Reactome | hypoxanthine + (deoxy)ribose 1-phosphate <=> (deoxy)inosine + orthophosphate (NP)

hypoxanthine + (deoxy)ribose 1-phosphate <=> (deoxy)inosine + orthophosphate (NP)

Stable Identifier

R-HSA-112033

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

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hypoxanthine + (deoxy)ribose 1-phosphate <=> (deoxy)inosine + orthophosphate (NP)

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Cytosolic nucleoside phosphorylase (NP) trimer catalyzes the reversible reaction of hypoxanthine with ribose 1-phosphate or deoxyribose 1-phosphate to form inosine or deoxyinosine and orthophosphate (Ealick et al. 1990; Wiginton et al. 1980). While NP is active with either ribose 1-phosphate or deoxyribose 1-phosphate in vitro, levels of deoxyribose 1-phosphate are normally low in vivo, limiting the extent of this reaction. NP deficiency in vivo is associated with defects in purine nucleotide salvage and leads to immunodeficiency (Williams et al. 1987).

Literature References

PubMed ID	Title	Journal	Year
6771276	Characterization of purine nucleoside phosphorylase from human granulocytes and its metabolism of deoxyribonucleosides Wiginton, DA, Coleman, MS, Hutton, JJ	J Biol Chem	1980
3029074	A human purine nucleoside phosphorylase deficiency caused by a single base change Williams, SR, Gekeler, V, McIvor, RS, Martin, Jr, DW	J Biol Chem	1987
2104852	Three-dimensional structure of human erythrocytic purine nucleoside phosphorylase at 3.2 A resolution Ealick, SE, Rule, SA, Carter, DC, Greenhough, TJ, Babu, YS, Cook, WJ, Habash, J, Helliwell, JR, Stoeckler, JD, Parks, Jr, RE, Chen, SF, Bugg, CE	J Biol Chem	1990