NUDT18 hydrolyses 8-OH-dADP to 8-OH-dAMP

Stable Identifier
R-HSA-2395965
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
8-hydroxy-dADP + H2O => 8-hydroxy-dAMP + Pi
Locations in the PathwayBrowser
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NUDT18 (MTH3) catalyzes the reaction of 8-hydroxy-dADP and water to form 8-hydroxy-dAMP and Pi (orthophosphate) (Takagi et al. 2012). The subcellular location of NUDT18 has not been established but is assumed to be cytosolic like NUDT1.

Literature References
PubMed ID Title Journal Year
22556419 Human MTH3 (NUDT18) Protein Hydrolyzes Oxidized Forms of Guanosine and Deoxyguanosine Diphosphates: COMPARISON WITH MTH1 AND MTH2

Takagi, Y, Setoyama, D, Ito, R, Kamiya, H, Yamagata, Y, Sekiguchi, M

J. Biol. Chem. 2012
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
8-hydroxy-dADP phosphatase activity of NUDT18-1 [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created