Reactome | I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane

I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane

Stable Identifier

R-HSA-1855213

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane

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Type II inositol-1,4,5-trisphosphate 5-phosphatase (INPP5B) is attached to the plasma membrane where it dephosphorylates inositol 1,3,4,5-tetrakisphosphate (I(1,3,4,5)P4) to inositol 1,3,4-trisphosphate (I(1,3,4)P3 (Jefferson & Majerus 1995, Ross et al. 1991, Schmid et al. 2004). INPP5B is isoprenylated at its C-terminus for membrane attachment.

Literature References

PubMed ID	Title	Journal	Year
15474001	Type II phosphoinositide 5-phosphatases have unique sensitivities towards fatty acid composition and head group phosphorylation Schmid, AC, Wise, HM, Mitchell, CA, Nussbaum, R, Woscholski, R	FEBS Lett	2004
7721860	Properties of type II inositol polyphosphate 5-phosphatase Jefferson, AB, Majerus, PW	J Biol Chem	1995
1718960	Cloning and expression of human 75-kDa inositol polyphosphate-5-phosphatase Ross, TS, Jefferson, AB, Mitchell, CA, Majerus, PW	J Biol Chem	1991