Endosomal protein tyrosine phosphatases (PTPs) dephosphorylate the insulin receptor, which cannot rephosphorylate itself as insulin is removed leaving the receptor in its inactive conformation (Bevan et al. 1996; Drake & Posner 1998). The identity of these PTPs is not definitively established, but structural studies and studies of cell lines and gene-knockout mice indicate that PTPRF / LAR (Ahmed & Goldstein 1997) and PTPN1 / PTP1B (Li et al. 2005) are each capable of mediating this reaction.
The dephosphorylated receptor recycles to the plasma membrane.
Ahmad, F, Goldstein, BJ
Depetris, RS, Hubbard, SR, Li, S, Barford, D, Chernoff, J
Drake, PG, Posner, BI
Bevan, AP, Drake, PG, Bergeron, JJ, Posner, BI
protein tyrosine phosphatase activity of PTPN1, PTPRF [endosome membrane]
© 2023 Reactome
