Upon growth factor stimulation, KSR1 is dephosphorylated at S406 by PP2A, disrupting 14-3-3 binding and promoting membrane translocation of KSR1 (Ory et al, 2003; Muller et al, 2001; reviewed in Raabe and Raap, 2003).
Raabe, T, Rapp, UR
Piwnica-Worms, H, Muller, J, Ory, S, Copeland, T, Morrison, DK
Veenstra, TD, Ory, S, Zhou, M, Morrison, DK, Conrads, TP
protein serine/threonine phosphatase activity of PP2A [cytosol]
© 2023 Reactome