Activation of BAD by calcineurin

Stable Identifier
R-HSA-139906
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Calcineurin, the Ca2+ activated protein phosphatase, dephosphorylates BAD, promoting dissociation of BAD from 14-3-3 proteins and the translocation of BAD to the outer mitochondrial membrane (Wang et al. 1999).

Literature References
PubMed ID Title Journal Year
10195903 Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD

Wang, HG, Pathan, N, Ethell, IM, Krajewski, S, Yamaguchi, Y, Shibasaki, F, McKeon, F, Bobo, T, Franke, TF, Reed, JC

Science 1999
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
calcium-dependent protein serine/threonine phosphatase regulator activity of Calcineurin B complex [cytosol]
Physical Entity
Activity
Orthologous Events
Created