SLC37A1, SLC37A2 exchange G6P for Pi across the endoplasmic reticulum membrane

Stable Identifier
R-HSA-3257122
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
alpha-D-glucose 6-phosphate (cytosol) + orthophosphate (ER lumen) => alpha-D-glucose 6-phosphate (ER lumen) + orthophosphate (cytosol) (SLC37A1 or SLC37A2)
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The SLC37A1 and SLC37A2 transport proteins mediate the exchange of glucose-6-phosphate and orthophosphate across lipid bilayer membranes in vitro, and both proteins are located in the endoplasmic reticulum membrane. Their physiological function, however, is unknown (Pan et al. 2011; Chou et al. 2013).

Literature References
PubMed ID Title Journal Year
23506893 The SLC37 family of phosphate-linked sugar phosphate antiporters

Chou, JY, Sik Jun, H, Mansfield, BC

Mol. Aspects Med. 2013
21949678 SLC37A1 and SLC37A2 are phosphate-linked, glucose-6-phosphate antiporters

Pan, CJ, Chen, SY, Jun, HS, Lin, SR, Mansfield, BC, Chou, JY

PLoS ONE 2011
Participants
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Event Information
Catalyst Activity
Catalyst Activity
Title
glucose 6-phosphate:inorganic phosphate antiporter activity of SLC37A1,2 [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
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Reviewed
Created