THTPA:Mg2+ hydrolyzes ThTP to TDP

Stable Identifier
R-HSA-965067
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Thiamin triphosphate can be hydrolysed back to thiamin diphosphate
ReviewStatus
5/5
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THTPA:Mg2+ hydrolyzes ThTP to TDP
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Thiamin triphosphate (ThTP) can transfer phosphate to a few proteins. Animal tissues contain a membrane-associated as well as a soluble thiamine triphosphatase that can dephosphorylate ThTP. Only the soluble enzyme was characterized in calf (Lakaye et al, 2002).
Literature References
PubMed ID Title Journal Year
11827967 Molecular characterization of a specific thiamine triphosphatase widely expressed in mammalian tissues

Bettendorff, L, Coumans, B, Lakaye, B, Wins, P, De Pauw, E, Antunes, AF, Grisar, T, Zorzi, W, Makarchikov, AF

J Biol Chem 2002
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Catalyst Activity

thiamin-triphosphatase activity of THTPA:Mg2+ [cytosol]

Physical Entity
THTPA:Mg2+ [cytosol] (Homo sapiens)
Activity
thiamin-triphosphatase activity (GO:0050333)
Orthologous Events
THTPA:Mg2+ hydrolyzes ThTP to TDP (Bos taurus)
THTPA:Mg2+ hydrolyzes ThTP to TDP (Canis familiaris)
THTPA:Mg2+ hydrolyzes ThTP to TDP (Mus musculus)
THTPA:Mg2+ hydrolyzes ThTP to TDP (Rattus norvegicus)
THTPA:Mg2+ hydrolyzes ThTP to TDP (Sus scrofa)
THTPA:Mg2+ hydrolyzes ThTP to TDP (Xenopus tropicalis)
Cross References
Rhea
Authored
Stephan, R  (2010-09-16)
Reviewed
D'Eustachio, P  (2010-11-05)
Created
Jassal, B  (2010-09-20)
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