ATP12A:ATP4B exchanges K+ for H+

Stable Identifier
R-HSA-937311
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
The K+-transporting ATPase mediates the exchange of potassium and hydrogen ions
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The potassium-transporting ATPase heterodimer comprising of catalytic alpha and stabilising beta chains (ATP12A:ATP4B), catalyzes the hydrolysis of ATP coupled with the exchange of H+ and K+ ions across the plasma membrane. The human gene ATP12A encodes the catalytic alpha subunit (Grishin et al. 1994). One human gene encodes the beta subunit, ATP4B (Ma et al. 1991). ATP12A is responsible for potassium absorption in various tissues.

Literature References
PubMed ID Title Journal Year
1656976 cDNA cloning of the beta-subunit of the human gastric H,K-ATPase

Ma, JY, Song, YH, Sjöstrand, SE, Rask, L, Mårdh, S

Biochem Biophys Res Commun 1991
8045293 Cloning and characterization of the entire cDNA encoded by ATP1AL1--a member of the human Na,K/H,K-ATPase gene family

Grishin, AV, Sverdlov, VE, Kostina, MB, Modyanov, NN

FEBS Lett 1994
Participants
Participates
Catalyst Activity

P-type potassium:proton transporter activity of ATP12A:ATP4B [plasma membrane]

Orthologous Events
Authored
Reviewed
Created
Cite Us!