ASAP1 stimulates GTPase activity of ARF4

Stable Identifier
R-HSA-5623513
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Recruitment of RAB11FIP3 to the trans-Golgi network (TGN) simulates ASAP1 to activate the ARF4 GTPase activity, causing the hydrolysis of GTP and the release of ARF4:GDP from the Golgi membrane (Mazelova et al, 2009; Inoue et al, 2008; reviewed in Deretic, 2013).

Literature References
PubMed ID Title Journal Year
19153612 Ciliary targeting motif VxPx directs assembly of a trafficking module through Arf4

Mazelova, J, Astuto-Gribble, L, Inoue, H, Tam, BM, Schonteich, E, Prekeris, R, Moritz, OL, Randazzo, PA, Deretic, D

EMBO J. 2009
18685082 Arf GTPase-activating protein ASAP1 interacts with Rab11 effector FIP3 and regulates pericentrosomal localization of transferrin receptor-positive recycling endosome

Inoue, H, Ha, VL, Prekeris, R, Randazzo, PA

Mol. Biol. Cell 2008
23567335 Crosstalk of Arf and Rab GTPases en route to cilia

Deretic, D

Small GTPases 2013
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
GTPase activity of RAB11A:GTP:RAB11FIP3 dimer:ASAP1 dimer:ARF4:GTP:VxPx-containing ciliary membrane proteins [Golgi membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created