THTPA:Mg2+ hydrolyzes ThTP to TDP

Stable Identifier
R-HSA-965067
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Thiamin triphosphate can be hydrolysed back to thiamin diphosphate
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Thiamin triphosphate (ThTP) can transfer phosphate to a few proteins. Animal tissues contain a membrane-associated as well as a soluble thiamine triphosphatase that can dephosphorylate ThTP. Only the soluble enzyme was characterized in calf (Lakaye et al, 2002).

Literature References
PubMed ID Title Journal Year
11827967 Molecular characterization of a specific thiamine triphosphatase widely expressed in mammalian tissues

Lakaye, B, Makarchikov, AF, Antunes, AF, Zorzi, W, Coumans, B, De Pauw, E, Wins, P, Grisar, T, Bettendorff, L

J Biol Chem 2002
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
thiamin-triphosphatase activity of THTPA:Mg2+ [cytosol]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
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