I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane

Stable Identifier
R-HSA-1855213
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
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I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane
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Type II inositol-1,4,5-trisphosphate 5-phosphatase (INPP5B) is attached to the plasma membrane where it dephosphorylates inositol 1,3,4,5-tetrakisphosphate (I(1,3,4,5)P4) to inositol 1,3,4-trisphosphate (I(1,3,4)P3 (Jefferson & Majerus 1995, Ross et al. 1991, Schmid et al. 2004). INPP5B is isoprenylated at its C-terminus for membrane attachment.

Literature References
PubMed ID Title Journal Year
15474001 Type II phosphoinositide 5-phosphatases have unique sensitivities towards fatty acid composition and head group phosphorylation

Woscholski, R, Schmid, AC, Nussbaum, R, Mitchell, CA, Wise, HM

FEBS Lett 2004
7721860 Properties of type II inositol polyphosphate 5-phosphatase

Jefferson, AB, Majerus, PW

J Biol Chem 1995
1718960 Cloning and expression of human 75-kDa inositol polyphosphate-5-phosphatase

Ross, TS, Jefferson, AB, Majerus, PW, Mitchell, CA

J Biol Chem 1991
Participants
Input
Output
Participates
as an event of
Catalyst Activity

inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity of Inositol polyphosphate 5-phosphatase [plasma membrane]

Physical Entity
Inositol polyphosphate 5-phosphatase [plasma membrane] (Homo sapiens)
Activity
inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity (GO:0052659)
Orthologous Events
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Bos taurus)
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Caenorhabditis elegans)
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Canis familiaris)
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Danio rerio)
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Dictyostelium discoideum)
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Drosophila melanogaster)
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Gallus gallus)
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Mus musculus)
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Plasmodium falciparum)
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Rattus norvegicus)
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Saccharomyces cerevisiae)
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Schizosaccharomyces pombe)
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Sus scrofa)
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Xenopus tropicalis)
Cross References
Rhea
Authored
Williams, MG  (2011-10-28)
Created
Williams, MG  (2011-10-28)
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