Activation of BAD by calcineurin

Stable Identifier
R-HSA-139906
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Activation of BAD by calcineurin
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Calcineurin, the Ca2+ activated protein phosphatase, dephosphorylates BAD, promoting dissociation of BAD from 14-3-3 proteins and the translocation of BAD to the outer mitochondrial membrane (Wang et al. 1999).
Literature References
PubMed ID Title Journal Year
10195903 Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD

Shibasaki, F, Franke, TF, Wang, HG, Yamaguchi, Y, Krajewski, S, Pathan, N, McKeon, F, Reed, JC, Ethell, IM, Bobo, T

Science 1999
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Catalyst Activity

calcium-dependent protein serine/threonine phosphatase regulator activity of Calcineurin B complex [cytosol]

Physical Entity
Calcineurin B complex [cytosol] (Homo sapiens)
Activity
calcium-dependent protein serine/threonine phosphatase regulator activity (GO:0008597)
Orthologous Events
Activation of BAD by calcineurin (Bos taurus)
Activation of BAD by calcineurin (Canis familiaris)
Activation of BAD by calcineurin (Mus musculus)
Activation of BAD by calcineurin (Rattus norvegicus)
Activation of BAD by calcineurin (Sus scrofa)
Activation of BAD by calcineurin (Xenopus tropicalis)
Created
Hardwick, JM  (2004-08-09)
Tsujimoto, Y  (2004-08-09)
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