ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region

Stable Identifier
R-HSA-9661417
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, extracellular region, plasma membrane
ReviewStatus
5/5
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ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region
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Bilirubin glucuronides (BMG and BDG) are transported out of hepatocytes through their apical surfaces into the bile ducts, mainly by ABCC2 (MRP2) but also by the tetrameric efflux pump ATP-binding cassette sub-family G member 2 (ABCG2) (Xu et al. 2004).
Literature References
PubMed ID Title Journal Year
15001581 Characterization of oligomeric human half-ABC transporter ATP-binding cassette G2

Liu, Y, Xu, J, Bates, S, Zhang, JT, Yang, Y

J. Biol. Chem. 2004
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Catalyst Activity

bilirubin transmembrane transporter activity of ABCG2 tetramer [plasma membrane]

Physical Entity
ABCG2 tetramer [plasma membrane] (Homo sapiens)
Activity
bilirubin transmembrane transporter activity (GO:0015127)
Orthologous Events
ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Bos taurus)
ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Caenorhabditis elegans)
ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Canis familiaris)
ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Dictyostelium discoideum)
ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Drosophila melanogaster)
ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Mus musculus)
ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Plasmodium falciparum)
ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Rattus norvegicus)
ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Saccharomyces cerevisiae)
ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Sus scrofa)
ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Xenopus tropicalis)
Authored
Jassal, B  (2019-09-16)
Reviewed
D'Eustachio, P  (2019-10-03)
Created
Jassal, B  (2019-09-16)
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