NANS converts ManNAc-6-P to Neu5Ac-9-P

Stable Identifier
R-HSA-4084976
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Sialic acid synthase (NANS, SAS) can convert N-acetylmannosamine 6-phosphate (ManNAc-6-P) to N-acetylneuraminate 9-phosphate (Neu5Ac-9-P) (Lawrence et al. 2000). NANS shows lower activity towards ManNAc and can convert it to Neu5Ac (not shown here, Lawrence et al. 2000).

Literature References
PubMed ID Title Journal Year
10749855 Cloning and expression of the human N-acetylneuraminic acid phosphate synthase gene with 2-keto-3-deoxy-D-glycero- D-galacto-nononic acid biosynthetic ability

Lawrence, SM, Huddleston, KA, Pitts, LR, Nguyen, N, Lee, YC, Vann, WF, Coleman, TA, Betenbaugh, MJ

J. Biol. Chem. 2000
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
N-acylneuraminate-9-phosphate synthase activity of NANS [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created