NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP

Stable Identifier
R-HSA-2395965
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Synonyms
8-hydroxy-dADP + H2O => 8-hydroxy-dAMP + Pi
ReviewStatus
5/5
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NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
NUDT18 (MTH3) catalyzes the reaction of 8-oxo-dADP and water to form 8-oxo-dAMP and Pi (orthophosphate) (Takagi et al. 2012). The subcellular location of NUDT18 has not been established but is assumed to be cytosolic like NUDT1.
Literature References
PubMed ID Title Journal Year
22556419 Human MTH3 (NUDT18) Protein Hydrolyzes Oxidized Forms of Guanosine and Deoxyguanosine Diphosphates: COMPARISON WITH MTH1 AND MTH2

Takagi, Y, Ito, R, Sekiguchi, M, Yamagata, Y, Setoyama, D, Kamiya, H

J. Biol. Chem. 2012
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Catalyst Activity

8-hydroxy-dADP phosphatase activity of NUDT18-1 [cytosol]

Physical Entity
NUDT18-1 [cytosol] (Homo sapiens)
Activity
8-hydroxy-dADP phosphatase activity (GO:0044717)
Orthologous Events
NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Bos taurus)
NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Caenorhabditis elegans)
NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Canis familiaris)
NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Danio rerio)
NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Drosophila melanogaster)
NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Mus musculus)
NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Rattus norvegicus)
NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Sus scrofa)
NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Xenopus tropicalis)
Cross References
Rhea
Authored
D'Eustachio, P  (2012-07-06)
Reviewed
Ito, R  (2012-10-05)
Created
D'Eustachio, P  (2012-07-06)
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