Cytosolic CTP synthase 2 (CTPS) catalyzes the reaction of UTP, glutamine, ATP and water to form CTP, glutamate, ADP, and orthophosphate (Han et al. 2005; van Kuilenberg et al. 2000). Unpublished X-ray crystallographic data suggest that the enzyme is a tetramer (PDB 3IHL). Both CTPS2 and a second human gene product, CPTS, have CTP synthase activity in various test systems; their relative contributions to CTP metabolism in the body is not clear.
van Gennip, AH, Vreken, P, van Kuilenberg, AB, Waterham, HR, Meinsma, R
Martin, SS, Baldwin, EP, Choi, MG, Carman, GM, Chang, YF, Sreenivas, A, Han, GS
CTP synthase activity of CTPS2 tetramer [cytosol]
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