Reactome | trans-Golgi Network Derived Lysosomal Vesicle Uncoating

trans-Golgi Network Derived Lysosomal Vesicle Uncoating

Stable Identifier

R-HSA-432688

Type

Reaction [dissociation]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

trans-Golgi Network Derived Lysosomal Vesicle Uncoating

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The heat shock protein Hsc70 and auxilin, a J-domain containing protein, are responsible for clathrin disassembly through an ATP-dependent reaction. This uncoating step may be a point in the pathway subject to regulation. This final step releases the vesicle from the clathrin cage. The vesicle still contatins a specific Vamp molecule, part of the targeting and fusion mechanism that delivers the vesicle to its ultimate destination. This vesicle also contains its cargo, membrane proteins embeded in the lysosome membrane.

Literature References

PubMed ID	Title	Journal	Year
11994746	Regulated transport of the glucose transporter GLUT4. James, DE, Bryant, NJ, Govers, R	Nat Rev Mol Cell Biol	2002
8374173	Alteration of clathrin light chain expression by transfection and gene disruption Acton, SL, Jackson, AP, Brodsky, FM, Parham, P, Wong, DH	Mol Biol Cell	1993
16155256	Depletion of GAK/auxilin 2 inhibits receptor-mediated endocytosis and recruitment of both clathrin and clathrin adaptors Zhang, F, Eisenberg, E, Greene, LE, Zhao, X, Lee, DW	J Cell Sci	2005
17116749	Comparative proteomics of clathrin-coated vesicles Lilley, KS, Borner, GH, Hester, S, Robinson, MS, Harbour, M	J Cell Biol	2006
8524399	Role of auxilin in uncoating clathrin-coated vesicles Holstein, SE, Eisenberg, E, Greene, LE, Martin, B, Lindner, R, Ungewickell, H, Ungewickell, E, Barouch, W, Prasad, K	Nature	1995