Reactome | PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane

PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane

Stable Identifier

R-HSA-1675824

Type

Reaction [transition]

Species

Homo sapiens

Compartment

Golgi membrane, cytosol

ReviewStatus

5/5

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PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane

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At the Golgi membrane, phosphatidylinositol 4-phosphate (PI4P) inositol polyphosphate 5-phosphatase OCRL-1 (OCRL) (Choudhury et al. 2009, Suchy et al. 1995, Zhang et al. 1995) and 72 kDa inositol polyphosphate 5-phosphatase (INPP5E) (Bilas et al. 2009) dephosphorylate phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) to form phosphatidylinositol 4-phosphate (PI4P). INPP5E is located in the Golgi membrane, mediated by its N-terminal proline-rich domain (Kong et al. 2000).

Literature References

PubMed ID	Title	Journal	Year
19211563	Differential clathrin binding and subcellular localization of OCRL1 splice isoforms Choudhury, R, Noakes, CJ, McKenzie, E, Kox, C, Lowe, M	J Biol Chem	2009
10764818	The isolation and characterization of a cDNA encoding phospholipid-specific inositol polyphosphate 5-phosphatase Kisseleva, MV, Wilson, MP, Majerus, PW	J Biol Chem	2000
10806194	Cloning and characterization of a 72-kDa inositol-polyphosphate 5-phosphatase localized to the Golgi network Kong, AM, Speed, CJ, O'Malley, CJ, Layton, MJ, Meehan, T, Loveland, KL, Cheema, S, Ooms, LM, Mitchell, CA	J Biol Chem	2000
8634694	Lowe syndrome, a deficiency of phosphatidylinositol 4,5-bisphosphate 5-phosphatase in the Golgi apparatus Suchy, SF, Olivos-Glander, IM, Nussabaum, RL	Hum Mol Genet	1995
7761412	The protein deficient in Lowe syndrome is a phosphatidylinositol-4,5-bisphosphate 5-phosphatase Zhang, X, Jefferson, AB, Auethavekiat, V, Majerus, PW	Proc Natl Acad Sci U S A	1995
19668216	Mutations in INPP5E, encoding inositol polyphosphate-5-phosphatase E, link phosphatidyl inositol signaling to the ciliopathies Bielas, SL, Silhavy, JL, Brancati, F, Kisseleva, MV, Al-Gazali, L, Sztriha, L, Bayoumi, RA, Zaki, MS, Abdel-Aleem, A, Rosti, RO, Kayserili, H, Swistun, D, Scott, LC, Bertini, E, Boltshauser, E, Fazzi, E, Travaglini, L, Field, SJ, Gayral, S, Jacoby, M, Schurmans, S, Dallapiccola, B, Majerus, PW, Valente, EM, Gleeson, JG	Nat Genet	2009