NANS converts ManNAc-6-P to Neu5Ac-9-P

Stable Identifier
R-HSA-4084976
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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NANS converts ManNAc-6-P to Neu5Ac-9-P
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Sialic acid synthase (NANS, SAS) can convert N-acetylmannosamine 6-phosphate (ManNAc-6-P) to N-acetylneuraminate 9-phosphate (Neu5Ac-9-P) (Lawrence et al. 2000). NANS shows lower activity towards ManNAc and can convert it to Neu5Ac (not shown here, Lawrence et al. 2000).
Literature References
PubMed ID Title Journal Year
10749855 Cloning and expression of the human N-acetylneuraminic acid phosphate synthase gene with 2-keto-3-deoxy-D-glycero- D-galacto-nononic acid biosynthetic ability

Nguyen, N, Coleman, TA, Huddleston, KA, Lee, YC, Lawrence, SM, Betenbaugh, MJ, Vann, WF, Pitts, LR

J. Biol. Chem. 2000
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Catalyst Activity

N-acylneuraminate-9-phosphate synthase activity of NANS [cytosol]

Physical Entity
NANS [cytosol] (Homo sapiens)
Activity
N-acylneuraminate-9-phosphate synthase activity (GO:0047444)
Orthologous Events
NANS converts ManNAc-6-P to Neu5Ac-9-P (Bos taurus)
NANS converts ManNAc-6-P to Neu5Ac-9-P (Canis familiaris)
NANS converts ManNAc-6-P to Neu5Ac-9-P (Danio rerio)
NANS converts ManNAc-6-P to Neu5Ac-9-P (Drosophila melanogaster)
NANS converts ManNAc-6-P to Neu5Ac-9-P (Gallus gallus)
NANS converts ManNAc-6-P to Neu5Ac-9-P (Mus musculus)
NANS converts ManNAc-6-P to Neu5Ac-9-P (Rattus norvegicus)
NANS converts ManNAc-6-P to Neu5Ac-9-P (Sus scrofa)
NANS converts ManNAc-6-P to Neu5Ac-9-P (Xenopus tropicalis)
Authored
Jassal, B  (2013-08-01)
Reviewed
Wickramasinghe, S  (2014-01-08)
Medrano, JF  (2014-01-08)
Created
Jassal, B  (2013-08-01)
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