Recruitment of RAB11FIP3 to the trans-Golgi network (TGN) simulates ASAP1 to activate the ARF4 GTPase activity, causing the hydrolysis of GTP and the release of ARF4:GDP from the Golgi membrane (Mazelova et al, 2009; Inoue et al, 2008; reviewed in Deretic, 2013).
Inoue, H, Prekeris, R, Randazzo, PA, Ha, VL
Deretic, D, Schonteich, E, Inoue, H, Mazelova, J, Prekeris, R, Astuto-Gribble, L, Moritz, OL, Randazzo, PA, Tam, BM
Deretic, D
GTPase activity of RAB11A:GTP:RAB11FIP3 dimer:ASAP1 dimer:ARF4:GTP:VxPx-containing ciliary membrane proteins [Golgi membrane]
© 2023 Reactome