PP2A dephosphorylates KSR1

Stable Identifier
R-HSA-5672957
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
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PP2A dephosphorylates KSR1
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Upon growth factor stimulation, KSR1 is dephosphorylated at S406 by PP2A, disrupting 14-3-3 binding and promoting membrane translocation of KSR1 (Ory et al, 2003; Muller et al, 2001; reviewed in Raabe and Raap, 2003).

Literature References
PubMed ID Title Journal Year
11741534 C-TAK1 regulates Ras signaling by phosphorylating the MAPK scaffold, KSR1

Muller, J, Ory, S, Copeland, T, Piwnica-Worms, H, Morrison, DK

Mol Cell 2001
12932339 Ras signaling: PP2A puts Ksr and Raf in the right place

Raabe, T, Rapp, UR

Curr. Biol. 2003
12932319 Protein phosphatase 2A positively regulates Ras signaling by dephosphorylating KSR1 and Raf-1 on critical 14-3-3 binding sites

Ory, S, Zhou, M, Conrads, TP, Veenstra, TD, Morrison, DK

Curr Biol 2003
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine phosphatase activity of PP2A [cytosol]
Physical Entity
PP2A [cytosol]
Activity
protein serine/threonine phosphatase activity (0004722)
Orthologous Events
PP2A dephosphorylates KSR1 (Danio rerio)
PP2A dephosphorylates KSR1 (Dictyostelium discoideum)
PP2A dephosphorylates KSR1 (Gallus gallus)
PP2A dephosphorylates KSR1 (Mus musculus)
PP2A dephosphorylates KSR1 (Rattus norvegicus)
PP2A dephosphorylates KSR1 (Xenopus tropicalis)
Authored
Rothfels, K  (2015-02-06)
Reviewed
Roskoski, R Jr  (2015-04-29)
Created
Rothfels, K  (2015-02-06)