Reactome | (d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate (NT5C1A)

(d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate (NT5C1A)

Stable Identifier

R-HSA-109387

Type

Reaction

Species

Homo sapiens

Compartment

cytosol

Synonyms

(2'-deoxy)purine nucleoside 5'-monophosphate + H2O => (2'-deoxy)purine nucleoside + orthophosphate [NT5C1A]

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(d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate (NT5C1A)

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Cytosolic 5'-nucleotidase IA catalyzes the hydrolysis of purine ribo- and deoxyribonucleoside monophosphates to nucleosides plus orthophosphate. The enzyme is allosterically activated by ADP (Hunsucker et al. 2001). The human enzyme is inferred to be a homotetramer with one Mg++ ion bound per subunit, based on its similarity to the pigeon heart enzyme (Bianchi and Spychala 2003; Sala-Newby et al. 1999; Skladanowski and Newby 1990).

Literature References

PubMed ID	Title	Journal	Year
11133996	Human cytosolic 5'-nucleotidase I. Characterization and role in nucleoside analog resistance Hunsucker, SA, Spychala, J, Mitchell, BS	J Biol Chem	2001
10364222	The mechanism of adenosine formation in cells. Cloning of cytosolic 5'-nucleotidase-I Skladanowski, A, Newby, AC, Sala-Newby, GB	J Biol Chem	1999
12947102	Mammalian 5'-nucleotidases Spychala, J, Bianchi, V	J Biol Chem	2003
2344353	Partial purification and properties of an AMP-specific soluble 5'-nucleotidase from pigeon heart Skladanowski, A, Newby, AC	Biochem J	1990