Reactome | ATP12A:ATP4B exchanges K+ for H+

ATP12A:ATP4B exchanges K+ for H+

Stable Identifier

R-HSA-937311

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

The K+-transporting ATPase mediates the exchange of potassium and hydrogen ions

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The potassium-transporting ATPase heterodimer comprising of catalytic alpha and stabilising beta chains (ATP12A:ATP4B), catalyzes the hydrolysis of ATP coupled with the exchange of H+ and K+ ions across the plasma membrane. The human gene ATP12A encodes the catalytic alpha subunit (Grishin et al. 1994). One human gene encodes the beta subunit, ATP4B (Ma et al. 1991). ATP12A is responsible for potassium absorption in various tissues.

Literature References

PubMed ID	Title	Journal	Year
8045293	Cloning and characterization of the entire cDNA encoded by ATP1AL1--a member of the human Na,K/H,K-ATPase gene family Grishin, AV, Sverdlov, VE, Kostina, MB, Modyanov, NN	FEBS Lett	1994
1656976	cDNA cloning of the beta-subunit of the human gastric H,K-ATPase Ma, JY, Song, YH, Sjöstrand, SE, Rask, L, Mårdh, S	Biochem Biophys Res Commun	1991