PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane

Stable Identifier
Reaction [transition]
Homo sapiens
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At the Golgi membrane, phosphatidylinositol 4-phosphate (PI4P) inositol polyphosphate 5-phosphatase OCRL-1 (OCRL) (Choudhury et al. 2009, Suchy et al. 1995, Zhang et al. 1995) and 72 kDa inositol polyphosphate 5-phosphatase (INPP5E) (Bilas et al. 2009) dephosphorylate phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) to form phosphatidylinositol 4-phosphate (PI4P). INPP5E is located in the Golgi membrane, mediated by its N-terminal proline-rich domain (Kong et al. 2000).

Literature References
PubMed ID Title Journal Year
19211563 Differential clathrin binding and subcellular localization of OCRL1 splice isoforms

Kox, C, Noakes, CJ, Choudhury, R, Lowe, M, McKenzie, E

J Biol Chem 2009
10764818 The isolation and characterization of a cDNA encoding phospholipid-specific inositol polyphosphate 5-phosphatase

Majerus, PW, Kisseleva, MV, Wilson, MP

J Biol Chem 2000
10806194 Cloning and characterization of a 72-kDa inositol-polyphosphate 5-phosphatase localized to the Golgi network

Loveland, KL, Layton, MJ, Speed, CJ, Kong, AM, Cheema, S, Mitchell, CA, Meehan, T, Ooms, LM, O'Malley, CJ

J Biol Chem 2000
8634694 Lowe syndrome, a deficiency of phosphatidylinositol 4,5-bisphosphate 5-phosphatase in the Golgi apparatus

Olivos-Glander, IM, Suchy, SF, Nussabaum, RL

Hum Mol Genet 1995
7761412 The protein deficient in Lowe syndrome is a phosphatidylinositol-4,5-bisphosphate 5-phosphatase

Jefferson, AB, Auethavekiat, V, Majerus, PW, Zhang, X

Proc Natl Acad Sci U S A 1995
19668216 Mutations in INPP5E, encoding inositol polyphosphate-5-phosphatase E, link phosphatidyl inositol signaling to the ciliopathies

Schurmans, S, Kayserili, H, Gayral, S, Brancati, F, Dallapiccola, B, Jacoby, M, Gleeson, JG, Swistun, D, Majerus, PW, Zaki, MS, Valente, EM, Silhavy, JL, Boltshauser, E, Kisseleva, MV, Scott, LC, Travaglini, L, Abdel-Aleem, A, Fazzi, E, Bayoumi, RA, Bielas, SL, Bertini, E, Al-Gazali, L, Field, SJ, Sztriha, L, Rosti, RO

Nat Genet 2009
Catalyst Activity

phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity of OCRL/INPP5E [cytosol]

Orthologous Events
Cross References
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