Reactome | UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2]

UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2]

Stable Identifier

R-HSA-504054

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

amination of uridine 5'-triphosphate (UTP) to form cytidine 5'-triphosphate (CTP)

ReviewStatus

5/5

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UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2]

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Cytosolic CTP synthase 2 (CTPS) catalyzes the reaction of UTP, glutamine, ATP and water to form CTP, glutamate, ADP, and orthophosphate (Han et al. 2005; van Kuilenberg et al. 2000). Unpublished X-ray crystallographic data suggest that the enzyme is a tetramer (PDB 3IHL). Both CTPS2 and a second human gene product, CPTS, have CTP synthase activity in various test systems; their relative contributions to CTP metabolism in the body is not clear.

Literature References

PubMed ID	Title	Journal	Year
10899599	Identification of a cDNA encoding an isoform of human CTP synthetase van Kuilenberg, AB, Meinsma, R, Vreken, P, Waterham, HR, van Gennip, AH	Biochim Biophys Acta	2000
16179339	Expression of Human CTP synthetase in Saccharomyces cerevisiae reveals phosphorylation by protein kinase A Han, GS, Sreenivas, A, Choi, MG, Chang, YF, Martin, SS, Baldwin, EP, Carman, GM	J Biol Chem	2005