Reactome | FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG

FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG

Stable Identifier

R-HSA-200681

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Conversion of cytosolic 5-methyltetrahydrofolate (5-methylTHF) to 5-methylTHF-polyglutamate

ReviewStatus

5/5

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FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG

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Cytosolic folylpolyglutamate synthase catalyzes the reaction of 5-methylTHF-glutamate(n), L-glutamate, and ATP to form 5-methylTHF-glutamate(n+1), ADP, and orthophosphate. (The first glutamate residue is attached to the glutamate moiety of 5-methylTHF itself; for convenience the process is annotated here as if it proceeded in a single concerted step.) The extent of conjugation is variable, but the commonest cytosolic form of 5-methylTHF has five added glutamate residues. Although its properties as a donor of one-carbon units are not affected by glutamate addition, 5-methylTHF that lacks added glutamate residues cannot be retained in the cytosol so this reaction is needed for normal 5-methylTHF function under physiological conditions (Garrow et al. 1992; Chen et al. 1996).

Literature References

PubMed ID	Title	Journal	Year
1409616	Expression cloning of a human cDNA encoding folylpoly(gamma-glutamate) synthetase and determination of its primary structure Garrow, TA, Admon, A, Shane, B	Proc Natl Acad Sci U S A	1992
8662720	Purification and properties of human cytosolic folylpoly-gamma-glutamate synthetase and organization, localization, and differential splicing of its gene Chen, L, Qi, H, Korenberg, J, Garrow, TA, Choi, YJ, Shane, B	J Biol Chem	1996