LHPP:Mg2+ dimer hydrolyses PPi

Stable Identifier
R-HSA-6788912
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Inorganic pyrophosphate (PPi) is continuously produced as a result of ATP-utilising biosynthesis of protein, RNA, and DNA. Inorganic pyrophosphatase (PPase) catalyses the hydrolysis of PPi into two orthophosphates (Pi) thereby minimizing the cellular level of PPi and driving otherwise reversible reactions in the direction of PPi generation. Phospholysine phosphohistidine inorganic pyrophosphate phosphatase (LHPP) is a dimeric protein, binding a Mg2+ in each subunit which can mediate the hydrolysis of PPi to 2xPi (Yokoi et al. 2003, Koike et al. 2006). LHPP is expressed in thyrocytes, located in the cytosol and nucleoplasm. In addition, LHPP is more prominently expressed in hyperfunctional states of the thyroid, such as in Graves disease and autonomously functional thyroid nodule (AFTN) (Koike et al. 2006).

Literature References
PubMed ID Title Journal Year
16430861 Expression of new human inorganic pyrophosphatase in thyroid diseases: its intimate association with hyperthyroidism

Koike, E, Toda, S, Yokoi, F, Izuhara, K, Koike, N, Itoh, K, Miyazaki, K, Sugihara, H

Biochem. Biophys. Res. Commun. 2006
12801912 Molecular cloning of a cDNA for the human phospholysine phosphohistidine inorganic pyrophosphate phosphatase

Yokoi, F, Hiraishi, H, Izuhara, K

J. Biochem. 2003
Participants
Output
Participant Of
Catalyst Activity
Catalyst Activity
Title
inorganic diphosphatase activity of LHPP:Mg2+ dimer [cytosol]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created