Loss of SAR1B GTPase

Stable Identifier
Reaction [transition]
Homo sapiens
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Sar1p-GTP hydrolysis is increased 15-30-fold by Sec23p. Sar1p-GDP is released as a result of this hydrolysis and used in further vesicle sculpting cycles. Sar1p-GTP hydrolysis occurs at two critical points during the cycle, first (as represented here) as a proofreading step, insuring that the cargo is loaded. Later in the cycle Sar1p-GTP hydrolysis triggers the uncoating of the budded vesicle.

Literature References
PubMed ID Title Journal Year
10825291 COPI-coated ER-to-Golgi transport complexes segregate from COPII in close proximity to ER exit sites

Paccaud, JP, Lin-Marq, N, Stephens, DJ, Pagano, A, Pepperkok, R

J Cell Sci 2000
10982397 Dynamics of transitional endoplasmic reticulum sites in vertebrate cells

Glick, BS, Hammond, AT

Mol Biol Cell 2000
17316621 Mechanisms of COPII vesicle formation and protein sorting

Nakano, A, Sato, K

FEBS Lett 2007
Catalyst Activity

GTPase activity of COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane]

Orthologous Events
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