ATP Hydrolysis By Myosin

Stable Identifier
Reaction [transition]
Homo sapiens
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Once ATP is bound, myosin, which is an ATPase, uses the energy from the cleavage of the terminal phosphate to pivot the myosin head back, away from the actin filamentous chain. This change in conformation "resets" the myosin molecule, leaving it ready to bind the actin filament once more and slide the myosin filament along the actin filament, continuing the contractile cycle.

Literature References
PubMed ID Title Journal Year
2526655 Characterization and differential expression of human vascular smooth muscle myosin light chain 2 isoform in nonmuscle cells

Kumar, CC, Leibowitz, PJ, Zavodny, PJ, Mohan, SR, Narula, SK

Biochemistry 1989
3780718 Isoforms of myosin and actin in human, monkey and rat myometrium. Comparison of pregnant and non-pregnant uterus proteins

d'Albis, A, Ropert, S, Janmot, C, Cavaillé, F

Eur J Biochem 1986
Catalyst Activity

myosin phosphatase activity of ATP Bound Smooth Muscle Myosin Complex [cytosol]

Orthologous Events
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