Polyglutamylase complex (Ttll1) polyglutamylates alpha subunits of tubulin

Stable Identifier
R-NUL-8955873
Type
Reaction [transition]
Species
Homo sapiens
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General
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Polyglutamylase complex (Ttll1) polyglutamylates alpha subunits of tubulin

Polyglutamylase complex polyglutamylates alpha subunits of tubulin. The complex contains Ttll1 (Tubulin tyrosine ligase-like 1) protein. The complex has been isolated from mouse tissue and four additional protein components have been identified (Janke et al. 2005). A mouse mutation that disrupts one of these, Tpgs1, is associated with failure of polyglytamylation of alpha-chains in microtubules (Ikegami et al. 2007).

Literature References
PubMed ID Title Journal Year
17360631 Loss of alpha-tubulin polyglutamylation in ROSA22 mice is associated with abnormal targeting of KIF1A and modulated synaptic function

Ikegami, K, Heier, RL, Taruishi, M, Takagi, H, Mukai, M, Shimma, S, Taira, S, Hatanaka, K, Morone, N, Yao, I, Campbell, PK, Yuasa, S, Janke, C, Macgregor, GR, Setou, M

Proc. Natl. Acad. Sci. U.S.A. 2007
15890843 Tubulin polyglutamylase enzymes are members of the TTL domain protein family

Janke, C, Rogowski, K, Wloga, D, Regnard, C, Kajava, AV, Strub, JM, Temurak, N, van Dijk, J, Boucher, D, van Dorsselaer, A, Suryavanshi, S, Gaertig, J, Eddé, B

Science 2005
Participants
Event Information
Go Biological Process
Catalyst Activity
Catalyst Activity
Title
tubulin-glutamic acid ligase activity of polyglutamylase complex [cytosol]
Physical Entity
Activity
Orthologous Events
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Created