Reactome | ABCC1 transports cytosolic RCbl to extracellular region

ABCC1 transports cytosolic RCbl to extracellular region

Stable Identifier

R-HSA-3095901

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, lysosomal lumen, lysosomal membrane

Synonyms

an R-cob(III)alamin(out) + ATP + H2O => ADP + an R-cob(III)alamin(in) + H(+) + phosphate

ReviewStatus

5/5

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ABCC1 transports cytosolic RCbl to extracellular region

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Multidrug resistance associated protein 1 (ABCC1, MRP1) mediates the ATP dependent export of free cobalamins (RCbl) from small intestine cells to the portal vein (Shah et al. 2011, Nielsen et al. 2012).

Literature References

PubMed ID	Title	Journal	Year
21511966	Investigation of the ABC transporter MRP1 in selected patients with presumed defects in vitamin B12 absorption Shah, NP, Beech, CM, Sturm, AC, Tanner, SM	Blood	2011
22547309	Vitamin B12 transport from food to the body's cells--a sophisticated, multistep pathway Nielsen, MJ, Rasmussen, MR, Andersen, CB, Nexø, E, Moestrup, SK	Nat Rev Gastroenterol Hepatol	2012