Reactome | I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane

I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane

Stable Identifier

R-HSA-1855213

Type

Reaction

Species

Homo sapiens

Compartment

plasma membrane, cytosol

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I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane

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Type II inositol-1,4,5-trisphosphate 5-phosphatase (INPP5B) is attached to the plasma membrane where it dephosphorylates inositol 1,3,4,5-tetrakisphosphate (I(1,3,4,5)P4) to inositol 1,3,4-trisphosphate (I(1,3,4)P3 (Jefferson & Majerus 1995, Ross et al. 1991, Schmid et al. 2004). INPP5B is isoprenylated at its C-terminus for membrane attachment.

Literature References

PubMed ID	Title	Journal	Year
15474001	Type II phosphoinositide 5-phosphatases have unique sensitivities towards fatty acid composition and head group phosphorylation Woscholski, R, Schmid, AC, Nussbaum, R, Mitchell, CA, Wise, HM	FEBS Lett	2004
7721860	Properties of type II inositol polyphosphate 5-phosphatase Jefferson, AB, Majerus, PW	J Biol Chem	1995
1718960	Cloning and expression of human 75-kDa inositol polyphosphate-5-phosphatase Ross, TS, Jefferson, AB, Majerus, PW, Mitchell, CA	J Biol Chem	1991