Vesicle budding

Stable Identifier
R-HSA-203973
Type
Reaction
Species
Homo sapiens
Compartment
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Once loaded the vesicles become fully sculpted, pinch off from the ER and bud into the cytosol. Budding depends on SAR1:GTPase activity and likely releases the SEC16 complex. SAR1:GTPase activity may result in partial uncoating of the emerging vesicle, allowing SEC23 to be exposed for subsequent TRAPPCII binding.

Literature References
PubMed ID Title Journal Year
10825291 COPI-coated ER-to-Golgi transport complexes segregate from COPII in close proximity to ER exit sites

Paccaud, JP, Lin-Marq, N, Stephens, DJ, Pagano, A, Pepperkok, R

J Cell Sci 2000
10982397 Dynamics of transitional endoplasmic reticulum sites in vertebrate cells

Glick, BS, Hammond, AT

Mol Biol Cell 2000
Participants
Participates
Catalyst Activity

GTPase activity of COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer:SEC13:SEC31:SEC23IP:v-SNARES [endoplasmic reticulum membrane]

Orthologous Events
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