The PP2A complex that contains the regulatory subunit PPP2R2A (B55-alpha) is the only phosphatase essential for mitotic exit (Schmitz et al. 2010). It is also necessary for BANF1 (BAF) dephosphorylation in anaphase/telophase. ANKLE2 binds the PP2A complex that contains the B55-alpha regulatory subunit and facilitates BANF1 dephosphorylation (Asencio et al. 2012).
Hyman, AA, Poser, I, Hudecz, O, Peters, JM, Held, M, Hutchins, JR, Mechtler, K, Trinkle-Mulcahy, L, Lamond, AI, Janssens, V, Ivanova, E, Gerlich, DW, Goris, J, Schmitz, MH
Wallenfang, MR, Mall, M, Davidson, IF, Santarella-Mellwig, R, Ly-Hartig, TB, Asencio, C, Gorjánácz, M, Mattaj, IW
protein serine/threonine phosphatase activity of ANKLE2:PP2A [endoplasmic reticulum membrane]
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