Reactome | ABCAs mediate lipid efflux

ABCAs mediate lipid efflux

Stable Identifier

R-HSA-1369028

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol, extracellular region

ReviewStatus

5/5

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The exact roles of ABCA2 (Vulevic et al. 2001, Kaminski et al. 2001), ABCA6 (Kaminski & Wenzel et al. 2001), ABCA9 (Piehler et al. 2002) and ABCA10 (Wenzel et al. 2003), candidates for ABC lipid transporter-related activities, need to be elucidated. Even thought cholesterol-responsiveness has been noted in experimental systems, contribution of these proteins in regulation or in active transport is not yet clear.

Literature References

PubMed ID	Title	Journal	Year
11178988	Complete coding sequence, promoter region, and genomic structure of the human ABCA2 gene and evidence for sterol-dependent regulation in macrophages Schmitz, G, Büchler, C, Püllmann, K, Duong, C, Bared, GM, Kaminski, WE, Porsch-Ozcürümez, M, Piehler, A	Biochem Biophys Res Commun	2001
12150964	Molecular structure of a novel cholesterol-responsive A subclass ABC transporter, ABCA9 Schmitz, G, Langmann, T, Wenzel, JJ, Kaminski, WE, Piehler, A	Biochem Biophys Res Commun	2002
11478798	ABCA6, a novel a subclass ABC transporter Schmitz, G, Langmann, T, Wenzel, JJ, Kaminski, WE, Piehler, A	Biochem Biophys Res Commun	2001
12821155	ABCA10, a novel cholesterol-regulated ABCA6-like ABC transporter Schmitz, G, Langmann, T, Heimerl, S, Wenzel, JJ, Kaminski, WE, Piehler, A	Biochem Biophys Res Commun	2003
11309290	Cloning and characterization of human adenosine 5'-triphosphate-binding cassette, sub-family A, transporter 2 (ABCA2) Belinsky, MG, Boyd, JT, Walsh, ES, Vulevic, B, Tew, KD, Davis W, Jr, Chen, Z	Cancer Res	2001