ATP4A/12A:ATP4B exchanges K+ for H+

Stable Identifier
Reaction [transition]
Homo sapiens
The K+-transporting ATPase mediates the exchange of potassium and hydrogen ions
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The potassium-transporting ATPase heterodimer (ATP4A/12A:ATP4B) catalyzes the hydrolysis of ATP coupled with the exchange of H+ and K+ ions across the plasma membrane. It is composed of alpha and beta chains. Two human genes encode the catalytic alpha subunit, ATP4A and ATP12A (Maeda et al, 1990; Grishin et al, 1994). ATP4A is responsible for acid production in the stomach. ATP12A is responsible for potassium absorption in various tissues. One human gene encodes the beta subunit, ATP4B (Ma et al, 1991).

Literature References
PubMed ID Title Journal Year
2160952 Human gastric (H+ + K+)-ATPase gene. Similarity to (Na+ + K+)-ATPase genes in exon/intron organization but difference in control region

Maeda, M, Oshiman, K, Tamura, S, Futai, M

J Biol Chem 1990
8045293 Cloning and characterization of the entire cDNA encoded by ATP1AL1--a member of the human Na,K/H,K-ATPase gene family

Grishin, AV, Sverdlov, VE, Kostina, MB, Modyanov, NN

FEBS Lett 1994
1656976 cDNA cloning of the beta-subunit of the human gastric H,K-ATPase

Ma, JY, Song, YH, Sjöstrand, SE, Rask, L, Mårdh, S

Biochem Biophys Res Commun 1991
Participant Of
Catalyst Activity
Catalyst Activity
potassium:proton exchanging ATPase activity of ATP4A/12A:ATP4B [plasma membrane]
Physical Entity
Orthologous Events
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