PP2A dephosphorylates BANF1

Stable Identifier
R-HSA-2995388
Type
Reaction
Species
Homo sapiens
Compartment
cytosol, endoplasmic reticulum membrane
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PP2A dephosphorylates BANF1
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The PP2A complex that contains the regulatory subunit PPP2R2A (B55-alpha) is the only phosphatase essential for mitotic exit (Schmitz et al. 2010). It is also necessary for BANF1 (BAF) dephosphorylation in anaphase/telophase. ANKLE2 binds the PP2A complex that contains the B55-alpha regulatory subunit and facilitates BANF1 dephosphorylation (Asencio et al. 2012).

Literature References
PubMed ID Title Journal Year
20711181 Live-cell imaging RNAi screen identifies PP2A-B55alpha and importin-beta1 as key mitotic exit regulators in human cells

Hyman, AA, Poser, I, Hudecz, O, Peters, JM, Held, M, Hutchins, JR, Mechtler, K, Trinkle-Mulcahy, L, Lamond, AI, Janssens, V, Ivanova, E, Gerlich, DW, Goris, J, Schmitz, MH

Nat. Cell Biol. 2010
22770216 Coordination of kinase and phosphatase activities by Lem4 enables nuclear envelope reassembly during mitosis

Wallenfang, MR, Mall, M, Davidson, IF, Santarella-Mellwig, R, Ly-Hartig, TB, Asencio, C, Gorjánácz, M, Mattaj, IW

Cell 2012
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Output
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as an event of
Catalyst Activity

protein serine/threonine phosphatase activity of ANKLE2:PP2A [endoplasmic reticulum membrane]

Physical Entity
ANKLE2:PP2A [endoplasmic reticulum membrane] (Homo sapiens)
Activity
protein serine/threonine phosphatase activity (GO:0004722)
Authored
Orlic-Milacic, M  (2013-01-22)
Reviewed
Mattaj, IW  (2013-01-30)
Gorjánácz, M  (2013-01-30)
Created
Orlic-Milacic, M  (2013-01-22)
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