UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2]

Stable Identifier
R-HSA-504054
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
amination of uridine 5'-triphosphate (UTP) to form cytidine 5'-triphosphate (CTP)
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Cytosolic CTP synthase 2 (CTPS) catalyzes the reaction of UTP, glutamine, ATP and water to form CTP, glutamate, ADP, and orthophosphate (Han et al. 2005; van Kuilenberg et al. 2000). Unpublished X-ray crystallographic data suggest that the enzyme is a tetramer (PDB 3IHL). Both CTPS2 and a second human gene product, CPTS, have CTP synthase activity in various test systems; their relative contributions to CTP metabolism in the body is not clear.

Literature References
PubMed ID Title Journal Year
16179339 Expression of Human CTP synthetase in Saccharomyces cerevisiae reveals phosphorylation by protein kinase A

Han, GS, Sreenivas, A, Choi, MG, Chang, YF, Martin, SS, Baldwin, EP, Carman, GM

J Biol Chem 2005
10899599 Identification of a cDNA encoding an isoform of human CTP synthetase

van Kuilenberg, AB, Meinsma, R, Vreken, P, Waterham, HR, van Gennip, AH

Biochim Biophys Acta 2000
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
CTP synthase activity of CTPS2 tetramer [cytosol]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Created