Reactome | PP2A dephosphorylates BANF1

PP2A dephosphorylates BANF1

Stable Identifier

R-HSA-2995388

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, endoplasmic reticulum membrane

Locations in the PathwayBrowser

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Cell Cycle (Homo sapiens)

- Cell Cycle, Mitotic (Homo sapiens)
  - M Phase (Homo sapiens)
    - Mitotic Metaphase and Anaphase (Homo sapiens)
      - Mitotic Anaphase (Homo sapiens)
        
        Nuclear Envelope Reassembly (Homo sapiens)
        
        Initiation of Nuclear Envelope Reformation (Homo sapiens)
        
        PP2A dephosphorylates BANF1 (Homo sapiens)

General

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The PP2A complex that contains the regulatory subunit B55-alpha (PPP2R2A) is the only phosphatase essential for mitotic exit (Schmitz et al. 2010). The PP2A complex is necessary for BANF1 (BAF) dephosphorylation in late mitotic anaphase. ANKLE2 (LEM4) binds the PP2A complex that contains the B55-alpha regulatory subunit and facilitates BANF1 dephosphorylation, but as ANKLE2 does not interact with BANF1 (BAF) directly, the exact mechanism has not been determined (Asencio et al. 2012).

Literature References

PubMed ID	Title	Journal	Year
22770216	Coordination of kinase and phosphatase activities by Lem4 enables nuclear envelope reassembly during mitosis Asencio, C, Davidson, IF, Santarella-Mellwig, R, Ly-Hartig, TB, Mall, M, Wallenfang, MR, Mattaj, IW, Gorjánácz, M	Cell	2012
20711181	Live-cell imaging RNAi screen identifies PP2A-B55alpha and importin-beta1 as key mitotic exit regulators in human cells Schmitz, MH, Held, M, Janssens, V, Hutchins, JR, Hudecz, O, Ivanova, E, Goris, J, Trinkle-Mulcahy, L, Lamond, AI, Poser, I, Hyman, AA, Mechtler, K, Peters, JM, Gerlich, DW	Nat. Cell Biol.	2010