eIF2:GTP is hydrolyzed, eIFs are released

Stable Identifier
R-HSA-72619
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
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Once the Met-tRNAi has recognized the AUG, eIF2-bound GTP is hydrolyzed. The reaction is catalyzed by eIF5 (or eIF5B) and is thought to cause dissociation of all other initiation factors and allow joining of the large 60S ribosomal subunit. Release of the initiation factors from 40S leaves the Met-tRNAi in the ribosomal P-site base-paired to the start codon on the mRNA.

Participants
Participant Of
This event is regulated
Orthologous Events
Created