PP2A dephosphorylates BANF1

Stable Identifier
Reaction [transition]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The PP2A complex that contains the regulatory subunit B55-alpha (PPP2R2A) is the only phosphatase essential for mitotic exit (Schmitz et al. 2010). The PP2A complex is necessary for BANF1 (BAF) dephosphorylation in late mitotic anaphase. ANKLE2 (LEM4) binds the PP2A complex that contains the B55-alpha regulatory subunit and facilitates BANF1 dephosphorylation, but as ANKLE2 does not interact with BANF1 (BAF) directly, the exact mechanism has not been determined (Asencio et al. 2012).

Literature References
PubMed ID Title Journal Year
22770216 Coordination of kinase and phosphatase activities by Lem4 enables nuclear envelope reassembly during mitosis

Asencio, C, Davidson, IF, Santarella-Mellwig, R, Ly-Hartig, TB, Mall, M, Wallenfang, MR, Mattaj, IW, Gorjánácz, M

Cell 2012
20711181 Live-cell imaging RNAi screen identifies PP2A-B55alpha and importin-beta1 as key mitotic exit regulators in human cells

Schmitz, MH, Held, M, Janssens, V, Hutchins, JR, Hudecz, O, Ivanova, E, Goris, J, Trinkle-Mulcahy, L, Lamond, AI, Poser, I, Hyman, AA, Mechtler, K, Peters, JM, Gerlich, DW

Nat. Cell Biol. 2010
Participant Of
Catalyst Activity
Catalyst Activity
protein serine/threonine phosphatase activity of PP2A (Aalpha:B55alpha:Calpha) [cytosol]
Physical Entity
This event is regulated
Orthologous Events