ABCC1 transports cytosolic Cbl to extracellular region

Stable Identifier
R-HSA-3095901
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Multidrug resistance-associated protein 1 (ABCC1, MRP1) can specifically mediate the ATP-dependant export of free cobalamin (Cbl aka vitamin B12) from small intestine cells to the portal vein (Shah et al. 2011).

Literature References
PubMed ID Title Journal Year
21511966 Investigation of the ABC transporter MRP1 in selected patients with presumed defects in vitamin B12 absorption

Shah, NP, Beech, CM, Sturm, AC, Tanner, SM

Blood 2011
Participants
Participates
Catalyst Activity

ABC-type vitamin B12 transporter activity of ABCC1 [plasma membrane]

Orthologous Events
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