Hydrolysis of ATP and release of folded actin from CCT/TriC

Stable Identifier
R-NUL-391437
Type
Reaction [dissociation]
Species
Bos taurus
Compartment
cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Hydrolysis of ATP and release of folded actin from CCT/TriC
TriC/CCT-mediated beta-actin folding involves rapid ATP-independent formation of a binary complex, followed by a slower ATP-dependent release of the native product (Gao et al., 1992). Group II chaperonins enclose substrate proteins following substrate binding through the formation of a "built- in" lid over the central cavity. Upon ATP binding, lid formation is triggered by the transition state of ATP hydrolysis (Meyer, et al., 2003).
Literature References
PubMed ID Title Journal Year
1351421 A cytoplasmic chaperonin that catalyzes beta-actin folding

Gao, Y, Thomas, JO, Chow, RL, Lee, GH, Cowan, NJ

Cell 1992
Participants
Input
Output
Orthologous Events
Hydrolysis of ATP and release of folded actin from CCT/TriC (Homo sapiens)
Authored
Matthews, L  (2009-02-06)
Reviewed
Cowan, NJ  (2009-01-21)
Created
Matthews, L  (2009-02-21)
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