Cytosolic CTP synthase 2 (CTPS) catalyzes the reaction of UTP, glutamine, ATP and water to form CTP, glutamate, ADP, and orthophosphate (Han et al. 2005; van Kuilenberg et al. 2000). Unpublished X-ray crystallographic data suggest that the enzyme is a tetramer (PDB 3IHL). Both CTPS2 and a second human gene product, CPTS, have CTP synthase activity in various test systems; their relative contributions to CTP metabolism in the body is not clear.
Han, GS, Sreenivas, A, Choi, MG, Chang, YF, Martin, SS, Baldwin, EP, Carman, GM
van Kuilenberg, AB, Meinsma, R, Vreken, P, Waterham, HR, van Gennip, AH
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