Reactome | Loss of SAR1B GTPase

Loss of SAR1B GTPase

Stable Identifier

R-HSA-5694527

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, endoplasmic reticulum membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - ER to Golgi Anterograde Transport (Homo sapiens)
        
        COPII-mediated vesicle transport (Homo sapiens)
        
        Loss of SAR1B GTPase (Homo sapiens)

General

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Sar1p-GTP hydrolysis is increased 15-30-fold by Sec23p. Sar1p-GDP is released as a result of this hydrolysis and used in further vesicle sculpting cycles. Sar1p-GTP hydrolysis occurs at two critical points during the cycle, first (as represented here) as a proofreading step, insuring that the cargo is loaded. Later in the cycle Sar1p-GTP hydrolysis triggers the uncoating of the budded vesicle.

Literature References

PubMed ID	Title	Journal	Year
10825291	COPI-coated ER-to-Golgi transport complexes segregate from COPII in close proximity to ER exit sites Paccaud, JP, Lin-Marq, N, Stephens, DJ, Pagano, A, Pepperkok, R	J Cell Sci	2000
10982397	Dynamics of transitional endoplasmic reticulum sites in vertebrate cells Glick, BS, Hammond, AT	Mol Biol Cell	2000
17316621	Mechanisms of COPII vesicle formation and protein sorting Nakano, A, Sato, K	FEBS Lett	2007