Reactome | PP2A dephosphorylates BANF1

PP2A dephosphorylates BANF1

Stable Identifier

R-HSA-2995388

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, endoplasmic reticulum membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

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Cell Cycle (Homo sapiens)

- Cell Cycle, Mitotic (Homo sapiens)
  - M Phase (Homo sapiens)
    - Mitotic Metaphase and Anaphase (Homo sapiens)
      - Mitotic Anaphase (Homo sapiens)
        
        Nuclear Envelope (NE) Reassembly (Homo sapiens)
        
        Initiation of Nuclear Envelope (NE) Reformation (Homo sapiens)
        
        PP2A dephosphorylates BANF1 (Homo sapiens)

General

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The PP2A complex that contains the regulatory subunit PPP2R2A (B55-alpha) is the only phosphatase essential for mitotic exit (Schmitz et al. 2010). It is also necessary for BANF1 (BAF) dephosphorylation in anaphase/telophase. ANKLE2 binds the PP2A complex that contains the B55-alpha regulatory subunit and facilitates BANF1 dephosphorylation (Asencio et al. 2012).

Literature References

PubMed ID	Title	Journal	Year
20711181	Live-cell imaging RNAi screen identifies PP2A-B55alpha and importin-beta1 as key mitotic exit regulators in human cells Schmitz, MH, Held, M, Janssens, V, Hutchins, JR, Hudecz, O, Ivanova, E, Goris, J, Trinkle-Mulcahy, L, Lamond, AI, Poser, I, Hyman, AA, Mechtler, K, Peters, JM, Gerlich, DW	Nat. Cell Biol.	2010
22770216	Coordination of kinase and phosphatase activities by Lem4 enables nuclear envelope reassembly during mitosis Asencio, C, Davidson, IF, Santarella-Mellwig, R, Ly-Hartig, TB, Mall, M, Wallenfang, MR, Mattaj, IW, Gorjánácz, M	Cell	2012