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What is Reactome ?
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Table of Contents
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Pi [cytosol]
Stable Identifier
R-ALL-29372
Type
Chemical Compound [SimpleEntity]
Compartment
cytosol
Synonyms
Orthophosphate, hydrogenphosphate, Phosphate, Inorganic Phosphate
Icon
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Dictyostelium discoideum
Drosophila melanogaster
Gallus gallus
Mus musculus
Mycobacterium tuberculosis
Plasmodium falciparum
Rattus norvegicus
Saccharomyces cerevisiae
Schizosaccharomyces pombe
Sus scrofa
Xenopus tropicalis
Expand all
Autophagy (Bos taurus)
Macroautophagy (Bos taurus)
ULK1 is dephosphorylated (Bos taurus)
Pi [cytosol]
Cell Cycle (Bos taurus)
Cell Cycle, Mitotic (Bos taurus)
M Phase (Bos taurus)
Mitotic Metaphase and Anaphase (Bos taurus)
Mitotic Anaphase (Bos taurus)
Nuclear Envelope (NE) Reassembly (Bos taurus)
Initiation of Nuclear Envelope (NE) Reformation (Bos taurus)
PP2A dephosphorylates BANF1 (Bos taurus)
Pi [cytosol]
Postmitotic nuclear pore complex (NPC) reformation (Bos taurus)
RAN stimulates fusion of nuclear envelope (NE) membranes (Bos taurus)
Pi [cytosol]
Sealing of the nuclear envelope (NE) by ESCRT-III (Bos taurus)
SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites (Bos taurus)
Pi [cytosol]
Mitotic Prometaphase (Bos taurus)
Condensation of Prometaphase Chromosomes (Bos taurus)
Dephosphorylation of CK2-modified condensin I (Bos taurus)
Pi [cytosol]
Resolution of Sister Chromatid Cohesion (Bos taurus)
PP2A-B56 dephosphorylates centromeric cohesin (Bos taurus)
Pi [cytosol]
Mitotic G2-G2/M phases (Bos taurus)
G2/M Transition (Bos taurus)
Cyclin A/B1/B2 associated events during G2/M transition (Bos taurus)
Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B (Bos taurus)
Pi [cytosol]
Cellular responses to stimuli (Bos taurus)
Cellular responses to stress (Bos taurus)
Cellular response to heat stress (Bos taurus)
Regulation of HSF1-mediated heat shock response (Bos taurus)
HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Bos taurus)
Pi [cytosol]
Cellular response to starvation (Bos taurus)
Amino acids regulate mTORC1 (Bos taurus)
RRAGA,B hydrolyzes GTP (Bos taurus)
Pi [cytosol]
RRAGC,D hydrolyzes GTP (Bos taurus)
Pi [cytosol]
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand (Bos taurus)
ATP hydrolysis by HSP70 (Bos taurus)
Pi [cytosol]
Developmental Biology (Bos taurus)
Nervous system development (Bos taurus)
Axon guidance (Bos taurus)
EPH-Ephrin signaling (Bos taurus)
EPHB-mediated forward signaling (Bos taurus)
p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Bos taurus)
Pi [cytosol]
L1CAM interactions (Bos taurus)
Recycling pathway of L1 (Bos taurus)
Formation of clathrin coated vesicle (Bos taurus)
Pi [cytosol]
Semaphorin interactions (Bos taurus)
Sema4D in semaphorin signaling (Bos taurus)
Sema4D mediated inhibition of cell attachment and migration (Bos taurus)
Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity (Bos taurus)
Pi [cytosol]
Inactivation of Rho-GTP by p190RhoGAP (Bos taurus)
Pi [cytosol]
Signaling by ROBO receptors (Bos taurus)
SLIT2:ROBO1 increases RHOA activity (Bos taurus)
MYO9B inactivates RHOA (Bos taurus)
Pi [cytosol]
Drug ADME (Bos taurus)
Aspirin ADME (Bos taurus)
ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Bos taurus)
Pi [cytosol]
Azathioprine ADME (Bos taurus)
ABCC4 transports TPMP substrates from cytosol to extracellular region (Bos taurus)
Pi [cytosol]
ABCC5 transports TPMP substrates from cytosol to extracellular region (Bos taurus)
Pi [cytosol]
Paracetamol ADME (Bos taurus)
ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Bos taurus)
Pi [cytosol]
ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Bos taurus)
Pi [cytosol]
ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Bos taurus)
Pi [cytosol]
Prednisone ADME (Bos taurus)
ABCB1 transports PREDN,PREDL out of hepatic cells (Bos taurus)
Pi [cytosol]
ABCB1 transports PREDN,PREDL out of kidney cells (Bos taurus)
Pi [cytosol]
ABCB1 transports xenobiotics out of the cell (Bos taurus)
Pi [cytosol]
Gene expression (Transcription) (Bos taurus)
RNA Polymerase II Transcription (Bos taurus)
Generic Transcription Pathway (Bos taurus)
Transcriptional Regulation by TP53 (Bos taurus)
TP53 Regulates Metabolic Genes (Bos taurus)
RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Bos taurus)
Pi [cytosol]
TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate (Bos taurus)
Pi [cytosol]
Hemostasis (Bos taurus)
Platelet activation, signaling and aggregation (Bos taurus)
Platelet Aggregation (Plug Formation) (Bos taurus)
Integrin signaling (Bos taurus)
Dephosphorylation of inactive SRC by PTPB1 (Bos taurus)
Pi [cytosol]
Response to elevated platelet cytosolic Ca2+ (Bos taurus)
Platelet degranulation (Bos taurus)
ABCC4 accumulation of dense granule contents (Bos taurus)
Pi [cytosol]
Immune System (Bos taurus)
Adaptive Immune System (Bos taurus)
Class I MHC mediated antigen processing & presentation (Bos taurus)
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (Bos taurus)
Transport of Antigen peptide in to ER (Bos taurus)
Pi [cytosol]
MHC class II antigen presentation (Bos taurus)
Dissociation of Arf1:GDP, AP-1 Clathrin coated nonameric complex (Bos taurus)
Pi [cytosol]
Internalization of MHC II:Ii clathrin coated vesicle (Bos taurus)
Pi [cytosol]
Translocation of TGN-lysosome vesicle to lysosome (Bos taurus)
Pi [cytosol]
TCR signaling (Bos taurus)
Downstream TCR signaling (Bos taurus)
Hydrolysis of PIP3 to PI(3,4)P2 (Bos taurus)
Pi [cytosol]
PTEN dephosphorylates PIP3 (Bos taurus)
Pi [cytosol]
Phosphorylation of CD3 and TCR zeta chains (Bos taurus)
Dephosphorylation of Lck-pY505 by CD45 (Bos taurus)
Pi [cytosol]
Inactivation of LCK by PTPN22 (Bos taurus)
Pi [cytosol]
Translocation of ZAP-70 to Immunological synapse (Bos taurus)
PTPN22 dephosphorylates ZAP70 (Bos taurus)
Pi [cytosol]
Cytokine Signaling in Immune system (Bos taurus)
FLT3 Signaling (Bos taurus)
Negative regulation of FLT3 (Bos taurus)
PTPRJ dephosphorylates active FLT3 (Bos taurus)
Pi [cytosol]
Growth hormone receptor signaling (Bos taurus)
PTP1B dephosphorylates GHR (Bos taurus)
Pi [cytosol]
Interferon Signaling (Bos taurus)
Interferon alpha/beta signaling (Bos taurus)
Regulation of IFNA/IFNB signaling (Bos taurus)
Dephosphorylation of JAK1 by SHP1 (Bos taurus)
Pi [cytosol]
Dephosphorylation of STAT1 by SHP2 (Bos taurus)
Pi [cytosol]
Dephosphorylation of TYK2 by PTP1B (Bos taurus)
Pi [cytosol]
Signaling by CSF3 (G-CSF) (Bos taurus)
p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS (Bos taurus)
Pi [cytosol]
Innate Immune System (Bos taurus)
C-type lectin receptors (CLRs) (Bos taurus)
CLEC7A (Dectin-1) signaling (Bos taurus)
CLEC7A (Dectin-1) induces NFAT activation (Bos taurus)
Calcineurin binds and dephosphorylates NFAT (Bos taurus)
Pi [cytosol]
Fc epsilon receptor (FCERI) signaling (Bos taurus)
FCERI mediated Ca+2 mobilization (Bos taurus)
Calcineurin binds and dephosphorylates NFAT (Bos taurus)
Pi [cytosol]
Fcgamma receptor (FCGR) dependent phagocytosis (Bos taurus)
Regulation of actin dynamics for phagocytic cup formation (Bos taurus)
Extension of pseudopodia by myosin-X in a PI3K dependent manner (Bos taurus)
Pi [cytosol]
Role of phospholipids in phagocytosis (Bos taurus)
Conversion of PA into DAG by PAP-1 (Bos taurus)
Pi [cytosol]
Metabolism (Bos taurus)
Biological oxidations (Bos taurus)
Phase II - Conjugation of compounds (Bos taurus)
Cytosolic sulfonation of small molecules (Bos taurus)
Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Bos taurus)
Pi [cytosol]
Glutathione conjugation (Bos taurus)
Glutathione synthesis and recycling (Bos taurus)
GCL ligates L-Glu to L-Cys (Bos taurus)
Pi [cytosol]
GSS:Mg2+ dimer synthesizes GSH (Bos taurus)
Pi [cytosol]
OPLAH hydrolyses OPRO to L-Glu (Bos taurus)
Pi [cytosol]
Methylation (Bos taurus)
MAT1A multimers transfer Ado from ATP to L-Met (Bos taurus)
Pi [cytosol]
MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met (Bos taurus)
Pi [cytosol]
Inositol phosphate metabolism (Bos taurus)
Synthesis of IP2, IP, and Ins in the cytosol (Bos taurus)
I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol (Bos taurus)
Pi [cytosol]
I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol (Bos taurus)
Pi [cytosol]
I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol (Bos taurus)
Pi [cytosol]
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Bos taurus)
Pi [cytosol]
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Bos taurus)
Pi [cytosol]
I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol (Bos taurus)
Pi [cytosol]
I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Bos taurus)
Pi [cytosol]
I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Bos taurus)
Pi [cytosol]
I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Bos taurus)
Pi [cytosol]
Synthesis of IP3 and IP4 in the cytosol (Bos taurus)
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Bos taurus)
Pi [cytosol]
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Bos taurus)
Pi [cytosol]
I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Bos taurus)
Pi [cytosol]
I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol (Bos taurus)
Pi [cytosol]
I(1,3,4,6)P4 is dephosphorylated to I(3,4,6)P3 by ITPK1 in the cytosol (Bos taurus)
Pi [cytosol]
Synthesis of pyrophosphates in the cytosol (Bos taurus)
(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Bos taurus)
Pi [cytosol]
(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Bos taurus)
Pi [cytosol]
1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Bos taurus)
Pi [cytosol]
5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Bos taurus)
Pi [cytosol]
I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol (Bos taurus)
Pi [cytosol]
PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Bos taurus)
Pi [cytosol]
Metabolism of amino acids and derivatives (Bos taurus)
Glutamate and glutamine metabolism (Bos taurus)
glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Bos taurus)
Pi [cytosol]
Histidine catabolism (Bos taurus)
CARNS1 transforms ATP, L-His, b-Ala to CARN (Bos taurus)
Pi [cytosol]
Selenoamino acid metabolism (Bos taurus)
Metabolism of ingested SeMet, Sec, MeSec into H2Se (Bos taurus)
SeMet is converted to AdoSeMet by MAT (Bos taurus)
Pi [cytosol]
Serine biosynthesis (Bos taurus)
PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Bos taurus)
Pi [cytosol]
Sulfur amino acid metabolism (Bos taurus)
MAT1A multimers transfer Ado from ATP to L-Met (Bos taurus)
Pi [cytosol]
Methionine salvage pathway (Bos taurus)
Acireductone is created (Bos taurus)
Pi [cytosol]
MTA is cleaved and phosphorylated (Bos taurus)
Pi [cytosol]
Metabolism of carbohydrates (Bos taurus)
Glucose metabolism (Bos taurus)
Gluconeogenesis (Bos taurus)
FBP tetramers hydrolyze F1,6PP to Fru(6)P (Bos taurus)
Pi [cytosol]
GAPDH tetramers reduce 1,3BPG to GA3P (Bos taurus)
Pi [cytosol]
SLC25A10 mediates exchange of malate and phosphate (Bos taurus)
Pi [cytosol]
SLC37A1, SLC37A2 exchange G6P for Pi across the ER membrane (Bos taurus)
Pi [cytosol]
SLC7A4 exchanges G6P for Pi across the ER membrane (Bos taurus)
Pi [cytosol]
Glycolysis (Bos taurus)
D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ (Bos taurus)
Pi [cytosol]
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism (Bos taurus)
Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Bos taurus)
Pi [cytosol]
Glycogen metabolism (Bos taurus)
Glycogen breakdown (glycogenolysis) (Bos taurus)
glycogen-glycogenin-2 + n orthophosphate => limit dextrin-glycogenin-2 + n D-glucose 1-phosphate [PYGL] (Bos taurus)
Pi [cytosol]
poly((1,4)-alpha-glucosyl) glycogenin-2 + n orthophosphate => glycogenin-2 + n D-glucose 1-phosphate [PYGL] (Bos taurus)
Pi [cytosol]
Glycogen synthesis (Bos taurus)
EPM2A dimer dephosphorylates phosphoglycogen-GYG1 (Bos taurus)
Pi [cytosol]
EPM2A dimer dephosphorylates phosphoglycogen-GYG2 (Bos taurus)
Pi [cytosol]
Pentose phosphate pathway (Bos taurus)
5-Phosphoribose 1-diphosphate biosynthesis (Bos taurus)
D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate (Bos taurus)
Pi [cytosol]
Metabolism of lipids (Bos taurus)
Fatty acid metabolism (Bos taurus)
Carnitine metabolism (Bos taurus)
Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Bos taurus)
Pi [cytosol]
Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Bos taurus)
Pi [cytosol]
Fatty acyl-CoA biosynthesis (Bos taurus)
ACLY tetramer transforms CIT to Ac-CoA (Bos taurus)
Pi [cytosol]
acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate (Bos taurus)
Pi [cytosol]
Metabolism of steroids (Bos taurus)
Bile acid and bile salt metabolism (Bos taurus)
Recycling of bile acids and salts (Bos taurus)
ABCB11 transports bile salts from cytosol to extracellular region (Bos taurus)
Pi [cytosol]
ABCC3 transports bile salts from cytosol to extracellular region (Bos taurus)
Pi [cytosol]
Synthesis of bile acids and bile salts (Bos taurus)
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (Bos taurus)
ABCB11 transports bile salts from cytosol to extracellular region (Bos taurus)
Pi [cytosol]
Cholesterol biosynthesis (Bos taurus)
MVD decarboxylates MVA5PP to IPPP (Bos taurus)
Pi [cytosol]
Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Bos taurus)
Pi [cytosol]
Phospholipid metabolism (Bos taurus)
Glycerophospholipid biosynthesis (Bos taurus)
Synthesis of PC (Bos taurus)
PA is dephosphorylated to DAG by LPIN (Bos taurus)
Pi [cytosol]
PCho is dephosphorylated to Cho by PHOSPHO1 (Bos taurus)
Pi [cytosol]
Synthesis of PE (Bos taurus)
PA is dephosphorylated to DAG by LPIN (Bos taurus)
Pi [cytosol]
PETA is dephosphorylated to ETA by PHOSPHO1 (Bos taurus)
Pi [cytosol]
PI Metabolism (Bos taurus)
Synthesis of PIPs at the ER membrane (Bos taurus)
PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 (Bos taurus)
Pi [cytosol]
PI3P is dephosphorylated to PI by MTMR2:SBF1 (Bos taurus)
Pi [cytosol]
PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Bos taurus)
Pi [cytosol]
Synthesis of PIPs at the Golgi membrane (Bos taurus)
PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane (Bos taurus)
Pi [cytosol]
PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane (Bos taurus)
Pi [cytosol]
PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Bos taurus)
Pi [cytosol]
PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Bos taurus)
Pi [cytosol]
PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane (Bos taurus)
Pi [cytosol]
Synthesis of PIPs at the early endosome membrane (Bos taurus)
PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane (Bos taurus)
Pi [cytosol]
PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the early endosome membrane (Bos taurus)
Pi [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Bos taurus)
Pi [cytosol]
PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Bos taurus)
Pi [cytosol]
PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Bos taurus)
Pi [cytosol]
PI3P is dephosphorylated to PI by MTM1:MTMR12 (Bos taurus)
Pi [cytosol]
Synthesis of PIPs at the late endosome membrane (Bos taurus)
PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane (Bos taurus)
Pi [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Bos taurus)
Pi [cytosol]
PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Bos taurus)
Pi [cytosol]
Synthesis of PIPs at the plasma membrane (Bos taurus)
PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane (Bos taurus)
Pi [cytosol]
PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Bos taurus)
Pi [cytosol]
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Bos taurus)
Pi [cytosol]
PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Bos taurus)
Pi [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane (Bos taurus)
Pi [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Bos taurus)
Pi [cytosol]
PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Bos taurus)
Pi [cytosol]
PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Bos taurus)
Pi [cytosol]
PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Bos taurus)
Pi [cytosol]
PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Bos taurus)
Pi [cytosol]
PTEN dephosphorylates PIP3 (Bos taurus)
Pi [cytosol]
Sphingolipid metabolism (Bos taurus)
Sphingolipid de novo biosynthesis (Bos taurus)
multiphospho-CERT:PPM1L:VAPA/B + 3 H2O => CERT:PPM1L:VAPA/B + 3 orthophosphate (Bos taurus)
Pi [cytosol]
sphinganine 1-phosphate + H2O => sphinganine + orthophosphate (Bos taurus)
Pi [cytosol]
sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - PPAP] (Bos taurus)
Pi [cytosol]
sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - SGPP] (Bos taurus)
Pi [cytosol]
Triglyceride metabolism (Bos taurus)
Triglyceride biosynthesis (Bos taurus)
1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Bos taurus)
Pi [cytosol]
Metabolism of nucleotides (Bos taurus)
Interconversion of nucleotide di- and triphosphates (Bos taurus)
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Bos taurus)
Pi [cytosol]
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Bos taurus)
Pi [cytosol]
Nucleotide biosynthesis (Bos taurus)
Purine ribonucleoside monophosphate biosynthesis (Bos taurus)
5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Bos taurus)
Pi [cytosol]
CAIR + Aspartate + ATP => SAICAR + ADP + Pi (Bos taurus)
Pi [cytosol]
FGAM + ATP => AIR + ADP + Pi (Bos taurus)
Pi [cytosol]
FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Bos taurus)
Pi [cytosol]
IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Bos taurus)
Pi [cytosol]
Pyrimidine biosynthesis (Bos taurus)
CAD hexamer transforms CAP to N-carb-L-Asp (Bos taurus)
Pi [cytosol]
CAD hexamer transforms L-Gln to CAP (Bos taurus)
Pi [cytosol]
Nucleotide catabolism (Bos taurus)
Purine catabolism (Bos taurus)
(d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate (NT5C1A) (Bos taurus)
Pi [cytosol]
(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) (Bos taurus)
Pi [cytosol]
(d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate (NT5C) (Bos taurus)
Pi [cytosol]
AMP + H2O => adenosine + orthophosphate [NT5C1B] (Bos taurus)
Pi [cytosol]
PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose (Bos taurus)
Pi [cytosol]
PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose (Bos taurus)
Pi [cytosol]
Phosphate bond hydrolysis by NUDT proteins (Bos taurus)
NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Bos taurus)
Pi [cytosol]
NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Bos taurus)
Pi [cytosol]
NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Bos taurus)
Pi [cytosol]
NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Bos taurus)
Pi [cytosol]
Pyrimidine catabolism (Bos taurus)
(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A) (Bos taurus)
Pi [cytosol]
(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3) (Bos taurus)
Pi [cytosol]
(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP) (Bos taurus)
Pi [cytosol]
TMP, uridine 2', 3', or 5' monophosphates, or deoxyuridine 3' or 5' monophosphates + H2O => thymidine or (deoxy)uridine + orthophosphate [NT5C] (Bos taurus)
Pi [cytosol]
Nucleotide salvage (Bos taurus)
Purine salvage (Bos taurus)
PNP catalyzes the conversion of guanine and (deoxy)ribose to (deoxy)guanosine (Bos taurus)
Pi [cytosol]
PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine (Bos taurus)
Pi [cytosol]
Pyrimidine salvage (Bos taurus)
HDHD1:Mg2+ dephosphorylates PURIDP (Bos taurus)
Pi [cytosol]
uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP] (Bos taurus)
Pi [cytosol]
Metabolism of porphyrins (Bos taurus)
Heme biosynthesis (Bos taurus)
ABCG2 tetramer transports heme from cytosol to extracellular region (Bos taurus)
Pi [cytosol]
Heme degradation (Bos taurus)
ABCC2 transports BMG,BDG from cytosol to extracellular region (Bos taurus)
Pi [cytosol]
ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Bos taurus)
Pi [cytosol]
Metabolism of vitamins and cofactors (Bos taurus)
Metabolism of water-soluble vitamins and cofactors (Bos taurus)
Cobalamin (Cbl, vitamin B12) transport and metabolism (Bos taurus)
Transport of RCbl within the body (Bos taurus)
ABCC1 transports cytosolic RCbl to extracellular region (Bos taurus)
Pi [cytosol]
ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (Bos taurus)
Pi [cytosol]
Uptake of dietary cobalamins into enterocytes (Bos taurus)
ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (gut mucosal cells) (Bos taurus)
Pi [cytosol]
Metabolism of folate and pterines (Bos taurus)
FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Bos taurus)
Pi [cytosol]
FPGS-2 transforms THF to THFPG (Bos taurus)
Pi [cytosol]
MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Bos taurus)
Pi [cytosol]
MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Bos taurus)
Pi [cytosol]
Vitamin B1 (thiamin) metabolism (Bos taurus)
THTPA:Mg2+ hydrolyzes ThTP to TDP (Bos taurus)
Pi [cytosol]
Vitamin B2 (riboflavin) metabolism (Bos taurus)
2xTRAP hydrolyzes FMN to RIB (Bos taurus)
Pi [cytosol]
Vitamin B5 (pantothenate) metabolism (Bos taurus)
PANK4 hydrolyzes PPANT to pantetheine (Bos taurus)
Pi [cytosol]
Pyrophosphate hydrolysis (Bos taurus)
LHPP:Mg2+ dimer hydrolyses PPi (Bos taurus)
Pi [cytosol]
PPA1 hydrolyzes pyrophosphate to orthophosphate (Bos taurus)
Pi [cytosol]
Metabolism of RNA (Bos taurus)
Deadenylation-dependent mRNA decay (Bos taurus)
mRNA decay by 3' to 5' exoribonuclease (Bos taurus)
NT5C3B hydrolyses 7MGP to 7MG (Bos taurus)
Pi [cytosol]
Metabolism of proteins (Bos taurus)
Post-translational protein modification (Bos taurus)
Asparagine N-linked glycosylation (Bos taurus)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Bos taurus)
Synthesis of substrates in N-glycan biosythesis (Bos taurus)
Sialic acid metabolism (Bos taurus)
NANP dephosphorylates Neu5Ac-9-P to Neu5Ac (Bos taurus)
Pi [cytosol]
NANS converts ManNAc-6-P to Neu5Ac-9-P (Bos taurus)
Pi [cytosol]
Synthesis of Dolichyl-phosphate (Bos taurus)
DOLPP1 dephosphorylates DOLDP to DOLP (Bos taurus)
Pi [cytosol]
MVD decarboxylates MVA5PP to IPPP (Bos taurus)
Pi [cytosol]
Transport to the Golgi and subsequent modification (Bos taurus)
ER to Golgi Anterograde Transport (Bos taurus)
COPI-mediated anterograde transport (Bos taurus)
NSF ATPase activity dissociates cis-SNARE at cis-Golgi (Bos taurus)
Pi [cytosol]
COPII-mediated vesicle transport (Bos taurus)
Loss of SAR1B GTPase (Bos taurus)
Pi [cytosol]
NSF ATPase activity dissociates cis-SNARE (Bos taurus)
Pi [cytosol]
PP6 dephosphorylates SEC24 (Bos taurus)
Pi [cytosol]
Vesicle budding (Bos taurus)
Pi [cytosol]
Carboxyterminal post-translational modifications of tubulin (Bos taurus)
TTLL3, TTLL8, TTLL10 polyglycylate tubulin (Bos taurus)
Pi [cytosol]
TTLLs polyglutamylate tubulin (Bos taurus)
Pi [cytosol]
Protein folding (Bos taurus)
Chaperonin-mediated protein folding (Bos taurus)
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding (Bos taurus)
ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT (Bos taurus)
Pi [cytosol]
Surfactant metabolism (Bos taurus)
ABCA3 transports PC, PG from ER membrane to lamellar body (Bos taurus)
Pi [cytosol]
SLC34A1,2 cotransports Pi, 3Na+ from extracellular region to cytosol (Bos taurus)
Pi [cytosol]
Translation (Bos taurus)
Eukaryotic Translation Initiation (Bos taurus)
Cap-dependent Translation Initiation (Bos taurus)
GTP hydrolysis and joining of the 60S ribosomal subunit (Bos taurus)
eIF5B:GTP is hydrolyzed and released (Bos taurus)
Pi [cytosol]
Ribosomal scanning and start codon recognition (Bos taurus)
Ribosomal scanning (Bos taurus)
Pi [cytosol]
tRNA Aminoacylation (Bos taurus)
Cytosolic tRNA aminoacylation (Bos taurus)
PPA1 hydrolyzes pyrophosphate to orthophosphate (Bos taurus)
Pi [cytosol]
Muscle contraction (Bos taurus)
Cardiac conduction (Bos taurus)
Ion homeostasis (Bos taurus)
ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ (Bos taurus)
Pi [cytosol]
Smooth Muscle Contraction (Bos taurus)
ATP Hydrolysis By Myosin (Bos taurus)
Pi [cytosol]
Striated Muscle Contraction (Bos taurus)
ATP Hydrolysis By Myosin (Bos taurus)
Pi [cytosol]
Neuronal System (Bos taurus)
Transmission across Chemical Synapses (Bos taurus)
Neurotransmitter receptors and postsynaptic signal transmission (Bos taurus)
GABA receptor activation (Bos taurus)
GABA B receptor activation (Bos taurus)
Activation of GABAB receptors (Bos taurus)
Adenylate cyclase inhibitory pathway (Bos taurus)
Adenylate cyclase increases the GTPase activity of G alpha-olf (Bos taurus)
Pi [cytosol]
Adenylate cyclase increases the GTPase activity of Gi alpha (Bos taurus)
Pi [cytosol]
Glutamate binding, activation of AMPA receptors and synaptic plasticity (Bos taurus)
Trafficking of AMPA receptors (Bos taurus)
Trafficking of GluR1-containing AMPA receptors (Bos taurus)
Pi [cytosol]
Trafficking of GluR2-containing AMPA receptors (Bos taurus)
Endocytosis of Ca impermeable AMPA receptors (Bos taurus)
Pi [cytosol]
Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites (Bos taurus)
Pi [cytosol]
Trafficking of GluR2-containing AMPA receptors to synapse (Bos taurus)
Pi [cytosol]
Neurotransmitter uptake and metabolism In glial cells (Bos taurus)
Astrocytic Glutamate-Glutamine Uptake And Metabolism (Bos taurus)
glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Bos taurus)
Pi [cytosol]
Organelle biogenesis and maintenance (Bos taurus)
Cilium Assembly (Bos taurus)
Cargo trafficking to the periciliary membrane (Bos taurus)
VxPx cargo-targeting to cilium (Bos taurus)
ASAP1 stimulates GTPase activity of ARF4 (Bos taurus)
Pi [cytosol]
Programmed Cell Death (Bos taurus)
Apoptosis (Bos taurus)
Intrinsic Pathway for Apoptosis (Bos taurus)
Activation of BH3-only proteins (Bos taurus)
Activation of BAD and translocation to mitochondria (Bos taurus)
Activation of BAD by calcineurin (Bos taurus)
Pi [cytosol]
Sensory Perception (Bos taurus)
Visual phototransduction (Bos taurus)
The canonical retinoid cycle in rods (twilight vision) (Bos taurus)
ABCA4 mediates atRAL transport (Bos taurus)
Pi [cytosol]
The phototransduction cascade (Bos taurus)
Inactivation, recovery and regulation of the phototransduction cascade (Bos taurus)
GNAT1-GTP hydrolyses its bound GTP to GDP (Bos taurus)
Pi [cytosol]
PP2A dephosphorylates p-RHO to RHO (Bos taurus)
Pi [cytosol]
Signal Transduction (Bos taurus)
Integrin signaling (Bos taurus)
Dephosphorylation of inactive SRC by PTPB1 (Bos taurus)
Pi [cytosol]
Intracellular signaling by second messengers (Bos taurus)
PIP3 activates AKT signaling (Bos taurus)
Negative regulation of the PI3K/AKT network (Bos taurus)
PTEN dephosphorylates PIP3 (Bos taurus)
Pi [cytosol]
MAPK family signaling cascades (Bos taurus)
MAPK1/MAPK3 signaling (Bos taurus)
RAF-independent MAPK1/3 activation (Bos taurus)
Cytosolic DUSPs dephosphorylate MAPKs (Bos taurus)
Pi [cytosol]
RAF/MAP kinase cascade (Bos taurus)
Negative regulation of MAPK pathway (Bos taurus)
Cytosolic DUSPs dephosphorylate MAPKs (Bos taurus)
Pi [cytosol]
PP2A dephosphorylates RAF1 (Bos taurus)
Pi [cytosol]
PP5 dephosphorylates RAF1 S338 (Bos taurus)
Pi [cytosol]
PTPN3 dephosphorylates MAPK12 (Bos taurus)
Pi [cytosol]
PTPN7 dephosphorylates p-T,Y-MAPKs (Bos taurus)
Pi [cytosol]
RAF activation (Bos taurus)
MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs (Bos taurus)
Pi [cytosol]
PP2A dephosphorylates KSR1 (Bos taurus)
Pi [cytosol]
PP2A dephosphorylates inactive RAFs (Bos taurus)
Pi [cytosol]
MTOR signalling (Bos taurus)
Energy dependent regulation of mTOR by LKB1-AMPK (Bos taurus)
AMPK is dephosphorylated (Bos taurus)
Pi [cytosol]
RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Bos taurus)
Pi [cytosol]
Signaling by GPCR (Bos taurus)
GPCR downstream signalling (Bos taurus)
G alpha (i) signalling events (Bos taurus)
G alpha (i)–i1/i2/i3 in G (i):RGS complex is inactivated (Bos taurus)
Pi [cytosol]
Opioid Signalling (Bos taurus)
DARPP-32 events (Bos taurus)
DARPP-32 is dephosphorylated on Thr75 by PP2A (Bos taurus)
Pi [cytosol]
G-protein mediated events (Bos taurus)
Adenylate cyclase activating pathway (Bos taurus)
Adenylaye cyclase increases the GTPase activity of G alpha-olf (Bos taurus)
Pi [cytosol]
Adenylate cyclase inhibitory pathway (Bos taurus)
Adenylate cyclase increases the GTPase activity of G alpha-olf (Bos taurus)
Pi [cytosol]
Adenylate cyclase increases the GTPase activity of Gi alpha (Bos taurus)
Pi [cytosol]
PLC beta mediated events (Bos taurus)
Inactivation of PLC beta (Bos taurus)
Pi [cytosol]
G alpha (q) signalling events (Bos taurus)
G alpha (q) in G (q):RGS complex is inactivated (Bos taurus)
Pi [cytosol]
G alpha (z) signalling events (Bos taurus)
G alpha (z) in G alpha (z):RGS complex is inactivated (Bos taurus)
Pi [cytosol]
Signaling by Non-Receptor Tyrosine Kinases (Bos taurus)
Signaling by PTK6 (Bos taurus)
PTK6 Down-Regulation (Bos taurus)
PTPN1 dephosphorylates PTK6 (Bos taurus)
Pi [cytosol]
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases (Bos taurus)
ARHGAP35 stimulates RHOA GTPase activity (Bos taurus)
Pi [cytosol]
Signaling by Receptor Tyrosine Kinases (Bos taurus)
Signaling by ALK (Bos taurus)
PTPN6 dephosphorylates JAK3 (Bos taurus)
Pi [cytosol]
PTPRZ dephosphorylates ligand-bound ALK dimers (Bos taurus)
Pi [cytosol]
Signaling by EGFR (Bos taurus)
EGFR downregulation (Bos taurus)
PTPN3 dephosphorylates EPS15 (Bos taurus)
Pi [cytosol]
GAB1 signalosome (Bos taurus)
Dephosphorylation of Gab1 by SHP2 (Bos taurus)
Pi [cytosol]
Dephosphorylation of PAG by SHP2 (Bos taurus)
Pi [cytosol]
SHP2 dephosphorylates Tyr 992 on EGFR (Bos taurus)
Pi [cytosol]
Sustained activation of SRC kinase by SHP2 (Bos taurus)
Pi [cytosol]
Signaling by ERBB2 (Bos taurus)
Downregulation of ERBB2 signaling (Bos taurus)
PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 (Bos taurus)
Pi [cytosol]
PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 (Bos taurus)
Pi [cytosol]
Signaling by FGFR (Bos taurus)
Signaling by FGFR1 (Bos taurus)
Negative regulation of FGFR1 signaling (Bos taurus)
Spry regulation of FGF signaling (Bos taurus)
PPA2A dephosphorylates SPRY2 (Bos taurus)
Pi [cytosol]
Signaling by FGFR2 (Bos taurus)
Negative regulation of FGFR2 signaling (Bos taurus)
Spry regulation of FGF signaling (Bos taurus)
PPA2A dephosphorylates SPRY2 (Bos taurus)
Pi [cytosol]
Signaling by FGFR3 (Bos taurus)
Negative regulation of FGFR3 signaling (Bos taurus)
Spry regulation of FGF signaling (Bos taurus)
PPA2A dephosphorylates SPRY2 (Bos taurus)
Pi [cytosol]
Signaling by FGFR4 (Bos taurus)
Negative regulation of FGFR4 signaling (Bos taurus)
Spry regulation of FGF signaling (Bos taurus)
PPA2A dephosphorylates SPRY2 (Bos taurus)
Pi [cytosol]
Signaling by Insulin receptor (Bos taurus)
Insulin receptor recycling (Bos taurus)
Insulin receptor de-phosphorylation (Bos taurus)
Pi [cytosol]
Signaling by MET (Bos taurus)
Negative regulation of MET activity (Bos taurus)
PTPN1 and PTPN2 dephosphorylate MET (Bos taurus)
Pi [cytosol]
PTPRJ dephosphorylates MET (Bos taurus)
Pi [cytosol]
Signaling by PDGF (Bos taurus)
PTPN12 dephosphorylates PDGFRB at Y1021 (Bos taurus)
Pi [cytosol]
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Bos taurus)
Miro GTPase Cycle (Bos taurus)
RHOT1 GTPase cycle (Bos taurus)
RHOT1 hydrolyzes GTP (Bos taurus)
Pi [cytosol]
RHOT2 GTPase cycle (Bos taurus)
RHOT2 hydrolyzes GTP (Bos taurus)
Pi [cytosol]
RHOBTB3 ATPase cycle (Bos taurus)
RHOBTB3 hydrolyzes ATP (Bos taurus)
Pi [cytosol]
Signaling by Rho GTPases (Bos taurus)
RHO GTPase Effectors (Bos taurus)
RHO GTPases Activate Formins (Bos taurus)
SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments (Bos taurus)
Pi [cytosol]
RHO GTPase cycle (Bos taurus)
CDC42 GTPase cycle (Bos taurus)
CDC42 GAPs stimulate CDC42 GTPase activity (Bos taurus)
Pi [cytosol]
RAC1 GTPase cycle (Bos taurus)
RAC1 GAPs stimulate RAC1 GTPase activity (Bos taurus)
Pi [cytosol]
RAC2 GTPase cycle (Bos taurus)
RAC2 GAPs stimulate RAC2 GTPase activity (Bos taurus)
Pi [cytosol]
RAC3 GTPase cycle (Bos taurus)
RAC3 GAPs stimulate RAC3 GTPase activity (Bos taurus)
Pi [cytosol]
RHOA GTPase cycle (Bos taurus)
RHOA GAPs stimulate RHOA GTPase activity (Bos taurus)
Pi [cytosol]
RHOC GTPase cycle (Bos taurus)
RHOC GAPs stimulate RHOC GTPase activity (Bos taurus)
Pi [cytosol]
RHOD GTPase cycle (Bos taurus)
RHOD GAPs stimulate RHOD GTPase activity (Bos taurus)
Pi [cytosol]
RHOF GTPase cycle (Bos taurus)
RHOF GAPs stimulate RHOF GTPase activity (Bos taurus)
Pi [cytosol]
RHOG GTPase cycle (Bos taurus)
RHOG GAPs stimulate RHOG GTPase activity (Bos taurus)
Pi [cytosol]
RHOJ GTPase cycle (Bos taurus)
RHOJ GAPs stimulate RHOJ GTPase activity (Bos taurus)
Pi [cytosol]
RHOQ GTPase cycle (Bos taurus)
RHOQ GAPs stimulate RHOQ GTPase activity (Bos taurus)
Pi [cytosol]
Signaling by TGFB family members (Bos taurus)
Signaling by TGF-beta Receptor Complex (Bos taurus)
TGF-beta receptor signaling activates SMADs (Bos taurus)
Downregulation of TGF-beta receptor signaling (Bos taurus)
MTMR4 dephosphorylates SMAD2/3 (Bos taurus)
Pi [cytosol]
Signaling by WNT (Bos taurus)
Beta-catenin independent WNT signaling (Bos taurus)
Ca2+ pathway (Bos taurus)
Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling (Bos taurus)
Pi [cytosol]
Transport of small molecules (Bos taurus)
ABC-family proteins mediated transport (Bos taurus)
ABC transporters in lipid homeostasis (Bos taurus)
ABCA12 transports lipids from cytosol to extracellular region (Bos taurus)
Pi [cytosol]
ABCA3 transports PC, PG from ER membrane to lamellar body (Bos taurus)
Pi [cytosol]
ABCA5 transports CHOL from lysosomal lumen to cytosol (Bos taurus)
Pi [cytosol]
ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Bos taurus)
Pi [cytosol]
ABCG1-mediated transport of intracellular cholesterol to the cell surface (Bos taurus)
Pi [cytosol]
ABCG4 may mediate cholesterol efflux (Bos taurus)
Pi [cytosol]
ABCG5:ABCG8 transports sterols from cytosol to extracellular region (Bos taurus)
Pi [cytosol]
ABCA4 mediates atRAL transport (Bos taurus)
Pi [cytosol]
ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region (Bos taurus)
Pi [cytosol]
ABCB4 transports PC from plasma membrane to extracellular region (Bos taurus)
Pi [cytosol]
ABCB9 transports peptides from cytosol to lysosomal lumen (Bos taurus)
Pi [cytosol]
CFTR transports Cl- from cytosol to extracellular region (Bos taurus)
Pi [cytosol]
HCO3- transport through ion channel (Bos taurus)
Pi [cytosol]
Mitochondrial ABC transporters (Bos taurus)
ABCB6 transports porphyrin from cytosol to mitchondrial matrix (Bos taurus)
Pi [cytosol]
The ABCC family mediates organic anion transport (Bos taurus)
Pi [cytosol]
VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Bos taurus)
Pi [cytosol]
Ion channel transport (Bos taurus)
Ion transport by P-type ATPases (Bos taurus)
ATP12A:ATP4B exchanges K+ for H+ (Bos taurus)
Pi [cytosol]
ATP13A1 transports Mn2+ from cytosol to ER lumen (Bos taurus)
Pi [cytosol]
ATP13A2 transports cations from cytosol to lysosomal lumen (Bos taurus)
Pi [cytosol]
ATP13A4,5 transport divalent ions from extracellular region to cytosol (Bos taurus)
Pi [cytosol]
ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ (Bos taurus)
Pi [cytosol]
ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Bos taurus)
Pi [cytosol]
ATP4A:ATP4B exchanges K+ for H+ (Bos taurus)
Pi [cytosol]
P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Bos taurus)
Pi [cytosol]
P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Bos taurus)
Pi [cytosol]
Stimuli-sensing channels (Bos taurus)
SLC17A3-1 cotransports extracellular Na+ and Pi to cytosol (Bos taurus)
Pi [cytosol]
Iron uptake and transport (Bos taurus)
ABCG2 tetramer transports heme from cytosol to extracellular region (Bos taurus)
Pi [cytosol]
Transferrin endocytosis and recycling (Bos taurus)
Acidification of Tf:TfR1 containing endosome (Bos taurus)
Pi [cytosol]
Plasma lipoprotein assembly, remodeling, and clearance (Bos taurus)
Plasma lipoprotein assembly (Bos taurus)
HDL assembly (Bos taurus)
4xPALM-C-p-2S-ABCA1 tetramer transports CHOL from transport vesicle membrane to plasma membrane (Bos taurus)
Pi [cytosol]
4xPALM-C-p-2S-ABCA1 tetramer transports PL from transport vesicle membrane to plasma membrane (Bos taurus)
Pi [cytosol]
Plasma lipoprotein remodeling (Bos taurus)
HDL remodeling (Bos taurus)
ABCG1-mediated transport of intracellular cholesterol to the cell surface (Bos taurus)
Pi [cytosol]
SLC-mediated transmembrane transport (Bos taurus)
Transport of inorganic cations/anions and amino acids/oligopeptides (Bos taurus)
Organic anion transporters (Bos taurus)
SLC25A10 mediates exchange of malate and phosphate (Bos taurus)
Pi [cytosol]
Type I Na+-coupled phosphate co-transport (Bos taurus)
Pi [cytosol]
Sodium-coupled phosphate cotransporters (Bos taurus)
SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol (Bos taurus)
Pi [cytosol]
Type II Na+/Pi cotransporters (Bos taurus)
SLC34A1,2 cotransports Pi, 3Na+ from extracellular region to cytosol (Bos taurus)
Pi [cytosol]
SLC34A3 cotransports Pi, 2Na+ (Bos taurus)
Pi [cytosol]
Vesicle-mediated transport (Bos taurus)
Membrane Trafficking (Bos taurus)
Clathrin-mediated endocytosis (Bos taurus)
Dynamin-mediated GTP hydrolysis promotes vesicle scission (Bos taurus)
Pi [cytosol]
HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Bos taurus)
Pi [cytosol]
SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Bos taurus)
Pi [cytosol]
ER to Golgi Anterograde Transport (Bos taurus)
COPI-mediated anterograde transport (Bos taurus)
NSF ATPase activity dissociates cis-SNARE at cis-Golgi (Bos taurus)
Pi [cytosol]
COPII-mediated vesicle transport (Bos taurus)
Loss of SAR1B GTPase (Bos taurus)
Pi [cytosol]
NSF ATPase activity dissociates cis-SNARE (Bos taurus)
Pi [cytosol]
PP6 dephosphorylates SEC24 (Bos taurus)
Pi [cytosol]
Vesicle budding (Bos taurus)
Pi [cytosol]
Endosomal Sorting Complex Required For Transport (ESCRT) (Bos taurus)
ESCRT Disassembly (Bos taurus)
Pi [cytosol]
Intra-Golgi and retrograde Golgi-to-ER traffic (Bos taurus)
Golgi-to-ER retrograde transport (Bos taurus)
COPI-dependent Golgi-to-ER retrograde traffic (Bos taurus)
NSF ATPase activity dissociates cis-SNARE at the ER (Bos taurus)
Pi [cytosol]
Rab regulation of trafficking (Bos taurus)
TBC/RABGAPs (Bos taurus)
TBC RabGAPs accelerate GTP hydrolysis by RAB35 (Bos taurus)
Pi [cytosol]
TBC1D15 accelerates GTP hydrolysis by RAB7 (Bos taurus)
Pi [cytosol]
TBC1D16 accelerates GTP hydrolysis by RAB4A (Bos taurus)
Pi [cytosol]
TBC1D25 accelerates GTP hydrolysis by RAB33B (Bos taurus)
Pi [cytosol]
TBC1D2A accelerates GTP hydrolysis by RAB7 (Bos taurus)
Pi [cytosol]
trans-Golgi Network Vesicle Budding (Bos taurus)
Golgi Associated Vesicle Biogenesis (Bos taurus)
trans-Golgi Network Coat Assembly (Bos taurus)
Pi [cytosol]
trans-Golgi Network Vesicle Scission (Bos taurus)
Pi [cytosol]
Lysosome Vesicle Biogenesis (Bos taurus)
trans-Golgi Network Lysosomal Vesicle Scission (Bos taurus)
Pi [cytosol]
trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly (Bos taurus)
Pi [cytosol]
Autophagy (Caenorhabditis elegans)
Macroautophagy (Caenorhabditis elegans)
ULK1 is dephosphorylated (Caenorhabditis elegans)
Pi [cytosol]
Cell Cycle (Caenorhabditis elegans)
Cell Cycle, Mitotic (Caenorhabditis elegans)
M Phase (Caenorhabditis elegans)
Mitotic Metaphase and Anaphase (Caenorhabditis elegans)
Mitotic Anaphase (Caenorhabditis elegans)
Nuclear Envelope (NE) Reassembly (Caenorhabditis elegans)
Initiation of Nuclear Envelope (NE) Reformation (Caenorhabditis elegans)
PP2A dephosphorylates BANF1 (Caenorhabditis elegans)
Pi [cytosol]
Postmitotic nuclear pore complex (NPC) reformation (Caenorhabditis elegans)
RAN stimulates fusion of nuclear envelope (NE) membranes (Caenorhabditis elegans)
Pi [cytosol]
Mitotic G2-G2/M phases (Caenorhabditis elegans)
G2/M Transition (Caenorhabditis elegans)
Cyclin A/B1/B2 associated events during G2/M transition (Caenorhabditis elegans)
Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B (Caenorhabditis elegans)
Pi [cytosol]
Cellular responses to stimuli (Caenorhabditis elegans)
Cellular responses to stress (Caenorhabditis elegans)
Cellular response to heat stress (Caenorhabditis elegans)
Regulation of HSF1-mediated heat shock response (Caenorhabditis elegans)
HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Caenorhabditis elegans)
Pi [cytosol]
Cellular response to starvation (Caenorhabditis elegans)
Amino acids regulate mTORC1 (Caenorhabditis elegans)
RRAGA,B hydrolyzes GTP (Caenorhabditis elegans)
Pi [cytosol]
RRAGC,D hydrolyzes GTP (Caenorhabditis elegans)
Pi [cytosol]
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand (Caenorhabditis elegans)
ATP hydrolysis by HSP70 (Caenorhabditis elegans)
Pi [cytosol]
Developmental Biology (Caenorhabditis elegans)
Nervous system development (Caenorhabditis elegans)
Axon guidance (Caenorhabditis elegans)
EPH-Ephrin signaling (Caenorhabditis elegans)
EPHB-mediated forward signaling (Caenorhabditis elegans)
p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Caenorhabditis elegans)
Pi [cytosol]
L1CAM interactions (Caenorhabditis elegans)
Recycling pathway of L1 (Caenorhabditis elegans)
Formation of clathrin coated vesicle (Caenorhabditis elegans)
Pi [cytosol]
Semaphorin interactions (Caenorhabditis elegans)
Sema4D in semaphorin signaling (Caenorhabditis elegans)
Sema4D mediated inhibition of cell attachment and migration (Caenorhabditis elegans)
Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity (Caenorhabditis elegans)
Pi [cytosol]
Inactivation of Rho-GTP by p190RhoGAP (Caenorhabditis elegans)
Pi [cytosol]
Signaling by ROBO receptors (Caenorhabditis elegans)
SLIT2:ROBO1 increases RHOA activity (Caenorhabditis elegans)
MYO9B inactivates RHOA (Caenorhabditis elegans)
Pi [cytosol]
Drug ADME (Caenorhabditis elegans)
Aspirin ADME (Caenorhabditis elegans)
ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Caenorhabditis elegans)
Pi [cytosol]
Azathioprine ADME (Caenorhabditis elegans)
ABCC4 transports TPMP substrates from cytosol to extracellular region (Caenorhabditis elegans)
Pi [cytosol]
ABCC5 transports TPMP substrates from cytosol to extracellular region (Caenorhabditis elegans)
Pi [cytosol]
Paracetamol ADME (Caenorhabditis elegans)
ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Caenorhabditis elegans)
Pi [cytosol]
ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Caenorhabditis elegans)
Pi [cytosol]
ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Caenorhabditis elegans)
Pi [cytosol]
Gene expression (Transcription) (Caenorhabditis elegans)
RNA Polymerase II Transcription (Caenorhabditis elegans)
Generic Transcription Pathway (Caenorhabditis elegans)
Transcriptional Regulation by TP53 (Caenorhabditis elegans)
TP53 Regulates Metabolic Genes (Caenorhabditis elegans)
RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Caenorhabditis elegans)
Pi [cytosol]
Hemostasis (Caenorhabditis elegans)
Platelet activation, signaling and aggregation (Caenorhabditis elegans)
Response to elevated platelet cytosolic Ca2+ (Caenorhabditis elegans)
Platelet degranulation (Caenorhabditis elegans)
ABCC4 accumulation of dense granule contents (Caenorhabditis elegans)
Pi [cytosol]
Immune System (Caenorhabditis elegans)
Adaptive Immune System (Caenorhabditis elegans)
Class I MHC mediated antigen processing & presentation (Caenorhabditis elegans)
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (Caenorhabditis elegans)
Transport of Antigen peptide in to ER (Caenorhabditis elegans)
Pi [cytosol]
Costimulation by the CD28 family (Caenorhabditis elegans)
CTLA4 inhibitory signaling (Caenorhabditis elegans)
Dephosphorylation of AKT by PP2A (Caenorhabditis elegans)
Pi [cytosol]
Metabolism (Caenorhabditis elegans)
Biological oxidations (Caenorhabditis elegans)
Phase II - Conjugation of compounds (Caenorhabditis elegans)
Cytosolic sulfonation of small molecules (Caenorhabditis elegans)
Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Caenorhabditis elegans)
Pi [cytosol]
Glutathione conjugation (Caenorhabditis elegans)
Glutathione synthesis and recycling (Caenorhabditis elegans)
GCL ligates L-Glu to L-Cys (Caenorhabditis elegans)
Pi [cytosol]
GSS:Mg2+ dimer synthesizes GSH (Caenorhabditis elegans)
Pi [cytosol]
OPLAH hydrolyses OPRO to L-Glu (Caenorhabditis elegans)
Pi [cytosol]
Methylation (Caenorhabditis elegans)
MAT1A multimers transfer Ado from ATP to L-Met (Caenorhabditis elegans)
Pi [cytosol]
Inositol phosphate metabolism (Caenorhabditis elegans)
Synthesis of IP2, IP, and Ins in the cytosol (Caenorhabditis elegans)
I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol (Caenorhabditis elegans)
Pi [cytosol]
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Caenorhabditis elegans)
Pi [cytosol]
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Caenorhabditis elegans)
Pi [cytosol]
I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol (Caenorhabditis elegans)
Pi [cytosol]
I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Caenorhabditis elegans)
Pi [cytosol]
I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Caenorhabditis elegans)
Pi [cytosol]
I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Caenorhabditis elegans)
Pi [cytosol]
Synthesis of IP3 and IP4 in the cytosol (Caenorhabditis elegans)
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Caenorhabditis elegans)
Pi [cytosol]
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Caenorhabditis elegans)
Pi [cytosol]
Synthesis of pyrophosphates in the cytosol (Caenorhabditis elegans)
(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Caenorhabditis elegans)
Pi [cytosol]
(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Caenorhabditis elegans)
Pi [cytosol]
1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Caenorhabditis elegans)
Pi [cytosol]
5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Caenorhabditis elegans)
Pi [cytosol]
PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Caenorhabditis elegans)
Pi [cytosol]
Metabolism of amino acids and derivatives (Caenorhabditis elegans)
Glutamate and glutamine metabolism (Caenorhabditis elegans)
glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Caenorhabditis elegans)
Pi [cytosol]
Selenoamino acid metabolism (Caenorhabditis elegans)
Metabolism of ingested SeMet, Sec, MeSec into H2Se (Caenorhabditis elegans)
SeMet is converted to AdoSeMet by MAT (Caenorhabditis elegans)
Pi [cytosol]
Selenocysteine synthesis (Caenorhabditis elegans)
SEPHS2 phosphorylates H2Se to form SELP (Caenorhabditis elegans)
Pi [cytosol]
Serine biosynthesis (Caenorhabditis elegans)
PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Caenorhabditis elegans)
Pi [cytosol]
Sulfur amino acid metabolism (Caenorhabditis elegans)
MAT1A multimers transfer Ado from ATP to L-Met (Caenorhabditis elegans)
Pi [cytosol]
Methionine salvage pathway (Caenorhabditis elegans)
Acireductone is created (Caenorhabditis elegans)
Pi [cytosol]
MTA is cleaved and phosphorylated (Caenorhabditis elegans)
Pi [cytosol]
Metabolism of carbohydrates (Caenorhabditis elegans)
Glucose metabolism (Caenorhabditis elegans)
Gluconeogenesis (Caenorhabditis elegans)
FBP tetramers hydrolyze F1,6PP to Fru(6)P (Caenorhabditis elegans)
Pi [cytosol]
GAPDH tetramers reduce 1,3BPG to GA3P (Caenorhabditis elegans)
Pi [cytosol]
SLC25A10 mediates exchange of malate and phosphate (Caenorhabditis elegans)
Pi [cytosol]
SLC7A4 exchanges G6P for Pi across the ER membrane (Caenorhabditis elegans)
Pi [cytosol]
Glycolysis (Caenorhabditis elegans)
D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ (Caenorhabditis elegans)
Pi [cytosol]
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism (Caenorhabditis elegans)
Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Caenorhabditis elegans)
Pi [cytosol]
Glycogen metabolism (Caenorhabditis elegans)
Glycogen synthesis (Caenorhabditis elegans)
EPM2A dimer dephosphorylates phosphoglycogen-GYG1 (Caenorhabditis elegans)
Pi [cytosol]
EPM2A dimer dephosphorylates phosphoglycogen-GYG2 (Caenorhabditis elegans)
Pi [cytosol]
Metabolism of lipids (Caenorhabditis elegans)
Fatty acid metabolism (Caenorhabditis elegans)
Carnitine metabolism (Caenorhabditis elegans)
Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Caenorhabditis elegans)
Pi [cytosol]
Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Caenorhabditis elegans)
Pi [cytosol]
Fatty acyl-CoA biosynthesis (Caenorhabditis elegans)
ACLY tetramer transforms CIT to Ac-CoA (Caenorhabditis elegans)
Pi [cytosol]
acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate (Caenorhabditis elegans)
Pi [cytosol]
Metabolism of steroids (Caenorhabditis elegans)
Cholesterol biosynthesis (Caenorhabditis elegans)
MVD decarboxylates MVA5PP to IPPP (Caenorhabditis elegans)
Pi [cytosol]
Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Caenorhabditis elegans)
Pi [cytosol]
Phospholipid metabolism (Caenorhabditis elegans)
Glycerophospholipid biosynthesis (Caenorhabditis elegans)
Synthesis of PC (Caenorhabditis elegans)
PA is dephosphorylated to DAG by LPIN (Caenorhabditis elegans)
Pi [cytosol]
Synthesis of PE (Caenorhabditis elegans)
PA is dephosphorylated to DAG by LPIN (Caenorhabditis elegans)
Pi [cytosol]
PI Metabolism (Caenorhabditis elegans)
Synthesis of PIPs at the ER membrane (Caenorhabditis elegans)
PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 (Caenorhabditis elegans)
Pi [cytosol]
PI3P is dephosphorylated to PI by MTMR2:SBF1 (Caenorhabditis elegans)
Pi [cytosol]
PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Caenorhabditis elegans)
Pi [cytosol]
Synthesis of PIPs at the Golgi membrane (Caenorhabditis elegans)
PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane (Caenorhabditis elegans)
Pi [cytosol]
PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Caenorhabditis elegans)
Pi [cytosol]
PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Caenorhabditis elegans)
Pi [cytosol]
PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane (Caenorhabditis elegans)
Pi [cytosol]
Synthesis of PIPs at the early endosome membrane (Caenorhabditis elegans)
PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane (Caenorhabditis elegans)
Pi [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Caenorhabditis elegans)
Pi [cytosol]
PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Caenorhabditis elegans)
Pi [cytosol]
PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Caenorhabditis elegans)
Pi [cytosol]
PI3P is dephosphorylated to PI by MTM1:MTMR12 (Caenorhabditis elegans)
Pi [cytosol]
Synthesis of PIPs at the late endosome membrane (Caenorhabditis elegans)
PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Caenorhabditis elegans)
Pi [cytosol]
PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Caenorhabditis elegans)
Pi [cytosol]
Synthesis of PIPs at the plasma membrane (Caenorhabditis elegans)
PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane (Caenorhabditis elegans)
Pi [cytosol]
PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Caenorhabditis elegans)
Pi [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane (Caenorhabditis elegans)
Pi [cytosol]
PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Caenorhabditis elegans)
Pi [cytosol]
PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Caenorhabditis elegans)
Pi [cytosol]
PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Caenorhabditis elegans)
Pi [cytosol]
PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Caenorhabditis elegans)
Pi [cytosol]
PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Caenorhabditis elegans)
Pi [cytosol]
Sphingolipid metabolism (Caenorhabditis elegans)
sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - PPAP] (Caenorhabditis elegans)
Pi [cytosol]
Triglyceride metabolism (Caenorhabditis elegans)
Triglyceride biosynthesis (Caenorhabditis elegans)
1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Caenorhabditis elegans)
Pi [cytosol]
Metabolism of nucleotides (Caenorhabditis elegans)
Interconversion of nucleotide di- and triphosphates (Caenorhabditis elegans)
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Caenorhabditis elegans)
Pi [cytosol]
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Caenorhabditis elegans)
Pi [cytosol]
Nucleotide biosynthesis (Caenorhabditis elegans)
Purine ribonucleoside monophosphate biosynthesis (Caenorhabditis elegans)
5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Caenorhabditis elegans)
Pi [cytosol]
CAIR + Aspartate + ATP => SAICAR + ADP + Pi (Caenorhabditis elegans)
Pi [cytosol]
FGAM + ATP => AIR + ADP + Pi (Caenorhabditis elegans)
Pi [cytosol]
FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Caenorhabditis elegans)
Pi [cytosol]
IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Caenorhabditis elegans)
Pi [cytosol]
Pyrimidine biosynthesis (Caenorhabditis elegans)
CAD hexamer transforms CAP to N-carb-L-Asp (Caenorhabditis elegans)
Pi [cytosol]
CAD hexamer transforms L-Gln to CAP (Caenorhabditis elegans)
Pi [cytosol]
Nucleotide catabolism (Caenorhabditis elegans)
Purine catabolism (Caenorhabditis elegans)
(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) (Caenorhabditis elegans)
Pi [cytosol]
PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose (Caenorhabditis elegans)
Pi [cytosol]
PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose (Caenorhabditis elegans)
Pi [cytosol]
Phosphate bond hydrolysis by NUDT proteins (Caenorhabditis elegans)
NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Caenorhabditis elegans)
Pi [cytosol]
NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Caenorhabditis elegans)
Pi [cytosol]
NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Caenorhabditis elegans)
Pi [cytosol]
Pyrimidine catabolism (Caenorhabditis elegans)
(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3) (Caenorhabditis elegans)
Pi [cytosol]
(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP) (Caenorhabditis elegans)
Pi [cytosol]
Nucleotide salvage (Caenorhabditis elegans)
Purine salvage (Caenorhabditis elegans)
PNP catalyzes the conversion of guanine and (deoxy)ribose to (deoxy)guanosine (Caenorhabditis elegans)
Pi [cytosol]
PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine (Caenorhabditis elegans)
Pi [cytosol]
Pyrimidine salvage (Caenorhabditis elegans)
HDHD1:Mg2+ dephosphorylates PURIDP (Caenorhabditis elegans)
Pi [cytosol]
uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP] (Caenorhabditis elegans)
Pi [cytosol]
Metabolism of porphyrins (Caenorhabditis elegans)
Heme degradation (Caenorhabditis elegans)
ABCC2 transports BMG,BDG from cytosol to extracellular region (Caenorhabditis elegans)
Pi [cytosol]
Metabolism of vitamins and cofactors (Caenorhabditis elegans)
Metabolism of water-soluble vitamins and cofactors (Caenorhabditis elegans)
Cobalamin (Cbl, vitamin B12) transport and metabolism (Caenorhabditis elegans)
Transport of RCbl within the body (Caenorhabditis elegans)
ABCC1 transports cytosolic RCbl to extracellular region (Caenorhabditis elegans)
Pi [cytosol]
Metabolism of folate and pterines (Caenorhabditis elegans)
FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Caenorhabditis elegans)
Pi [cytosol]
FPGS-2 transforms THF to THFPG (Caenorhabditis elegans)
Pi [cytosol]
MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Caenorhabditis elegans)
Pi [cytosol]
MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Caenorhabditis elegans)
Pi [cytosol]
Vitamin B2 (riboflavin) metabolism (Caenorhabditis elegans)
2xTRAP hydrolyzes FMN to RIB (Caenorhabditis elegans)
Pi [cytosol]
Vitamin B5 (pantothenate) metabolism (Caenorhabditis elegans)
PANK4 hydrolyzes PPANT to pantetheine (Caenorhabditis elegans)
Pi [cytosol]
Pyrophosphate hydrolysis (Caenorhabditis elegans)
LHPP:Mg2+ dimer hydrolyses PPi (Caenorhabditis elegans)
Pi [cytosol]
PPA1 hydrolyzes pyrophosphate to orthophosphate (Caenorhabditis elegans)
Pi [cytosol]
Metabolism of RNA (Caenorhabditis elegans)
Deadenylation-dependent mRNA decay (Caenorhabditis elegans)
mRNA decay by 3' to 5' exoribonuclease (Caenorhabditis elegans)
NT5C3B hydrolyses 7MGP to 7MG (Caenorhabditis elegans)
Pi [cytosol]
Metabolism of proteins (Caenorhabditis elegans)
Post-translational protein modification (Caenorhabditis elegans)
Asparagine N-linked glycosylation (Caenorhabditis elegans)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Caenorhabditis elegans)
Synthesis of substrates in N-glycan biosythesis (Caenorhabditis elegans)
Synthesis of Dolichyl-phosphate (Caenorhabditis elegans)
MVD decarboxylates MVA5PP to IPPP (Caenorhabditis elegans)
Pi [cytosol]
Transport to the Golgi and subsequent modification (Caenorhabditis elegans)
ER to Golgi Anterograde Transport (Caenorhabditis elegans)
COPII-mediated vesicle transport (Caenorhabditis elegans)
Loss of SAR1B GTPase (Caenorhabditis elegans)
Pi [cytosol]
NSF ATPase activity dissociates cis-SNARE (Caenorhabditis elegans)
Pi [cytosol]
Vesicle budding (Caenorhabditis elegans)
Pi [cytosol]
Protein folding (Caenorhabditis elegans)
Chaperonin-mediated protein folding (Caenorhabditis elegans)
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding (Caenorhabditis elegans)
ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT (Caenorhabditis elegans)
Pi [cytosol]
Surfactant metabolism (Caenorhabditis elegans)
ABCA3 transports PC, PG from ER membrane to lamellar body (Caenorhabditis elegans)
Pi [cytosol]
SLC34A1,2 cotransports Pi, 3Na+ from extracellular region to cytosol (Caenorhabditis elegans)
Pi [cytosol]
Translation (Caenorhabditis elegans)
Eukaryotic Translation Initiation (Caenorhabditis elegans)
Cap-dependent Translation Initiation (Caenorhabditis elegans)
GTP hydrolysis and joining of the 60S ribosomal subunit (Caenorhabditis elegans)
eIF5B:GTP is hydrolyzed and released (Caenorhabditis elegans)
Pi [cytosol]
Ribosomal scanning and start codon recognition (Caenorhabditis elegans)
Ribosomal scanning (Caenorhabditis elegans)
Pi [cytosol]
tRNA Aminoacylation (Caenorhabditis elegans)
Cytosolic tRNA aminoacylation (Caenorhabditis elegans)
PPA1 hydrolyzes pyrophosphate to orthophosphate (Caenorhabditis elegans)
Pi [cytosol]
Muscle contraction (Caenorhabditis elegans)
Smooth Muscle Contraction (Caenorhabditis elegans)
ATP Hydrolysis By Myosin (Caenorhabditis elegans)
Pi [cytosol]
Striated Muscle Contraction (Caenorhabditis elegans)
ATP Hydrolysis By Myosin (Caenorhabditis elegans)
Pi [cytosol]
Neuronal System (Caenorhabditis elegans)
Transmission across Chemical Synapses (Caenorhabditis elegans)
Neurotransmitter uptake and metabolism In glial cells (Caenorhabditis elegans)
Astrocytic Glutamate-Glutamine Uptake And Metabolism (Caenorhabditis elegans)
glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Caenorhabditis elegans)
Pi [cytosol]
Signal Transduction (Caenorhabditis elegans)
Intracellular signaling by second messengers (Caenorhabditis elegans)
PIP3 activates AKT signaling (Caenorhabditis elegans)
Negative regulation of the PI3K/AKT network (Caenorhabditis elegans)
PHLPP dephosphorylates S473 in AKT (Caenorhabditis elegans)
Pi [cytosol]
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Caenorhabditis elegans)
AKT1 dephosphorylation by PP2A-B56-beta,gamma (Caenorhabditis elegans)
Pi [cytosol]
MAPK family signaling cascades (Caenorhabditis elegans)
MAPK1/MAPK3 signaling (Caenorhabditis elegans)
RAF-independent MAPK1/3 activation (Caenorhabditis elegans)
Cytosolic DUSPs dephosphorylate MAPKs (Caenorhabditis elegans)
Pi [cytosol]
RAF/MAP kinase cascade (Caenorhabditis elegans)
Negative regulation of MAPK pathway (Caenorhabditis elegans)
Cytosolic DUSPs dephosphorylate MAPKs (Caenorhabditis elegans)
Pi [cytosol]
PP2A dephosphorylates RAF1 (Caenorhabditis elegans)
Pi [cytosol]
PP5 dephosphorylates RAF1 S338 (Caenorhabditis elegans)
Pi [cytosol]
PTPN3 dephosphorylates MAPK12 (Caenorhabditis elegans)
Pi [cytosol]
PTPN7 dephosphorylates p-T,Y-MAPKs (Caenorhabditis elegans)
Pi [cytosol]
RAF activation (Caenorhabditis elegans)
MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs (Caenorhabditis elegans)
Pi [cytosol]
PP2A dephosphorylates inactive RAFs (Caenorhabditis elegans)
Pi [cytosol]
MTOR signalling (Caenorhabditis elegans)
Energy dependent regulation of mTOR by LKB1-AMPK (Caenorhabditis elegans)
AMPK is dephosphorylated (Caenorhabditis elegans)
Pi [cytosol]
RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Caenorhabditis elegans)
Pi [cytosol]
Signaling by GPCR (Caenorhabditis elegans)
GPCR downstream signalling (Caenorhabditis elegans)
G alpha (i) signalling events (Caenorhabditis elegans)
G alpha (i)–i1/i2/i3 in G (i):RGS complex is inactivated (Caenorhabditis elegans)
Pi [cytosol]
Opioid Signalling (Caenorhabditis elegans)
G-protein mediated events (Caenorhabditis elegans)
PLC beta mediated events (Caenorhabditis elegans)
Inactivation of PLC beta (Caenorhabditis elegans)
Pi [cytosol]
G alpha (q) signalling events (Caenorhabditis elegans)
G alpha (q) in G (q):RGS complex is inactivated (Caenorhabditis elegans)
Pi [cytosol]
G alpha (z) signalling events (Caenorhabditis elegans)
G alpha (z) in G alpha (z):RGS complex is inactivated (Caenorhabditis elegans)
Pi [cytosol]
Signaling by Non-Receptor Tyrosine Kinases (Caenorhabditis elegans)
Signaling by PTK6 (Caenorhabditis elegans)
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases (Caenorhabditis elegans)
ARHGAP35 stimulates RHOA GTPase activity (Caenorhabditis elegans)
Pi [cytosol]
Signaling by Receptor Tyrosine Kinases (Caenorhabditis elegans)
Signaling by EGFR (Caenorhabditis elegans)
EGFR downregulation (Caenorhabditis elegans)
PTPN3 dephosphorylates EPS15 (Caenorhabditis elegans)
Pi [cytosol]
Signaling by ERBB2 (Caenorhabditis elegans)
Downregulation of ERBB2 signaling (Caenorhabditis elegans)
PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 (Caenorhabditis elegans)
Pi [cytosol]
Signaling by MET (Caenorhabditis elegans)
Negative regulation of MET activity (Caenorhabditis elegans)
PTPRJ dephosphorylates MET (Caenorhabditis elegans)
Pi [cytosol]
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Caenorhabditis elegans)
Miro GTPase Cycle (Caenorhabditis elegans)
RHOT1 GTPase cycle (Caenorhabditis elegans)
RHOT1 hydrolyzes GTP (Caenorhabditis elegans)
Pi [cytosol]
RHOT2 GTPase cycle (Caenorhabditis elegans)
RHOT2 hydrolyzes GTP (Caenorhabditis elegans)
Pi [cytosol]
Signaling by Rho GTPases (Caenorhabditis elegans)
RHO GTPase cycle (Caenorhabditis elegans)
CDC42 GTPase cycle (Caenorhabditis elegans)
CDC42 GAPs stimulate CDC42 GTPase activity (Caenorhabditis elegans)
Pi [cytosol]
RAC1 GTPase cycle (Caenorhabditis elegans)
RAC1 GAPs stimulate RAC1 GTPase activity (Caenorhabditis elegans)
Pi [cytosol]
RAC3 GTPase cycle (Caenorhabditis elegans)
RAC3 GAPs stimulate RAC3 GTPase activity (Caenorhabditis elegans)
Pi [cytosol]
RHOA GTPase cycle (Caenorhabditis elegans)
RHOA GAPs stimulate RHOA GTPase activity (Caenorhabditis elegans)
Pi [cytosol]
RHOD GTPase cycle (Caenorhabditis elegans)
RHOD GAPs stimulate RHOD GTPase activity (Caenorhabditis elegans)
Pi [cytosol]
RHOF GTPase cycle (Caenorhabditis elegans)
RHOF GAPs stimulate RHOF GTPase activity (Caenorhabditis elegans)
Pi [cytosol]
RHOJ GTPase cycle (Caenorhabditis elegans)
RHOJ GAPs stimulate RHOJ GTPase activity (Caenorhabditis elegans)
Pi [cytosol]
RHOQ GTPase cycle (Caenorhabditis elegans)
RHOQ GAPs stimulate RHOQ GTPase activity (Caenorhabditis elegans)
Pi [cytosol]
Signaling by TGFB family members (Caenorhabditis elegans)
Signaling by TGF-beta Receptor Complex (Caenorhabditis elegans)
TGF-beta receptor signaling activates SMADs (Caenorhabditis elegans)
Downregulation of TGF-beta receptor signaling (Caenorhabditis elegans)
MTMR4 dephosphorylates SMAD2/3 (Caenorhabditis elegans)
Pi [cytosol]
Transport of small molecules (Caenorhabditis elegans)
ABC-family proteins mediated transport (Caenorhabditis elegans)
ABC transporters in lipid homeostasis (Caenorhabditis elegans)
ABCA12 transports lipids from cytosol to extracellular region (Caenorhabditis elegans)
Pi [cytosol]
ABCA3 transports PC, PG from ER membrane to lamellar body (Caenorhabditis elegans)
Pi [cytosol]
ABCA5 transports CHOL from lysosomal lumen to cytosol (Caenorhabditis elegans)
Pi [cytosol]
ABCAs mediate lipid efflux (Caenorhabditis elegans)
Pi [cytosol]
ABCAs mediate lipid influx (Caenorhabditis elegans)
Pi [cytosol]
ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Caenorhabditis elegans)
Pi [cytosol]
ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region (Caenorhabditis elegans)
Pi [cytosol]
CFTR transports Cl- from cytosol to extracellular region (Caenorhabditis elegans)
Pi [cytosol]
HCO3- transport through ion channel (Caenorhabditis elegans)
Pi [cytosol]
Mitochondrial ABC transporters (Caenorhabditis elegans)
ABCB6 transports porphyrin from cytosol to mitchondrial matrix (Caenorhabditis elegans)
Pi [cytosol]
The ABCC family mediates organic anion transport (Caenorhabditis elegans)
Pi [cytosol]
VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Caenorhabditis elegans)
Pi [cytosol]
Ion channel transport (Caenorhabditis elegans)
Ion transport by P-type ATPases (Caenorhabditis elegans)
ATP12A:ATP4B exchanges K+ for H+ (Caenorhabditis elegans)
Pi [cytosol]
ATP13A1 transports Mn2+ from cytosol to ER lumen (Caenorhabditis elegans)
Pi [cytosol]
ATP13A4,5 transport divalent ions from extracellular region to cytosol (Caenorhabditis elegans)
Pi [cytosol]
ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Caenorhabditis elegans)
Pi [cytosol]
ATP4A:ATP4B exchanges K+ for H+ (Caenorhabditis elegans)
Pi [cytosol]
ATP7B transports cytosolic Cu2+ to Golgi lumen (Caenorhabditis elegans)
Pi [cytosol]
P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Caenorhabditis elegans)
Pi [cytosol]
P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Caenorhabditis elegans)
Pi [cytosol]
Iron uptake and transport (Caenorhabditis elegans)
Transferrin endocytosis and recycling (Caenorhabditis elegans)
Acidification of Tf:TfR1 containing endosome (Caenorhabditis elegans)
Pi [cytosol]
SLC-mediated transmembrane transport (Caenorhabditis elegans)
Transport of inorganic cations/anions and amino acids/oligopeptides (Caenorhabditis elegans)
Organic anion transporters (Caenorhabditis elegans)
SLC25A10 mediates exchange of malate and phosphate (Caenorhabditis elegans)
Pi [cytosol]
Sodium-coupled phosphate cotransporters (Caenorhabditis elegans)
SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol (Caenorhabditis elegans)
Pi [cytosol]
Type II Na+/Pi cotransporters (Caenorhabditis elegans)
SLC34A1,2 cotransports Pi, 3Na+ from extracellular region to cytosol (Caenorhabditis elegans)
Pi [cytosol]
SLC34A3 cotransports Pi, 2Na+ (Caenorhabditis elegans)
Pi [cytosol]
Vesicle-mediated transport (Caenorhabditis elegans)
Membrane Trafficking (Caenorhabditis elegans)
Clathrin-mediated endocytosis (Caenorhabditis elegans)
Dynamin-mediated GTP hydrolysis promotes vesicle scission (Caenorhabditis elegans)
Pi [cytosol]
HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Caenorhabditis elegans)
Pi [cytosol]
SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Caenorhabditis elegans)
Pi [cytosol]
ER to Golgi Anterograde Transport (Caenorhabditis elegans)
COPII-mediated vesicle transport (Caenorhabditis elegans)
Loss of SAR1B GTPase (Caenorhabditis elegans)
Pi [cytosol]
NSF ATPase activity dissociates cis-SNARE (Caenorhabditis elegans)
Pi [cytosol]
Vesicle budding (Caenorhabditis elegans)
Pi [cytosol]
Intra-Golgi and retrograde Golgi-to-ER traffic (Caenorhabditis elegans)
Golgi-to-ER retrograde transport (Caenorhabditis elegans)
COPI-dependent Golgi-to-ER retrograde traffic (Caenorhabditis elegans)
NSF ATPase activity dissociates cis-SNARE at the ER (Caenorhabditis elegans)
Pi [cytosol]
Rab regulation of trafficking (Caenorhabditis elegans)
TBC/RABGAPs (Caenorhabditis elegans)
TBC RabGAPs accelerate GTP hydrolysis by RAB35 (Caenorhabditis elegans)
Pi [cytosol]
TBC1D15 accelerates GTP hydrolysis by RAB7 (Caenorhabditis elegans)
Pi [cytosol]
TBC1D2A accelerates GTP hydrolysis by RAB7 (Caenorhabditis elegans)
Pi [cytosol]
trans-Golgi Network Vesicle Budding (Caenorhabditis elegans)
Golgi Associated Vesicle Biogenesis (Caenorhabditis elegans)
trans-Golgi Network Coat Assembly (Caenorhabditis elegans)
Pi [cytosol]
trans-Golgi Network Vesicle Scission (Caenorhabditis elegans)
Pi [cytosol]
Lysosome Vesicle Biogenesis (Caenorhabditis elegans)
trans-Golgi Network Lysosomal Vesicle Scission (Caenorhabditis elegans)
Pi [cytosol]
trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly (Caenorhabditis elegans)
Pi [cytosol]
Autophagy (Canis familiaris)
Macroautophagy (Canis familiaris)
ULK1 is dephosphorylated (Canis familiaris)
Pi [cytosol]
Cell Cycle (Canis familiaris)
Cell Cycle, Mitotic (Canis familiaris)
M Phase (Canis familiaris)
Mitotic Metaphase and Anaphase (Canis familiaris)
Mitotic Anaphase (Canis familiaris)
Nuclear Envelope (NE) Reassembly (Canis familiaris)
Initiation of Nuclear Envelope (NE) Reformation (Canis familiaris)
PP2A dephosphorylates BANF1 (Canis familiaris)
Pi [cytosol]
Mitotic Prometaphase (Canis familiaris)
Condensation of Prometaphase Chromosomes (Canis familiaris)
Dephosphorylation of CK2-modified condensin I (Canis familiaris)
Pi [cytosol]
Resolution of Sister Chromatid Cohesion (Canis familiaris)
PP2A-B56 dephosphorylates centromeric cohesin (Canis familiaris)
Pi [cytosol]
Mitotic G2-G2/M phases (Canis familiaris)
G2/M Transition (Canis familiaris)
Cyclin A/B1/B2 associated events during G2/M transition (Canis familiaris)
Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B (Canis familiaris)
Pi [cytosol]
Cellular responses to stimuli (Canis familiaris)
Cellular responses to stress (Canis familiaris)
Cellular response to heat stress (Canis familiaris)
Regulation of HSF1-mediated heat shock response (Canis familiaris)
HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Canis familiaris)
Pi [cytosol]
Cellular response to starvation (Canis familiaris)
Amino acids regulate mTORC1 (Canis familiaris)
RRAGA,B hydrolyzes GTP (Canis familiaris)
Pi [cytosol]
RRAGC,D hydrolyzes GTP (Canis familiaris)
Pi [cytosol]
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand (Canis familiaris)
ATP hydrolysis by HSP70 (Canis familiaris)
Pi [cytosol]
Developmental Biology (Canis familiaris)
Nervous system development (Canis familiaris)
Axon guidance (Canis familiaris)
EPH-Ephrin signaling (Canis familiaris)
EPHB-mediated forward signaling (Canis familiaris)
p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Canis familiaris)
Pi [cytosol]
L1CAM interactions (Canis familiaris)
Recycling pathway of L1 (Canis familiaris)
Formation of clathrin coated vesicle (Canis familiaris)
Pi [cytosol]
Semaphorin interactions (Canis familiaris)
Sema4D in semaphorin signaling (Canis familiaris)
Sema4D mediated inhibition of cell attachment and migration (Canis familiaris)
Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity (Canis familiaris)
Pi [cytosol]
Inactivation of Rho-GTP by p190RhoGAP (Canis familiaris)
Pi [cytosol]
Signaling by ROBO receptors (Canis familiaris)
SLIT2:ROBO1 increases RHOA activity (Canis familiaris)
MYO9B inactivates RHOA (Canis familiaris)
Pi [cytosol]
Drug ADME (Canis familiaris)
Aspirin ADME (Canis familiaris)
ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Canis familiaris)
Pi [cytosol]
Azathioprine ADME (Canis familiaris)
ABCC4 transports TPMP substrates from cytosol to extracellular region (Canis familiaris)
Pi [cytosol]
ABCC5 transports TPMP substrates from cytosol to extracellular region (Canis familiaris)
Pi [cytosol]
Paracetamol ADME (Canis familiaris)
ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Canis familiaris)
Pi [cytosol]
ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Canis familiaris)
Pi [cytosol]
ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Canis familiaris)
Pi [cytosol]
Prednisone ADME (Canis familiaris)
ABCB1 transports PREDN,PREDL out of hepatic cells (Canis familiaris)
Pi [cytosol]
ABCB1 transports PREDN,PREDL out of kidney cells (Canis familiaris)
Pi [cytosol]
ABCB1 transports xenobiotics out of the cell (Canis familiaris)
Pi [cytosol]
Gene expression (Transcription) (Canis familiaris)
RNA Polymerase II Transcription (Canis familiaris)
Generic Transcription Pathway (Canis familiaris)
Transcriptional Regulation by TP53 (Canis familiaris)
TP53 Regulates Metabolic Genes (Canis familiaris)
RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Canis familiaris)
Pi [cytosol]
TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate (Canis familiaris)
Pi [cytosol]
Hemostasis (Canis familiaris)
Platelet activation, signaling and aggregation (Canis familiaris)
Platelet Aggregation (Plug Formation) (Canis familiaris)
Integrin signaling (Canis familiaris)
Dephosphorylation of inactive SRC by PTPB1 (Canis familiaris)
Pi [cytosol]
Response to elevated platelet cytosolic Ca2+ (Canis familiaris)
Platelet degranulation (Canis familiaris)
ABCC4 accumulation of dense granule contents (Canis familiaris)
Pi [cytosol]
Immune System (Canis familiaris)
Adaptive Immune System (Canis familiaris)
Costimulation by the CD28 family (Canis familiaris)
CTLA4 inhibitory signaling (Canis familiaris)
Dephosphorylation of AKT by PP2A (Canis familiaris)
Pi [cytosol]
MHC class II antigen presentation (Canis familiaris)
Dissociation of Arf1:GDP, AP-1 Clathrin coated nonameric complex (Canis familiaris)
Pi [cytosol]
Internalization of MHC II:Ii clathrin coated vesicle (Canis familiaris)
Pi [cytosol]
Translocation of TGN-lysosome vesicle to lysosome (Canis familiaris)
Pi [cytosol]
TCR signaling (Canis familiaris)
Downstream TCR signaling (Canis familiaris)
Hydrolysis of PIP3 to PI(3,4)P2 (Canis familiaris)
Pi [cytosol]
PTEN dephosphorylates PIP3 (Canis familiaris)
Pi [cytosol]
Phosphorylation of CD3 and TCR zeta chains (Canis familiaris)
Dephosphorylation of Lck-pY505 by CD45 (Canis familiaris)
Pi [cytosol]
Inactivation of LCK by PTPN22 (Canis familiaris)
Pi [cytosol]
Translocation of ZAP-70 to Immunological synapse (Canis familiaris)
PTPN22 dephosphorylates ZAP70 (Canis familiaris)
Pi [cytosol]
Cytokine Signaling in Immune system (Canis familiaris)
FLT3 Signaling (Canis familiaris)
Negative regulation of FLT3 (Canis familiaris)
PTPRJ dephosphorylates active FLT3 (Canis familiaris)
Pi [cytosol]
Growth hormone receptor signaling (Canis familiaris)
PTP1B dephosphorylates GHR (Canis familiaris)
Pi [cytosol]
Interferon Signaling (Canis familiaris)
Interferon alpha/beta signaling (Canis familiaris)
Regulation of IFNA/IFNB signaling (Canis familiaris)
Dephosphorylation of JAK1 by SHP1 (Canis familiaris)
Pi [cytosol]
Dephosphorylation of STAT1 by SHP2 (Canis familiaris)
Pi [cytosol]
Dephosphorylation of TYK2 by PTP1B (Canis familiaris)
Pi [cytosol]
Signaling by CSF3 (G-CSF) (Canis familiaris)
p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS (Canis familiaris)
Pi [cytosol]
Innate Immune System (Canis familiaris)
Antimicrobial peptides (Canis familiaris)
Ion influx/efflux at host-pathogen interface (Canis familiaris)
ATP7A transports cytosolic Cu2+ to phagosomal lumen (Canis familiaris)
Pi [cytosol]
C-type lectin receptors (CLRs) (Canis familiaris)
CLEC7A (Dectin-1) signaling (Canis familiaris)
CLEC7A (Dectin-1) induces NFAT activation (Canis familiaris)
Calcineurin binds and dephosphorylates NFAT (Canis familiaris)
Pi [cytosol]
Fc epsilon receptor (FCERI) signaling (Canis familiaris)
FCERI mediated Ca+2 mobilization (Canis familiaris)
Calcineurin binds and dephosphorylates NFAT (Canis familiaris)
Pi [cytosol]
Fcgamma receptor (FCGR) dependent phagocytosis (Canis familiaris)
Regulation of actin dynamics for phagocytic cup formation (Canis familiaris)
Extension of pseudopodia by myosin-X in a PI3K dependent manner (Canis familiaris)
Pi [cytosol]
Role of myosins in phagosome formation (Canis familiaris)
Pi [cytosol]
Role of phospholipids in phagocytosis (Canis familiaris)
Conversion of PA into DAG by PAP-1 (Canis familiaris)
Pi [cytosol]
Metabolism (Canis familiaris)
Biological oxidations (Canis familiaris)
Phase II - Conjugation of compounds (Canis familiaris)
Cytosolic sulfonation of small molecules (Canis familiaris)
Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Canis familiaris)
Pi [cytosol]
Methylation (Canis familiaris)
MAT1A multimers transfer Ado from ATP to L-Met (Canis familiaris)
Pi [cytosol]
MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met (Canis familiaris)
Pi [cytosol]
Inositol phosphate metabolism (Canis familiaris)
Synthesis of IP2, IP, and Ins in the cytosol (Canis familiaris)
I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol (Canis familiaris)
Pi [cytosol]
I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol (Canis familiaris)
Pi [cytosol]
I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol (Canis familiaris)
Pi [cytosol]
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Canis familiaris)
Pi [cytosol]
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Canis familiaris)
Pi [cytosol]
I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol (Canis familiaris)
Pi [cytosol]
I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Canis familiaris)
Pi [cytosol]
I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Canis familiaris)
Pi [cytosol]
I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Canis familiaris)
Pi [cytosol]
Synthesis of IP3 and IP4 in the cytosol (Canis familiaris)
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Canis familiaris)
Pi [cytosol]
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Canis familiaris)
Pi [cytosol]
I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Canis familiaris)
Pi [cytosol]
I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol (Canis familiaris)
Pi [cytosol]
I(1,3,4,6)P4 is dephosphorylated to I(3,4,6)P3 by ITPK1 in the cytosol (Canis familiaris)
Pi [cytosol]
Synthesis of pyrophosphates in the cytosol (Canis familiaris)
(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Canis familiaris)
Pi [cytosol]
(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Canis familiaris)
Pi [cytosol]
1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Canis familiaris)
Pi [cytosol]
5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Canis familiaris)
Pi [cytosol]
![Pi [cytosol] icon](/icon/R-ICO-014111.svg){kind=icon}