MTA is cleaved and phosphorylated

Stable Identifier
R-HSA-1237160
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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MTA phosphorylase catalyzes the cleavage of adenine from S-methylthioadenosine (MTA) and subsequent phosphorylation of the product, yielding 5'-methylthio ribose-1-phosphate (Kamatani et al. 1981). The active form of the enzyme is a homotrimer (Della Ragione et al. 1985). Mutations in the gene are associated with a rare bone dysplasia and cancer syndrome, DMS-MFH (Camacho-Vanegas et al. 2012).

Literature References
PubMed ID Title Journal Year
3091600 Purification and characterization of 5'-deoxy-5'-methylthioadenosine phosphorylase from human placenta

Della Ragione, F, Cartenì-Farina, M, Gragnaniello, V, Schettino, MI, Zappia, V

J Biol Chem 1986
6785752 Selective killing of human malignant cell lines deficient in methylthioadenosine phosphorylase, a purine metabolic enzyme

Kamatani, N, Nelson-Rees, WA, Carson, DA

Proc Natl Acad Sci U S A 1981
22464254 Primate Genome Gain and Loss: A Bone Dysplasia, Muscular Dystrophy, and Bone Cancer Syndrome Resulting from Mutated Retroviral-Derived MTAP Transcripts

Camacho-Vanegas, O, Camacho, SC, Till, J, Miranda-Lorenzo, I, Terzo, E, Ramirez, MC, Schramm, V, Cordovano, G, Watts, G, Mehta, S, Kimonis, V, Hoch, B, Philibert, KD, Raabe, CA, Bishop, DF, Glucksman, MJ, Martignetti, JA

Am J Hum Genet 2012
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
S-methyl-5-thioadenosine phosphorylase activity of MTAP trimer [cytosol]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created