ABCC1 transports cytosolic RCbl to extracellular region

Stable Identifier
R-HSA-3095901
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
an R-cob(III)alamin(out) + ATP + H2O => ADP + an R-cob(III)alamin(in) + H(+) + phosphate
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Multidrug resistance associated protein 1 (ABCC1, MRP1) mediates the ATP dependent export of free cobalamins (RCbl) from small intestine cells to the portal vein (Shah et al. 2011, Nielsen et al. 2012).

Literature References
PubMed ID Title Journal Year
21511966 Investigation of the ABC transporter MRP1 in selected patients with presumed defects in vitamin B12 absorption

Tanner, SM, Sturm, AC, Beech, CM, Shah, NP

Blood 2011
22547309 Vitamin B12 transport from food to the body's cells--a sophisticated, multistep pathway

Rasmussen, MR, Moestrup, SK, Andersen, CB, Nielsen, MJ, Nexø, E

Nat Rev Gastroenterol Hepatol 2012
Participants
Participates
Catalyst Activity

ABC-type vitamin B12 transporter activity of ABCC1 [plasma membrane]

Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
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