ASAP1 stimulates GTPase activity of ARF4

Stable Identifier
Reaction [transition]
Homo sapiens
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Recruitment of RAB11FIP3 to the trans-Golgi network (TGN) simulates ASAP1 to activate the ARF4 GTPase activity, causing the hydrolysis of GTP and the release of ARF4:GDP from the Golgi membrane (Mazelova et al, 2009; Inoue et al, 2008; reviewed in Deretic, 2013).

Literature References
PubMed ID Title Journal Year
18685082 Arf GTPase-activating protein ASAP1 interacts with Rab11 effector FIP3 and regulates pericentrosomal localization of transferrin receptor-positive recycling endosome

Inoue, H, Prekeris, R, Randazzo, PA, Ha, VL

Mol. Biol. Cell 2008
19153612 Ciliary targeting motif VxPx directs assembly of a trafficking module through Arf4

Deretic, D, Schonteich, E, Inoue, H, Mazelova, J, Prekeris, R, Astuto-Gribble, L, Moritz, OL, Randazzo, PA, Tam, BM

EMBO J. 2009
23567335 Crosstalk of Arf and Rab GTPases en route to cilia

Deretic, D

Small GTPases 2013
Catalyst Activity

GTPase activity of RAB11A:GTP:RAB11FIP3 dimer:ASAP1 dimer:ARF4:GTP:VxPx-containing ciliary membrane proteins [Golgi membrane]

Orthologous Events
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