Translocation of TGN-lysosome vesicle to lysosome

Stable Identifier
Reaction [transition]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Budding vesicles loaded with the nonameric complex bud off from the TGN to reach the late-endosome/lysosome membrane.

Literature References
PubMed ID Title Journal Year
7650016 A role for acidic residues in di-leucine motif-based targeting to the endocytic pathway

Peterson, PA, Tainer, JA, Pond, L, Schutze, MP, Jackson, MR, Teyton, L, Kuhn, LA

J Biol Chem 1995
10480952 Direct transport of newly synthesized HLA-DR from the trans-Golgi network to major histocompatibility complex class II containing compartments (MIICS) demonstrated using a novel tyrosine-sulfated chimera

Davidson, HW

J Biol Chem 1999
8939989 Expression of major histocompatibility complex class II molecules in HeLa cells promotes the recruitment of AP-1 Golgi-specific assembly proteins on Golgi membranes

Goud, B, Hoflack, B, Salamero, J, Le Borgne, R, Saudrais, C

J Biol Chem 1996
7592972 Structure-activity relationship of the leucine-based sorting motifs in the cytosolic tail of the major histocompatibility complex-associated invariant chain

Morelli, MA, Frank, RW, Saviano, G, Bremnes, B, Motta, A, Bakke, O

J Biol Chem 1995
9497313 Medium chains of adaptor complexes AP-1 and AP-2 recognize leucine-based sorting signals from the invariant chain

Rodionov, DG, Bakke, O

J Biol Chem 1998
10593899 The leucine-based sorting motifs in the cytoplasmic domain of the invariant chain are recognized by the clathrin adaptors AP1 and AP2 and their medium chains

Dobberstein, B, Rodionov, D, von Figura, K, Höning, S, Bakke, O, Hofmann, MW

J Biol Chem 1999
2121367 MHC class II-associated invariant chain contains a sorting signal for endosomal compartments

Dobberstein, B, Bakke, O

Cell 1990
Catalyst Activity

GTPase activity of Dynamin [cytosol]

Orthologous Events
Cite Us!