Loss of SAR1B GTPase

Stable Identifier
R-HSA-5694527
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Sar1p-GTP hydrolysis is increased 15-30-fold by Sec23p. Sar1p-GDP is released as a result of this hydrolysis and used in further vesicle sculpting cycles. Sar1p-GTP hydrolysis occurs at two critical points during the cycle, first (as represented here) as a proofreading step, insuring that the cargo is loaded. Later in the cycle Sar1p-GTP hydrolysis triggers the uncoating of the budded vesicle.

Literature References
PubMed ID Title Journal Year
10982397 Dynamics of transitional endoplasmic reticulum sites in vertebrate cells

Hammond, AT, Glick, BS

Mol Biol Cell 2000
10825291 COPI-coated ER-to-Golgi transport complexes segregate from COPII in close proximity to ER exit sites

Stephens, DJ, Lin-Marq, N, Pagano, A, Pepperkok, R, Paccaud, JP

J Cell Sci 2000
17316621 Mechanisms of COPII vesicle formation and protein sorting

Sato, K, Nakano, A

FEBS Lett 2007
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
GTPase activity of COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created