Reactome | PTPN12 dephosphorylates PDGFRB at Y1021

PTPN12 dephosphorylates PDGFRB at Y1021

Stable Identifier

R-HSA-8864036

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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Protein tyrosine phosphatase PTNP12 dephosphorylates activated PDFRB (PDGF receptor beta) at tyrosine residue Y1021, which contributes to the tumor suppressor role of PTPN12 in triple negative breast cancer in addition to PTPN12-mediated dephosphorylation of ERBB2 (HER2) at Y1248 (Sun et al. 2011).

Literature References

PubMed ID	Title	Journal	Year
21376233	Activation of multiple proto-oncogenic tyrosine kinases in breast cancer via loss of the PTPN12 phosphatase Schmitt, E, Creighton, CJ, Hilsenbeck, SG, Gygi, SP, Bernardi, RJ, Osborne, CK, Westbrook, TF, Muzny, D, Kessler, JD, Shaw, CA, Pavlova, NN, Schiff, R, Hu, G, Sun, T, Elledge, SJ, Zhou, C, Bentires-Alj, M, Wheeler, DA, Dephoure, N, Huang, J, Li, MZ, Gibbs, RA, Rao, M, Nguyen, DX, Aceto, N, Meerbrey, KL, Migliaccio, I, Botero, M	Cell	2011