Reactome | ASAP1 stimulates GTPase activity of ARF4

ASAP1 stimulates GTPase activity of ARF4

Stable Identifier

R-HSA-5623513

Type

Reaction [transition]

Species

Homo sapiens

Compartment

Golgi membrane

ReviewStatus

5/5

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ASAP1 stimulates GTPase activity of ARF4

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Recruitment of RAB11FIP3 to the trans-Golgi network (TGN) simulates ASAP1 to activate the ARF4 GTPase activity, causing the hydrolysis of GTP and the release of ARF4:GDP from the Golgi membrane (Mazelova et al, 2009; Inoue et al, 2008; reviewed in Deretic, 2013).

Literature References

PubMed ID	Title	Journal	Year
18685082	Arf GTPase-activating protein ASAP1 interacts with Rab11 effector FIP3 and regulates pericentrosomal localization of transferrin receptor-positive recycling endosome Inoue, H, Ha, VL, Prekeris, R, Randazzo, PA	Mol. Biol. Cell	2008
19153612	Ciliary targeting motif VxPx directs assembly of a trafficking module through Arf4 Mazelova, J, Astuto-Gribble, L, Inoue, H, Tam, BM, Schonteich, E, Prekeris, R, Moritz, OL, Randazzo, PA, Deretic, D	EMBO J.	2009
23567335	Crosstalk of Arf and Rab GTPases en route to cilia Deretic, D	Small GTPases	2013