiens)
TNC:Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1 [plasma membrane] (Homo sapiens)
Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1 [plasma membrane] (Homo sapiens)
ITGA2:ITGB1 [plasma membrane] (Homo sapiens)
ITGA2 [plasma membrane] (Homo sapiens)
Integrin cell surface interactions (Homo sapiens)
AGRN binds Integrins alphaVbeta1 (Other beta1-containing integrins) (Homo sapiens)
Agrin:Integrin alphaVbeta1 (other beta1) [plasma membrane] (Homo sapiens)
Integrins alphaVbeta1 (other beta 1) [plasma membrane] (Homo sapiens)
ITGA2:ITGB1 [plasma membrane] (Homo sapiens)
ITGA2 [plasma membrane] (Homo sapiens)
Integrins alphaVbeta1 (other beta 1) [plasma membrane] (Homo sapiens)
ITGA2:ITGB1 [plasma membrane] (Homo sapiens)
ITGA2 [plasma membrane] (Homo sapiens)
Collagen type I binds integrin alpha1beta1, alpha2beta1, alpha10beta1 (Homo sapiens)
Integrin alpha1beta1, alpha2beta1, alpha10beta1 [plasma membrane] (Homo sapiens)
ITGA2:ITGB1 [plasma membrane] (Homo sapiens)
ITGA2 [plasma membrane] (Homo sapiens)
Integrins alpha1beta1, alpha2beta1:Collagen type I fibril:Mg2+ [plasma membrane] (Homo sapiens)
Integrin alpha1beta1, alpha2beta1, alpha10beta1 [plasma membrane] (Homo sapiens)
ITGA2:ITGB1 [plasma membrane] (Homo sapiens)
ITGA2 [plasma membrane] (Homo sapiens)
Collagen type II binds integrin alpha2beta1, alpha1beta1, alpha11beta1 (Homo sapiens)
Collagen type II fibril:Integrins alpha2beta1, alpha1beta1, alpha11beta1 [plasma membrane] (Homo sapiens)
Integrins alpha1beta1, alpha2beta1, alpha11beta1 [plasma membrane] (Homo sapiens)
ITGA2:ITGB1 [plasma membrane] (Homo sapiens)
ITGA2 [plasma membrane] (Homo sapiens)
Integrins alpha1beta1, alpha2beta1, alpha11beta1 [plasma membrane] (Homo sapiens)
ITGA2:ITGB1 [plasma membrane] (Homo sapiens)
ITGA2 [plasma membrane] (Homo sapiens)
Collagen type IV networks bind integrins alpha1beta1, alpha2beta1 (Homo sapiens)
Integrin alpha1beta1, alpha2beta1, alpha10beta1 [plasma membrane] (Homo sapiens)
ITGA2:ITGB1 [plasma membrane] (Homo sapiens)
ITGA2 [plasma membrane] (Homo sapiens)
Integrins alpha1beta1, alpha2beta1:Collagen type IV networks:Mg2+ [plasma membrane] (Homo sapiens)
Integrin alpha1beta1, alpha2beta1, alpha10beta1 [plasma membrane] (Homo sapiens)
ITGA2:ITGB1 [plasma membrane] (Homo sapiens)
ITGA2 [plasma membrane] (Homo sapiens)
Collagen type VII binds integrin alpha2beta1 (Homo sapiens)
Collagen type VII fibril:Integrin alpha2beta1 [plasma membrane] (Homo sapiens)
ITGA2:ITGB1 [plasma membrane] (Homo sapiens)
ITGA2 [plasma membrane] (Homo sapiens)
ITGA2:ITGB1 [plasma membrane] (Homo sapiens)
ITGA2 [plasma membrane] (Homo sapiens)
Collagen type X binds Integrin alpha2beta1 (Homo sapiens)
Collagen type X network:Integrin alpha2beta1 [plasma membrane] (Homo sapiens)
ITGA2:ITGB1 [plasma membrane] (Homo sapiens)
ITGA2 [plasma membrane] (Homo sapiens)
ITGA2:ITGB1 [plasma membrane] (Homo sapiens)
ITGA2 [plasma membrane] (Homo sapiens)
Collagen type XXIII binds Integrin alpha2beta1 (Homo sapiens)
Collagen type XXIII:Integrin alpha2beta1 [plasma membrane] (Homo sapiens)
ITGA2:ITGB1 [plasma membrane] (Homo sapiens)
ITGA2 [plasma membrane] (Homo sapiens)
ITGA2:ITGB1 [plasma membrane] (Homo sapiens)
ITGA2 [plasma membrane] (Homo sapiens)
Collagen types III, IV, V, VI, VIII, IX, XVI bind integrins alpha1beta1 and alpha2beta1 (Homo sapiens)
Collagen types III, IV, V, VI, VIII, IX, XVI:Integrins alpha1beta 1, alpha2beta1 [plasma membrane] (Homo sapiens)
Integrin alpha1beta1, alpha2beta1, alpha10beta1 [plasma membrane] (Homo sapiens)
ITGA2:ITGB1 [plasma membrane] (Homo sapiens)
ITGA2 [plasma membrane] (Homo sapiens)
Integrin alpha1beta1, alpha2beta1, alpha10beta1 [plasma membrane] (Homo sapiens)
ITGA2:ITGB1 [plasma membrane] (Homo sapiens)
ITGA2 [plasma membrane] (Homo sapiens)
Endorepellin binds alpha2beta1 integrin (Homo sapiens)
HSPG2(3687-4391):Integrin alpha2beta1 [plasma membrane] (Homo sapiens)
ITGA2:ITGB1 [plasma membrane] (Homo sapiens)
ITGA2 [plasma membrane] (Homo sapiens)
ITGA2:ITGB1 [plasma membrane] (Homo sapiens)
ITGA2 [plasma membrane] (Homo sapiens)
LUM (lumican) binds integrin alpha2beta1 (Homo sapiens)
ITGA2:ITGB1 [plasma membrane] (Homo sapiens)
ITGA2 [plasma membrane] (Homo sapiens)
LUM:Integrin alpha2beta1 [plasma membrane] (Homo sapiens)
ITGA2:ITGB1 [plasma membrane] (Homo sapiens)
ITGA2 [plasma membrane] (Homo sapiens)
Laminin interactions (Homo sapiens)
Integrin alpha2beta1 binds laminin-332 (Homo sapiens)
ITGA2:ITGB1 [plasma membrane] (Homo sapiens)
ITGA2 [plasma membrane] (Homo sapiens)
Integrin alpha2beta1:Laminin-332 [plasma membrane] (Homo sapiens)
ITGA2:ITGB1 [plasma membrane] (Homo sapiens)
ITGA2 [plasma membrane] (Homo sapiens)
Integrin alpha6beta1, alpha7beta1, alpha1beta1, alpha2beta1 bind laminin-111 (Homo sapiens)
Integrin alpha6beta1, alpha7beta1, alpha1beta1, alpha2beta1, alphaVbeta1 [plasma membrane] (Homo sapiens)
ITGA2:ITGB1 [plasma membrane] (Homo sapiens)
ITGA2 [plasma membrane] (Homo sapiens)
Integrin alpha6beta1, alpha7beta1, alpha1beta1, alpha2beta1, alphaVbeta1:Laminin-111 [plasma membrane] (Homo sapiens)
Integrin alpha6beta1, alpha7beta1, alpha1beta1, alpha2beta1, alphaVbeta1 [plasma membrane] (Homo sapiens)
ITGA2:ITGB1 [plasma membrane] (Homo sapiens)
ITGA2 [plasma membrane] (Homo sapiens)
Non-integrin membrane-ECM interactions (Homo sapiens)
Syndecan interactions (Homo sapiens)
Syndecan-1 binds Integrins alpha2beta1, (alpha6beta4) (Homo sapiens)
Integrin alpha2beta1, (alpha6beta4) [plasma membrane] (Homo sapiens)
ITGA2:ITGB1 [plasma membrane] (Homo sapiens)
ITGA2 [plasma membrane] (Homo sapiens)
Syndecan-1:Integrin alpha2beta1 (alpha6beta4) [plasma membrane] (Homo sapiens)
Integrin alpha2beta1, (alpha6beta4) [plasma membrane] (Homo sapiens)
ITGA2:ITGB1 [plasma membrane] (Homo sapiens)
ITGA2 [plasma membrane] (Homo sapiens)
Hemostasis (Homo sapiens)
Platelet Adhesion to exposed collagen (Homo sapiens)
Collagen type I binds integrin alpha1beta1, alpha2beta1, alpha10beta1 (Homo sapiens)
Integrin alpha1beta1, alpha2beta1, alpha10beta1 [plasma membrane] (Homo sapiens)
ITGA2:ITGB1 [plasma membrane] (Homo sapiens)
ITGA2 [plasma membrane] (Homo sapiens)
Integrins alpha1beta1, alpha2beta1:Collagen type I fibril:Mg2+ [plasma membrane] (Homo sapiens)
Integrin alpha1beta1, alpha2beta1, alpha10beta1 [plasma membrane] (Homo sapiens)
ITGA2:ITGB1 [plasma membrane] (Homo sapiens)
ITGA2 [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by MET (Homo sapiens)
MET promotes cell motility (Homo sapiens)
MET activates PTK2 signaling (Homo sapiens)
PTK2 binds activated MET (Homo sapiens)
Integrin alpha2beta1,alpha3:beta1:(collagen,laminin,fibronectin) [plasma membrane] (Homo sapiens)
Integrin alpha2beta1,alpha3beta1 [plasma membrane] (Homo sapiens)
ITGA2:ITGB1 [plasma membrane] (Homo sapiens)
ITGA2 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P17301 ITGA2
Gene Names
ITGA2, CD49B
Chain
signal peptide:1-29, chain:30-1181
Reference Genes
BioGPS Gene:3673 ITGA2
COSMIC (genes):ITGA2 ITGA2
CTD Gene:3673 ITGA2
dbSNP Gene:3673 ITGA2
ENSEMBL:ENSG00000164171 ITGA2
ENSEMBL_homo_sapiens_GENE:ENSG00000164171.11 ITGA2
HGNC:6137 ITGA2
KEGG Gene (Homo sapiens):3673 ITGA2
Monarch:3673 ITGA2
NCBI Gene:3673 ITGA2
OMIM:192974 ITGA2
UCSC:P17301 ITGA2
Reference Transcript
RefSeq:NM_002203.3 ITGA2
Other Identifiers
11743617_at
11743618_at
16984689
1978_at
205032_PM_at
205032_at
227314_PM_at
227314_at
2809246
2809247
2809256
2809263
2809268
2809269
2809271
2809272
2809273
2809274
2809275
2809276
2809277
2809278
2809279
2809280
2809281
2809283
2809284
2809285
2809286
2809287
2809290
2809291
2809292
2809294
2809295
2809296
2809297
2809298
2809299
2809301
2809302
2809303
2809304
2809305
3673
41481_at
46919_at
8105267
A_14_P126228
A_23_P70161
A_32_P178800
A_32_P208076
GE62439
GE87545
GO:0001540
GO:0001618
GO:0001666
GO:0002376
GO:0002687
GO:0003012
GO:0005178
GO:0005515
GO:0005518
GO:0005886
GO:0005925
GO:0006929
GO:0006971
GO:0007155
GO:0007160
GO:0007229
GO:0007565
GO:0007596
GO:0008305
GO:0009410
GO:0009887
GO:0009897
GO:0009986
GO:0010634
GO:0014070
GO:0014075
GO:0014850
GO:0014911
GO:0016020
GO:0016192
GO:0022414
GO:0023052
GO:0030154
GO:0030424
GO:0030879
GO:0031346
GO:0031589
GO:0032967
GO:0033591
GO:0033627
GO:0034330
GO:0034666
GO:0038064
GO:0038065
GO:0042060
GO:0042995
GO:0043236
GO:0043395
GO:0043589
GO:0043679
GO:0044877
GO:0045178
GO:0045727
GO:0045785
GO:0045987
GO:0046718
GO:0046872
GO:0048041
GO:0048333
GO:0048471
GO:0048661
GO:0048856
GO:0048870
GO:0050877
GO:0050927
GO:0050966
GO:0051971
GO:0060089
GO:0060100
GO:0061024
GO:0070365
GO:0071107
GO:0071260
GO:0071392
GO:0071407
GO:0098609
GO:0098631
GO:0098639
GO:0098793
HMNXSV003046194
Hs.55168.0.A1_3p_at
ILMN_1665792
M28249_at
PH_hs_0024434
TC05000218.hg
g6006008_3p_at
Participates
as a component of
ITGA2:ITGB1 [plasma membrane] (Homo sapiens)
Inferred To
Itga2 [plasma membrane]
(Rattus norvegicus)
if [plasma membrane]
(Drosophila melanogaster)
itga2 [plasma membrane]
(Xenopus tropicalis)
pat-2 [plasma membrane]
(Caenorhabditis elegans)
ITGA2 [plasma membrane]
(Bos taurus)
ITGA2 [plasma membrane]
(Canis familiaris)
ITGA2 [plasma membrane]
(Gallus gallus)
ITGA2 [plasma membrane]
(Mus musculus)
ITGA2 [plasma membrane]
(Sus scrofa)
Cross References
RefSeq
NP_002194.2
Guide to Pharmacology - Targets
2440
OpenTargets
ENSG00000164171
ZINC - Substances
ITA2_HUMAN
ZINC target
P17301
PRO
P17301
PDB
5THP
,
6NDF
,
6NDA
,
6NDE
,
6NDG
,
1DZI
,
1V7P
,
4BJ3
,
6NDB
,
6NDD
,
6NDC
,
5HJ2
,
6ND9
,
6ND8
,
6NDH
,
1AOX
HPA
ENSG00000164171-ITGA2
GeneCards
P17301
Ensembl
ENST00000296585
,
ENSP00000296585
,
ENSG00000164171
Pharos - Targets
P17301
Orphanet
21897
ZINC - Predictions - Purchasable
ITA2_HUMAN
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P05556 ITGB1
2
ITGB1 [endosome membrane]
(R-HSA-9611157)
ITGB1 [plasma membrane]
(R-HSA-57596)
0.678
5
UniProt:Q9H0F6 SHARPIN
1
SHARPIN [cytosol]
(R-HSA-5212666)
0.664
5
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.483
5
UniProt:P21926 CD9
4
CD9 [plasma membrane]
(R-HSA-51717)
CD9 [endocytic vesicle membrane]
(R-HSA-5334774)
CD9 [clathrin-coated endocytic vesicle membrane]
(R-HSA-5334779)
CD9 [platelet alpha granule membrane]
(R-HSA-114585)
0.462
2
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