Reactome | SLC37A1, SLC37A2 exchange G6P for Pi across the ER membrane

SLC37A1, SLC37A2 exchange G6P for Pi across the ER membrane

Stable Identifier

R-HSA-3257122

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, endoplasmic reticulum membrane, endoplasmic reticulum lumen

Synonyms

alpha-D-glucose 6-phosphate (cytosol) + orthophosphate (ER lumen) => alpha-D-glucose 6-phosphate (ER lumen) + orthophosphate (cytosol) (SLC37A1 or SLC37A2)

ReviewStatus

5/5

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SLC37A1, SLC37A2 exchange G6P for Pi across the ER membrane

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The SLC37A1 and SLC37A2 transport proteins mediate the exchange of G6P (glucose-6-phosphate) and Pi (orthophosphate) across lipid bilayer membranes in vitro, and both proteins are located in the endoplasmic reticulum membrane. Their physiological function, however, is unknown (Pan et al. 2011; Chou et al. 2013).

Literature References

PubMed ID	Title	Journal	Year
21949678	SLC37A1 and SLC37A2 are phosphate-linked, glucose-6-phosphate antiporters Pan, CJ, Chen, SY, Jun, HS, Lin, SR, Mansfield, BC, Chou, JY	PLoS ONE	2011
23506893	The SLC37 family of phosphate-linked sugar phosphate antiporters Chou, JY, Sik Jun, H, Mansfield, BC	Mol. Aspects Med.	2013