Reactome | PP2A dephosphorylates KSR1

PP2A dephosphorylates KSR1

Stable Identifier

R-HSA-5672957

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Upon growth factor stimulation, KSR1 is dephosphorylated at S406 by PP2A, disrupting 14-3-3 binding and promoting membrane translocation of KSR1 (Ory et al, 2003; Muller et al, 2001; reviewed in Raabe and Raap, 2003).

Literature References

PubMed ID	Title	Journal	Year
12932339	Ras signaling: PP2A puts Ksr and Raf in the right place Raabe, T, Rapp, UR	Curr. Biol.	2003
11741534	C-TAK1 regulates Ras signaling by phosphorylating the MAPK scaffold, KSR1 Muller, J, Ory, S, Copeland, T, Piwnica-Worms, H, Morrison, DK	Mol Cell	2001
12932319	Protein phosphatase 2A positively regulates Ras signaling by dephosphorylating KSR1 and Raf-1 on critical 14-3-3 binding sites Ory, S, Zhou, M, Conrads, TP, Veenstra, TD, Morrison, DK	Curr Biol	2003