UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2]

Stable Identifier
Reaction [transition]
Homo sapiens
amination of uridine 5'-triphosphate (UTP) to form cytidine 5'-triphosphate (CTP)
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Cytosolic CTP synthase 2 (CTPS) catalyzes the reaction of UTP, glutamine, ATP and water to form CTP, glutamate, ADP, and orthophosphate (Han et al. 2005; van Kuilenberg et al. 2000). Unpublished X-ray crystallographic data suggest that the enzyme is a tetramer (PDB 3IHL). Both CTPS2 and a second human gene product, CPTS, have CTP synthase activity in various test systems; their relative contributions to CTP metabolism in the body is not clear.

Literature References
PubMed ID Title Journal Year
10899599 Identification of a cDNA encoding an isoform of human CTP synthetase

van Gennip, AH, Vreken, P, van Kuilenberg, AB, Waterham, HR, Meinsma, R

Biochim Biophys Acta 2000
16179339 Expression of Human CTP synthetase in Saccharomyces cerevisiae reveals phosphorylation by protein kinase A

Martin, SS, Baldwin, EP, Choi, MG, Carman, GM, Chang, YF, Sreenivas, A, Han, GS

J Biol Chem 2005
Catalyst Activity

CTP synthase activity of CTPS2 tetramer [cytosol]

Orthologous Events
Cross References
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