PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane

Stable Identifier
R-HSA-1676162
Type
Reaction
Species
Homo sapiens
Compartment
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At the early endosome membrane, type I (INPP4A) (Norris et al. 1995, Ivetac et al. 2005) and type II inositol-3,4-bisphosphate 4-phosphatase (INPP4B) (Norris et al. 1997) colocalise with early and recycling endosomes through their C2 domains which bind to the phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2) present in these membranes. It is here that phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2) is dephosphorylated by INPP4A/B to phosphatidylinositol 3-phosphate (PI3P).

Literature References
PubMed ID Title Journal Year
7608176 The isolation and characterization of cDNA encoding human and rat brain inositol polyphosphate 4-phosphatase

Auethavekiat, V, Majerus, PW, Norris, FA

J Biol Chem 1995
15716355 The type Ialpha inositol polyphosphate 4-phosphatase generates and terminates phosphoinositide 3-kinase signals on endosomes and the plasma membrane

Luff, S, Majerus, PW, Kisseleva, MV, Rowe, T, Zhang, XM, Tiganis, T, Munday, AD, Ivetac, I, Mitchell, CA, Whisstock, JC

Mol Biol Cell 2005
9295334 The cDNA cloning and characterization of inositol polyphosphate 4-phosphatase type II. Evidence for conserved alternative splicing in the 4-phosphatase family

Atkins, RC, Majerus, PW, Norris, FA

J Biol Chem 1997
Participants
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Catalyst Activity

phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity of INPP4A/B [cytosol]

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