trans-Golgi Network Derived Lysosomal Vesicle Uncoating

Stable Identifier
R-HSA-432688
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
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The heat shock protein Hsc70 and auxilin, a J-domain containing protein, are responsible for clathrin disassembly through an ATP-dependent reaction. This uncoating step may be a point in the pathway subject to regulation. This final step releases the vesicle from the clathrin cage. The vesicle still contatins a specific Vamp molecule, part of the targeting and fusion mechanism that delivers the vesicle to its ultimate destination. This vesicle also contains its cargo, membrane proteins embeded in the lysosome membrane.

Literature References
PubMed ID Title Journal Year
8374173 Alteration of clathrin light chain expression by transfection and gene disruption

Acton, SL, Wong, DH, Parham, P, Brodsky, FM, Jackson, AP

Mol Biol Cell 1993
11994746 Regulated transport of the glucose transporter GLUT4.

Bryant, NJ, Govers, R, James, DE

Nat Rev Mol Cell Biol 2002
16155256 Depletion of GAK/auxilin 2 inhibits receptor-mediated endocytosis and recruitment of both clathrin and clathrin adaptors

Lee, DW, Zhao, X, Zhang, F, Eisenberg, E, Greene, LE

J Cell Sci 2005
17116749 Comparative proteomics of clathrin-coated vesicles

Borner, GH, Harbour, M, Hester, S, Lilley, KS, Robinson, MS

J Cell Biol 2006
8524399 Role of auxilin in uncoating clathrin-coated vesicles

Ungewickell, E, Ungewickell, H, Holstein, SE, Lindner, R, Prasad, K, Barouch, W, Martin, B, Greene, LE, Eisenberg, E

Nature 1995
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