Reactome | MTA is cleaved and phosphorylated

MTA is cleaved and phosphorylated

Stable Identifier

R-HSA-1237160

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

phosphate + S-methyl-5'-thioadenosine => adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate

ReviewStatus

5/5

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MTA phosphorylase catalyzes the cleavage of adenine from S-methylthioadenosine (MTA) and subsequent phosphorylation of the product, yielding 5'-methylthio ribose-1-phosphate (Kamatani et al. 1981). The active form of the enzyme is a homotrimer (Della Ragione et al. 1985). Mutations in the gene are associated with a rare bone dysplasia and cancer syndrome, DMS-MFH (Camacho-Vanegas et al. 2012).

Literature References

PubMed ID	Title	Journal	Year
6785752	Selective killing of human malignant cell lines deficient in methylthioadenosine phosphorylase, a purine metabolic enzyme Kamatani, N, Nelson-Rees, WA, Carson, DA	Proc Natl Acad Sci U S A	1981
3091600	Purification and characterization of 5'-deoxy-5'-methylthioadenosine phosphorylase from human placenta Della Ragione, F, Cartenì-Farina, M, Gragnaniello, V, Schettino, MI, Zappia, V	J Biol Chem	1986
22464254	Primate Genome Gain and Loss: A Bone Dysplasia, Muscular Dystrophy, and Bone Cancer Syndrome Resulting from Mutated Retroviral-Derived MTAP Transcripts Camacho-Vanegas, O, Camacho, SC, Till, J, Miranda-Lorenzo, I, Terzo, E, Ramirez, MC, Schramm, V, Cordovano, G, Watts, G, Mehta, S, Kimonis, V, Hoch, B, Philibert, KD, Raabe, CA, Bishop, DF, Glucksman, MJ, Martignetti, JA	Am J Hum Genet	2012