Endocytosis (internalization) of clathrin-coated vesicle

Stable Identifier
R-HSA-177501
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Dynamin is a microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. It is involved in vesicle trafficking processes and is necessary for endocytosis. Dynamins are large GTPases that bind to PIP2-containing membranes, several SH3-domain containing proteins and cytoskeletal modifiers. They self-polymerize in a GTP dependent manner, catalyzing the scission of invaginating membranes during endocytosis (Praefcke & McMahon, 2004). There are three dynamins in humans: dynamin I is neuron-specific; dynamin II shows ubiquitous expression; dynamin III is expressed in testis, brain, lung and blood platelets.

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
GTPase activity of Dynamin-1/2/3 [plasma membrane]
Physical Entity
Activity
Inferred From
Authored
Reviewed
Created