Vesicle budding

Stable Identifier
R-HSA-203973
Type
Reaction [transition]
Species
Homo sapiens
Compartment
COPII-coated ER to Golgi transport vesicle, endoplasmic reticulum membrane
ReviewStatus
5/5
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Vesicle budding
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Once loaded the vesicles become fully sculpted, pinch off from the ER and bud into the cytosol. Budding depends on SAR1:GTPase activity and likely releases the SEC16 complex. SAR1:GTPase activity may result in partial uncoating of the emerging vesicle, allowing SEC23 to be exposed for subsequent TRAPPCII binding.
Literature References
PubMed ID Title Journal Year
10825291 COPI-coated ER-to-Golgi transport complexes segregate from COPII in close proximity to ER exit sites

Stephens, DJ, Lin-Marq, N, Pagano, A, Pepperkok, R, Paccaud, JP

J Cell Sci 2000
10982397 Dynamics of transitional endoplasmic reticulum sites in vertebrate cells

Hammond, AT, Glick, BS

Mol Biol Cell 2000
Participants
Input
Output
Participates
as an event of
Catalyst Activity

GTPase activity of COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer:SEC13:SEC31:SEC23IP:v-SNARES [endoplasmic reticulum membrane]

Physical Entity
COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer:SEC13:SEC31:SEC23IP:v-SNARES [endoplasmic reticulum membrane] (Homo sapiens)
Activity
GTPase activity (GO:0003924)
Orthologous Events
Vesicle budding (Bos taurus)
Vesicle budding (Caenorhabditis elegans)
Vesicle budding (Canis familiaris)
Vesicle budding (Gallus gallus)
Vesicle budding (Mus musculus)
Vesicle budding (Rattus norvegicus)
Vesicle budding (Sus scrofa)
Authored
Gillespie, ME  (2007-07-14)
Reviewed
Gagneux, P  (2010-11-18)
Created
Gillespie, ME  (2007-11-22)
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