Insulin receptor de-phosphorylation

Stable Identifier
R-HSA-74733
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, endosome membrane
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Insulin receptor de-phosphorylation
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With insulin dissociated from its receptor the signal to sustain the receptor kinase's activity is also removed. Thus endosomally-associated protein tyrosine phosphatases (PTPs) are able to dephosphorylate the receptor which now can not rephosphorylate themselves since insulin is removed and the receptor is in the inactive protein conformation. (The identity of these PTPs is not clearly established yet.)

The dephosphorylation of the receptor is also a signal for the receptor to recycle back to the plasma membrane.

Literature References
PubMed ID Title Journal Year
9609117 Insulin receptor-associated protein tyrosine phosphatase(s): role in insulin action.

Drake, PG, Posner, BI

Mol Cell Biochem 1999
18406720 Intracellular Signal Transduction: The Role of Endosomes

Bevan, AP, Drake, PG, Bergeron, JJ, Posner, BI

Trends in Endocrinology and Metabolism 1996
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein tyrosine phosphatase activity of protein tyrosine phosphatase [cytosol]
Physical Entity
protein tyrosine phosphatase [cytosol]
Activity
protein tyrosine phosphatase activity (0004725)
Authored
Bevan, AP  (2003-07-31)
Created
Bevan, AP  (2003-07-31)