I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane

Stable Identifier
R-HSA-1855213
Type
Reaction
Species
Homo sapiens
Compartment
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Type II inositol-1,4,5-trisphosphate 5-phosphatase (INPP5B) is attached to the plasma membrane where it dephosphorylates inositol 1,3,4,5-tetrakisphosphate (I(1,3,4,5)P4) to inositol 1,3,4-trisphosphate (I(1,3,4)P3 (Jefferson & Majerus 1995, Ross et al. 1991, Schmid et al. 2004). INPP5B is isoprenylated at its C-terminus for membrane attachment.

Literature References
PubMed ID Title Journal Year
15474001 Type II phosphoinositide 5-phosphatases have unique sensitivities towards fatty acid composition and head group phosphorylation

Woscholski, R, Schmid, AC, Nussbaum, R, Mitchell, CA, Wise, HM

FEBS Lett 2004
7721860 Properties of type II inositol polyphosphate 5-phosphatase

Jefferson, AB, Majerus, PW

J Biol Chem 1995
1718960 Cloning and expression of human 75-kDa inositol polyphosphate-5-phosphatase

Ross, TS, Jefferson, AB, Majerus, PW, Mitchell, CA

J Biol Chem 1991
Participants
Participates
Catalyst Activity

inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity of Inositol polyphosphate 5-phosphatase [plasma membrane]

Orthologous Events
Cross References
Rhea
Authored
Created
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